{"id":"https://openalex.org/W7220969397","doi":"https://doi.org/10.1016/j.ebiom.2026.106509","title":"Immune effects of faecal microbiota transplantation in amyotrophic lateral sclerosis: a pilot multicentre, randomised, masked, sham-controlled, proof-of concept trial","display_name":"Immune effects of faecal microbiota transplantation in amyotrophic lateral sclerosis: a pilot multicentre, randomised, masked, sham-controlled, proof-of concept trial","publication_year":2026,"publication_date":"2026-10-08","ids":{"openalex":"https://openalex.org/W7220969397","doi":"https://doi.org/10.1016/j.ebiom.2026.106509","pmid":"https://pubmed.ncbi.nlm.nih.gov/42849176","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13676721"},"language":"en","primary_location":{"id":"doi:10.1016/j.ebiom.2026.106509","doi":"https://doi.org/10.1016/j.ebiom.2026.106509","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2026.106509","pdf_url":null,"source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eBioMedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.ebiom.2026.106509","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017248165","display_name":"Elisabetta Zucchi","orcid":"https://orcid.org/0000-0001-5604-4529","observed_orcids":["https://orcid.org/0000-0001-5604-4529"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisabetta Zucchi","raw_affiliation_strings":["Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria Di Modena, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria Di Modena, Modena, Italy","institution_ids":["https://openalex.org/I122346577","https://openalex.org/I4210109058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079832202","display_name":"Elena Niccolai","orcid":"https://orcid.org/0000-0002-9205-8079","observed_orcids":["https://orcid.org/0000-0002-9205-8079"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Niccolai","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9205-8079","affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005270626","display_name":"Flavio De Maio","orcid":"https://orcid.org/0000-0002-4744-9820","observed_orcids":["https://orcid.org/0000-0002-4744-9820"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Flavio De Maio","raw_affiliation_strings":["Department of Laboratory and Hematological Sciences, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory and Hematological Sciences, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038823998","display_name":"Riccardo Cuoghi Costantini","orcid":"https://orcid.org/0000-0002-9116-5198","observed_orcids":["https://orcid.org/0000-0002-9116-5198"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Riccardo Cuoghi Costantini","raw_affiliation_strings":["Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena, 41121, Italy; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, 41124, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9116-5198","affiliations":[{"raw_affiliation_string":"Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena, 41121, Italy; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, 41124, Italy","institution_ids":["https://openalex.org/I122346577","https://openalex.org/I4210109058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000739751","display_name":"Gianluca Quaranta","orcid":"https://orcid.org/0000-0002-9094-2936","observed_orcids":["https://orcid.org/0000-0002-9094-2936","https://orcid.org/0000-0002-8164-4857"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Quaranta","raw_affiliation_strings":["Department of Laboratory and Hematological Sciences, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory and Hematological Sciences, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057697761","display_name":"Alessandra Guarnaccia","orcid":"https://orcid.org/0000-0001-7290-8761","observed_orcids":["https://orcid.org/0000-0001-7290-8761"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Guarnaccia","raw_affiliation_strings":["Department of Laboratory and Hematological Sciences, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory and Hematological Sciences, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054710123","display_name":"Stefano Bibb\u00f2","orcid":"https://orcid.org/0000-0002-8043-4807","observed_orcids":["https://orcid.org/0000-0002-8043-4807"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Bibb\u00f2","raw_affiliation_strings":["Department of Medical and Surgical Sciences, UOC Gastroenterologia, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Surgical Sciences, UOC Gastroenterologia, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042225964","display_name":"Ilaria Martinelli","orcid":"https://orcid.org/0000-0003-2566-3671","observed_orcids":["https://orcid.org/0000-0003-2566-3671"]},"institutions":[{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ilaria Martinelli","raw_affiliation_strings":["Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria Di Modena, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria Di Modena, Modena, Italy","institution_ids":["https://openalex.org/I4210109058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061958104","display_name":"Giulia Gianferrari","orcid":"https://orcid.org/0000-0002-4260-0915","observed_orcids":["https://orcid.org/0000-0002-4260-0915"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Gianferrari","raw_affiliation_strings":["Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria Di Modena, Modena, Italy"],"raw_orcid":"https://orcid.org/0000-0002-4260-0915","affiliations":[{"raw_affiliation_string":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria Di Modena, Modena, Italy","institution_ids":["https://openalex.org/I122346577","https://openalex.org/I4210109058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002986919","display_name":"Cecilia Simonini","orcid":"https://orcid.org/0000-0001-5456-2365","observed_orcids":["https://orcid.org/0000-0001-5456-2365"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cecilia Simonini","raw_affiliation_strings":["Transfusion Medicine Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5456-2365","affiliations":[{"raw_affiliation_string":"Transfusion Medicine Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004620012","display_name":"Giulia Nannini","orcid":"https://orcid.org/0000-0002-6481-6864","observed_orcids":["https://orcid.org/0000-0002-6481-6864"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Nannini","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072176931","display_name":"Matteo Lulli","orcid":"https://orcid.org/0000-0002-8528-4094","observed_orcids":["https://orcid.org/0000-0002-8528-4094"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Lulli","raw_affiliation_strings":["Department of Experimental and Clinical Biomedical Sciences, Biochemical Sciences Section, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Biomedical Sciences, Biochemical Sciences Section, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011544731","display_name":"Simone Baldi","orcid":"https://orcid.org/0000-0002-5151-2618","observed_orcids":["https://orcid.org/0000-0002-5151-2618"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simone Baldi","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"],"raw_orcid":"https://orcid.org/0000-0002-5151-2618","affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031427179","display_name":"Bartolucci Gianluca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Bartolucci","raw_affiliation_strings":["Department of Neurosciences, Psychology, Drug Research and Child Health Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Psychology, Drug Research and Child Health Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061442440","display_name":"Roberto Vicini","orcid":"https://orcid.org/0000-0002-1799-6567","observed_orcids":["https://orcid.org/0000-0002-1799-6567"]},"institutions":[{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Vicini","raw_affiliation_strings":["Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena, 41121, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1799-6567","affiliations":[{"raw_affiliation_string":"Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena, 41121, Italy","institution_ids":["https://openalex.org/I4210109058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016431034","display_name":"Margherita Capasso","orcid":"https://orcid.org/0000-0003-1150-8881","observed_orcids":["https://orcid.org/0000-0003-1150-8881"]},"institutions":[{"id":"https://openalex.org/I4210149564","display_name":"Ospedale SS. Annunziata","ror":"https://ror.org/04hd4qy94","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210149564"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Margherita Capasso","raw_affiliation_strings":["Neuromuscular Centre, Clinica Neurologica, Ospedale \"S.S. Annunziata\", Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuromuscular Centre, Clinica Neurologica, Ospedale \"S.S. Annunziata\", Chieti, Italy","institution_ids":["https://openalex.org/I4210149564"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072252835","display_name":"Giulia Bisogni","orcid":"https://orcid.org/0000-0001-7314-3393","observed_orcids":["https://orcid.org/0000-0001-7314-3393"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Bisogni","raw_affiliation_strings":["Centro Clinico Nemo \"Armida Barelli\"- Fondazione Serena Onlus, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Clinico Nemo \"Armida Barelli\"- Fondazione Serena Onlus, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111586596","display_name":"Amelia Conte","orcid":"https://orcid.org/0009-0009-9802-8821","observed_orcids":["https://orcid.org/0009-0009-9802-8821"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Amelia Conte","raw_affiliation_strings":["Centro Clinico Nemo \"Armida Barelli\"- Fondazione Serena Onlus, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Clinico Nemo \"Armida Barelli\"- Fondazione Serena Onlus, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088391371","display_name":"Paola Brunori","orcid":"https://orcid.org/0000-0002-5680-8848","observed_orcids":["https://orcid.org/0000-0002-5680-8848"]},"institutions":[{"id":"https://openalex.org/I4210089241","display_name":"Azienda Ospedaliera di Perugia","ror":"https://ror.org/006jktr69","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210089241"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Brunori","raw_affiliation_strings":["Department of Neurophysiopathology, Perugia Hospital, Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurophysiopathology, Perugia Hospital, Perugia, Italy","institution_ids":["https://openalex.org/I4210089241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085399427","display_name":"Giovanni Cammarota","orcid":"https://orcid.org/0000-0002-3626-6148","observed_orcids":["https://orcid.org/0000-0002-3626-6148"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Cammarota","raw_affiliation_strings":["Department of Medical and Surgical Sciences, UOC Gastroenterologia, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Surgical Sciences, UOC Gastroenterologia, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018168468","display_name":"Sabrina Paganoni","orcid":"https://orcid.org/0000-0003-0505-1168","observed_orcids":["https://orcid.org/0000-0003-0505-1168"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2799748957","display_name":"Spaulding Rehabilitation Hospital","ror":"https://ror.org/011dvr318","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799748957","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabrina Paganoni","raw_affiliation_strings":["Department of Neurology, Sean M. Healey & AMG Center for ALS and the Neurological Clinical Research Institute, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA; Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Sean M. Healey & AMG Center for ALS and the Neurological Clinical Research Institute, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA; Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2799748957","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016597149","display_name":"Roberto D\u2019Amico","orcid":"https://orcid.org/0000-0002-3211-6687","observed_orcids":["https://orcid.org/0000-0002-3211-6687"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto D'Amico","raw_affiliation_strings":["Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena, 41121, Italy; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, 41124, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena, 41121, Italy; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, 41124, Italy","institution_ids":["https://openalex.org/I122346577","https://openalex.org/I4210109058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082342925","display_name":"Amedeo Amedei","orcid":"https://orcid.org/0000-0002-6797-9343","observed_orcids":["https://orcid.org/0000-0002-6797-9343"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Amedeo Amedei","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021409727","display_name":"Luca Masucci","orcid":"https://orcid.org/0000-0002-8358-6726","observed_orcids":["https://orcid.org/0000-0002-8358-6726"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Masucci","raw_affiliation_strings":["Department of Laboratory and Hematological Sciences, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy; Department of Basic, Clinical, Intensive and Perioperative Biotechnology Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory and Hematological Sciences, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy; Department of Basic, Clinical, Intensive and Perioperative Biotechnology Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053912816","display_name":"Jessica Mandrioli","orcid":"https://orcid.org/0000-0002-9244-9782","observed_orcids":["https://orcid.org/0000-0002-9244-9782"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Jessica Mandrioli","raw_affiliation_strings":["Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria Di Modena, Modena, Italy. Electronic address: jessica.mandrioli@unimore.it"],"raw_orcid":"https://orcid.org/0000-0002-9244-9782","affiliations":[{"raw_affiliation_string":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria Di Modena, Modena, Italy. Electronic address: jessica.mandrioli@unimore.it","institution_ids":["https://openalex.org/I122346577","https://openalex.org/I4210109058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017248165","display_name":"Elisabetta Zucchi","orcid":"https://orcid.org/0000-0001-5604-4529","observed_orcids":["https://orcid.org/0000-0001-5604-4529"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisabetta Zucchi","raw_affiliation_strings":["Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria Di Modena, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria Di Modena, Modena, Italy","institution_ids":["https://openalex.org/I122346577","https://openalex.org/I4210109058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038823998","display_name":"Riccardo Cuoghi Costantini","orcid":"https://orcid.org/0000-0002-9116-5198","observed_orcids":["https://orcid.org/0000-0002-9116-5198"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Riccardo Cuoghi Costantini","raw_affiliation_strings":["Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena, 41121, Italy; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, 41124, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena, 41121, Italy; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, 41124, Italy","institution_ids":["https://openalex.org/I122346577","https://openalex.org/I4210109058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042225964","display_name":"Ilaria Martinelli","orcid":"https://orcid.org/0000-0003-2566-3671","observed_orcids":["https://orcid.org/0000-0003-2566-3671"]},"institutions":[{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ilaria Martinelli","raw_affiliation_strings":["Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria Di Modena, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria Di Modena, Modena, Italy","institution_ids":["https://openalex.org/I4210109058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061958104","display_name":"Giulia Gianferrari","orcid":"https://orcid.org/0000-0002-4260-0915","observed_orcids":["https://orcid.org/0000-0002-4260-0915"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Gianferrari","raw_affiliation_strings":["Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria Di Modena, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria Di Modena, Modena, Italy","institution_ids":["https://openalex.org/I122346577","https://openalex.org/I4210109058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002986919","display_name":"Cecilia Simonini","orcid":"https://orcid.org/0000-0001-5456-2365","observed_orcids":["https://orcid.org/0000-0001-5456-2365"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cecilia Simonini","raw_affiliation_strings":["Transfusion Medicine Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transfusion Medicine Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025030197","display_name":"Andrea Ghezzi","orcid":"https://orcid.org/0000-0002-6073-0107","observed_orcids":["https://orcid.org/0000-0002-6073-0107"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Ghezzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068014750","display_name":"Roberta Bedin","orcid":"https://orcid.org/0000-0001-5006-3294","observed_orcids":["https://orcid.org/0000-0001-5006-3294"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberta Bedin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016597149","display_name":"Roberto D\u2019Amico","orcid":"https://orcid.org/0000-0002-3211-6687","observed_orcids":["https://orcid.org/0000-0002-3211-6687"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto D'Amico","raw_affiliation_strings":["Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena, 41121, Italy; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, 41124, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena, 41121, Italy; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, 41124, Italy","institution_ids":["https://openalex.org/I122346577","https://openalex.org/I4210109058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087428456","display_name":"Nicola Fini","orcid":"https://orcid.org/0000-0002-5828-0928","observed_orcids":["https://orcid.org/0000-0002-5828-0928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicola Fini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061442440","display_name":"Roberto Vicini","orcid":"https://orcid.org/0000-0002-1799-6567","observed_orcids":["https://orcid.org/0000-0002-1799-6567"]},"institutions":[{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Vicini","raw_affiliation_strings":["Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena, 41121, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena, 41121, Italy","institution_ids":["https://openalex.org/I4210109058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062636871","display_name":"Annalisa Gessani","orcid":"https://orcid.org/0000-0002-3494-5788","observed_orcids":["https://orcid.org/0000-0002-3494-5788"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annalisa Gessani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107011676","display_name":"Francesca Prompicai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesca Prompicai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046288017","display_name":"Silvia Parisi","orcid":"https://orcid.org/0000-0002-1944-9110","observed_orcids":["https://orcid.org/0000-0002-1944-9110"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silvia Parisi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053912816","display_name":"Jessica Mandrioli","orcid":"https://orcid.org/0000-0002-9244-9782","observed_orcids":["https://orcid.org/0000-0002-9244-9782"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Jessica Mandrioli","raw_affiliation_strings":["Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria Di Modena, Modena, Italy. Electronic address: jessica.mandrioli@unimore.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria Di Modena, Modena, Italy. Electronic address: jessica.mandrioli@unimore.it","institution_ids":["https://openalex.org/I122346577","https://openalex.org/I4210109058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079832202","display_name":"Elena Niccolai","orcid":"https://orcid.org/0000-0002-9205-8079","observed_orcids":["https://orcid.org/0000-0002-9205-8079"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Niccolai","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159625573","display_name":"Amedeo Amedei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Amedeo Amedei","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004620012","display_name":"Giulia Nannini","orcid":"https://orcid.org/0000-0002-6481-6864","observed_orcids":["https://orcid.org/0000-0002-6481-6864"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Nannini","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072176931","display_name":"Matteo Lulli","orcid":"https://orcid.org/0000-0002-8528-4094","observed_orcids":["https://orcid.org/0000-0002-8528-4094"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Lulli","raw_affiliation_strings":["Department of Experimental and Clinical Biomedical Sciences, Biochemical Sciences Section, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Biomedical Sciences, Biochemical Sciences Section, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159643788","display_name":"Simone Baldi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simone Baldi","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031427179","display_name":"Bartolucci Gianluca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Bartolucci","raw_affiliation_strings":["Department of Neurosciences, Psychology, Drug Research and Child Health Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Psychology, Drug Research and Child Health Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000739751","display_name":"Gianluca Quaranta","orcid":"https://orcid.org/0000-0002-9094-2936","observed_orcids":["https://orcid.org/0000-0002-9094-2936","https://orcid.org/0000-0002-8164-4857"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Quaranta","raw_affiliation_strings":["Department of Laboratory and Hematological Sciences, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory and Hematological Sciences, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021409727","display_name":"Luca Masucci","orcid":"https://orcid.org/0000-0002-8358-6726","observed_orcids":["https://orcid.org/0000-0002-8358-6726"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Masucci","raw_affiliation_strings":["Department of Laboratory and Hematological Sciences, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy; Department of Basic, Clinical, Intensive and Perioperative Biotechnology Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory and Hematological Sciences, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy; Department of Basic, Clinical, Intensive and Perioperative Biotechnology Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057697761","display_name":"Alessandra Guarnaccia","orcid":"https://orcid.org/0000-0001-7290-8761","observed_orcids":["https://orcid.org/0000-0001-7290-8761"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Guarnaccia","raw_affiliation_strings":["Department of Laboratory and Hematological Sciences, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory and Hematological Sciences, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159579019","display_name":"Flavio De Maio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Flavio De Maio","raw_affiliation_strings":["Department of Laboratory and Hematological Sciences, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory and Hematological Sciences, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012165824","display_name":"Giovanni Fancello","orcid":"https://orcid.org/0000-0003-4863-3061","observed_orcids":["https://orcid.org/0000-0003-4863-3061"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giovanni Fancello","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019937452","display_name":"Chiara Agrillo","orcid":"https://orcid.org/0000-0002-7120-7274","observed_orcids":["https://orcid.org/0000-0002-7120-7274"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chiara Agrillo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091380579","display_name":"Vanessa Di Pietro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vanessa Di Pietro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029128164","display_name":"Desy De Lorenzis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Desy De Lorenzis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102794931","display_name":"Roberto Rosato","orcid":"https://orcid.org/0000-0003-1570-6973","observed_orcids":["https://orcid.org/0000-0003-1570-6973"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberto Rosato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012884879","display_name":"Francesca Romana Monzo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesca Romana Monzo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154293886","display_name":"Giovanni Cammarota","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Cammarota","raw_affiliation_strings":["Department of Medical and Surgical Sciences, UOC Gastroenterologia, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Surgical Sciences, UOC Gastroenterologia, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054710123","display_name":"Stefano Bibb\u00f2","orcid":"https://orcid.org/0000-0002-8043-4807","observed_orcids":["https://orcid.org/0000-0002-8043-4807"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Bibb\u00f2","raw_affiliation_strings":["Department of Medical and Surgical Sciences, UOC Gastroenterologia, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Surgical Sciences, UOC Gastroenterologia, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109709775","display_name":"Irene Venturini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irene Venturini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000292619","display_name":"Debora Rondinella","orcid":"https://orcid.org/0000-0002-3174-5094","observed_orcids":["https://orcid.org/0000-0002-3174-5094"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Debora Rondinella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032692058","display_name":"Nausicaa Antonini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nausicaa Antonini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111229422","display_name":"Chiara Chiarini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chiara Chiarini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157932885","display_name":"Regina Manica","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Regina Manica","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157984585","display_name":"Micaela Angeletti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Micaela Angeletti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158223734","display_name":"Marco Rossi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marco Rossi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159698276","display_name":"Tommaso Cosimo Caputo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tommaso Cosimo Caputo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022524234","display_name":"Mario Sabatelli","orcid":"https://orcid.org/0000-0001-6635-4985","observed_orcids":["https://orcid.org/0000-0001-6635-4985"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mario Sabatelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111586596","display_name":"Amelia Conte","orcid":"https://orcid.org/0009-0009-9802-8821","observed_orcids":["https://orcid.org/0009-0009-9802-8821"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Amelia Conte","raw_affiliation_strings":["Centro Clinico Nemo \"Armida Barelli\"- Fondazione Serena Onlus, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Clinico Nemo \"Armida Barelli\"- Fondazione Serena Onlus, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072252835","display_name":"Giulia Bisogni","orcid":"https://orcid.org/0000-0001-7314-3393","observed_orcids":["https://orcid.org/0000-0001-7314-3393"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Bisogni","raw_affiliation_strings":["Centro Clinico Nemo \"Armida Barelli\"- Fondazione Serena Onlus, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Clinico Nemo \"Armida Barelli\"- Fondazione Serena Onlus, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084288527","display_name":"Teresa Anna Cantisani","orcid":"https://orcid.org/0000-0003-3442-7718","observed_orcids":["https://orcid.org/0000-0003-3442-7718"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teresa Anna Cantisani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088391371","display_name":"Paola Brunori","orcid":"https://orcid.org/0000-0002-5680-8848","observed_orcids":["https://orcid.org/0000-0002-5680-8848"]},"institutions":[{"id":"https://openalex.org/I4210089241","display_name":"Azienda Ospedaliera di Perugia","ror":"https://ror.org/006jktr69","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210089241"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Brunori","raw_affiliation_strings":["Department of Neurophysiopathology, Perugia Hospital, Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurophysiopathology, Perugia Hospital, Perugia, Italy","institution_ids":["https://openalex.org/I4210089241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157908188","display_name":"Rosella Papetti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosella Papetti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016431034","display_name":"Margherita Capasso","orcid":"https://orcid.org/0000-0003-1150-8881","observed_orcids":["https://orcid.org/0000-0003-1150-8881"]},"institutions":[{"id":"https://openalex.org/I4210149564","display_name":"Ospedale SS. Annunziata","ror":"https://ror.org/04hd4qy94","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210149564"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Margherita Capasso","raw_affiliation_strings":["Neuromuscular Centre, Clinica Neurologica, Ospedale \"S.S. Annunziata\", Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuromuscular Centre, Clinica Neurologica, Ospedale \"S.S. Annunziata\", Chieti, Italy","institution_ids":["https://openalex.org/I4210149564"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055951916","display_name":"Laura Ferri","orcid":"https://orcid.org/0000-0003-2105-5038","observed_orcids":["https://orcid.org/0000-0003-2105-5038"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Ferri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5031232284","display_name":"Paola Ajdinaj","orcid":"https://orcid.org/0000-0002-8173-1723","observed_orcids":["https://orcid.org/0000-0002-8173-1723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paola Ajdinaj","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5053912816"],"corresponding_institution_ids":["https://openalex.org/I122346577","https://openalex.org/I4210109058"],"apc_list":{"value":5780,"currency":"USD","value_usd":5780},"apc_paid":{"value":5780,"currency":"USD","value_usd":5780},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.75284386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"133","issue":null,"first_page":"106509","last_page":"106509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.5166000127792358,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.5166000127792358,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.37299999594688416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.921999990940094},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9200000166893005},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/peripheral-immunity","display_name":"peripheral immunity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/alsfrs-r","display_name":"ALSFRS-R","score":0.7179999947547913},{"id":"https://openalex.org/keywords/respiratory-function","display_name":"respiratory function","score":0.5680000185966492},{"id":"https://openalex.org/keywords/nutritional-status","display_name":"nutritional status","score":0.7749999761581421},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.6489999890327454},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.640999972820282},{"id":"https://openalex.org/keywords/early-stage-als","display_name":"early-stage ALS","score":0.5799999833106995},{"id":"https://openalex.org/keywords/sham-procedure","display_name":"sham procedure","score":0.35100001096725464},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.5789999961853027},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7437000274658203},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.739300012588501},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6448000073432922},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.5468000173568726},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4375999867916107},{"id":"https://openalex.org/C137923570","wikidata":"https://www.wikidata.org/wiki/Q2121103","display_name":"Fecal bacteriotherapy","level":4,"score":0.4253999888896942},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.36880001425743103},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.367000013589859},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2863999903202057},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.2784000039100647},{"id":"https://openalex.org/C2994577977","wikidata":"https://www.wikidata.org/wiki/Q1203526","display_name":"Pilot trial","level":3,"score":0.2745000123977661},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.2718999981880188},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.26919999718666077},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.26579999923706055},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26350000500679016},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.25690001249313354},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.2558000087738037}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.ebiom.2026.106509","doi":"https://doi.org/10.1016/j.ebiom.2026.106509","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2026.106509","pdf_url":null,"source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eBioMedicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13676721","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13676721/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13676721/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eBioMedicine","raw_type":"Text"},{"id":"pmid:42849176","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42849176","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"Journal Article"},{"id":"pmh:oai:flore.unifi.it:2158/1499140","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2158/1499140","pdf_url":"https://flore.unifi.it/bitstream/2158/1499140/1/FMT_ALS_eBiomedicine.pdf","source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:2bb50c40a3c54a6cb184705c6904ca25","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2bb50c40a3c54a6cb184705c6904ca25","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EBioMedicine, Vol 133, Iss , Pp 106509- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ebiom.2026.106509","doi":"https://doi.org/10.1016/j.ebiom.2026.106509","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2026.106509","pdf_url":null,"source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eBioMedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G704319355","display_name":null,"funder_award_id":"RF-2016-02361616","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"}],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220969397.pdf","grobid_xml":"https://content.openalex.org/works/W7220969397.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1999906527","https://openalex.org/W2056279562","https://openalex.org/W2078754045","https://openalex.org/W2086639871","https://openalex.org/W2108381339","https://openalex.org/W2147661671","https://openalex.org/W2161938104","https://openalex.org/W2179438025","https://openalex.org/W2207819727","https://openalex.org/W2910445001","https://openalex.org/W2910657247","https://openalex.org/W2973416631","https://openalex.org/W2991012357","https://openalex.org/W3026019136","https://openalex.org/W3094129766","https://openalex.org/W3111836013","https://openalex.org/W3126208996","https://openalex.org/W3126519734","https://openalex.org/W3127310493","https://openalex.org/W3134157209","https://openalex.org/W3139212922","https://openalex.org/W3159839833","https://openalex.org/W3176888555","https://openalex.org/W3203070815","https://openalex.org/W3205045604","https://openalex.org/W3217309048","https://openalex.org/W4220793283","https://openalex.org/W4220827127","https://openalex.org/W4295925800","https://openalex.org/W4295929883","https://openalex.org/W4308135426","https://openalex.org/W4308590523","https://openalex.org/W4311515569","https://openalex.org/W4315926031","https://openalex.org/W4321503800","https://openalex.org/W4327709720","https://openalex.org/W4386601930","https://openalex.org/W4386818399","https://openalex.org/W4392398031","https://openalex.org/W4393224953","https://openalex.org/W4399530146","https://openalex.org/W4401075949","https://openalex.org/W4404120111","https://openalex.org/W4404895347","https://openalex.org/W4405782439","https://openalex.org/W4407698071","https://openalex.org/W4409018316","https://openalex.org/W7154056157"],"related_works":["https://openalex.org/W2973416631","https://openalex.org/W4401512787","https://openalex.org/W4404895347","https://openalex.org/W4392398031","https://openalex.org/W7135822867","https://openalex.org/W7128394912","https://openalex.org/W7133198870","https://openalex.org/W4398255097","https://openalex.org/W4406963193","https://openalex.org/W4285186963"],"abstract_inverted_index":{"Background":[0],"The":[1,76,95,195],"gut":[2],"microbiota":[3,16],"modulates":[4],"peripheral":[5],"immunity,":[6],"which":[7],"is":[8],"altered":[9],"in":[10,26,100,218,248,255,263,284,289,318,351],"amyotrophic":[11],"lateral":[12],"sclerosis":[13],"(ALS).":[14],"Faecal":[15],"transplantation":[17],"(FMT)":[18],"may":[19],"exert":[20],"immunological":[21],"effects,":[22],"but":[23],"its":[24],"impact":[25],"ALS":[27,44,48,115],"remains":[28],"unclear.":[29],"Methods":[30],"FETR-ALS":[31],"was":[32,98,198,232,282,306,330,341,345],"a":[33,72,215,260,348],"multicentre,":[34],"randomised,":[35],"masked,":[36],"sham-controlled":[37],"proof-of-concept":[38],"trial":[39],"conducted":[40],"at":[41,60,87,108,201,276],"four":[42],"Italian":[43,355],"centres.":[45],"Adults":[46],"with":[47,237,259,308,333,347],"of":[49,59,79,83,266,357],"18":[50],"months":[51],"duration":[52],"or":[53,71,167,322],"less":[54],"and":[55,89,121,125,140,146,150,185,188,252],"forced":[56],"vital":[57],"capacity":[58],"least":[61],"70%":[62],"predicted":[63],"were":[64,144,148,191],"randomly":[65,151],"assigned":[66,152],"(2:1)":[67],"to":[68,153,302],"receive":[69],"FMT":[70,154,208,238,257,270,286,305,329,344],"sham":[73],"procedure":[74,184],"(SP).":[75],"intervention":[77],"consisted":[78],"two":[80],"nasojejunal":[81],"administrations":[82],"screened-donor":[84],"faecal":[85],"suspension":[86],"baseline":[88],"month":[90,277],"6,":[91,278],"without":[92],"antibiotic":[93],"preconditioning.":[94],"primary":[96,196,339],"endpoint":[97,340],"change":[99],"circulating":[101,219,352],"Tregs":[102,220],"among":[103],"CD4":[104],"+":[105],"T":[106],"cells":[107],"6":[109,202],"months.":[110],"Secondary":[111],"endpoints":[112],"included":[113],"safety,":[114],"Functional":[116],"Rating":[117],"Scale\u2013Revised":[118],"slope,":[119],"respiratory":[120],"nutritional":[122],"measures,":[123],"survival,":[124],"exploratory":[126,327],"biomarker":[127],"profiles.":[128],"Analyses":[129],"followed":[130],"the":[131,182,249,256,279,285,290,338],"intention-to-treat":[132],"principle.":[133],"ClinicalTrials.gov":[134],"identifier:":[135],"NCT03766321.":[136],"Findings":[137],"Between":[138],"2020":[139],"2024,":[141],"43":[142],"individuals":[143],"screened":[145],"42":[147],"enrolled":[149],"(n":[155,169],"=":[156,170],"28;":[157],"mean":[158,296],"age":[159],"56.1":[160],"years":[161,173],"[SD":[162],"8.2];":[163],"14":[164,315],"[50%]":[165],"male)":[166],"SP":[168,213,250,291],"14;":[171],"59.6":[172],"[9.1];":[174],"eight":[175],"[57%]":[176],"male).":[177],"Overall,":[178],"29":[179],"participants":[180],"completed":[181],"second":[183],"6-month":[186],"follow-up,":[187],"Treg":[189,230],"measurements":[190],"available":[192],"for":[193],"28.":[194],"outcome":[197],"not":[199,331,342],"met:":[200],"months,":[203],"8/18":[204],"(44%)":[205],"participant":[206],"receiving":[207,212],"versus":[209,294,314],"2/10":[210],"(20%)":[211],"achieved":[214],"\u226520%":[216],"increase":[217,231,350],"(odds":[221],"ratio":[222],"[OR]":[223],"3.20,":[224],"95%":[225,299],"CI":[226,240,272,300],"0.59\u201325.36;":[227],"p=0.21).":[228],"Mean":[229],"2.36":[233],"percentage":[234],"points":[235],"higher":[236],"(95%":[239,271],"0.19\u20134.55;":[241],"p=0.04).":[242],"ALSFRS-R":[243],"declined":[244],"by":[245],"\u22121.07":[246],"points/month":[247,254,268],"group":[251,287,292],"\u22120.76":[253],"group,":[258],"between-group":[261],"difference":[262,297],"monthly":[264],"decline":[265],"0.31":[267],"favouring":[269],"0.11\u20130.51;":[273],"p=0.002).":[274],"Conversely,":[275],"MRC":[280],"score":[281],"lower":[283],"than":[288],"(0.75":[293],"0.89;":[295],"\u22120.13,":[298],"\u20130.26":[301],"0.00;":[303],"p=0.042).":[304],"associated":[307,332,346],"32":[309],"adverse":[310],"events":[311],"(12.5%":[312],"severe)":[313,317],"(28.6%":[316],"SP,":[319],"mostly":[320],"gastrointestinal":[321],"infectious.":[323],"Interpretation":[324],"In":[325],"this":[326],"trial,":[328],"major":[334],"safety":[335],"concerns.":[336],"Although":[337],"met,":[343],"modest":[349],"Tregs.":[353],"Funding":[354],"Ministry":[356],"Health.":[358]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-09T00:00:00"}