{"id":"https://openalex.org/W7220974685","doi":"https://doi.org/10.1038/s44320-026-00249-y","title":"Crowdsourcing functional cell therapy binders from generative artificial intelligence","display_name":"Crowdsourcing functional cell therapy binders from generative artificial intelligence","publication_year":2026,"publication_date":"2026-10-08","ids":{"openalex":"https://openalex.org/W7220974685","doi":"https://doi.org/10.1038/s44320-026-00249-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/42850287","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13728171"},"language":"en","primary_location":{"id":"doi:10.1038/s44320-026-00249-y","doi":"https://doi.org/10.1038/s44320-026-00249-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s44320-026-00249-y","pdf_url":"https://link.springer.com/content/pdf/10.1038/s44320-026-00249-y.pdf","source":{"id":"https://openalex.org/S200893805","display_name":"Molecular Systems Biology","issn_l":"1744-4292","issn":["1744-4292"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Systems Biology","raw_type":"journal-article"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1038/s44320-026-00249-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5098621025","display_name":"Abdul Vehab Dozic","orcid":"https://orcid.org/0009-0001-8754-1234","observed_orcids":["https://orcid.org/0009-0001-8754-1234"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdul Vehab Dozic","raw_affiliation_strings":["Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA"],"raw_orcid":"https://orcid.org/0009-0001-8754-1234","affiliations":[{"raw_affiliation_string":"Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054483679","display_name":"Caleb A. Lareau","orcid":"https://orcid.org/0000-0003-4179-4807","observed_orcids":["https://orcid.org/0000-0003-4179-4807"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Caleb A Lareau","raw_affiliation_strings":["Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. lareauc@mskcc.org"],"raw_orcid":"https://orcid.org/0000-0003-4179-4807","affiliations":[{"raw_affiliation_string":"Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. lareauc@mskcc.org","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054483679"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":{"value":7990,"currency":"USD","value_usd":7990},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"11","first_page":"1665","last_page":"1667"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.5985999703407288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.5985999703407288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.10819999873638153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.10350000113248825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/generative-ai","display_name":"generative AI","score":0.7570000290870667},{"id":"https://openalex.org/keywords/protein-binder-design","display_name":"protein binder design","score":0.8970000147819519},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.8849999904632568},{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.7160000205039978},{"id":"https://openalex.org/keywords/protein-structure-prediction","display_name":"protein structure prediction","score":0.5429999828338623},{"id":"https://openalex.org/keywords/crowdsourcing","display_name":"crowdsourcing","score":0.5180000066757202},{"id":"https://openalex.org/keywords/engineered-t-cells","display_name":"engineered T cells","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C62230096","wikidata":"https://www.wikidata.org/wiki/Q275969","display_name":"Crowdsourcing","level":2,"score":0.7249000072479248},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6622999906539917},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5260999798774719},{"id":"https://openalex.org/C39890363","wikidata":"https://www.wikidata.org/wiki/Q36108","display_name":"Generative grammar","level":2,"score":0.5128999948501587},{"id":"https://openalex.org/C167966045","wikidata":"https://www.wikidata.org/wiki/Q5532625","display_name":"Generative model","level":3,"score":0.38589999079704285},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33899998664855957},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3296999931335449},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.30640000104904175},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2727000117301941},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.24879999458789825}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1038/s44320-026-00249-y","doi":"https://doi.org/10.1038/s44320-026-00249-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s44320-026-00249-y","pdf_url":"https://link.springer.com/content/pdf/10.1038/s44320-026-00249-y.pdf","source":{"id":"https://openalex.org/S200893805","display_name":"Molecular Systems Biology","issn_l":"1744-4292","issn":["1744-4292"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Systems Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13728171","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13728171/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13728171/pdf/44320_2026_Article_249.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Syst Biol","raw_type":"Text"},{"id":"pmid:42850287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42850287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular systems biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s44320-026-00249-y","doi":"https://doi.org/10.1038/s44320-026-00249-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s44320-026-00249-y","pdf_url":"https://link.springer.com/content/pdf/10.1038/s44320-026-00249-y.pdf","source":{"id":"https://openalex.org/S200893805","display_name":"Molecular Systems Biology","issn_l":"1744-4292","issn":["1744-4292"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220974685.pdf","grobid_xml":"https://content.openalex.org/works/W7220974685.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W2017285544","https://openalex.org/W3084236163","https://openalex.org/W3125484908","https://openalex.org/W3177828909","https://openalex.org/W3178087467","https://openalex.org/W4391849760","https://openalex.org/W4403492327","https://openalex.org/W4414169548","https://openalex.org/W7212064624","https://openalex.org/W7221000185"],"related_works":["https://openalex.org/W7221000185","https://openalex.org/W7212020626","https://openalex.org/W7150726132","https://openalex.org/W7160614923","https://openalex.org/W7154908807","https://openalex.org/W4413882900","https://openalex.org/W4410388528","https://openalex.org/W7172247553","https://openalex.org/W4417303482","https://openalex.org/W2970801846"],"abstract_inverted_index":{"Over":[0],"thirty":[1],"years":[2],"ago,":[3],"structural":[4],"biologists":[5],"established":[6,43],"the":[7,30,86,90,113,142,192],"Critical":[8],"Assessment":[9],"of":[10,92,103,115,124,138,152],"Structure":[11],"Prediction":[12],"(CASP)":[13],"to":[14,88,110,128,131,144,194],"rigorously":[15],"assess":[16],"methods":[17,120],"for":[18,70,168,209],"predicting":[19],"protein":[20,129,183],"structures":[21,33],"from":[22,126],"amino":[23],"acid":[24],"sequences.":[25],"Participants":[26],"submitted":[27],"predictions":[28,66],"before":[29],"corresponding":[31],"experimental":[32,68],"became":[34,56],"publicly":[35],"available":[36],"(Moult":[37],"et":[38,74,78,176],"al,":[39,75,79,177],"1995).":[40],"This":[41],"framework":[42],"a":[44],"common":[45],"standard":[46],"against":[47],"which":[48,197],"methodological":[49],"advances":[50],"could":[51],"be":[52],"measured.":[53],"Its":[54],"value":[55],"particularly":[57],"evident":[58],"at":[59],"CASP14":[60],"in":[61,149,201],"2020,":[62],"when":[63],"AlphaFold2":[64],"produced":[65],"approaching":[67],"accuracy":[69],"many":[71],"targets":[72],"(Jumper":[73],"2021;":[76],"Pereira":[77],"2021).":[80],"CASP\u2019s":[81],"independent,":[82],"prospective":[83],"assessment":[84],"enabled":[85],"community":[87],"recognize":[89],"scale":[91],"this":[93,150],"advance":[94],"by":[95],"providing":[96],"rapid,":[97],"independent":[98],"validation.":[99],"The":[100,134],"next":[101],"generation":[102],"CASP-like":[104],"open":[105],"competitions":[106],"is":[107,181],"similarly":[108],"poised":[109],"help":[111],"discern":[112],"impact":[114],"emerging":[116],"artificial":[117],"intelligence":[118],"(AI)-based":[119],"across":[121],"several":[122],"domains":[123,167],"biology,":[125],"genomics":[127],"design":[130],"therapeutic":[132],"discovery.":[133],"implementation":[135],"and":[136,159,188,205],"results":[137],"one":[139],"such":[140],"effort,":[141],"Bits":[143,193],"Binders":[145,195],"competition,":[146,196],"are":[147],"described":[148],"issue":[151],"Molecular":[153],"Systems":[154],"Biology,":[155],"where":[156],"Kosonocky,":[157,186],"Abel":[158,187],"colleagues":[160,189],"evaluated":[161],"12,000":[162,199],"designed":[163],"proteins":[164],"as":[165],"recognition":[166],"chimeric":[169],"antigen":[170],"receptor":[171],"(CAR)":[172],"T":[173,203],"cells":[174,204],"(Kosonocky":[175],"2026).":[178],"Generative":[179],"AI":[180],"advancing":[182],"binder":[184],"design.":[185],"report":[190],"on":[191],"tested":[198],"designs":[200],"engineered":[202],"identified":[206],"promising":[207],"candidates":[208],"future":[210],"cell":[211],"therapies.":[212]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-09T00:00:00"}
