{"id":"https://openalex.org/W7220989355","doi":"https://doi.org/10.59467/ijhc.2026.36.409","title":"Synthesis, pharmacological evaluation, drug-likeness prediction, and molecular docking studies of some new N-[4-(5-phenyl-[1,3,4]oxadiazol-2-yl)-naphthalen-1-yl]-acetamide derivatives as potential anticonvulsants","display_name":"Synthesis, pharmacological evaluation, drug-likeness prediction, and molecular docking studies of some new N-[4-(5-phenyl-[1,3,4]oxadiazol-2-yl)-naphthalen-1-yl]-acetamide derivatives as potential anticonvulsants","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7220989355","doi":"https://doi.org/10.59467/ijhc.2026.36.409"},"language":"en","primary_location":{"id":"doi:10.59467/ijhc.2026.36.409","doi":"https://doi.org/10.59467/ijhc.2026.36.409","is_oa":false,"landing_page_url":"https://doi.org/10.59467/ijhc.2026.36.409","pdf_url":null,"source":{"id":"https://openalex.org/S189771143","display_name":"Indian Journal of Heterocyclic Chemistry","issn_l":"0971-1627","issn":["0971-1627","2456-4311"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","norway-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021527053","display_name":"Ranjeet Kumar Yadav","orcid":"https://orcid.org/0000-0003-1817-3914","observed_orcids":["https://orcid.org/0000-0003-1817-3914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ranjeet Kumar Yadav","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022020799","display_name":"Rajnish Kumar","orcid":"https://orcid.org/0000-0002-7021-6996","observed_orcids":["https://orcid.org/0000-0002-7021-6996"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rajnish Kumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113120030","display_name":"Avijit Mazumder","orcid":"https://orcid.org/0000-0002-3053-8106","observed_orcids":["https://orcid.org/0000-0002-3053-8106"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Avijit Mazumder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"3","first_page":"409","last_page":"409"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds","score":0.8330000042915344,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds","score":0.8330000042915344,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.04910000041127205,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.0421999990940094,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-3-4-oxadiazole-derivatives","display_name":"1,3,4-oxadiazole derivatives","score":0.9190000295639038},{"id":"https://openalex.org/keywords/anticonvulsant-activity","display_name":"anticonvulsant activity","score":0.8949999809265137},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.9480000138282776},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.6790000200271606},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9620000123977661},{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.8700000047683716},{"id":"https://openalex.org/keywords/drug-likeness-prediction","display_name":"drug-likeness prediction","score":0.8870000243186951},{"id":"https://openalex.org/keywords/lipinski-s-rule-of-five","display_name":"Lipinski's rule of five","score":0.8399999737739563},{"id":"https://openalex.org/keywords/phenytoin-comparison","display_name":"phenytoin comparison","score":0.777999997138977},{"id":"https://openalex.org/keywords/heterocyclic-hybrids","display_name":"hybrid heterocyclic compounds","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8338000178337097},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.8159999847412109},{"id":"https://openalex.org/C2776730177","wikidata":"https://www.wikidata.org/wiki/Q421721","display_name":"Acetamide","level":2,"score":0.734000027179718},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5314000248908997},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5282999873161316},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4641000032424927},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.460999995470047},{"id":"https://openalex.org/C178910836","wikidata":"https://www.wikidata.org/wiki/Q2196961","display_name":"Molecular model","level":2,"score":0.3763999938964844},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3635999858379364},{"id":"https://openalex.org/C201399114","wikidata":"https://www.wikidata.org/wiki/Q898401","display_name":"Lipophilicity","level":2,"score":0.3573000133037567},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3564999997615814},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.3481000065803528},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.3407999873161316},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.31929999589920044},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.31540000438690186},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.30489999055862427},{"id":"https://openalex.org/C116263406","wikidata":"https://www.wikidata.org/wiki/Q3299024","display_name":"Acute toxicity","level":3,"score":0.2766000032424927},{"id":"https://openalex.org/C2777752112","wikidata":"https://www.wikidata.org/wiki/Q903238","display_name":"Lead compound","level":3,"score":0.25209999084472656},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.25099998712539673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.59467/ijhc.2026.36.409","doi":"https://doi.org/10.59467/ijhc.2026.36.409","is_oa":false,"landing_page_url":"https://doi.org/10.59467/ijhc.2026.36.409","pdf_url":null,"source":{"id":"https://openalex.org/S189771143","display_name":"Indian Journal of Heterocyclic Chemistry","issn_l":"0971-1627","issn":["0971-1627","2456-4311"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","norway-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2903612407","https://openalex.org/W3215030581","https://openalex.org/W4411929178","https://openalex.org/W3047097232","https://openalex.org/W2253653338","https://openalex.org/W4405847719","https://openalex.org/W3012231272","https://openalex.org/W7134843809","https://openalex.org/W3112100476","https://openalex.org/W7089239715"],"abstract_inverted_index":{"Some":[0],"new":[1],"N-[4-(5-phenyl-[1,3,4]oxadiazol-2-yl)-naphthalen-1-yl]-acetamide":[2],"derivatives":[3,118,175],"(6a-p)":[4],"were":[5,46,59,69,140],"synthesized":[6,20],"by":[7,48,61,161],"a":[8],"four-step":[9],"synthetic":[10],"route":[11],"starting":[12],"from":[13],"N-(4-hydroxynaphthalen-1-yl)-acetamide.":[14],"The":[15,40,80,90,169],"acute":[16],"toxicity":[17],"of":[18,42,55,82,93,104,115,130,172,183,203],"the":[19,43,49,83,102,116,132,151,173,201],"compounds":[21,45,58,134,199],"6a-p":[22],"was":[23,29,86,99,159,176],"evaluated,":[24],"and":[25,35,52,97,110,138,165,190],"their":[26],"anticonvulsant":[27,91],"activity":[28,54],"determined":[30],"using":[31],"maximal":[32],"electroshock":[33],"(MES)":[34],"subcutaneous":[36],"pentylenetetrazole":[37],"(scPTZ)":[38],"assays.":[39],"neurotoxicities":[41],"investigated":[44],"assessed":[47,60],"rotarod":[50],"test":[51],"antidepressant":[53],"most":[56],"active":[57],"actophotometer":[62],"assay.":[63],"In":[64],"addition,":[65],"molecular":[66],"docking":[67,148],"experiments":[68],"carried":[70],"out":[71],"on":[72],"human":[73],"GABAA":[74],"receptor":[75,157,216],"3":[76,158],"(PDB":[77],"ID:":[78],"4COF).":[79],"drug-likeness":[81],"best":[84,133],"candidates":[85],"predicted":[87,141],"in":[88,107],"silico.":[89],"effect":[92],"6c,":[94,135],"6d,":[95,136],"6f":[96,137],"6o":[98,139,166],"proven":[100],"at":[101],"dose":[103],"30":[105],"mg/kg":[106],"both":[108],"MES":[109],"scPTZ":[111],"tests.":[112],"Moreover,":[113],"none":[114],"tested":[117],"showed":[119],"neurotoxic":[120],"effects":[121],"or":[122],"impaired":[123],"locomotor":[124],"activity.":[125],"According":[126],"to":[127,142,155,178],"Lipinski's":[128],"rule":[129],"five,":[131],"have":[143],"optimal":[144],"pharmacokinetic":[145],"properties.":[146],"Molecular":[147,212],"revealed":[149],"that":[150,182],"highest":[152],"binding":[153,170],"affinity":[154],"GABA(A)":[156,215],"demonstrated":[160],"6c":[162],"(-8.60":[163],"kcal/mol)":[164],"(-8.58":[167],"kcal/mol).":[168],"ability":[171],"obtained":[174],"found":[177],"be":[179,194],"better":[180],"than":[181],"phenytoin.":[184],"Therefore,":[185],"hybrid":[186],"molecules":[187],"containing":[188],"1,3,4-oxadiazole":[189],"acetamide":[191],"fragments":[192],"can":[193],"considered":[195],"as":[196],"promising":[197],"lead":[198],"for":[200],"development":[202],"novel":[204],"antiepileptic":[205],"agents..":[206],"KEYWORDS":[207],":1,3,4-Oxadiazole,":[208],"Anticonvulsant":[209],"potential,":[210],"Naphthalene,":[211],"docking,":[213],"Drug-likeness,":[214],"\u03b23.":[217]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-09T00:00:00"}
