{"id":"https://openalex.org/W7220976592","doi":"https://doi.org/10.1136/bmjopen-2026-127044","title":"Association between invasive mechanical ventilation and acute kidney injury in critically ill patients: a protocol for a systematic review and meta-analysis of randomised controlled trials","display_name":"Association between invasive mechanical ventilation and acute kidney injury in critically ill patients: a protocol for a systematic review and meta-analysis of randomised controlled trials","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7220976592","doi":"https://doi.org/10.1136/bmjopen-2026-127044","pmid":"https://pubmed.ncbi.nlm.nih.gov/42849961","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13656135"},"language":"en","primary_location":{"id":"doi:10.1136/bmjopen-2026-127044","doi":"https://doi.org/10.1136/bmjopen-2026-127044","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2026-127044","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/16/10/e127044.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmjopen.bmj.com/content/bmjopen/16/10/e127044.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009601957","display_name":"Prit Kusirisin","orcid":"https://orcid.org/0000-0002-3885-9377","observed_orcids":["https://orcid.org/0000-0002-3885-9377"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]},{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]}],"countries":["CA","TH"],"is_corresponding":false,"raw_author_name":"Prit Kusirisin","raw_affiliation_strings":["Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada","Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"],"raw_orcid":"https://orcid.org/0000-0002-3885-9377","affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038141511","display_name":"Janice Yu Chen Kung","orcid":"https://orcid.org/0000-0001-8676-8675","observed_orcids":["https://orcid.org/0000-0001-8676-8675"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Janice Y Kung","raw_affiliation_strings":["Geoffrey and Robyn Sperber Health Sciences Library, University of Alberta, Edmonton, Alberta, Canada"],"raw_orcid":"https://orcid.org/0000-0001-8676-8675","affiliations":[{"raw_affiliation_string":"Geoffrey and Robyn Sperber Health Sciences Library, University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089353142","display_name":"Fernando Godinho Zampieri","orcid":"https://orcid.org/0000-0001-9315-6386","observed_orcids":["https://orcid.org/0000-0001-9315-6386"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Fernando G Zampieri","raw_affiliation_strings":["Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089228359","display_name":"Mark Hepokoski","orcid":"https://orcid.org/0000-0002-9267-9262","observed_orcids":["https://orcid.org/0000-0002-9267-9262"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Hepokoski","raw_affiliation_strings":["Division of Pulmonary and Critical Care and Sleep Medicine, University of California San Diego, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care and Sleep Medicine, University of California San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039409201","display_name":"Ewan C. Goligher","orcid":"https://orcid.org/0000-0002-0990-6701","observed_orcids":["https://orcid.org/0000-0002-0990-6701"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ewan C Goligher","raw_affiliation_strings":["Division of Respirology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Respirology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124460023","display_name":"D'Arcy Duquette","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D\u2019Arcy Duquette","raw_affiliation_strings":["Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036301763","display_name":"Sean M. Bagshaw","orcid":"https://orcid.org/0000-0003-3633-6596","observed_orcids":["https://orcid.org/0000-0003-3633-6596"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Sean M Bagshaw","raw_affiliation_strings":["Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5036301763"],"corresponding_institution_ids":["https://openalex.org/I154425047"],"apc_list":{"value":1500,"currency":"GBP","value_usd":1839},"apc_paid":{"value":1500,"currency":"GBP","value_usd":1839},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60722348,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"10","first_page":"e127044","last_page":"e127044"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.050700001418590546,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11681","display_name":"Nosocomial Infections in ICU","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/invasive-mechanical-ventilation","display_name":"invasive mechanical ventilation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.9539999961853027},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.6729999780654907},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.32100000977516174},{"id":"https://openalex.org/keywords/critical-care","display_name":"intensive care","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9760000109672546},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.7652999758720398},{"id":"https://openalex.org/C2991859549","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critically ill","level":2,"score":0.6988999843597412},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6754999756813049},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.6449999809265137},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.6028000116348267},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.45750001072883606},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.3630000054836273},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3515999913215637},{"id":"https://openalex.org/C3018737135","wikidata":"https://www.wikidata.org/wiki/Q105726","display_name":"Urine output","level":3,"score":0.3343999981880188},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3264999985694885},{"id":"https://openalex.org/C2779541074","wikidata":"https://www.wikidata.org/wiki/Q185643","display_name":"Renal replacement therapy","level":2,"score":0.3093000054359436},{"id":"https://openalex.org/C2993568657","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critical illness","level":3,"score":0.28850001096725464},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.28690001368522644},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.2736000120639801}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1136/bmjopen-2026-127044","doi":"https://doi.org/10.1136/bmjopen-2026-127044","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2026-127044","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/16/10/e127044.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13656135","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13656135/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13656135/pdf/bmjopen-16-10.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"Text"},{"id":"pmid:42849961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42849961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ open","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:119029a2b236435d913dccf753266ab0","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/119029a2b236435d913dccf753266ab0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"BMJ Open, Vol 16, Iss 10 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/bmjopen-2026-127044","doi":"https://doi.org/10.1136/bmjopen-2026-127044","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2026-127044","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/16/10/e127044.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Study Protocol","id":"https://openalex.org/study-designs/study-protocol"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320319946","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220976592.pdf","grobid_xml":"https://content.openalex.org/works/W7220976592.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W2098923148","https://openalex.org/W2146846681","https://openalex.org/W2149687213","https://openalex.org/W2159740577","https://openalex.org/W2170892587","https://openalex.org/W2272534858","https://openalex.org/W2552492436","https://openalex.org/W2994563255","https://openalex.org/W3030514460","https://openalex.org/W3127425621","https://openalex.org/W3176719829","https://openalex.org/W4387734816"],"related_works":["https://openalex.org/W2159740577","https://openalex.org/W7098137307","https://openalex.org/W4406815648","https://openalex.org/W4283836345","https://openalex.org/W4394422457","https://openalex.org/W4387890835","https://openalex.org/W4405524572","https://openalex.org/W7129014548","https://openalex.org/W2079397487","https://openalex.org/W2088017911"],"abstract_inverted_index":{"Introduction":[0],"Invasive":[1],"mechanical":[2],"ventilation":[3],"(IMV)":[4],"may":[5],"contribute":[6],"to":[7,87,144],"the":[8,22,26,30,35,82,117,129,155,172,182],"development":[9],"and":[10,25,47,53,59,81,93,113,164,208,213,230,249],"progression":[11],"of":[12,67,77,131,138,157,166,184,196,205,210],"acute":[13],"kidney":[14],"injury":[15],"(AKI)":[16],"in":[17,29,140,149,251],"critically":[18,185],"ill":[19,186],"patients.":[20],"Given":[21],"expanding":[23],"evidence-base":[24],"immense":[27],"variation":[28],"association":[31,52],"described,":[32],"particularly":[33],"following":[34,136],"COVID-19":[36],"pandemic":[37],"era,":[38],"a":[39,64,252],"rigorous":[40],"synthesis":[41],"is":[42,217],"warranted.":[43],"This":[44],"systematic":[45],"review":[46],"meta-analysis":[48],"will":[49,62,97,109,123,159,168,180,200,223,231,241],"evaluate":[50],"this":[51,221],"identify":[54],"potential":[55],"risk-mitigation":[56],"strategies.":[57],"Methods":[58],"analysis":[60],"We":[61],"conduct":[63],"comprehensive":[65],"search":[66,96],"databases,":[68],"including":[69],"Ovid":[70,72],"MEDLINE,":[71],"Embase,":[73],"CINAHL,":[74],"Scopus,":[75],"Web":[76],"Science":[78],"Core":[79],"Collection":[80],"Cochrane":[83,173],"Library,":[84],"using":[85,116,171],"keywords":[86],"capture":[88],"relevant":[89],"literature":[90],"on":[91],"IMV":[92,139,151],"AKI.":[94],"The":[95,177,239],"include":[98,124,201],"studies":[99,115,122,229],"published":[100,228],"from":[101,226],"database":[102],"inception":[103],"through":[104,244],"March":[105],"2026.":[106],"Two":[107],"reviewers":[108],"independently":[110],"screen,":[111],"select":[112],"extract":[114],"web-based":[118],"platform":[119],"Covidence.":[120],"Eligible":[121],"randomised":[125],"controlled":[126],"trials":[127],"reporting":[128],"occurrence":[130],"new-onset":[132,190],"or":[133,191],"worsening":[134,192],"AKI":[135,158,193,202],"initiation":[137,195],"adult":[141],"patients":[142,187],"admitted":[143],"intensive":[145],"care":[146],"units.":[147],"Studies":[148],"which":[150],"was":[152],"initiated":[153],"after":[154,194],"onset":[156],"be":[160,169,181,242],"excluded.":[161],"Study":[162],"quality":[163],"risk":[165],"bias":[167],"assessed":[170],"Risk-of-Bias":[174],"2":[175],"Tool.":[176],"primary":[178],"outcome":[179],"proportion":[183],"who":[188],"develop":[189],"IMV.":[197],"Secondary":[198],"outcomes":[199],"trajectory,":[203],"use":[204],"organ":[206],"support":[207],"length":[209],"stay.":[211],"Ethics":[212,215],"dissemination":[214],"approval":[216],"not":[218,232],"required,":[219],"as":[220],"study":[222],"synthesise":[224],"data":[225],"previously":[227],"involve":[233],"direct":[234],"contact":[235],"with":[236],"human":[237],"participants.":[238],"findings":[240],"disseminated":[243],"presentations":[245],"at":[246],"academic":[247],"conferences":[248],"publication":[250],"peer-reviewed":[253],"journal.":[254],"PROSPERO":[255],"registration":[256],"number":[257],"CRD420261303862.":[258]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-09T00:00:00"}