{"id":"https://openalex.org/W7220985028","doi":"https://doi.org/10.1038/s41598-026-74389-4","title":"Joint association of eGDR and long-term maintenance of healthy BMI range with light BioAge acceleration","display_name":"Joint association of eGDR and long-term maintenance of healthy BMI range with light BioAge acceleration","publication_year":2026,"publication_date":"2026-10-08","ids":{"openalex":"https://openalex.org/W7220985028","doi":"https://doi.org/10.1038/s41598-026-74389-4"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-74389-4","doi":"https://doi.org/10.1038/s41598-026-74389-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-74389-4","pdf_url":"https://www.nature.com/articles/s41598-026-74389-4_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-74389-4_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157950114","display_name":"Puhan Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113348","display_name":"Guangxi University of Chinese Medicine","ror":"https://ror.org/024v0gx67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113348"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Puhan Zhou","raw_affiliation_strings":["Faculty of Chinese Medicine Science, Guangxi University of Chinese Medicine, Nanning, 530000, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Chinese Medicine Science, Guangxi University of Chinese Medicine, Nanning, 530000, Guangxi, China","institution_ids":["https://openalex.org/I4210113348"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157917256","display_name":"Shuo Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuo Yang","raw_affiliation_strings":["Department of Hernia and Abdominal Wall Surgery, Peking University People\u2019s Hospital, Beijing, 100044, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hernia and Abdominal Wall Surgery, Peking University People\u2019s Hospital, Beijing, 100044, China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157913521","display_name":"Yu-Jun Xiong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210119648","display_name":"Beijing Hospital","ror":"https://ror.org/02jwb5s28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Jun Xiong","raw_affiliation_strings":["Department of Gastroenterology, Beijing Hospital, National Center for Gerontology; National Clinical Research Center for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Beijing Hospital, National Center for Gerontology; National Clinical Research Center for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210119648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136751696","display_name":"Xiang-Da Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang-Da Meng","raw_affiliation_strings":["Department of Hernia and Abdominal Wall Surgery, Peking University People\u2019s Hospital, Beijing, 100044, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hernia and Abdominal Wall Surgery, Peking University People\u2019s Hospital, Beijing, 100044, China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066554797","display_name":"Tian Lv","orcid":"https://orcid.org/0000-0002-9580-9990","observed_orcids":["https://orcid.org/0000-0002-9580-9990"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tian Lv","raw_affiliation_strings":["Department of Neurology, Zhuji Affiliated Hospital of Wenzhou Medical University, Zhuji, Zhejiang, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Zhuji Affiliated Hospital of Wenzhou Medical University, Zhuji, Zhejiang, People\u2019s Republic of China","institution_ids":["https://openalex.org/I27781120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5066554797"],"corresponding_institution_ids":["https://openalex.org/I27781120"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.75851577,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.5443999767303467,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.5443999767303467,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.04100000113248825,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.03530000150203705,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biological-aging","display_name":"biological aging","score":0.6200000047683716},{"id":"https://openalex.org/keywords/estimated-glucose-disposal-rate","display_name":"estimated glucose disposal rate","score":0.8600000143051147},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9599999785423279},{"id":"https://openalex.org/keywords/weight-maintenance","display_name":"weight maintenance","score":0.6460000276565552},{"id":"https://openalex.org/keywords/accelerated-aging","display_name":"accelerated aging","score":0.6489999890327454},{"id":"https://openalex.org/keywords/metabolic-health","display_name":"metabolic health","score":0.699999988079071},{"id":"https://openalex.org/keywords/mediation-analysis","display_name":"mediation analysis","score":0.4580000042915344},{"id":"https://openalex.org/keywords/china-health-and-retirement-longitudinal-study","display_name":"China Health and Retirement Longitudinal Study","score":0.8050000071525574},{"id":"https://openalex.org/keywords/uk-biobank","display_name":"UK Biobank","score":1.0}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.715499997138977},{"id":"https://openalex.org/C18555067","wikidata":"https://www.wikidata.org/wiki/Q8375051","display_name":"Joint (building)","level":2,"score":0.5633999705314636},{"id":"https://openalex.org/C117896860","wikidata":"https://www.wikidata.org/wiki/Q11376","display_name":"Acceleration","level":2,"score":0.5583999752998352},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4950999915599823},{"id":"https://openalex.org/C204323151","wikidata":"https://www.wikidata.org/wiki/Q905424","display_name":"Range (aeronautics)","level":2,"score":0.4731000065803528},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.4424999952316284},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3222000002861023},{"id":"https://openalex.org/C3019316490","wikidata":"https://www.wikidata.org/wiki/Q7685903","display_name":"Target range","level":2,"score":0.27950000762939453},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.24469999969005585},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.23989999294281006}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s41598-026-74389-4","doi":"https://doi.org/10.1038/s41598-026-74389-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-74389-4","pdf_url":"https://www.nature.com/articles/s41598-026-74389-4_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:2739ff4c61814545831d6458efefc5bf","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2739ff4c61814545831d6458efefc5bf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 16, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-74389-4","doi":"https://doi.org/10.1038/s41598-026-74389-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-74389-4","pdf_url":"https://www.nature.com/articles/s41598-026-74389-4_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9921000003814697,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1532847035","display_name":null,"funder_award_id":"IRB00001052\u201311015","funder_id":"https://openalex.org/F4320324787","funder_display_name":"Peking University"}],"funders":[{"id":"https://openalex.org/F4320324787","display_name":"Peking University","ror":"https://ror.org/02v51f717"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220985028.pdf","grobid_xml":"https://content.openalex.org/works/W7220985028.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W4392709828","https://openalex.org/W7125715539"],"related_works":["https://openalex.org/W7164351501","https://openalex.org/W7203744070","https://openalex.org/W4413858133","https://openalex.org/W7221336990","https://openalex.org/W4399509380","https://openalex.org/W4413290374","https://openalex.org/W4229444533","https://openalex.org/W4411161480","https://openalex.org/W4410214406","https://openalex.org/W4415588057"],"abstract_inverted_index":{"Biological":[0,84],"aging":[1,144,242],"trajectories":[2,226],"vary":[3],"considerably":[4],"among":[5],"individuals":[6,150],"of":[7,23,113,142,171,187,199,213,240],"the":[8,20,44,53,78,89,154,165,206,210,228,260],"same":[9],"chronological":[10,95],"age,":[11,96],"partly":[12],"attributable":[13],"to":[14,67],"differences":[15],"in":[16,57,145,201,205,243],"metabolic":[17],"health.":[18],"Nevertheless,":[19],"combined":[21],"influence":[22],"long-term":[24,69],"weight":[25],"maintenance":[26],"and":[27,47,52,101,115,117,129,203,215,231,251,259],"insulin":[28,73,180,270],"resistance":[29],"on":[30],"Light":[31,90],"BioAge":[32,91],"acceleration":[33],"remains":[34],"insufficiently":[35],"characterized.":[36],"Data":[37],"were":[38,121,182,235],"derived":[39],"from":[40],"two":[41,244],"population-based":[42],"cohorts:":[43],"China":[45],"Health":[46],"Retirement":[48],"Longitudinal":[49],"Study":[50],"(CHARLS)":[51],"UK":[54,131,207],"Biobank.":[55],"Time":[56],"target":[58,166],"range":[59,167,230],"for":[60],"body":[61],"mass":[62],"index":[63],"(TTR-BMI)":[64],"was":[65,75,86,136],"used":[66],"characterize":[68],"BMI":[70,156,225],"stability,":[71],"while":[72],"sensitivity":[74],"assessed":[76],"using":[77,88],"estimated":[79,87,194],"glucose":[80],"disposal":[81],"rate":[82],"(eGDR).":[83],"age":[85,217],"model,":[92],"which":[93],"incorporates":[94],"serum":[97],"creatinine,":[98],"fasting":[99],"glucose,":[100],"C-reactive":[102],"protein.":[103],"Multivariable":[104],"logistic":[105],"regression,":[106],"restricted":[107],"cubic":[108],"spline":[109],"analyses,":[110],"joint":[111],"analyses":[112,120,192],"TTR-BMI":[114,135],"eGDR,":[116],"exploratory":[118,261],"mediation":[119,191,222,262],"performed.":[122],"The":[123],"analysis":[124],"included":[125],"7,962":[126],"CHARLS":[127,202],"participants":[128],"11,142":[130],"Biobank":[132],"participants.":[133],"Higher":[134],"consistently":[137],"associated":[138,183,236],"with":[139,149,159,184,237],"lower":[140,185,238],"odds":[141,170,186,239],"accelerated":[143,172,188,241],"both":[146],"cohorts.":[147,246],"Compared":[148],"who":[151],"remained":[152],"within":[153,164,227],"healthy":[155,229],"range,":[157],"those":[158],"never":[160],"or":[161],"partial":[162],"time":[163],"showed":[168],"higher":[169,175,232],"aging.":[173,189],"Similarly,":[174],"eGDR":[176,198,214,233],"levels,":[177],"indicating":[178],"better":[179],"sensitivity,":[181],"Exploratory":[190],"yielded":[193],"proportions":[195],"mediated":[196],"by":[197],"83.9%":[200],"81.4%":[204],"Biobank;":[208],"however,":[209],"concurrent":[211],"assessment":[212],"biological":[216],"precluded":[218],"establishing":[219],"a":[220,267],"temporal":[221],"sequence.":[223],"Long-term":[224],"levels":[234],"independent":[245],"Residual":[247],"confounding,":[248],"reverse":[249],"causation,":[250],"selection":[252],"into":[253],"repeated":[254],"assessments":[255],"limit":[256],"causal":[257],"interpretation,":[258],"findings":[263],"do":[264],"not":[265],"establish":[266],"pathway":[268],"through":[269],"sensitivity.":[271]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-09T00:00:00"}