{"id":"https://openalex.org/W7220936178","doi":"https://doi.org/10.64898/2026.10.06.757033","title":"CCT2 expression marks a translation-activated state in sporadic ALS motor neurons and is associated with functional decline","display_name":"CCT2 expression marks a translation-activated state in sporadic ALS motor neurons and is associated with functional decline","publication_year":2026,"publication_date":"2026-10-08","ids":{"openalex":"https://openalex.org/W7220936178","doi":"https://doi.org/10.64898/2026.10.06.757033","pmid":"https://pubmed.ncbi.nlm.nih.gov/42926625","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13692182"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.06.757033","doi":"https://doi.org/10.64898/2026.10.06.757033","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.757033","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/08/2026.10.06.757033.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/08/2026.10.06.757033.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084570095","display_name":"Priyanka Bhandary","orcid":"https://orcid.org/0000-0002-6962-9638","observed_orcids":["https://orcid.org/0000-0002-6962-9638"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priyanka Bhandary","raw_affiliation_strings":["Department of Computational Biomedicine, Cedars Sinai Medical Center, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Biomedicine, Cedars Sinai Medical Center, CA, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100602401","display_name":"Yizhou Wang","orcid":"https://orcid.org/0000-0002-9378-745X","observed_orcids":["https://orcid.org/0000-0002-9378-745X"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yizhou Wang","raw_affiliation_strings":["Department of Computational Biomedicine, Cedars Sinai Medical Center, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Biomedicine, Cedars Sinai Medical Center, CA, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157972899","display_name":"Mohamed Omar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed Omar","raw_affiliation_strings":["Department of Computational Biomedicine, Cedars Sinai Medical Center, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Biomedicine, Cedars Sinai Medical Center, CA, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032971510","display_name":"Jason H. Moore","orcid":"https://orcid.org/0000-0002-5015-1099","observed_orcids":["https://orcid.org/0000-0002-5015-1099"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason H. Moore","raw_affiliation_strings":["Department of Computational Biomedicine, Cedars Sinai Medical Center, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Biomedicine, Cedars Sinai Medical Center, CA, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076732420","display_name":"Zhiping Paul Wang","orcid":"https://orcid.org/0000-0002-3796-3164","observed_orcids":["https://orcid.org/0000-0002-3796-3164"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhiping Paul Wang","raw_affiliation_strings":["Department of Computational Biomedicine, Cedars Sinai Medical Center, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Biomedicine, Cedars Sinai Medical Center, CA, USA","institution_ids":["https://openalex.org/I1282927834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076732420"],"corresponding_institution_ids":["https://openalex.org/I1282927834"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sporadic-als","display_name":"sporadic ALS","score":0.9269999861717224},{"id":"https://openalex.org/keywords/cct2","display_name":"CCT2","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tric-chaperonin","display_name":"TRiC chaperonin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/motor-neurons","display_name":"motor neurons","score":0.8389999866485596},{"id":"https://openalex.org/keywords/ipsc-derived-neurons","display_name":"iPSC-derived neurons","score":0.7900000214576721},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.7239999771118164},{"id":"https://openalex.org/keywords/c9orf72","display_name":"C9orf72","score":0.8050000071525574},{"id":"https://openalex.org/keywords/sod1","display_name":"SOD1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bioenergetic-stress","display_name":"bioenergetic stress","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.9750000238418579},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.8389999866485596},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.984000027179718},{"id":"https://openalex.org/keywords/projection-neurons","display_name":"projection neurons","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.8195000290870667},{"id":"https://openalex.org/C2777898937","wikidata":"https://www.wikidata.org/wiki/Q5008447","display_name":"C9orf72","level":5,"score":0.7071999907493591},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6930000185966492},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5885000228881836},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5522000193595886},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4165000021457672},{"id":"https://openalex.org/C2778373776","wikidata":"https://www.wikidata.org/wiki/Q18696","display_name":"Motor cortex","level":3,"score":0.41519999504089355},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.3725999891757965},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.3644999861717224},{"id":"https://openalex.org/C2780989783","wikidata":"https://www.wikidata.org/wiki/Q7578557","display_name":"splice","level":3,"score":0.358599990606308},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35280001163482666},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.34950000047683716},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.3330000042915344},{"id":"https://openalex.org/C191172861","wikidata":"https://www.wikidata.org/wiki/Q7899321","display_name":"Upstream (networking)","level":2,"score":0.3190000057220459},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.3167000114917755},{"id":"https://openalex.org/C2777615887","wikidata":"https://www.wikidata.org/wiki/Q15328137","display_name":"SOD1","level":4,"score":0.31459999084472656},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3125999867916107},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.3122999966144562},{"id":"https://openalex.org/C2776752467","wikidata":"https://www.wikidata.org/wiki/Q1133903","display_name":"Motor neuron","level":3,"score":0.31189998984336853},{"id":"https://openalex.org/C64618202","wikidata":"https://www.wikidata.org/wiki/Q3733697","display_name":"Genetic heterogeneity","level":4,"score":0.30970001220703125},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.2818000018596649},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.26339998841285706},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.2605000138282776},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.2603999972343445},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2587999999523163}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.10.06.757033","doi":"https://doi.org/10.64898/2026.10.06.757033","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.757033","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/08/2026.10.06.757033.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13692182","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13692182/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13692182/pdf/nihpp-2026.10.06.757033v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42926625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42926625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.10.06.757033","doi":"https://doi.org/10.64898/2026.10.06.757033","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.757033","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/08/2026.10.06.757033.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000887641","display_name":"Los Angeles Claude D. Pepper Older Americans Independence Center","funder_award_id":"P30AG094848","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220936178.pdf","grobid_xml":"https://content.openalex.org/works/W7220936178.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1523304533","https://openalex.org/W1576514072","https://openalex.org/W1797572428","https://openalex.org/W1853546723","https://openalex.org/W1981876866","https://openalex.org/W1984068087","https://openalex.org/W2021168188","https://openalex.org/W2033599203","https://openalex.org/W2035618305","https://openalex.org/W2046762273","https://openalex.org/W2063363475","https://openalex.org/W2069089843","https://openalex.org/W2073864172","https://openalex.org/W2083459920","https://openalex.org/W2100905208","https://openalex.org/W2106083699","https://openalex.org/W2113792524","https://openalex.org/W2115462905","https://openalex.org/W2116149846","https://openalex.org/W2122982115","https://openalex.org/W2125987139","https://openalex.org/W2132429277","https://openalex.org/W2138977668","https://openalex.org/W2146512944","https://openalex.org/W2153574614","https://openalex.org/W2159707944","https://openalex.org/W2161633633","https://openalex.org/W2179438025","https://openalex.org/W2214074259","https://openalex.org/W2550109145","https://openalex.org/W2562565311","https://openalex.org/W2594036075","https://openalex.org/W2771265500","https://openalex.org/W2790053519","https://openalex.org/W2791554627","https://openalex.org/W2887838825","https://openalex.org/W2945804912","https://openalex.org/W2953614388","https://openalex.org/W2982641702","https://openalex.org/W2991360048","https://openalex.org/W2998030065","https://openalex.org/W3007530406","https://openalex.org/W3037470576","https://openalex.org/W3041917243","https://openalex.org/W3157095124","https://openalex.org/W4206363717","https://openalex.org/W4210469056","https://openalex.org/W4220778713","https://openalex.org/W4226286160","https://openalex.org/W4252979096","https://openalex.org/W4285077789","https://openalex.org/W4309076667","https://openalex.org/W4313640271","https://openalex.org/W4316466471","https://openalex.org/W4360619479","https://openalex.org/W4365135317","https://openalex.org/W4387516299","https://openalex.org/W4390051944","https://openalex.org/W4390584412","https://openalex.org/W4392470193","https://openalex.org/W4393098841","https://openalex.org/W4394716778","https://openalex.org/W4402001719","https://openalex.org/W4405535445","https://openalex.org/W4406991848","https://openalex.org/W4407731828","https://openalex.org/W4408274406","https://openalex.org/W4410960956","https://openalex.org/W4412980566","https://openalex.org/W4414690630","https://openalex.org/W4416599783","https://openalex.org/W4417145564","https://openalex.org/W7130364779","https://openalex.org/W7131081674","https://openalex.org/W7160430069"],"related_works":["https://openalex.org/W2000268516","https://openalex.org/W4311709712","https://openalex.org/W4310984293","https://openalex.org/W4310165755","https://openalex.org/W4311305852","https://openalex.org/W4307525983","https://openalex.org/W2946643793","https://openalex.org/W4297919753","https://openalex.org/W4307125976","https://openalex.org/W4294756188"],"abstract_inverted_index":{"Sporadic":[0],"disease":[1],"accounts":[2],"for":[3,45,86,186,234],"about":[4],"90%":[5],"of":[6,23,75,162,177,196],"amyotrophic":[7],"lateral":[8],"sclerosis":[9],"(ALS)":[10],"cases,":[11],"and":[12,64,67,102,134,172,198,222],"its":[13],"biological":[14,41],"heterogeneity":[15],"is":[16,43],"a":[17,29,36,76,83,110,145],"major":[18],"contributor":[19],"to":[20,90],"the":[21,71,95,153,160,169,175,218,223],"failure":[22],"trials":[24],"that":[25,117,217],"enroll":[26],"patients":[27,125],"under":[28,159],"single":[30],"diagnosis.":[31],"Because":[32],"sporadic":[33,80,124],"ALS":[34,99,214],"lacks":[35],"shared":[37],"genetic":[38],"anchor,":[39],"identifying":[40],"signals":[42],"critical":[44],"effective":[46],"patient":[47],"stratification.":[48],"We":[49,92],"analyzed":[50],"induced":[51],"pluripotent":[52],"stem":[53],"cell-derived":[54],"motor":[55,104],"neurons":[56,105],"from":[57,152],"619":[58],"AnswerALS":[59],"participants":[60],"using":[61,212],"transcriptomics,":[62],"proteomics,":[63],"whole-genome":[65],"sequencing":[66],"identified":[68],"CCT2":[69,164,221],"as":[70],"first":[72,93],"single-gene":[73],"marker":[74],"molecular":[77],"state":[78,140,155,194],"within":[79],"ALS,":[81],"providing":[82],"measurable":[84],"basis":[85],"trial":[87],"enrollment":[88],"according":[89],"biology.":[91],"anchored":[94],"analysis":[96,191],"in":[97,230],"known":[98],"genotypes.":[100],"C9orf72":[101],"SOD1":[103],"did":[106],"not":[107],"converge":[108],"on":[109],"common":[111],"signature":[112],"but":[113],"retained":[114],"genotype-specific":[115],"differences":[116],"bulk":[118],"postmortem":[119,231],"tissue":[120],"compresses.":[121],"Scoring":[122],"391":[123],"along":[126],"three":[127,137],"transcriptomic":[128],"axes":[129],"(bioenergetic":[130],"stress,":[131],"cell":[132,224],"cycle,":[133],"inflammation)":[135],"resolved":[136],"states.":[138,210],"One":[139],"was":[141,165,227],"marked":[142],"by":[143],"CCT2,":[144],"TRiC":[146],"chaperonin":[147],"subunit,":[148],"which":[149],"distinguished":[150],"it":[151],"quiescent":[154],"with":[156,174],"an":[157],"area":[158],"curve":[161],"0.892.":[163],"also":[166,228],"elevated":[167],"at":[168],"protein":[170],"level":[171],"associated":[173],"rate":[176],"ALSFRS-R":[178],"decline,":[179],"although":[180],"this":[181,193],"association":[182],"weakened":[183],"after":[184],"adjustment":[185],"culture":[187],"composition.":[188],"Upstream":[189],"regulator":[190],"placed":[192],"downstream":[195],"MYC":[197],"mTORC1":[199],"activation.":[200],"No":[201],"germline":[202],"test":[203],"across":[204],"360":[205],"whole":[206],"genomes":[207],"explained":[208],"these":[209],"Validation":[211],"Target":[213],"data":[215],"showed":[216],"relationship":[219],"between":[220],"cycle":[225],"program":[226],"present":[229],"cortex":[232],"enriched":[233],"layer":[235],"5b":[236],"projection":[237],"neurons.":[238]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-09T00:00:00"}
