{"id":"https://openalex.org/W7221015409","doi":"https://doi.org/10.3389/fphar.2026.1972486","title":"Cellular senescence in ovarian cancer: a proposed geroncogenic shift linking aging, plasticity, and therapy resistance","display_name":"Cellular senescence in ovarian cancer: a proposed geroncogenic shift linking aging, plasticity, and therapy resistance","publication_year":2026,"publication_date":"2026-10-08","ids":{"openalex":"https://openalex.org/W7221015409","doi":"https://doi.org/10.3389/fphar.2026.1972486","pmid":"https://pubmed.ncbi.nlm.nih.gov/42923116","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13687671"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2026.1972486","doi":"https://doi.org/10.3389/fphar.2026.1972486","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1972486","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1972486/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1972486/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157956904","display_name":"Yubo Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119987","display_name":"Qingdao Municipal Hospital","ror":"https://ror.org/02jqapy19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119987"]},{"id":"https://openalex.org/I4405280210","display_name":"University of Health and Rehabilitation Sciences","ror":"https://ror.org/02kjtx631","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280210"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yubo Zhang","raw_affiliation_strings":["Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital)","institution_ids":["https://openalex.org/I4210119987","https://openalex.org/I4405280210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157946561","display_name":"Yufei Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119987","display_name":"Qingdao Municipal Hospital","ror":"https://ror.org/02jqapy19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119987"]},{"id":"https://openalex.org/I4405280210","display_name":"University of Health and Rehabilitation Sciences","ror":"https://ror.org/02kjtx631","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280210"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yufei Han","raw_affiliation_strings":["Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital)","institution_ids":["https://openalex.org/I4210119987","https://openalex.org/I4405280210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157940590","display_name":"Ping Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119987","display_name":"Qingdao Municipal Hospital","ror":"https://ror.org/02jqapy19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119987"]},{"id":"https://openalex.org/I4405280210","display_name":"University of Health and Rehabilitation Sciences","ror":"https://ror.org/02kjtx631","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280210"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Hou","raw_affiliation_strings":["Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital)","institution_ids":["https://openalex.org/I4210119987","https://openalex.org/I4405280210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100647260","display_name":"Weina Zhang","orcid":"https://orcid.org/0000-0003-0904-6008","observed_orcids":["https://orcid.org/0000-0003-0904-6008"]},"institutions":[{"id":"https://openalex.org/I4210119987","display_name":"Qingdao Municipal Hospital","ror":"https://ror.org/02jqapy19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119987"]},{"id":"https://openalex.org/I4405280210","display_name":"University of Health and Rehabilitation Sciences","ror":"https://ror.org/02kjtx631","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280210"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weina Zhang","raw_affiliation_strings":["Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital)","institution_ids":["https://openalex.org/I4210119987","https://openalex.org/I4405280210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157982695","display_name":"Meng Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119987","display_name":"Qingdao Municipal Hospital","ror":"https://ror.org/02jqapy19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119987"]},{"id":"https://openalex.org/I4405280210","display_name":"University of Health and Rehabilitation Sciences","ror":"https://ror.org/02kjtx631","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280210"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Wu","raw_affiliation_strings":["Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital)","institution_ids":["https://openalex.org/I4210119987","https://openalex.org/I4405280210"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086110592","display_name":"Mengqi Deng","orcid":"https://orcid.org/0000-0003-1710-0094","observed_orcids":["https://orcid.org/0000-0003-1710-0094"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210163952","display_name":"Beijing Obstetrics and Gynecology Hospital","ror":"https://ror.org/05787my06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163952"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mengqi Deng","raw_affiliation_strings":["Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Healthcare Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Healthcare Hospital, Capital Medical University","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210163952"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5086110592"],"corresponding_institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210163952"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.47747748,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1972486","last_page":"1972486"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8679999709129333},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8169999718666077},{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.9779999852180481},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.7160000205039978},{"id":"https://openalex.org/keywords/cellular-plasticity","display_name":"cellular plasticity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/senescence-escape","display_name":"senescence escape","score":0.8849999904632568},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6909999847412109},{"id":"https://openalex.org/keywords/stromal-fibroblasts","display_name":"stromal fibroblasts","score":0.9269999861717224},{"id":"https://openalex.org/keywords/polyploidy","display_name":"polyploidy","score":0.7929999828338623},{"id":"https://openalex.org/keywords/senolytics","display_name":"senolytics","score":0.6690000295639038},{"id":"https://openalex.org/keywords/senescence-associated-inflammation","display_name":"senescence-associated inflammation","score":0.4909999966621399},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.8330000042915344},{"id":"https://openalex.org/keywords/tumor-evolution","display_name":"tumor evolution","score":0.4959999918937683},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.7904000282287598},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7608000040054321},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6431999802589417},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5932000279426575},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.576200008392334},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5730999708175659},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.4724000096321106},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.43059998750686646},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42559999227523804},{"id":"https://openalex.org/C2780096491","wikidata":"https://www.wikidata.org/wiki/Q60574533","display_name":"Cellular stress response","level":4,"score":0.4185999929904938},{"id":"https://openalex.org/C156902634","wikidata":"https://www.wikidata.org/wiki/Q5058346","display_name":"Cellular adaptation","level":3,"score":0.41429999470710754},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4068000018596649},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.37720000743865967},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.36959999799728394},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.362199991941452},{"id":"https://openalex.org/C2779523775","wikidata":"https://www.wikidata.org/wiki/Q9075999","display_name":"Cellular senescence","level":4,"score":0.3571999967098236},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3555999994277954},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.34279999136924744},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3375999927520752},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33649998903274536},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.3357999920845032},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.32199999690055847},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.31049999594688416},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3070000112056732},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.30379998683929443},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.2921000123023987},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.2881999909877777},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.2879999876022339},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.28630000352859497},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.2824000120162964},{"id":"https://openalex.org/C78885561","wikidata":"https://www.wikidata.org/wiki/Q189055","display_name":"Cellular compartment","level":3,"score":0.2809000015258789},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.2696000039577484},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26190000772476196},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2551000118255615},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.25429999828338623},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.2522999942302704},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.25049999356269836}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2026.1972486","doi":"https://doi.org/10.3389/fphar.2026.1972486","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1972486","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1972486/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13687671","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13687671/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13687671/pdf/fphar-17-1972486.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:42923116","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42923116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9f12617b409e4cfea685a06142df4953","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9f12617b409e4cfea685a06142df4953","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2026.1972486","doi":"https://doi.org/10.3389/fphar.2026.1972486","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1972486","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1972486/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3568865137","display_name":null,"funder_award_id":"82503173","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6776561762","display_name":null,"funder_award_id":"2025M782191","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321496","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320323068","display_name":"Beijing Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221015409.pdf","grobid_xml":"https://content.openalex.org/works/W7221015409.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1033197108","https://openalex.org/W1664805715","https://openalex.org/W2061765285","https://openalex.org/W2067401053","https://openalex.org/W2071225892","https://openalex.org/W2087404852","https://openalex.org/W2095898647","https://openalex.org/W2104908670","https://openalex.org/W2115852450","https://openalex.org/W2147030667","https://openalex.org/W2147915491","https://openalex.org/W2155462862","https://openalex.org/W2216554257","https://openalex.org/W2283712035","https://openalex.org/W2529083907","https://openalex.org/W2609784527","https://openalex.org/W2682764345","https://openalex.org/W2793353239","https://openalex.org/W2902300797","https://openalex.org/W2912918280","https://openalex.org/W2951114010","https://openalex.org/W2952156113","https://openalex.org/W2988310131","https://openalex.org/W2995771616","https://openalex.org/W3000364256","https://openalex.org/W3000984298","https://openalex.org/W3003996234","https://openalex.org/W3035532414","https://openalex.org/W3099043519","https://openalex.org/W3112632289","https://openalex.org/W3128646645","https://openalex.org/W3153190759","https://openalex.org/W3202107994","https://openalex.org/W3206022180","https://openalex.org/W4210615291","https://openalex.org/W4213091566","https://openalex.org/W4280535717","https://openalex.org/W4281913683","https://openalex.org/W4285732944","https://openalex.org/W4287958571","https://openalex.org/W4289545008","https://openalex.org/W4313531093","https://openalex.org/W4320484909","https://openalex.org/W4366827290","https://openalex.org/W4385056503","https://openalex.org/W4387578776","https://openalex.org/W4388733804","https://openalex.org/W4389286866","https://openalex.org/W4391619368","https://openalex.org/W4392082086","https://openalex.org/W4393041934","https://openalex.org/W4393258188","https://openalex.org/W4396851465","https://openalex.org/W4398223359","https://openalex.org/W4400526721","https://openalex.org/W4401559256","https://openalex.org/W4401801150","https://openalex.org/W4403289916","https://openalex.org/W4406617325","https://openalex.org/W4407874996","https://openalex.org/W4410506801","https://openalex.org/W4412631722","https://openalex.org/W7154829549","https://openalex.org/W7162857756"],"related_works":["https://openalex.org/W3034838851","https://openalex.org/W3112632289","https://openalex.org/W7202096978","https://openalex.org/W4406756580","https://openalex.org/W2799671034","https://openalex.org/W4416020059","https://openalex.org/W4282572715","https://openalex.org/W4414583921","https://openalex.org/W3000984298","https://openalex.org/W3137794328"],"abstract_inverted_index":{"Ovarian":[0],"cancer":[1],"develops":[2],"within":[3,51],"a":[4,46,89,156,187,292,368],"biological":[5],"environment":[6],"that":[7,104,167,251,316],"changes":[8,96,226],"substantially":[9],"with":[10,219,375],"age.":[11],"Beyond":[12],"chronological":[13],"aging,":[14,135],"progressive":[15,127],"alterations":[16],"in":[17,38,97,227,340],"genome":[18],"maintenance,":[19],"telomere":[20],"integrity,":[21],"epigenetic":[22],"regulation,":[23],"mitochondrial":[24],"function,":[25],"metabolism,":[26],"inflammation,":[27,277],"and":[28,35,72,110,131,136,204,222,229,237,242,272,278,309,321,351,358,378],"immune":[29],"surveillance":[30],"can":[31,56,73,233,252],"reshape":[32,234],"the":[33,58,78,86,120,126,141,163,196,246,261,318],"cellular":[34,130,189,199,249,319],"tissue":[36,98,132],"context":[37,320],"which":[39],"tumor":[40,179,271,376],"evolution":[41,377],"occurs.":[42],"Cellular":[43,153],"senescence":[44,55,154,184,211,264,289,312,325,332],"represents":[45],"critical":[47],"point":[48],"of":[49,60,88,119,129,144,248,263,311,324],"convergence":[50],"this":[52],"process.":[53],"Although":[54],"restrict":[57],"proliferation":[59,214],"damaged":[61,169],"or":[62,150,174,208,295,338],"oncogenically":[63],"stressed":[64],"cells,":[65],"persistent":[66,173],"senescent":[67],"cells":[68,170,267],"remain":[69],"metabolically":[70],"active":[71],"alter":[74],"their":[75],"surroundings":[76],"through":[77],"senescence-associated":[79],"secretory":[80],"phenotype":[81],"(SASP).":[82],"Here,":[83],"we":[84],"propose":[85,315],"concept":[87],"geroncogenic":[90,363],"shift":[91,364],"to":[92,125,140,178,195,384],"describe":[93],"how":[94],"age-associated":[95],"homeostasis":[99,133],"may":[100,212],"create":[101],"stress-response":[102,146],"states":[103,244],"are":[105],"subsequently":[106],"exploited":[107],"by":[108,268],"malignant":[109],"stromal":[111,231,273],"cells.":[112],"We":[113,314],"distinguish":[114,301],"two":[115],"named,":[116],"complementary":[117],"components":[118],"framework:":[121],"systemic":[122],"decline,":[123],"referring":[124,139],"deterioration":[128],"during":[134],"pathway-specific":[137],"hijacking,":[138],"selective":[142,382],"co-option":[143],"altered":[145],"pathways":[147],"under":[148],"oncogenic":[149],"therapeutic":[151,223,255,284,298,344],"pressure.":[152],"provides":[155,367],"functional":[157],"interface":[158],"between":[159,302],"these":[160],"processes":[161],"because":[162],"same":[164],"stress":[165],"responses":[166],"constrain":[168],"can,":[171],"when":[172,331],"incompletely":[175],"resolved,":[176],"contribute":[177],"adaptation.":[180],"In":[181],"ovarian":[182,341],"cancer,":[183],"is":[185],"not":[186],"uniform":[188],"endpoint.":[190],"Its":[191],"consequences":[192],"vary":[193],"according":[194],"initiating":[197],"stress,":[198],"compartment,":[200],"molecular":[201],"program,":[202],"duration,":[203],"capacity":[205],"for":[206,329,346,371,379],"recovery":[207],"escape.":[209,313],"Tumor-cell":[210],"suppress":[213],"yet":[215],"also":[216],"be":[217,327,334],"associated":[218],"stem-like":[220],"adaptation":[221],"persistence.":[224],"Senescence-associated":[225],"fibroblasts":[228],"other":[230],"populations":[232],"inflammatory":[235],"signaling":[236],"treatment":[238,360],"response,":[239],"while":[240],"polyploid":[241],"senescence-like":[243],"illustrate":[245],"extent":[247],"plasticity":[250],"exist":[253],"after":[254],"stress.":[256],"The":[257,362],"SASP":[258,305],"further":[259],"extends":[260],"effects":[262],"beyond":[265],"individual":[266],"influencing":[269],"neighboring":[270],"populations,":[274],"extracellular-matrix":[275],"remodeling,":[276],"dissemination.":[279],"This":[280],"perspective":[281],"has":[282],"important":[283],"implications.":[285],"Rather":[286],"than":[287],"treating":[288],"as":[290],"either":[291],"uniformly":[293],"protective":[294],"pathogenic":[296],"state,":[297],"strategies":[299,348],"should":[300,333],"senescent-cell":[303],"elimination,":[304],"modulation,":[306],"metabolic":[307],"vulnerabilities,":[308],"prevention":[310],"understanding":[317],"temporal":[322],"dynamics":[323],"will":[326,354],"essential":[328],"determining":[330],"induced,":[335],"maintained,":[336],"modulated,":[337],"eliminated":[339],"cancer.":[342],"Most":[343],"evidence":[345],"senescence-directed":[347,385],"remains":[349],"preclinical,":[350],"clinical":[352],"translation":[353],"require":[355],"cell-type-specific":[356],"biomarkers":[357],"optimized":[359],"timing.":[361],"framework":[365],"therefore":[366],"conceptual":[369],"basis":[370],"linking":[372],"aging":[373],"biology":[374],"developing":[380],"more":[381],"approaches":[383],"therapy.":[386]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-09T00:00:00"}
