{"id":"https://openalex.org/W7220927285","doi":"https://doi.org/10.3389/fendo.2026.1943954","title":"Cross-scale genetic, molecular, and cellular triangulation prioritizes ACSL5 as a T3-responsive candidate linking hypothyroidism liability to anemia","display_name":"Cross-scale genetic, molecular, and cellular triangulation prioritizes ACSL5 as a T3-responsive candidate linking hypothyroidism liability to anemia","publication_year":2026,"publication_date":"2026-10-08","ids":{"openalex":"https://openalex.org/W7220927285","doi":"https://doi.org/10.3389/fendo.2026.1943954","pmid":"https://pubmed.ncbi.nlm.nih.gov/42922834","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13686861"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2026.1943954","doi":"https://doi.org/10.3389/fendo.2026.1943954","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2026.1943954","pdf_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1943954/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1943954/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157908910","display_name":"Hui Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hui Li","raw_affiliation_strings":["Department of Hematology, The People\u2019s Hospital of Jianyang City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The People\u2019s Hospital of Jianyang City","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157972798","display_name":"Tao Jiang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao Jiang","raw_affiliation_strings":["Department of Hematology, The People\u2019s Hospital of Jianyang City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The People\u2019s Hospital of Jianyang City","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157988428","display_name":"Huan Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huan Wang","raw_affiliation_strings":["Department of Hematology, The People\u2019s Hospital of Jianyang City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The People\u2019s Hospital of Jianyang City","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157923175","display_name":"Mei Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mei Wang","raw_affiliation_strings":["Department of Hematology, The People\u2019s Hospital of Jianyang City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The People\u2019s Hospital of Jianyang City","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157953038","display_name":"Sixi Xie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sixi Xie","raw_affiliation_strings":["Department of Hematology, The People\u2019s Hospital of Jianyang City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The People\u2019s Hospital of Jianyang City","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5157908910"],"corresponding_institution_ids":[],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.68547718,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1943954","last_page":"1943954"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7890999913215637,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7890999913215637,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.14390000700950623,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.9779999852180481},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.9879999756813049},{"id":"https://openalex.org/keywords/acsl5","display_name":"ACSL5","score":0.8410000205039978},{"id":"https://openalex.org/keywords/triiodothyronine","display_name":"triiodothyronine","score":0.8930000066757202},{"id":"https://openalex.org/keywords/erythroid-cells","display_name":"erythroid cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.7200000286102295},{"id":"https://openalex.org/keywords/cpg-methylation","display_name":"CpG methylation","score":0.6740000247955322},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"expression quantitative trait loci","score":0.8849999904632568}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.585099995136261},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5802000164985657},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.5386999845504761},{"id":"https://openalex.org/C2778997081","wikidata":"https://www.wikidata.org/wiki/Q1208654","display_name":"Diamond\u2013Blackfan anemia","level":5,"score":0.3361000120639801},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31940001249313354},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.31779998540878296},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29820001125335693},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.2881999909877777},{"id":"https://openalex.org/C139265228","wikidata":"https://www.wikidata.org/wiki/Q5283089","display_name":"Distress","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.27239999175071716},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2678000032901764},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2549000084400177}],"mesh":[{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003066","descriptor_name":"Coenzyme A Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003066","descriptor_name":"Coenzyme A Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fendo.2026.1943954","doi":"https://doi.org/10.3389/fendo.2026.1943954","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2026.1943954","pdf_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1943954/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13686861","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13686861/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13686861/pdf/fendo-17-1943954.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmid:42922834","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42922834","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5ca43b367cfe454ba348c1c085fd24b5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5ca43b367cfe454ba348c1c085fd24b5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2026.1943954","doi":"https://doi.org/10.3389/fendo.2026.1943954","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2026.1943954","pdf_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1943954/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220927285.pdf","grobid_xml":"https://content.openalex.org/works/W7220927285.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1848939527","https://openalex.org/W1996143474","https://openalex.org/W2006938530","https://openalex.org/W2047851688","https://openalex.org/W2100855877","https://openalex.org/W2105766695","https://openalex.org/W2107277218","https://openalex.org/W2113699335","https://openalex.org/W2168420558","https://openalex.org/W2328393125","https://openalex.org/W2520048741","https://openalex.org/W2609602633","https://openalex.org/W2611485172","https://openalex.org/W2613373507","https://openalex.org/W2746058314","https://openalex.org/W2755302476","https://openalex.org/W2770598799","https://openalex.org/W2803072880","https://openalex.org/W2805983714","https://openalex.org/W2887125318","https://openalex.org/W2895486342","https://openalex.org/W2949437525","https://openalex.org/W2950598813","https://openalex.org/W2997020475","https://openalex.org/W3125340327","https://openalex.org/W3133859624","https://openalex.org/W3201148157","https://openalex.org/W3202212354","https://openalex.org/W3210406414","https://openalex.org/W4211103501","https://openalex.org/W4214630608","https://openalex.org/W4310860308","https://openalex.org/W4317390883","https://openalex.org/W4318566988","https://openalex.org/W4319068312","https://openalex.org/W4321764970","https://openalex.org/W4385577954","https://openalex.org/W4388007007","https://openalex.org/W4388699267","https://openalex.org/W4390939305","https://openalex.org/W4400216167","https://openalex.org/W4408974063","https://openalex.org/W4409736934","https://openalex.org/W7130728411"],"related_works":["https://openalex.org/W3201148157","https://openalex.org/W4292805223","https://openalex.org/W6977446068","https://openalex.org/W4380871666","https://openalex.org/W4298140870","https://openalex.org/W4386614806","https://openalex.org/W4412785158","https://openalex.org/W4400299222","https://openalex.org/W4401577169","https://openalex.org/W7033709770"],"abstract_inverted_index":{"Purpose":[0],"Anemia":[1],"is":[2],"a":[3,15,82,111,141,318,330,344,356],"recognized":[4],"complication":[5],"of":[6],"hypothyroidism,":[7],"but":[8],"disease-level":[9],"genetic":[10,22],"studies":[11,195],"have":[12],"not":[13,206,252],"identified":[14],"clear":[16],"erythroid":[17,30],"cell-intrinsic":[18],"target.":[19],"We":[20],"integrated":[21],"validation,":[23],"molecular-QTL":[24],"prioritization,":[25],"and":[26,41,51,61,103,129,155,200,260,306,338,351,362],"replicated":[27],"triiodothyronine":[28],"(T3)-responsive":[29],"experiments":[31,148],"to":[32,38,271,336],"identify":[33],"candidates":[34],"linking":[35,333],"hypothyroidism":[36,50,172,334],"liability":[37,173,335],"anemia.":[39,52],"Materials":[40],"methods":[42],"Two-sample":[43],"Mendelian":[44,100],"randomization":[45,101],"(MR)":[46],"assessed":[47],"genetically":[48],"predicted":[49],"Source":[53],"metadata":[54],"were":[55,66,107,197],"reviewed":[56],"for":[57,115],"possible":[58],"sample":[59],"overlap,":[60],"two":[62,116,269],"cross-biobank":[63],"forward":[64],"validations":[65],"performed.":[67],"Strict":[68,247],"reverse":[69,249],"MR":[70,250],"used":[71,86],"the":[72,130,221,237,254],"original":[73],"OpenGWAS":[74],"identifiers;":[75],"because":[76],"anemia":[77,176,218,242,337],"provided":[78],"no":[79,287],"genome-wide-significant":[80],"instruments,":[81],"post":[83],"hoc":[84],"analysis":[85,170,243,257],"p":[87,184,230],"<":[88],"5":[89,122],"\u00d7":[90,187,233],"10":[91,188,234],"\u22126":[92],".":[93],"Non-major":[94],"histocompatibility":[95],"complex":[96],"(MHC)":[97],"methylation":[98],"summary-based":[99],"(SMR)":[102],"whole-blood":[104,275],"expression":[105,277],"SMR":[106,281],"integrated,":[108],"followed":[109],"by":[110],"public":[112,210,284],"fine-mapping/colocalization":[113],"lookup":[114,285],"acyl-CoA":[117],"synthetase":[118],"long-chain":[119,340],"family":[120],"member":[121],"(":[123],"ACSL5":[124,131,133,272,276,307,328,360],")":[125],"cytosine-phosphate-guanine":[126],"(CpG)":[127],"sites":[128],"eQTL.":[132],"was":[134,244,251,258],"examined":[135],"in":[136],"three":[137,293],"independent":[138],"hemin-induced":[139],"K562,":[140],"human":[142],"chronic":[143],"myelogenous":[144],"leukemia":[145],"cell":[146],"line":[147],"with":[149,174],"or":[150],"without":[151,321],"T3;":[152],"Triacsin":[153,309],"C":[154,310],"oleic":[156,315],"acid-bovine":[157],"serum":[158],"albumin":[159],"(BSA)":[160],"served":[161],"as":[162,329,343],"pathway-level":[163],"perturbations.":[164],"Results":[165],"Primary":[166],"inverse-variance":[167],"weighted":[168],"(IVW)":[169],"associated":[171],"higher":[175],"odds":[177],"(OR":[178],"=":[179,185,228,231],"1.0304;":[180],"95%":[181],"CI,":[182],"1.0195\u20131.0414;":[183],"3.42":[186],"\u22128":[189],").":[190],"Both":[191],"primary":[192,363],"genome-wide":[193],"association":[194],"(GWASs)":[196],"UK":[198,239],"Biobank-derived,":[199],"their":[201],"exact":[202],"participant":[203],"overlap":[204],"could":[205],"be":[207],"determined":[208],"from":[209],"summary-level":[211],"information.":[212],"A":[213],"participant-independent":[214],"FinnGen":[215],"hypothyroidism-to-UK":[216],"Biobank":[217,240],"validation":[219,365],"reproduced":[220],"positive":[222],"direction":[223],"(28":[224],"instruments;":[225],"IVW":[226],"beta":[227],"0.001448,":[229],"4.14":[232],"\u22124":[235],");":[236],"complementary":[238],"hypothyroidism-to-FinnGen":[241],"also":[245],"positive.":[246],"original-ID":[248],"estimable;":[253],"exploratory":[255],"eight-instrument":[256],"null":[259],"heterogeneous.":[261],"Six":[262],"non-MHC":[263],"CpGs":[264],"passed":[265],"Bonferroni":[266],"correction,":[267],"including":[268],"mapped":[270],",":[273,301,303,305],"while":[274],"showed":[278],"an":[279],"inverse":[280],"estimate.":[282],"The":[283],"returned":[286],"pairwise":[288],"CpG-expression":[289,349],"colocalization.":[290],"In":[291],"all":[292],"K562":[294],"experiments,":[295],"hemin":[296],"plus":[297],"T3":[298],"increased":[299],"HBA1":[300],"HBA2":[302],"GYPA":[304],"expression.":[308],"suppressed":[311],"erythroid-marker":[312],"expression,":[313],"whereas":[314],"acid-BSA":[316],"produced":[317],"partial":[319],"increase":[320],"exogenous":[322],"T3.":[323],"Conclusion":[324],"Cross-scale":[325],"evidence":[326],"prioritizes":[327],"T3-responsive":[331],"candidate":[332],"implicates":[339],"fatty-acid":[341],"handling":[342],"research":[345],"direction.":[346],"However,":[347],"negative":[348],"colocalization":[350],"nongene-specific":[352],"pharmacological":[353],"interventions":[354],"preclude":[355],"mechanistic":[357],"conclusion.":[358],"Direct":[359],"perturbation":[361],"erythroid-cell":[364],"are":[366],"required.":[367]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-09T00:00:00"}