{"id":"https://openalex.org/W7220928633","doi":"https://doi.org/10.1111/jbg.70079","title":"Characterizing Runs of Homozygosity and Inbreeding in American Mink Using SNP Data and Pedigree Information","display_name":"Characterizing Runs of Homozygosity and Inbreeding in American Mink Using SNP Data and Pedigree Information","publication_year":2026,"publication_date":"2026-10-08","ids":{"openalex":"https://openalex.org/W7220928633","doi":"https://doi.org/10.1111/jbg.70079","pmid":"https://pubmed.ncbi.nlm.nih.gov/42847611"},"language":"en","primary_location":{"id":"doi:10.1111/jbg.70079","doi":"https://doi.org/10.1111/jbg.70079","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jbg.70079","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jbg.70079","source":{"id":"https://openalex.org/S158490989","display_name":"Journal of Animal Breeding and Genetics","issn_l":"0044-3581","issn":["0044-3581","0931-2668","1439-0388"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Breeding and Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jbg.70079","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055777392","display_name":"Persia Carol Thapa","orcid":"https://orcid.org/0009-0000-3327-7012","observed_orcids":["https://orcid.org/0009-0000-3327-7012"]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Persia Carol Thapa","raw_affiliation_strings":["Department of Animal Science and Aquaculture Dalhousie University  Truro Nova Scotia Canada"],"raw_orcid":"https://orcid.org/0009-0000-3327-7012","affiliations":[{"raw_affiliation_string":"Department of Animal Science and Aquaculture Dalhousie University  Truro Nova Scotia Canada","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153505080","display_name":"Duy Ngoc Do","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Duy Ngoc Do","raw_affiliation_strings":["Department of Animal Science and Aquaculture Dalhousie University  Truro Nova Scotia Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Science and Aquaculture Dalhousie University  Truro Nova Scotia Canada","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030953695","display_name":"Pourya Davoudi","orcid":"https://orcid.org/0000-0002-0862-5502","observed_orcids":["https://orcid.org/0000-0002-0862-5502"]},"institutions":[{"id":"https://openalex.org/I243155512","display_name":"Agriculture and Horticulture Development Board","ror":"https://ror.org/010gf7388","country_code":"GB","type":"government","lineage":["https://openalex.org/I1326803253","https://openalex.org/I243155512","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pourya Davoudi","raw_affiliation_strings":["Agriculture and Horticulture Development Board (AHDB)  Coventry UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agriculture and Horticulture Development Board (AHDB)  Coventry UK","institution_ids":["https://openalex.org/I243155512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005370792","display_name":"Ghader Manafiazar","orcid":"https://orcid.org/0000-0003-4681-8214","observed_orcids":["https://orcid.org/0000-0003-4681-8214"]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ghader Manafiazar","raw_affiliation_strings":["Department of Animal Science and Aquaculture Dalhousie University  Truro Nova Scotia Canada"],"raw_orcid":"https://orcid.org/0000-0003-4681-8214","affiliations":[{"raw_affiliation_string":"Department of Animal Science and Aquaculture Dalhousie University  Truro Nova Scotia Canada","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034091757","display_name":"Younes Miar","orcid":"https://orcid.org/0000-0001-9933-5414","observed_orcids":["https://orcid.org/0000-0001-9933-5414"]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Younes Miar","raw_affiliation_strings":["Department of Animal Science and Aquaculture Dalhousie University  Truro Nova Scotia Canada"],"raw_orcid":"https://orcid.org/0000-0001-9933-5414","affiliations":[{"raw_affiliation_string":"Department of Animal Science and Aquaculture Dalhousie University  Truro Nova Scotia Canada","institution_ids":["https://openalex.org/I129902397"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034091757"],"corresponding_institution_ids":["https://openalex.org/I129902397"],"apc_list":{"value":4750,"currency":"USD","value_usd":4750},"apc_paid":{"value":4750,"currency":"USD","value_usd":4750},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/runs-of-homozygosity","display_name":"runs of homozygosity","score":0.9750000238418579},{"id":"https://openalex.org/keywords/inbreeding","display_name":"inbreeding","score":0.9649999737739563},{"id":"https://openalex.org/keywords/american-mink","display_name":"American mink","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neogale-vison","display_name":"Neogale vison","score":0.9869999885559082},{"id":"https://openalex.org/keywords/autozygosity","display_name":"autozygosity","score":0.7929999828338623},{"id":"https://openalex.org/keywords/chromosome-level-genome-assembly","display_name":"chromosome-level genome assembly","score":0.7839999794960022},{"id":"https://openalex.org/keywords/snp-genotyping","display_name":"SNP genotyping","score":0.5649999976158142},{"id":"https://openalex.org/keywords/mating-decisions","display_name":"mating decisions","score":0.6029999852180481},{"id":"https://openalex.org/keywords/closed-population","display_name":"closed population","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C2776116246","wikidata":"https://www.wikidata.org/wiki/Q21067469","display_name":"Runs of Homozygosity","level":5,"score":0.9261999726295471},{"id":"https://openalex.org/C2780754187","wikidata":"https://www.wikidata.org/wiki/Q17700","display_name":"Mink","level":2,"score":0.8664000034332275},{"id":"https://openalex.org/C2777782036","wikidata":"https://www.wikidata.org/wiki/Q38978","display_name":"Inbreeding","level":3,"score":0.8492000102996826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.821399986743927},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7412999868392944},{"id":"https://openalex.org/C2910378429","wikidata":"https://www.wikidata.org/wiki/Q27179","display_name":"American mink","level":3,"score":0.5497000217437744},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.451200008392334},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.4189000129699707},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.3986000120639801},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.3059000074863434},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2904999852180481},{"id":"https://openalex.org/C163691529","wikidata":"https://www.wikidata.org/wiki/Q7391886","display_name":"SNP genotyping","level":5,"score":0.27720001339912415},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.2709999978542328},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.2703000009059906},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.26010000705718994},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.25540000200271606}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/jbg.70079","doi":"https://doi.org/10.1111/jbg.70079","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jbg.70079","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jbg.70079","source":{"id":"https://openalex.org/S158490989","display_name":"Journal of Animal Breeding and Genetics","issn_l":"0044-3581","issn":["0044-3581","0931-2668","1439-0388"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Breeding and Genetics","raw_type":"journal-article"},{"id":"pmid:42847611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42847611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/jbg.70079","doi":"https://doi.org/10.1111/jbg.70079","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jbg.70079","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jbg.70079","source":{"id":"https://openalex.org/S158490989","display_name":"Journal of Animal Breeding and Genetics","issn_l":"0044-3581","issn":["0044-3581","0931-2668","1439-0388"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Breeding and Genetics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F3581876645","display_name":"Canada Mink Breeders Association","ror":null},{"id":"https://openalex.org/F4320321629","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80"},{"id":"https://openalex.org/F4320322675","display_name":"Mitacs","ror":"https://ror.org/00cjrc276"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F967022428","display_name":"Nova Scotia Mink Breeders Association","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220928633.pdf","grobid_xml":"https://content.openalex.org/works/W7220928633.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1881900810","https://openalex.org/W2011310028","https://openalex.org/W2020466084","https://openalex.org/W2023926550","https://openalex.org/W2024438347","https://openalex.org/W2028651189","https://openalex.org/W2029395646","https://openalex.org/W2065035179","https://openalex.org/W2089528964","https://openalex.org/W2091239497","https://openalex.org/W2110371880","https://openalex.org/W2138863022","https://openalex.org/W2140247198","https://openalex.org/W2153362877","https://openalex.org/W2155800961","https://openalex.org/W2158170190","https://openalex.org/W2160538382","https://openalex.org/W2161633633","https://openalex.org/W2171205037","https://openalex.org/W2173382734","https://openalex.org/W2346465633","https://openalex.org/W2543436947","https://openalex.org/W2559013477","https://openalex.org/W2766592629","https://openalex.org/W2767933265","https://openalex.org/W2768437395","https://openalex.org/W2784309373","https://openalex.org/W2792754721","https://openalex.org/W2827411621","https://openalex.org/W2884432812","https://openalex.org/W2884961899","https://openalex.org/W2886248614","https://openalex.org/W2889361837","https://openalex.org/W2952255385","https://openalex.org/W2977036063","https://openalex.org/W2987943817","https://openalex.org/W2998947455","https://openalex.org/W3005873264","https://openalex.org/W3012170377","https://openalex.org/W3014042482","https://openalex.org/W3022819373","https://openalex.org/W3030210125","https://openalex.org/W3046503529","https://openalex.org/W3097600806","https://openalex.org/W3126515729","https://openalex.org/W3150570547","https://openalex.org/W3177355360","https://openalex.org/W3196805279","https://openalex.org/W3213390181","https://openalex.org/W4220901394","https://openalex.org/W4220905429","https://openalex.org/W4224251312","https://openalex.org/W4226162720","https://openalex.org/W4236790453","https://openalex.org/W4280529550","https://openalex.org/W4280588061","https://openalex.org/W4285091073","https://openalex.org/W4311899419","https://openalex.org/W4375950747","https://openalex.org/W4383100613","https://openalex.org/W4387052504","https://openalex.org/W4392107087","https://openalex.org/W4392456056","https://openalex.org/W4399050555","https://openalex.org/W4400515867"],"related_works":["https://openalex.org/W4230741285","https://openalex.org/W7067190670","https://openalex.org/W2475106212","https://openalex.org/W2997221014","https://openalex.org/W2028651189","https://openalex.org/W2155596705","https://openalex.org/W6991287796","https://openalex.org/W2800225649","https://openalex.org/W2774974380","https://openalex.org/W3003366319"],"abstract_inverted_index":{"ABSTRACT":[0],"Inbreeding":[1],"increases":[2],"the":[3,21,26,29,82,94,156,229,232,236],"likelihood":[4],"of":[5,18,25,38,126,143,148,155,160,190,231,238,267],"deleterious":[6],"recessive":[7],"alleles":[8],"becoming":[9],"homozygous":[10,23],"and":[11,28,44,64,98,105,151,165,170,179,186,203,206,212],"consequently":[12],"affecting":[13],"economically":[14],"important":[15],"traits.":[16],"Runs":[17],"homozygosity":[19,33],"(ROH),":[20],"continuous":[22],"segments":[24,130,223],"genome":[27,96],"higher":[30],"than":[31,135,225,248],"expected":[32],"(HOM)":[34],"are":[35],"genomic":[36,210,269],"indicators":[37],"inbreeding,":[39],"quantified":[40],"as":[41],"F":[42,45,100,103,158,163,166,201,204,213],"ROH":[43,50,76,101,117,150,159,173,202,218,246],"HOM":[46,104,164,205],",":[47,215],"respectively.":[48,172],"Previous":[49],"analyses":[51],"in":[52,77,120,140,257,263],"American":[53],"mink":[54,79],"(":[55],"Neogale":[56],"vison":[57],")":[58,111],"were":[59,118,168,174],"restricted":[60,244],"to":[61,220,245,274],"scaffold\u2010level":[62],"references":[63],"could":[65],"not":[66,138],"resolve":[67],"long":[68,268],"autozygous":[69],"segments.":[70,192],"In":[71],"this":[72,144,258],"study,":[73],"we":[74],"characterized":[75],"1413":[78],"genotyped":[80],"with":[81,102,106,123,217],"Affymetrix":[83],"Mink":[84],"70K":[85],"panel":[86,234],"(50,902":[87],"autosomal":[88],"SNPs":[89],"after":[90],"quality":[91],"control)":[92],"on":[93],"chromosome\u2010level":[95],"assembly":[97],"compared":[99],"pedigree\u2010based":[107],"inbreeding":[108,211],"(F":[109],"PED":[110,167,214],"derived":[112],"from":[113],"24,633":[114],"pedigree":[115],"records.":[116],"detected":[119],"all":[121,149,191],"individuals,":[122],"a":[124,264],"mean":[125,157],"149.61":[127],"\u00b1":[128],"13.82":[129],"per":[131],"individual.":[132],"Segments":[133],"longer":[134,224,247],"8":[136],"Mb,":[137],"detectable":[139],"earlier":[141],"studies":[142],"population,":[145],"represented":[146],"12.86%":[147],"accounted":[152],"for":[153,222],"0.10":[154],"0.28.":[161],"Mean":[162],"\u22120.03":[169],"0.02,":[171],"unevenly":[175],"distributed":[176],"across":[177],"chromosomes":[178,180],"1,":[181],"2,":[182],"3,":[183],"4,":[184],"6":[185],"11":[187],"harboured":[188],"78.59%":[189],"The":[193],"Pearson":[194],"correlation":[195],"coefficient":[196],"was":[197,243],"highest":[198],"(0.72)":[199],"between":[200,209],"moderate":[207],"(0.34)":[208],"increasing":[216],"length":[219],"0.35":[221],"16":[226],"Mb.":[227,250],"Because":[228],"density":[230],"marker":[233],"limits":[235],"resolution":[237],"short":[239],"segments,":[240,270],"quantitative":[241],"inference":[242],"4":[249],"Our":[251],"results":[252],"indicate":[253],"that":[254],"recent":[255],"autozygosity":[256],"closed":[259],"population":[260],"is":[261],"concentrated":[262],"small":[265],"number":[266],"providing":[271],"an":[272],"opportunity":[273],"inform":[275],"mating":[276],"decisions.":[277]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-10-09T00:00:00"}