{"id":"https://openalex.org/W7220977509","doi":"https://doi.org/10.64898/2026.10.01.755864","title":"Objective markers of altered neural gain dissociate tinnitus and self-reported listening problems in individuals with exceptional hearing thresholds","display_name":"Objective markers of altered neural gain dissociate tinnitus and self-reported listening problems in individuals with exceptional hearing thresholds","publication_year":2026,"publication_date":"2026-10-08","ids":{"openalex":"https://openalex.org/W7220977509","doi":"https://doi.org/10.64898/2026.10.01.755864"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.01.755864","doi":"https://doi.org/10.64898/2026.10.01.755864","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.01.755864","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.01.755864.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.01.755864.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073507004","display_name":"Matthew Paul O'Donohue","orcid":"https://orcid.org/0000-0002-6180-9554","observed_orcids":["https://orcid.org/0000-0002-6180-9554"]},"institutions":[{"id":"https://openalex.org/I4210092821","display_name":"Australian Hearing","ror":"https://ror.org/00ffcee24","country_code":"AU","type":"government","lineage":["https://openalex.org/I4210092821"]},{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Matthew Paul O\u2019Donohue","raw_affiliation_strings":["Department of Linguistics, The Australian Hearing Hub, Macquarie University, Australia","School of Psychological Sciences, The Australian Hearing Hub, Macquarie University, Australia"],"raw_orcid":"https://orcid.org/0000-0002-6180-9554","affiliations":[{"raw_affiliation_string":"Department of Linguistics, The Australian Hearing Hub, Macquarie University, Australia","institution_ids":["https://openalex.org/I4210092821","https://openalex.org/I99043593"]},{"raw_affiliation_string":"School of Psychological Sciences, The Australian Hearing Hub, Macquarie University, Australia","institution_ids":["https://openalex.org/I4210092821","https://openalex.org/I99043593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043899218","display_name":"Jason Mikiel\u2010Hunter","orcid":"https://orcid.org/0000-0002-6085-9269","observed_orcids":["https://orcid.org/0000-0002-6085-9269"]},"institutions":[{"id":"https://openalex.org/I4210092821","display_name":"Australian Hearing","ror":"https://ror.org/00ffcee24","country_code":"AU","type":"government","lineage":["https://openalex.org/I4210092821"]},{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jason Mikiel-Hunter","raw_affiliation_strings":["Department of Linguistics, The Australian Hearing Hub, Macquarie University, Australia"],"raw_orcid":"https://orcid.org/0000-0002-6085-9269","affiliations":[{"raw_affiliation_string":"Department of Linguistics, The Australian Hearing Hub, Macquarie University, Australia","institution_ids":["https://openalex.org/I4210092821","https://openalex.org/I99043593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012782127","display_name":"Heivet Hern\u00e1ndez-P\u00e9rez","orcid":"https://orcid.org/0000-0002-9135-3973","observed_orcids":["https://orcid.org/0000-0002-9135-3973"]},"institutions":[{"id":"https://openalex.org/I4210092821","display_name":"Australian Hearing","ror":"https://ror.org/00ffcee24","country_code":"AU","type":"government","lineage":["https://openalex.org/I4210092821"]},{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Heivet Hern\u00e1ndez-Per\u00e9z","raw_affiliation_strings":["Department of Linguistics, The Australian Hearing Hub, Macquarie University, Australia"],"raw_orcid":"https://orcid.org/0000-0002-9135-3973","affiliations":[{"raw_affiliation_string":"Department of Linguistics, The Australian Hearing Hub, Macquarie University, Australia","institution_ids":["https://openalex.org/I4210092821","https://openalex.org/I99043593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061153639","display_name":"David McAlpine","orcid":"https://orcid.org/0000-0001-5467-6725","observed_orcids":["https://orcid.org/0000-0001-5467-6725"]},"institutions":[{"id":"https://openalex.org/I4210092821","display_name":"Australian Hearing","ror":"https://ror.org/00ffcee24","country_code":"AU","type":"government","lineage":["https://openalex.org/I4210092821"]},{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David McAlpine","raw_affiliation_strings":["Department of Linguistics, The Australian Hearing Hub, Macquarie University, Australia"],"raw_orcid":"https://orcid.org/0000-0001-5467-6725","affiliations":[{"raw_affiliation_string":"Department of Linguistics, The Australian Hearing Hub, Macquarie University, Australia","institution_ids":["https://openalex.org/I4210092821","https://openalex.org/I99043593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022501575","display_name":"Juan Pablo Fa\u00fandez A","orcid":"https://orcid.org/0009-0006-9123-3441","observed_orcids":["https://orcid.org/0009-0006-9123-3441"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210092821","display_name":"Australian Hearing","ror":"https://ror.org/00ffcee24","country_code":"AU","type":"government","lineage":["https://openalex.org/I4210092821"]},{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Juan-Pablo Fa\u00fandez-Astudillo","raw_affiliation_strings":["Department of Audiology and Speech Pathology. The University of Melbourne, Australia","Department of Linguistics, The Australian Hearing Hub, Macquarie University, Australia"],"raw_orcid":"https://orcid.org/0009-0006-9123-3441","affiliations":[{"raw_affiliation_string":"Department of Audiology and Speech Pathology. The University of Melbourne, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Department of Linguistics, The Australian Hearing Hub, Macquarie University, Australia","institution_ids":["https://openalex.org/I4210092821","https://openalex.org/I99043593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10788","display_name":"Neuroscience and Music Perception","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tinnitus","display_name":"tinnitus","score":0.9620000123977661},{"id":"https://openalex.org/keywords/neural-gain","display_name":"neural gain","score":0.7590000033378601},{"id":"https://openalex.org/keywords/speech-perception-in-noise","display_name":"speech perception in noise","score":0.8130000233650208},{"id":"https://openalex.org/keywords/acoustic-reflex","display_name":"acoustic reflex","score":0.8809999823570251},{"id":"https://openalex.org/keywords/temporal-fine-structure","display_name":"temporal fine structure","score":0.6710000038146973},{"id":"https://openalex.org/keywords/auditory-spatial-cues","display_name":"auditory spatial cues","score":0.6539999842643738},{"id":"https://openalex.org/keywords/cochlear-nucleus","display_name":"cochlear nucleus","score":0.8930000066757202}],"concepts":[{"id":"https://openalex.org/C2779687425","wikidata":"https://www.wikidata.org/wiki/Q7166998","display_name":"Percept","level":3,"score":0.7675999999046326},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.7131999731063843},{"id":"https://openalex.org/C2776992516","wikidata":"https://www.wikidata.org/wiki/Q192309","display_name":"Tinnitus","level":2,"score":0.6801999807357788},{"id":"https://openalex.org/C177291462","wikidata":"https://www.wikidata.org/wiki/Q423038","display_name":"Active listening","level":2,"score":0.5864999890327454},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.5834000110626221},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5720000267028809},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.5357999801635742},{"id":"https://openalex.org/C201247586","wikidata":"https://www.wikidata.org/wiki/Q5612967","display_name":"Binaural recording","level":2,"score":0.5024999976158142},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.4359999895095825},{"id":"https://openalex.org/C2984127161","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neural activity","level":2,"score":0.4325000047683716},{"id":"https://openalex.org/C129564537","wikidata":"https://www.wikidata.org/wiki/Q1460873","display_name":"Neural correlates of consciousness","level":3,"score":0.39010000228881836},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.38989999890327454},{"id":"https://openalex.org/C2777939402","wikidata":"https://www.wikidata.org/wiki/Q1421356","display_name":"Hyperacusis","level":3,"score":0.3693999946117401},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.367900013923645},{"id":"https://openalex.org/C2780554537","wikidata":"https://www.wikidata.org/wiki/Q758881","display_name":"Audiometry","level":3,"score":0.36340001225471497},{"id":"https://openalex.org/C26760741","wikidata":"https://www.wikidata.org/wiki/Q160402","display_name":"Perception","level":2,"score":0.34209999442100525},{"id":"https://openalex.org/C68236139","wikidata":"https://www.wikidata.org/wiki/Q765652","display_name":"Sound localization","level":2,"score":0.34119999408721924},{"id":"https://openalex.org/C2908709693","wikidata":"https://www.wikidata.org/wiki/Q821413","display_name":"Auditory pathways","level":2,"score":0.3370000123977661},{"id":"https://openalex.org/C43791021","wikidata":"https://www.wikidata.org/wiki/Q608256","display_name":"Auditory brainstem response","level":3,"score":0.322299987077713},{"id":"https://openalex.org/C99209842","wikidata":"https://www.wikidata.org/wiki/Q643696","display_name":"Speech perception","level":3,"score":0.31310001015663147},{"id":"https://openalex.org/C9940772","wikidata":"https://www.wikidata.org/wiki/Q557399","display_name":"Psychoacoustics","level":3,"score":0.30559998750686646},{"id":"https://openalex.org/C3020799230","wikidata":"https://www.wikidata.org/wiki/Q160289","display_name":"Auditory perception","level":3,"score":0.29510000348091125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2946999967098236},{"id":"https://openalex.org/C2780297895","wikidata":"https://www.wikidata.org/wiki/Q18676","display_name":"Auditory cortex","level":2,"score":0.2847999930381775},{"id":"https://openalex.org/C100142294","wikidata":"https://www.wikidata.org/wiki/Q2070426","display_name":"Selective auditory attention","level":4,"score":0.28049999475479126},{"id":"https://openalex.org/C2777443451","wikidata":"https://www.wikidata.org/wiki/Q821413","display_name":"Auditory system","level":2,"score":0.2671999931335449}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.01.755864","doi":"https://doi.org/10.64898/2026.10.01.755864","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.01.755864","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.01.755864.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.01.755864","doi":"https://doi.org/10.64898/2026.10.01.755864","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.01.755864","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.01.755864.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320591","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220977509.pdf","grobid_xml":"https://content.openalex.org/works/W7220977509.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1996646214","https://openalex.org/W2016785002","https://openalex.org/W2023969516","https://openalex.org/W2030547026","https://openalex.org/W2035195182","https://openalex.org/W2038262310","https://openalex.org/W2056829537","https://openalex.org/W2057977793","https://openalex.org/W2073847640","https://openalex.org/W2079659218","https://openalex.org/W2086646726","https://openalex.org/W2087405603","https://openalex.org/W2092526100","https://openalex.org/W2096439661","https://openalex.org/W2097498366","https://openalex.org/W2109447493","https://openalex.org/W2113747279","https://openalex.org/W2115243428","https://openalex.org/W2127305990","https://openalex.org/W2128024483","https://openalex.org/W2154654678","https://openalex.org/W2182271310","https://openalex.org/W2269259465","https://openalex.org/W2341942623","https://openalex.org/W2406702197","https://openalex.org/W2473820510","https://openalex.org/W2508254932","https://openalex.org/W2516234370","https://openalex.org/W2520345395","https://openalex.org/W2556508994","https://openalex.org/W2557040722","https://openalex.org/W2560737292","https://openalex.org/W2584363998","https://openalex.org/W2621679690","https://openalex.org/W2736323072","https://openalex.org/W2768098827","https://openalex.org/W2778848544","https://openalex.org/W2782754651","https://openalex.org/W2787324996","https://openalex.org/W2791386295","https://openalex.org/W2802183707","https://openalex.org/W2887107698","https://openalex.org/W2889289129","https://openalex.org/W2896643981","https://openalex.org/W2898242559","https://openalex.org/W2905692926","https://openalex.org/W2921038291","https://openalex.org/W2950629677","https://openalex.org/W2978103898","https://openalex.org/W3023965896","https://openalex.org/W3092165548","https://openalex.org/W3128040373","https://openalex.org/W3135605731","https://openalex.org/W3159170200","https://openalex.org/W4220970802","https://openalex.org/W4286560081","https://openalex.org/W4313255428","https://openalex.org/W4317618537","https://openalex.org/W4389205368"],"related_works":["https://openalex.org/W7140012159","https://openalex.org/W2921038291","https://openalex.org/W4389205368","https://openalex.org/W2908501531","https://openalex.org/W1600409999","https://openalex.org/W2570725085","https://openalex.org/W3217276836","https://openalex.org/W4396650229","https://openalex.org/W2085191509","https://openalex.org/W7156276024"],"abstract_inverted_index":{"Abstract":[0],"Many":[1],"individuals":[2],"experience":[3],"problems":[4,37],"that":[5,158],"are":[6],"undetected":[7],"by":[8],"standard":[9],"hearing":[10,40],"tests,":[11],"such":[12],"as":[13],"persistent":[14,44],"tinnitus":[15],"and":[16,73],"difficulties":[17,97],"understanding":[18],"speech":[19],"in":[20,31,50,69,82,91,151,154,161],"background":[21],"noise.":[22],"Here,":[23],"we":[24,118],"report":[25],"evidence":[26],"of":[27,48,53,59,66,87,135,144],"altered":[28,67],"neural":[29,112,152],"gain":[30,68,153],"young":[32],"adults":[33],"with":[34,100,110],"self-reported":[35,95],"listening":[36,160],"despite":[38],"exceptional":[39],"thresholds.":[41],"Individuals":[42],"reporting":[43],"tinnitus\u2014the":[45],"daily":[46],"percept":[47],"sound":[49],"the":[51,60,83,106,140],"absence":[52],"an":[54],"external":[55],"source\u2014exhibited":[56],"elevated":[57,111],"thresholds":[58],"middle":[61],"ear":[62],"muscle":[63],"reflex,":[64],"suggestive":[65],"brainstem":[70],"reflexive":[71],"circuits,":[72],"reduced":[74,133],"cortical":[75,103],"responses":[76],"to":[77,122,139],"auditory":[78,124],"spatial":[79],"cues":[80],"conveyed":[81],"temporal":[84,141],"fine":[85,142],"structure":[86,143],"low-frequency":[88,145],"sounds.":[89],"Moreover,":[90],"both":[92],"groups,":[93],"greater":[94],"speech-in-noise":[96],"were":[98],"associated":[99],"higher":[101,155],"magnitude":[102],"responses\u2014particularly":[104],"at":[105],"highest":[107],"stimulus":[108],"intensity\u2014consistent":[109],"gain.":[113],"Using":[114],"a":[115,148],"conceptual":[116],"model,":[117],"demonstrate":[119],"how":[120],"damage":[121],"high-threshold":[123],"nerve":[125],"fibres":[126],"innervating":[127],"cochlear":[128],"nuclei":[129],"can":[130],"account":[131],"for":[132],"activity":[134],"binaural":[136],"neurons":[137],"sensitive":[138],"sounds,":[146],"generating":[147],"compensatory":[149],"increase":[150],"brain":[156],"centres":[157],"impacts":[159],"complex":[162],"environments.":[163]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-09T00:00:00"}
