{"id":"https://openalex.org/W7220932819","doi":"https://doi.org/10.1038/s41467-026-78424-w","title":"ACAT1/SOAT1 governs mitochondrial dynamics and thermogenesis via the mTOR-MFN2-USP2 axis in brown adipocytes","display_name":"ACAT1/SOAT1 governs mitochondrial dynamics and thermogenesis via the mTOR-MFN2-USP2 axis in brown adipocytes","publication_year":2026,"publication_date":"2026-10-08","ids":{"openalex":"https://openalex.org/W7220932819","doi":"https://doi.org/10.1038/s41467-026-78424-w"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-026-78424-w","doi":"https://doi.org/10.1038/s41467-026-78424-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-78424-w","pdf_url":"https://www.nature.com/articles/s41467-026-78424-w_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-026-78424-w_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5146393008","display_name":"Wei Duan","orcid":"https://orcid.org/0009-0006-9839-028X","observed_orcids":["https://orcid.org/0009-0006-9839-028X"]},"institutions":[{"id":"https://openalex.org/I4210096013","display_name":"Shanghai Institute of Nutrition and Health","ror":"https://ror.org/00rytkh49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Duan","raw_affiliation_strings":["Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China"],"raw_orcid":"https://orcid.org/0009-0006-9839-028X","affiliations":[{"raw_affiliation_string":"Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China","institution_ids":["https://openalex.org/I4210096013","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157913805","display_name":"Mengyao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096013","display_name":"Shanghai Institute of Nutrition and Health","ror":"https://ror.org/00rytkh49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengyao Wang","raw_affiliation_strings":["Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China","institution_ids":["https://openalex.org/I4210096013","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146430386","display_name":"Yaming Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096013","display_name":"Shanghai Institute of Nutrition and Health","ror":"https://ror.org/00rytkh49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaming Yuan","raw_affiliation_strings":["Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China","institution_ids":["https://openalex.org/I4210096013","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146007372","display_name":"Yufeng Zhang","orcid":"https://orcid.org/0009-0005-9162-7849","observed_orcids":["https://orcid.org/0009-0005-9162-7849"]},"institutions":[{"id":"https://openalex.org/I4210096013","display_name":"Shanghai Institute of Nutrition and Health","ror":"https://ror.org/00rytkh49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yufeng Zhang","raw_affiliation_strings":["Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China"],"raw_orcid":"https://orcid.org/0009-0005-9162-7849","affiliations":[{"raw_affiliation_string":"Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China","institution_ids":["https://openalex.org/I4210096013","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157920736","display_name":"Wei Jiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096013","display_name":"Shanghai Institute of Nutrition and Health","ror":"https://ror.org/00rytkh49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Jiao","raw_affiliation_strings":["Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China","institution_ids":["https://openalex.org/I4210096013","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157918063","display_name":"Nan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Wang","raw_affiliation_strings":["Jilin Province Neuro-oncology Engineering Laboratory, Jilin Provincial Key Laboratory of Neuro-oncology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin Province Neuro-oncology Engineering Laboratory, Jilin Provincial Key Laboratory of Neuro-oncology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157910743","display_name":"Ping Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096013","display_name":"Shanghai Institute of Nutrition and Health","ror":"https://ror.org/00rytkh49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Yang","raw_affiliation_strings":["Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China","institution_ids":["https://openalex.org/I4210096013","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019366710","display_name":"Xuelian Xiong","orcid":"https://orcid.org/0000-0002-7308-9830","observed_orcids":["https://orcid.org/0000-0002-7308-9830","https://orcid.org/0000-0002-1832-8202"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuelian Xiong","raw_affiliation_strings":["Ministry of Education Key Laboratory of Metabolism and Molecular Medicine, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Metabolism and Molecular Medicine, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004610865","display_name":"Shuang Tang","orcid":"https://orcid.org/0000-0002-3501-7836","observed_orcids":["https://orcid.org/0000-0002-3501-7836"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Tang","raw_affiliation_strings":["Department of Nuclear Medicine, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, 200032, China"],"raw_orcid":"https://orcid.org/0000-0002-3501-7836","affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157895062","display_name":"Yufei Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yufei Gao","raw_affiliation_strings":["Jilin Province Neuro-oncology Engineering Laboratory, Jilin Provincial Key Laboratory of Neuro-oncology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin Province Neuro-oncology Engineering Laboratory, Jilin Provincial Key Laboratory of Neuro-oncology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043478474","display_name":"Xiongwen Cao","orcid":"https://orcid.org/0009-0002-4746-127X","observed_orcids":["https://orcid.org/0009-0002-4746-127X"]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiongwen Cao","raw_affiliation_strings":["Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, 200241, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, 200241, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103185041","display_name":"Yewei Ji","orcid":"https://orcid.org/0000-0003-4960-9928","observed_orcids":["https://orcid.org/0000-0003-4960-9928"]},"institutions":[{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yewei Ji","raw_affiliation_strings":["Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Department of Infectious Diseases of The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":"https://orcid.org/0000-0003-4960-9928","affiliations":[{"raw_affiliation_string":"Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Department of Infectious Diseases of The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I4210097509","https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157893076","display_name":"Ben Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096013","display_name":"Shanghai Institute of Nutrition and Health","ror":"https://ror.org/00rytkh49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ben Zhou","raw_affiliation_strings":["Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China","institution_ids":["https://openalex.org/I4210096013","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157958279","display_name":"Lifeng Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096013","display_name":"Shanghai Institute of Nutrition and Health","ror":"https://ror.org/00rytkh49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lifeng Yang","raw_affiliation_strings":["Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China","institution_ids":["https://openalex.org/I4210096013","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043067285","display_name":"Yuyan Zhu","orcid":"https://orcid.org/0000-0002-2928-6167","observed_orcids":["https://orcid.org/0000-0002-2928-6167"]},"institutions":[{"id":"https://openalex.org/I14243506","display_name":"Hong Kong Polytechnic University","ror":"https://ror.org/0030zas98","country_code":"HK","type":"education","lineage":["https://openalex.org/I14243506"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Yuyan Zhu","raw_affiliation_strings":["Department of Food Science and Nutrition and Research Institute for Future Food, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong"],"raw_orcid":"https://orcid.org/0000-0002-2928-6167","affiliations":[{"raw_affiliation_string":"Department of Food Science and Nutrition and Research Institute for Future Food, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong","institution_ids":["https://openalex.org/I14243506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100776079","display_name":"Ming L\u00fc","orcid":"https://orcid.org/0000-0002-3749-5321","observed_orcids":["https://orcid.org/0000-0002-3749-5321"]},"institutions":[{"id":"https://openalex.org/I4210096013","display_name":"Shanghai Institute of Nutrition and Health","ror":"https://ror.org/00rytkh49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ming Lu","raw_affiliation_strings":["Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China"],"raw_orcid":"https://orcid.org/0000-0002-3749-5321","affiliations":[{"raw_affiliation_string":"Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China","institution_ids":["https://openalex.org/I4210096013","https://openalex.org/I4210165038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046567270","display_name":"Zhangsen Zhou","orcid":"https://orcid.org/0000-0001-7333-4624","observed_orcids":["https://orcid.org/0000-0001-7333-4624"]},"institutions":[{"id":"https://openalex.org/I4210096013","display_name":"Shanghai Institute of Nutrition and Health","ror":"https://ror.org/00rytkh49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhangsen Zhou","raw_affiliation_strings":["Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China"],"raw_orcid":"https://orcid.org/0000-0001-7333-4624","affiliations":[{"raw_affiliation_string":"Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200233, China","institution_ids":["https://openalex.org/I4210096013","https://openalex.org/I4210165038"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5043067285","https://openalex.org/A5046567270","https://openalex.org/A5100776079"],"corresponding_institution_ids":["https://openalex.org/I14243506","https://openalex.org/I4210096013","https://openalex.org/I4210165038"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.74317282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acat1","display_name":"ACAT1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/soat1","display_name":"SOAT1","score":0.968999981880188},{"id":"https://openalex.org/keywords/brown-adipocytes","display_name":"brown adipocytes","score":0.828000009059906},{"id":"https://openalex.org/keywords/brown-adipose-tissue-thermogenesis","display_name":"brown adipose tissue thermogenesis","score":0.925000011920929},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mitochondrial-fusion","display_name":"mitochondrial fusion","score":0.7450000047683716},{"id":"https://openalex.org/keywords/mfn2","display_name":"mitofusin 2","score":0.824999988079071},{"id":"https://openalex.org/keywords/usp2","display_name":"USP2","score":0.8349999785423279},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.925000011920929},{"id":"https://openalex.org/keywords/cholesterol-metabolism","display_name":"cholesterol metabolism","score":0.8190000057220459},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.8080000281333923},{"id":"https://openalex.org/keywords/er-mitochondria-contact-sites","display_name":"ER-mitochondria contact sites","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cold-sensitivity","display_name":"cold sensitivity","score":0.6420000195503235},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.8889999985694885},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.8920000195503235}],"concepts":[{"id":"https://openalex.org/C151279926","wikidata":"https://www.wikidata.org/wiki/Q965695","display_name":"Thermogenesis","level":3,"score":0.7943999767303467},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.5848000049591064},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5730999708175659},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.5570999979972839},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.47679999470710754},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4465000033378601},{"id":"https://openalex.org/C81979416","wikidata":"https://www.wikidata.org/wiki/Q419493","display_name":"Thermogenin","level":4,"score":0.41499999165534973},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3140000104904175},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2994000017642975},{"id":"https://openalex.org/C2779406938","wikidata":"https://www.wikidata.org/wiki/Q24720289","display_name":"Uncoupling protein","level":4,"score":0.28279998898506165},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.2533000111579895}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41467-026-78424-w","doi":"https://doi.org/10.1038/s41467-026-78424-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-78424-w","pdf_url":"https://www.nature.com/articles/s41467-026-78424-w_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41467-026-78424-w","doi":"https://doi.org/10.1038/s41467-026-78424-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-78424-w","pdf_url":"https://www.nature.com/articles/s41467-026-78424-w_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G563408198","display_name":null,"funder_award_id":"2021YFA0805500","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7224608573","display_name":null,"funder_award_id":"32300594","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8842110521","display_name":null,"funder_award_id":"32371208","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"},{"id":"https://openalex.org/F4320322598","display_name":"Hong Kong Polytechnic University","ror":"https://ror.org/0030zas98"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220932819.pdf","grobid_xml":"https://content.openalex.org/works/W7220932819.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2560528428","https://openalex.org/W6884902952","https://openalex.org/W1991888027","https://openalex.org/W2468606779","https://openalex.org/W2599212030","https://openalex.org/W4385813303","https://openalex.org/W2616919077","https://openalex.org/W2949020552","https://openalex.org/W2770114672","https://openalex.org/W3035234937"],"abstract_inverted_index":{"Mitochondrial":[0],"dynamics":[1,45],"are":[2],"crucial":[3],"for":[4,155],"brown":[5,50],"adipose":[6],"tissue":[7],"(BAT)":[8],"thermogenesis":[9,41,157],"and":[10,57,95,100,121,158],"systemic":[11,122],"energy":[12,123],"homeostasis;":[13],"yet,":[14],"the":[15,74,85,107,141,144],"cholesterol-sensing":[16],"pathways":[17],"regulating":[18],"these":[19],"processes":[20],"remain":[21],"poorly":[22],"defined.":[23],"Here":[24],"we":[25],"report":[26],"that":[27,69],"ACAT1,":[28],"an":[29],"endoplasmic":[30],"reticulum":[31],"(ER)-resident":[32],"cholesterol":[33,67,115,149],"esterase,":[34],"acts":[35],"as":[36,110],"a":[37,111],"critical":[38,127,154],"rheostat":[39],"of":[40,73],"by":[42,90],"governing":[43],"mitochondrial":[44,75,98,118,152],"in":[46,130,138],"BAT.":[47],"Mice":[48],"with":[49,117],"adipocyte-specific":[51],"Acat1":[52],"deletion":[53],"exhibit":[54],"cold":[55],"intolerance":[56],"exacerbated":[58],"Western":[59],"diet-induced":[60],"obesity.":[61,131],"Mechanistically,":[62],"ACAT1":[63],"inhibition":[64],"triggers":[65],"intracellular":[66],"accu7mulation":[68],"activates":[70],"mTOR-mediated":[71],"phosphorylation":[72],"fusion":[76,99],"protein":[77],"MFN2":[78,89],"at":[79],"Serine":[80],"200.":[81],"This":[82],"modification":[83],"recruits":[84],"deubiquitinase":[86],"USP2,":[87],"stabilizing":[88],"inhibiting":[91],"its":[92,126],"proteasomal":[93],"degradation":[94],"driving":[96],"pathological":[97],"ER-mitochondria":[101],"contacts.":[102],"Hence,":[103],"our":[104],"findings":[105],"establish":[106],"ACAT1-mTOR-MFN2-USP2":[108],"axis":[109,146],"fundamental":[112],"mechanism":[113],"coordinating":[114],"metabolism":[116,150],"dynamics,":[119],"thermogenesis,":[120],"balance,":[124],"revealing":[125],"pathophysiological":[128],"significance":[129],"Cholesterol":[132],"levels":[133],"must":[134],"be":[135],"precisely":[136],"controlled":[137],"cells.":[139],"Here,":[140],"authors":[142],"identify":[143],"mTOR-MFN2-USP2":[145],"linking":[147],"ACAT1-mediated":[148],"to":[151],"homeostasis,":[153],"brown-fat":[156],"whole-body":[159],"metabolism.":[160]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-09T00:00:00"}