{"id":"https://openalex.org/W7221009979","doi":"https://doi.org/10.64898/2026.10.02.756216","title":"Palmitoylation of the p75 neurotrophin receptor is required for retrograde regressive signaling","display_name":"Palmitoylation of the p75 neurotrophin receptor is required for retrograde regressive signaling","publication_year":2026,"publication_date":"2026-10-08","ids":{"openalex":"https://openalex.org/W7221009979","doi":"https://doi.org/10.64898/2026.10.02.756216","pmid":"https://pubmed.ncbi.nlm.nih.gov/42926557","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13692058"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.02.756216","doi":"https://doi.org/10.64898/2026.10.02.756216","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.756216","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.10.02.756216","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050943335","display_name":"Amrita Pathak","orcid":"https://orcid.org/0000-0003-1396-9868","observed_orcids":["https://orcid.org/0000-0003-1396-9868"]},"institutions":[{"id":"https://openalex.org/I191972202","display_name":"Amity University","ror":"https://ror.org/02n9z0v62","country_code":"IN","type":"education","lineage":["https://openalex.org/I191972202"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["IN","US"],"is_corresponding":true,"raw_author_name":"Amrita Pathak","raw_affiliation_strings":["Amity Institute of Neuropsychology and Neurosciences, Amity University Noida, India","Department of Biochemistry and Vanderbilt Brain Institute, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN"],"raw_orcid":"https://orcid.org/0000-0003-1396-9868","affiliations":[{"raw_affiliation_string":"Amity Institute of Neuropsychology and Neurosciences, Amity University Noida, India","institution_ids":["https://openalex.org/I191972202"]},{"raw_affiliation_string":"Department of Biochemistry and Vanderbilt Brain Institute, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090934066","display_name":"Hrishita Das","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hrishita Das","raw_affiliation_strings":["Department of Biochemistry and Vanderbilt Brain Institute, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Vanderbilt Brain Institute, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002116131","display_name":"Pooja Shukla","orcid":"https://orcid.org/0009-0006-7229-4783","observed_orcids":["https://orcid.org/0009-0006-7229-4783"]},"institutions":[{"id":"https://openalex.org/I191972202","display_name":"Amity University","ror":"https://ror.org/02n9z0v62","country_code":"IN","type":"education","lineage":["https://openalex.org/I191972202"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pooja Shukla","raw_affiliation_strings":["Amity Institute of Neuropsychology and Neurosciences, Amity University Noida, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amity Institute of Neuropsychology and Neurosciences, Amity University Noida, India","institution_ids":["https://openalex.org/I191972202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040793588","display_name":"Austin B. Keeler","orcid":"https://orcid.org/0000-0002-6148-0891","observed_orcids":["https://orcid.org/0000-0002-6148-0891"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]},{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Austin B. Keeler","raw_affiliation_strings":["Department of Biological Sciences, University of Delaware, Newark, DE","Department of Biology, University of Virginia, Charlottesville, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Delaware, Newark, DE","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Department of Biology, University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026328537","display_name":"Christopher D. Deppmann","orcid":"https://orcid.org/0000-0002-6591-1767","observed_orcids":["https://orcid.org/0000-0002-6591-1767"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher D. Deppmann","raw_affiliation_strings":["Department of Biology, University of Virginia, Charlottesville, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086563058","display_name":"Bruce Douglas Carter","orcid":"https://orcid.org/0000-0002-3242-6634","observed_orcids":["https://orcid.org/0000-0002-3242-6634"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce D. Carter","raw_affiliation_strings":["Department of Biochemistry and Vanderbilt Brain Institute, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN"],"raw_orcid":"https://orcid.org/0000-0002-3242-6634","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Vanderbilt Brain Institute, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5050943335"],"corresponding_institution_ids":["https://openalex.org/I191972202","https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p75-neurotrophin-receptor","display_name":"p75 neurotrophin receptor","score":1.0},{"id":"https://openalex.org/keywords/protein-palmitoylation","display_name":"palmitoylation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/retrograde-signaling","display_name":"retrograde signaling","score":0.8410000205039978},{"id":"https://openalex.org/keywords/regulated-intramembrane-proteolysis","display_name":"regulated intramembrane proteolysis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.8700000047683716},{"id":"https://openalex.org/keywords/neuronal-pruning","display_name":"neuronal pruning","score":0.550000011920929},{"id":"https://openalex.org/keywords/axon-degeneration","display_name":"axonal degeneration","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C146727910","wikidata":"https://www.wikidata.org/wiki/Q501620","display_name":"Palmitoylation","level":4,"score":0.9009000062942505},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.8198000192642212},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7694000005722046},{"id":"https://openalex.org/C134139212","wikidata":"https://www.wikidata.org/wiki/Q24719927","display_name":"Trk receptor","level":4,"score":0.6310999989509583},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.5644999742507935},{"id":"https://openalex.org/C56703729","wikidata":"https://www.wikidata.org/wiki/Q14897872","display_name":"Low-affinity nerve growth factor receptor","level":4,"score":0.559499979019165},{"id":"https://openalex.org/C171034665","wikidata":"https://www.wikidata.org/wiki/Q14897694","display_name":"Tropomyosin receptor kinase A","level":4,"score":0.5012000203132629},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4878999888896942},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4458000063896179},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.4406999945640564},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.43869999051094055},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.4291999936103821},{"id":"https://openalex.org/C2778283623","wikidata":"https://www.wikidata.org/wiki/Q18032200","display_name":"TSG101","level":5,"score":0.4174000024795532},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40639999508857727},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3937000036239624},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.37049999833106995},{"id":"https://openalex.org/C2777265534","wikidata":"https://www.wikidata.org/wiki/Q14916427","display_name":"Furin","level":3,"score":0.3278999924659729},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.325300008058548},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.31929999589920044},{"id":"https://openalex.org/C194082555","wikidata":"https://www.wikidata.org/wiki/Q7317034","display_name":"Retrograde signaling","level":3,"score":0.31439998745918274},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.29120001196861267},{"id":"https://openalex.org/C132538176","wikidata":"https://www.wikidata.org/wiki/Q24768287","display_name":"Semaphorin","level":3,"score":0.290800005197525},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.28619998693466187},{"id":"https://openalex.org/C83415579","wikidata":"https://www.wikidata.org/wiki/Q161973","display_name":"Arc (geometry)","level":2,"score":0.28139999508857727},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.2784000039100647},{"id":"https://openalex.org/C2779683492","wikidata":"https://www.wikidata.org/wiki/Q792615","display_name":"Axotomy","level":3,"score":0.26269999146461487},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.2612000107765198},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.2599000036716461},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.2538999915122986},{"id":"https://openalex.org/C97124661","wikidata":"https://www.wikidata.org/wiki/Q14897782","display_name":"Tropomyosin receptor kinase B","level":4,"score":0.2524999976158142},{"id":"https://openalex.org/C2780976139","wikidata":"https://www.wikidata.org/wiki/Q14906081","display_name":"Amphiphysin","level":5,"score":0.2524999976158142},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.25099998712539673}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.10.02.756216","doi":"https://doi.org/10.64898/2026.10.02.756216","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.756216","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42926557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42926557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13692058","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13692058/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.10.02.756216","doi":"https://doi.org/10.64898/2026.10.02.756216","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.756216","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1551390553","https://openalex.org/W1551938923","https://openalex.org/W1600856176","https://openalex.org/W1605328799","https://openalex.org/W1616842526","https://openalex.org/W1971615503","https://openalex.org/W1972871020","https://openalex.org/W1974513572","https://openalex.org/W1978332280","https://openalex.org/W1990073151","https://openalex.org/W1997831655","https://openalex.org/W2005301611","https://openalex.org/W2010592389","https://openalex.org/W2024559161","https://openalex.org/W2028489659","https://openalex.org/W2029730520","https://openalex.org/W2044024554","https://openalex.org/W2048752370","https://openalex.org/W2073374252","https://openalex.org/W2102252670","https://openalex.org/W2124910340","https://openalex.org/W2134678910","https://openalex.org/W2149187994","https://openalex.org/W2151320555","https://openalex.org/W2154745705","https://openalex.org/W2159951830","https://openalex.org/W2169826464","https://openalex.org/W2217207757","https://openalex.org/W2478278334","https://openalex.org/W2885639913","https://openalex.org/W2940865433","https://openalex.org/W2966058216","https://openalex.org/W3022596476","https://openalex.org/W4221089271","https://openalex.org/W4385689623","https://openalex.org/W4391945226","https://openalex.org/W4415676173"],"related_works":["https://openalex.org/W2048752370","https://openalex.org/W110788922","https://openalex.org/W2582918829","https://openalex.org/W2885639913","https://openalex.org/W2008133833","https://openalex.org/W2572596207","https://openalex.org/W2149187994","https://openalex.org/W1974513572","https://openalex.org/W2048937996","https://openalex.org/W2407681748"],"abstract_inverted_index":{"Abstract":[0],"Target-derived":[1],"neurotrophins":[2],"regulate":[3],"neuronal":[4],"survival":[5],"and":[6,77,87,113,191],"pruning":[7],"via":[8,100],"retrograde":[9,44,206],"signaling.":[10],"Unlike":[11],"Trk":[12],"receptors,":[13],"which":[14],"are":[15],"transported":[16],"as":[17,57,138],"transmembrane":[18],"proteins,":[19],"the":[20,88,106,151,197],"p75":[21],"neurotrophin":[22,163],"receptor":[23,164,189],"(p75NTR)":[24],"undergoes":[25],"regulated":[26],"intramembrane":[27],"proteolysis":[28],"to":[29,131,146,200,205],"release":[30],"a":[31,51,58,101,167,193],"soluble":[32],"intracellular":[33,159],"domain":[34,160],"(ICD)":[35,161],"that":[36,69,142],"must":[37],"somehow":[38],"associate":[39],"with":[40],"axonal":[41,111],"endosomes":[42,112,203],"for":[43,61,74,84,186,195],"transport.":[45],"Here,":[46],"we":[47,67],"identify":[48],"palmitoylation":[49,71,137],"of":[50,90,108,127,154,162],"conserved":[52,180],"juxta":[53],"membrane":[54],"cysteine":[55],"(C281)":[56],"critical":[59],"requirement":[60],"this":[62],"process.":[63],"In":[64,117],"sympathetic":[65,128],"neurons,":[66,129],"demonstrate":[68],"p75NTR":[70,132,144,165],"is":[72,81,166,184],"dispensable":[73],"surface":[75],"trafficking":[76],"proteolytic":[78],"cleavage":[79,145,175],"but":[80],"strictly":[82],"required":[83],"ligand-induced":[85],"internalization":[86,190],"biogenesis":[89],"p75ICD-positive":[91],"signaling":[92,202],"endosomes.":[93],"Consequently,":[94],"blocking":[95],"palmitoylation,":[96],"either":[97],"pharmacologically":[98],"or":[99],"palmitoylation-deficient":[102],"C281A":[103,120],"mutation,":[104],"prevents":[105],"accumulation":[107],"p75ICD":[109,199],"in":[110,176],"blocks":[114],"axon-initiated":[115],"apoptosis.":[116],"vivo":[118],",":[119],"knock-in":[121],"mice":[122],"exhibit":[123],"reduced":[124],"developmental":[125],"apoptosis":[126],"similar":[130],"deletion.":[133],"These":[134],"findings":[135],"define":[136],"an":[139],"essential":[140],"checkpoint":[141],"couples":[143],"endosomal":[147],"segregation,":[148],"thereby":[149],"enabling":[150],"long-distance":[152,168],"transmission":[153],"regressive":[155,201],"signals.":[156],"Synopsis":[157],"The":[158],"death":[169],"signal":[170],"generated":[171],"by":[172],"its":[173],"local":[174],"axons.":[177],"Palmitoylation":[178],"at":[179],"juxtamembrane":[181],"Cysteine":[182],"residue":[183],"necessary":[185],"ligand":[187],"induced":[188],"provides":[192],"tether":[194],"attaching":[196],"cleaved":[198],"leading":[204],"neuron":[207],"death.":[208]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-09T00:00:00"}
