{"id":"https://openalex.org/W7220924874","doi":"https://doi.org/10.1016/j.xcrm.2026.103097","title":"A spatiotemporal atlas of radiation-induced brain injury reveals dysfunction of the blood-CSF barrier","display_name":"A spatiotemporal atlas of radiation-induced brain injury reveals dysfunction of the blood-CSF barrier","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7220924874","doi":"https://doi.org/10.1016/j.xcrm.2026.103097","pmid":"https://pubmed.ncbi.nlm.nih.gov/42849444","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13710376"},"language":"en","primary_location":{"id":"doi:10.1016/j.xcrm.2026.103097","doi":"https://doi.org/10.1016/j.xcrm.2026.103097","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xcrm.2026.103097","pdf_url":null,"source":{"id":"https://openalex.org/S4210207453","display_name":"Cell Reports Medicine","issn_l":"2666-3791","issn":["2666-3791"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.xcrm.2026.103097","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035358019","display_name":"Cheng Quan","orcid":"https://orcid.org/0000-0003-1859-9683","observed_orcids":["https://orcid.org/0000-0003-1859-9683"]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Quan","raw_affiliation_strings":["Academy of Military Medical Sciences, Beijing 100850, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, Beijing 100850, P.R. China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125524425","display_name":"Yan Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Gao","raw_affiliation_strings":["Academy of Military Medical Sciences, Beijing 100850, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, Beijing 100850, P.R. China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157906162","display_name":"Xinyi Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyi Liu","raw_affiliation_strings":["Academy of Military Medical Sciences, Beijing 100850, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, Beijing 100850, P.R. China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064725349","display_name":"Jiabao Xiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiabao Xiang","raw_affiliation_strings":["Academy of Military Medical Sciences, Beijing 100850, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, Beijing 100850, P.R. China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134256500","display_name":"Jiashu Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiashu Zhang","raw_affiliation_strings":["Department of Neurosurgery, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, P.R. China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157901158","display_name":"Liping Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liping Chen","raw_affiliation_strings":["Academy of Military Medical Sciences, Beijing 100850, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, Beijing 100850, P.R. China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157903463","display_name":"Ying Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Li","raw_affiliation_strings":["Academy of Military Medical Sciences, Beijing 100850, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, Beijing 100850, P.R. China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157950969","display_name":"Weiming Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiming Gao","raw_affiliation_strings":["Academy of Military Medical Sciences, Beijing 100850, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, Beijing 100850, P.R. China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157952720","display_name":"Kaina Hao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaina Hao","raw_affiliation_strings":["Academy of Military Medical Sciences, Beijing 100850, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, Beijing 100850, P.R. China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157986845","display_name":"Guohang He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150807315","display_name":"Guangxi University","ror":"https://ror.org/02c9qn167","country_code":"CN","type":"education","lineage":["https://openalex.org/I150807315"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guohang He","raw_affiliation_strings":["School of Computer, Electronic and Information, Guangxi University, Nanning, Guangxi Zhuang Autonomous Region 530004, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer, Electronic and Information, Guangxi University, Nanning, Guangxi Zhuang Autonomous Region 530004, P.R. China","institution_ids":["https://openalex.org/I150807315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130577720","display_name":"Di Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Di Liu","raw_affiliation_strings":["Core Facility for Protein Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Facility for Protein Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, P.R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063303045","display_name":"Wang Aogang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aogang Wang","raw_affiliation_strings":["Academy of Military Medical Sciences, Beijing 100850, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, Beijing 100850, P.R. China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133633682","display_name":"Hongyue Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyue Tian","raw_affiliation_strings":["Academy of Military Medical Sciences, Beijing 100850, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, Beijing 100850, P.R. China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157944252","display_name":"Hao Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Lu","raw_affiliation_strings":["Academy of Military Medical Sciences, Beijing 100850, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, Beijing 100850, P.R. China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157973656","display_name":"Jie Ping","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Ping","raw_affiliation_strings":["Academy of Military Medical Sciences, Beijing 100850, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, Beijing 100850, P.R. China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139517341","display_name":"Siao Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siao Jiang","raw_affiliation_strings":["Academy of Military Medical Sciences, Beijing 100850, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, Beijing 100850, P.R. China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133668946","display_name":"Qilin Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qilin Huang","raw_affiliation_strings":["Academy of Military Medical Sciences, Beijing 100850, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, Beijing 100850, P.R. China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157964546","display_name":"Yinglong Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinglong Wu","raw_affiliation_strings":["Academy of Military Medical Sciences, Beijing 100850, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, Beijing 100850, P.R. China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157944375","display_name":"Haitao Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haitao Wu","raw_affiliation_strings":["Academy of Military Medical Sciences, Beijing 100850, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, Beijing 100850, P.R. China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129811554","display_name":"Yiming Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yiming Lu","raw_affiliation_strings":["Academy of Military Medical Sciences, Beijing 100850, P.R. China. Electronic address: ylu.phd@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, Beijing 100850, P.R. China. Electronic address: ylu.phd@gmail.com","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157968134","display_name":"Gangqiao Zhou","orcid":"https://orcid.org/0000-0002-4895-5063","observed_orcids":["https://orcid.org/0000-0002-4895-5063"]},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]},{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Gangqiao Zhou","raw_affiliation_strings":["Academy of Military Medical Sciences, Beijing 100850, P.R. China; Medical College of Guizhou University, Guiyang, Guizhou 550025, P.R. China; Collaborative Innovation Center for Personalized Cancer Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China. Electronic address: zhougq114@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, Beijing 100850, P.R. China; Medical College of Guizhou University, Guiyang, Guizhou 550025, P.R. China; Collaborative Innovation Center for Personalized Cancer Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China. Electronic address: zhougq114@126.com","institution_ids":["https://openalex.org/I178232147","https://openalex.org/I2802541053","https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5129811554","https://openalex.org/A5157968134"],"corresponding_institution_ids":["https://openalex.org/I178232147","https://openalex.org/I2802541053","https://openalex.org/I83519826"],"apc_list":{"value":5620,"currency":"USD","value_usd":5620},"apc_paid":{"value":5620,"currency":"USD","value_usd":5620},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.71550484,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"10","first_page":"103097","last_page":"103097"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.4214000105857849,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.4214000105857849,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.17659999430179596,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.10440000146627426,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiation-induced-brain-injury","display_name":"radiation-induced brain injury","score":0.9980000257492065},{"id":"https://openalex.org/keywords/blood-cerebrospinal-fluid-barrier","display_name":"blood-CSF barrier","score":0.8100000023841858},{"id":"https://openalex.org/keywords/choroid-plexus-epithelium","display_name":"choroid plexus epithelium","score":0.8489999771118164},{"id":"https://openalex.org/keywords/tmsb4x","display_name":"TMSB4X","score":0.8820000290870667},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8489999771118164},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.8500000238418579},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8930000066757202},{"id":"https://openalex.org/keywords/radiotherapy-complications","display_name":"radiotherapy complications","score":0.7409999966621399},{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.8159999847412109},{"id":"https://openalex.org/keywords/spatiotemporal-atlas","display_name":"spatiotemporal atlas","score":0.7710000276565552},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.8149999976158142},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48190000653266907},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45100000500679016},{"id":"https://openalex.org/C2776673561","wikidata":"https://www.wikidata.org/wiki/Q655357","display_name":"Atlas (anatomy)","level":2,"score":0.4487999975681305},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.34119999408721924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30250000953674316},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2800999879837036},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.2644999921321869},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.25060001015663147},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.2418999969959259},{"id":"https://openalex.org/C2780972224","wikidata":"https://www.wikidata.org/wiki/Q17047956","display_name":"Brain atlas","level":2,"score":0.23929999768733978}],"mesh":[{"descriptor_ui":"D000099285","descriptor_name":"Spatial Transcriptomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002831","descriptor_name":"Choroid Plexus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002831","descriptor_name":"Choroid Plexus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002831","descriptor_name":"Choroid Plexus","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011832","descriptor_name":"Radiation Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.xcrm.2026.103097","doi":"https://doi.org/10.1016/j.xcrm.2026.103097","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xcrm.2026.103097","pdf_url":null,"source":{"id":"https://openalex.org/S4210207453","display_name":"Cell Reports Medicine","issn_l":"2666-3791","issn":["2666-3791"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Medicine","raw_type":"journal-article"},{"id":"pmid:42849444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42849444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports. Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13710376","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710376/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Rep Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f7c7aa9ce5b242dda84a7ee746a9352b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f7c7aa9ce5b242dda84a7ee746a9352b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports Medicine, Vol 7, Iss 10, Pp 103097- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.xcrm.2026.103097","doi":"https://doi.org/10.1016/j.xcrm.2026.103097","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xcrm.2026.103097","pdf_url":null,"source":{"id":"https://openalex.org/S4210207453","display_name":"Cell Reports Medicine","issn_l":"2666-3791","issn":["2666-3791"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322919","display_name":"Natural Science Foundation of Beijing Municipality","ror":null},{"id":"https://openalex.org/F4320334978","display_name":"Beijing Nova Program","ror":"https://ror.org/034k14f91"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W1966327575","https://openalex.org/W1988856788","https://openalex.org/W2010467399","https://openalex.org/W2032036886","https://openalex.org/W2034351496","https://openalex.org/W2035618305","https://openalex.org/W2045683532","https://openalex.org/W2060705109","https://openalex.org/W2094522722","https://openalex.org/W2099300133","https://openalex.org/W2123491442","https://openalex.org/W2135484463","https://openalex.org/W2143827181","https://openalex.org/W2154575706","https://openalex.org/W2265854557","https://openalex.org/W2265953833","https://openalex.org/W2284512146","https://openalex.org/W2334802056","https://openalex.org/W2413931725","https://openalex.org/W2414195626","https://openalex.org/W2561338458","https://openalex.org/W2573339072","https://openalex.org/W2610627565","https://openalex.org/W2773247831","https://openalex.org/W2802670298","https://openalex.org/W2817838603","https://openalex.org/W2901466105","https://openalex.org/W2901838561","https://openalex.org/W2907514116","https://openalex.org/W2913221496","https://openalex.org/W2943220296","https://openalex.org/W2944565277","https://openalex.org/W2965570118","https://openalex.org/W2971144627","https://openalex.org/W2985366299","https://openalex.org/W2997280954","https://openalex.org/W2999300346","https://openalex.org/W3004544639","https://openalex.org/W3005382457","https://openalex.org/W3022836409","https://openalex.org/W3023007749","https://openalex.org/W3030182093","https://openalex.org/W3043793790","https://openalex.org/W3044030235","https://openalex.org/W3047141442","https://openalex.org/W3112281857","https://openalex.org/W3113032570","https://openalex.org/W3125753820","https://openalex.org/W3127341444","https://openalex.org/W3129476455","https://openalex.org/W3132661792","https://openalex.org/W3134482219","https://openalex.org/W3140224894","https://openalex.org/W3157400350","https://openalex.org/W3164692211","https://openalex.org/W3174246647","https://openalex.org/W3175961346","https://openalex.org/W3183687750","https://openalex.org/W3184560250","https://openalex.org/W3201104779","https://openalex.org/W3205139696","https://openalex.org/W3205986596","https://openalex.org/W4221010853","https://openalex.org/W4224216596","https://openalex.org/W4229067848","https://openalex.org/W4281478692","https://openalex.org/W4304778191","https://openalex.org/W4307432965","https://openalex.org/W4313490483","https://openalex.org/W4318486522","https://openalex.org/W4321019150","https://openalex.org/W4321481337","https://openalex.org/W4321748220","https://openalex.org/W4362661856","https://openalex.org/W4378980314","https://openalex.org/W4379259432","https://openalex.org/W4387115855","https://openalex.org/W4389334826","https://openalex.org/W4392802477","https://openalex.org/W4400159451","https://openalex.org/W4401174362","https://openalex.org/W4403219224","https://openalex.org/W4403510689","https://openalex.org/W4410065323","https://openalex.org/W4411160871","https://openalex.org/W4412451609"],"related_works":["https://openalex.org/W2610627565","https://openalex.org/W2081700879","https://openalex.org/W4410829723","https://openalex.org/W4386593175","https://openalex.org/W4413101698","https://openalex.org/W4318939616","https://openalex.org/W4411474935","https://openalex.org/W4313490483","https://openalex.org/W4288066894","https://openalex.org/W2409443002"],"abstract_inverted_index":{"Radiotherapy":[0],"for":[1,84,140],"brain":[2,28],"tumors":[3],"frequently":[4],"induces":[5],"irreversible":[6],"cognitive":[7,115],"decline,":[8],"yet":[9],"the":[10,34,42,53,65,76,85,92,111,128],"underlying":[11],"mechanisms":[12],"remain":[13],"poorly":[14],"understood.":[15],"Here,":[16],"we":[17],"present":[18],"an":[19],"integrated":[20],"single-cell":[21],"and":[22,95,114,126,135],"spatial":[23,98],"transcriptomic":[24],"atlas":[25],"of":[26,68],"radiation-induced":[27],"injury":[29],"(RIBI)":[30],"in":[31,75,97],"mice,":[32],"spanning":[33],"acute":[35],"to":[36],"chronic":[37,108],"phases.":[38],"We":[39],"reveal":[40],"that":[41],"early-delayed":[43],"phase":[44],"following":[45],"irradiation":[46],"represents":[47],"a":[48,69,82,122,131,136],"critical":[49],"window":[50],"during":[51],"which":[52,79],"blood-cerebrospinal":[54],"fluid":[55],"barrier":[56],"(BCSFB)":[57],"integrity":[58],"is":[59],"compromised.":[60],"This":[61,103],"disruption":[62],"results":[63],"from":[64],"selective":[66],"depletion":[67],"radiosensitive":[70],"Tmsb4x":[71],"+":[72],"epithelial":[73],"subpopulation":[74],"choroid":[77],"plexus,":[78],"functions":[80],"as":[81,130],"gatekeeper":[83],"BCSFB.":[86],"Consequently,":[87],"CSF-derived":[88],"macrophages":[89],"excessively":[90],"infiltrate":[91],"periventricular":[93],"niche":[94],"engage":[96],"crosstalk":[99],"with":[100],"interferon-responsive":[101],"microglia.":[102],"dysregulated":[104],"immune":[105,133],"axis":[106],"sustains":[107],"neuroinflammation,":[109],"driving":[110],"late-stage":[112],"neurodegeneration":[113],"impairment.":[116],"In":[117],"conclusion,":[118],"our":[119],"study":[120],"establishes":[121],"high-resolution":[123],"spatiotemporal":[124],"framework":[125],"positions":[127],"BCSFB":[129],"pivotal":[132],"gateway":[134],"promising":[137],"therapeutic":[138],"target":[139],"mitigating":[141],"RIBI.":[142]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-09T00:00:00"}
