{"id":"https://openalex.org/W7221006930","doi":"https://doi.org/10.3389/fphar.2026.1956477","title":"Gypenoside LI modulates autophagy-associated apoptosis in clear cell renal cell carcinoma by PPARG/PTEN/PI3K/AKT/mTOR/ULK1 signaling network","display_name":"Gypenoside LI modulates autophagy-associated apoptosis in clear cell renal cell carcinoma by PPARG/PTEN/PI3K/AKT/mTOR/ULK1 signaling network","publication_year":2026,"publication_date":"2026-10-08","ids":{"openalex":"https://openalex.org/W7221006930","doi":"https://doi.org/10.3389/fphar.2026.1956477","pmid":"https://pubmed.ncbi.nlm.nih.gov/42923378","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13687397"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2026.1956477","doi":"https://doi.org/10.3389/fphar.2026.1956477","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1956477","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1956477/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1956477/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112939528","display_name":"Ruyi Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107741","display_name":"Affiliated Hospital of Chengde Medical College","ror":"https://ror.org/01bgds823","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruyi Liu","raw_affiliation_strings":["Department of Urology, Affiliated Hospital of Chengde Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Affiliated Hospital of Chengde Medical University","institution_ids":["https://openalex.org/I4210107741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135954698","display_name":"Hao Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107741","display_name":"Affiliated Hospital of Chengde Medical College","ror":"https://ror.org/01bgds823","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Yu","raw_affiliation_strings":["Department of Urology, Affiliated Hospital of Chengde Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Affiliated Hospital of Chengde Medical University","institution_ids":["https://openalex.org/I4210107741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157913582","display_name":"Hui Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192578869","display_name":"Chengde Medical University","ror":"https://ror.org/02bzkv281","country_code":"CN","type":"education","lineage":["https://openalex.org/I192578869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Liu","raw_affiliation_strings":["Department of Prescription & TCM, School of Traditional Chinese Medicine, Chengde Medical University","Hebei Universities Characteristic Sericulture Application Technology Research and Development Center, Sericultural Research Institute, Chengde Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prescription & TCM, School of Traditional Chinese Medicine, Chengde Medical University","institution_ids":["https://openalex.org/I192578869"]},{"raw_affiliation_string":"Hebei Universities Characteristic Sericulture Application Technology Research and Development Center, Sericultural Research Institute, Chengde Medical University","institution_ids":["https://openalex.org/I192578869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140506897","display_name":"Yujie Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107741","display_name":"Affiliated Hospital of Chengde Medical College","ror":"https://ror.org/01bgds823","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujie Wei","raw_affiliation_strings":["Department of Urology, Affiliated Hospital of Chengde Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Affiliated Hospital of Chengde Medical University","institution_ids":["https://openalex.org/I4210107741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110440772","display_name":"Anxin Wang","orcid":"https://orcid.org/0000-0003-4351-2877","observed_orcids":["https://orcid.org/0000-0003-4351-2877"]},"institutions":[{"id":"https://openalex.org/I192578869","display_name":"Chengde Medical University","ror":"https://ror.org/02bzkv281","country_code":"CN","type":"education","lineage":["https://openalex.org/I192578869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anxin Wang","raw_affiliation_strings":["Department of Prescription & TCM, School of Traditional Chinese Medicine, Chengde Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prescription & TCM, School of Traditional Chinese Medicine, Chengde Medical University","institution_ids":["https://openalex.org/I192578869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135958300","display_name":"Qi Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192578869","display_name":"Chengde Medical University","ror":"https://ror.org/02bzkv281","country_code":"CN","type":"education","lineage":["https://openalex.org/I192578869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Huang","raw_affiliation_strings":["Department of Prescription & TCM, School of Traditional Chinese Medicine, Chengde Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prescription & TCM, School of Traditional Chinese Medicine, Chengde Medical University","institution_ids":["https://openalex.org/I192578869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100677936","display_name":"Hui Xu","orcid":"https://orcid.org/0000-0002-7596-8011","observed_orcids":["https://orcid.org/0000-0002-7596-8011"]},"institutions":[{"id":"https://openalex.org/I4210107741","display_name":"Affiliated Hospital of Chengde Medical College","ror":"https://ror.org/01bgds823","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Xu","raw_affiliation_strings":["Department of Urology, Affiliated Hospital of Chengde Medical University","Hebei Key Laboratory of Panvascular Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Affiliated Hospital of Chengde Medical University","institution_ids":["https://openalex.org/I4210107741"]},{"raw_affiliation_string":"Hebei Key Laboratory of Panvascular Diseases","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5121487886","display_name":"Xiuming Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107741","display_name":"Affiliated Hospital of Chengde Medical College","ror":"https://ror.org/01bgds823","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107741"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiuming Li","raw_affiliation_strings":["Department of Urology, Affiliated Hospital of Chengde Medical University","Hebei Key Laboratory of Panvascular Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Affiliated Hospital of Chengde Medical University","institution_ids":["https://openalex.org/I4210107741"]},{"raw_affiliation_string":"Hebei Key Laboratory of Panvascular Diseases","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5121487886"],"corresponding_institution_ids":["https://openalex.org/I4210107741"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67103506,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1956477","last_page":"1956477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.03530000150203705,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.025299999862909317,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.925000011920929},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9570000171661377},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.9470000267028809},{"id":"https://openalex.org/keywords/ulk1","display_name":"ULK1","score":0.984000027179718},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.6480000019073486},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.5950000286102295},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7009999752044678},{"id":"https://openalex.org/keywords/network-pharmacology","display_name":"network pharmacology","score":0.6209999918937683},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.6129999756813049},{"id":"https://openalex.org/keywords/anticancer-natural-products","display_name":"anticancer natural products","score":0.5839999914169312},{"id":"https://openalex.org/keywords/saponins","display_name":"saponins","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.6640999913215637},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6410999894142151},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.580299973487854},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.578499972820282},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5511000156402588},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5340999960899353},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.4462999999523163},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4408999979496002},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43650001287460327},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4334999918937683},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42570000886917114},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4205000102519989},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.39969998598098755},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.3698999881744385},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.3515999913215637},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.35019999742507935},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.3379000127315521},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.33570000529289246},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.310699999332428},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.28999999165534973},{"id":"https://openalex.org/C2780278673","wikidata":"https://www.wikidata.org/wiki/Q476743","display_name":"Nude mouse","level":3,"score":0.28110000491142273},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.27410000562667847},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.26899999380111694},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.25220000743865967}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2026.1956477","doi":"https://doi.org/10.3389/fphar.2026.1956477","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1956477","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1956477/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13687397","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13687397/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13687397/pdf/fphar-17-1956477.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:42923378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42923378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ccc307179a974be58b55310f63bdff66","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ccc307179a974be58b55310f63bdff66","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2026.1956477","doi":"https://doi.org/10.3389/fphar.2026.1956477","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1956477","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1956477/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3623670650","display_name":null,"funder_award_id":"H2021406054","funder_id":"https://openalex.org/F4320322163","funder_display_name":"Natural Science Foundation of Hebei Province"},{"id":"https://openalex.org/G4454373351","display_name":null,"funder_award_id":"CYCXZZ202606","funder_id":"https://openalex.org/F4320324398","funder_display_name":"Chengde Medical University"},{"id":"https://openalex.org/G5814328474","display_name":null,"funder_award_id":"H2023406033","funder_id":"https://openalex.org/F4320322163","funder_display_name":"Natural Science Foundation of Hebei Province"}],"funders":[{"id":"https://openalex.org/F4320322163","display_name":"Natural Science Foundation of Hebei Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324398","display_name":"Chengde Medical University","ror":"https://ror.org/02bzkv281"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221006930.pdf","grobid_xml":"https://content.openalex.org/works/W7221006930.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1970637701","https://openalex.org/W2017739035","https://openalex.org/W2055811314","https://openalex.org/W2066604995","https://openalex.org/W2073578030","https://openalex.org/W2091729639","https://openalex.org/W2103659405","https://openalex.org/W2532987289","https://openalex.org/W2560000662","https://openalex.org/W2740618823","https://openalex.org/W2793422726","https://openalex.org/W2887062707","https://openalex.org/W3031151503","https://openalex.org/W3127370626","https://openalex.org/W3137347296","https://openalex.org/W3179782507","https://openalex.org/W3206101222","https://openalex.org/W3207599257","https://openalex.org/W4220808712","https://openalex.org/W4220928922","https://openalex.org/W4224242262","https://openalex.org/W4307366279","https://openalex.org/W4309933493","https://openalex.org/W4322763428","https://openalex.org/W4386799896","https://openalex.org/W4392092898","https://openalex.org/W4392235976","https://openalex.org/W4392639551","https://openalex.org/W4394820335","https://openalex.org/W4399458702","https://openalex.org/W4401644501","https://openalex.org/W4407179763","https://openalex.org/W4410376739","https://openalex.org/W4414742817","https://openalex.org/W4415988097","https://openalex.org/W7128700466"],"related_works":["https://openalex.org/W4399127160","https://openalex.org/W4220928922","https://openalex.org/W4416906252","https://openalex.org/W3094463992","https://openalex.org/W3127370626","https://openalex.org/W4296035491","https://openalex.org/W3009237529","https://openalex.org/W3153737183","https://openalex.org/W4223506609","https://openalex.org/W2895020924"],"abstract_inverted_index":{"Objective":[0],"This":[1,524],"study":[2,525],"was":[3,111,187,227,250,389],"conducted":[4,148],"to":[5,70,149,397,512],"comprehensively":[6],"evaluate":[7,150],"the":[8,29,34,47,59,153,177,184,202,206,231,326,347,377,383,392,413,423,431,515,519,552,557],"anti-clear":[9],"cell":[10,12,84,109,260,272,300,531,539],"renal":[11],"carcinoma":[13],"(ccRCC)":[14],"activity":[15,235],"of":[16,36,50,104,156,238,279,325,336,382,395,405,426,466,489,497],"gypenoside":[17],"LI":[18,52,73,106,168,266,298,375,468,529,579],"(Gyp":[19],"LI)":[20],"through":[21,422],"in":[22,25,40,53,131,152,211,224,232,247,363,480,502,537,573],"vitro":[23,212],"and":[24,38,56,63,67,80,87,89,125,142,158,193,236,243,270,281,289,302,304,309,321,331,334,351,361,369,379,417,449,457,491,494,518,549,561],"vivo":[26,233,460,574],"models;":[27],"elucidate":[28,514],"specific":[30,393],"molecular":[31,310],"pathways":[32],"mediating":[33],"induction":[35],"apoptosis":[37,362,421],"autophagy":[39,456],"Gyp":[41,72,105,167,239,265,297,314,364,374,436,442,454,467,503,528,578],"LI-treated":[42,315,365,504],"ccRCC":[43,83,108,316,366,538],"cells,":[44],"focusing":[45],"on":[46,107],"regulatory":[48,203],"role":[49],"Gypenoside":[51],"upregulating":[54,547],"PPARG":[55,182,396,439,548],"coordinately":[57,550],"modulating":[58,551],"PTEN/PI3K/AKT/mTOR-ULK1":[60,553],"signaling":[61,207,415,554],"network;":[62],"render":[64],"experimental":[65],"evidence":[66],"theoretical":[68],"support":[69],"develop":[71],"as":[74,582],"a":[75,90,172,220],"novel":[76],"anti-ccRCC":[77],"agent.":[78],"Materials":[79],"Methods":[81],"Human":[82],"lines":[85],"(769-P":[86],"ACHN)":[88],"BALB/c":[91],"nude":[92,225,481],"mouse":[93],"xenograft":[94,222,471],"model":[95,223],"were":[96,134,147,169,353],"used":[97],"for":[98,229,585,589],"this":[99,542],"study.":[100],"The":[101,338,401,572],"suppressive":[102],"effect":[103],"proliferation":[110,301],"assessed":[112,251],"by":[113,136,181,189,252,391,435,546],"colony":[114],"formation":[115],"assay,":[116,121,124],"Cell":[117],"Counting":[118],"Kit-8":[119],"(CCK-8)":[120],"wound":[122,287],"healing":[123],"Hoechst":[126,290],"staining.":[127],"Autophagy-related":[128],"ultrastructural":[129],"changes":[130],"treated":[132],"cells":[133,317],"observed":[135],"transmission":[137],"electron":[138],"microscopy.":[139],"Western":[140,253],"blot":[141],"quantitative":[143,198],"real-time":[144],"PCR":[145],"(RT-qPCR)":[146],"fluctuations":[151],"expression":[154,246,381,488,496],"levels":[155],"autophagic":[157,432,516,535],"apoptotic":[159,306],"process":[160],"markers.":[161],"Putative":[162],"therapeutic":[163,587],"targets":[164],"associated":[165,411,533],"with":[166,197,274,323,412,534],"predicted":[170],"utilizing":[171],"network":[173],"pharmacology":[174],"framework.":[175],"Concurrently,":[176],"transcriptional":[178],"control":[179],"exerted":[180,305],"over":[183],"PTEN":[185,387,406,444],"gene":[186,217],"validated":[188],"dual-luciferase":[190],"reporter":[191],"systems":[192],"chromatin":[194],"immunoprecipitation":[195],"combined":[196],"PCR.":[199],"To":[200],"clarify":[201],"relationships":[204],"within":[205],"pathway,":[208],"we":[209],"performed":[210],"rescue":[213],"experiments":[214,461],"using":[215],"target":[216],"knockdown.":[218],"Additionally,":[219],"subcutaneous":[221],"mice":[226],"established":[228],"assessing":[230],"antitumor":[234],"biosafety":[237,563],"LI.":[240,437],"Apoptosis-,":[241],"autophagy-,":[242],"pathway-related":[244],"protein":[245,380],"tumor":[248,472,505],"tissues":[249],"blotting":[254],"(WB)":[255],"assay.":[256],"Results":[257],"CCK-8":[258],"reagent-based":[259],"viability":[261],"assay":[262,292,484],"revealed":[263,372,526],"that":[264,296,313,373,463,527,577],"dose-dependently":[267],"inhibited":[268,470],"769-P":[269],"ACHN":[271],"growth,":[273],"24-h":[275],"IC":[276],"50":[277],"values":[278],"62.57":[280],"79.30":[282],"\u03bcM,":[283],"respectively.":[284],"Colony":[285],"formation,":[286],"healing,":[288],"staining":[291],"results":[293],"collectively":[294],"showed":[295,312,462],"suppressed":[299],"migration":[303],"effects.":[307],"Morphological":[308],"assays":[311,371],"exhibited":[318,342],"prominent":[319],"autophagosomes":[320],"autolysosomes,":[322],"upregulation":[324],"autophagy-related":[327,359,492],"proteins":[328,493,501],"Beclin1,":[329],"ATG5,":[330],"LC3":[332],"I/II":[333],"downregulation":[335],"P62.":[337],"antiapoptotic":[339],"factor":[340,385],"Bcl-2":[341],"substantially":[343],"reduced":[344],"expression,":[345],"while":[346,452],"proapoptotic":[348,490],"mediators":[349],"caspase-3":[350],"Bax":[352],"upregulated,":[354],"these":[355],"findings":[356],"indicated":[357],"concurrent":[358],"alterations":[360,536],"cells.":[367],"WB":[368,483],"RT-qPCR":[370],"upregulated":[376],"mRNA":[378],"transcription":[384,388],"PPARG.":[386],"stimulated":[390],"binding":[394,521],"its":[398],"promoter":[399],"region.":[400],"resulting":[402],"intracellular":[403],"accumulation":[404],"effectively":[407],"blocked":[408],"abnormal":[409],"activation":[410,425],"PI3K/AKT/mTOR":[414,446],"axis":[416],"ultimately":[418],"modulated":[419,434],"autophagy-associated":[420],"phosphorylation-mediated":[424],"ULK1.":[427],"ULK1":[428,450],"knockdown":[429,440],"reversed":[430,441],"phenotype":[433],"Moreover,":[438],"LI-mediated":[443],"upregulation,":[445],"pathway":[447,500],"inhibition,":[448],"phosphorylation,":[451],"attenuating":[453],"LI-modulated":[455],"apoptosis.":[458],"In":[459],"oral":[464],"administration":[465],"significantly":[469],"growth":[473],"but":[474,556],"did":[475],"not":[476],"affect":[477],"body":[478],"weight":[479],"mice.":[482],"further":[485,508,566],"confirmed":[486],"increased":[487],"decreased":[495],"phosphorylated":[498],"AKT/mTOR":[499],"tissues.":[506],"However,":[507],"studies":[509],"are":[510],"required":[511],"fully":[513],"flux":[517],"direct":[520],"targets.":[522],"Conclusion":[523],"promotes":[530],"death":[532],"lines.":[540],"Mechanistically,":[541],"phenomenon":[543],"is":[544],"driven":[545],"network,":[555],"exact":[558],"causal":[559],"interdependencies":[560],"comprehensive":[562],"profile":[564],"warrant":[565],"investigation":[567],"before":[568],"any":[569],"clinical":[570],"translation.":[571],"efficacy":[575],"suggests":[576],"could":[580],"serve":[581],"promising":[583],"candidates":[584],"plant-derived":[586],"interventions":[588],"treating":[590],"RCC.":[591]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-09T00:00:00"}
