{"id":"https://openalex.org/W7220919113","doi":"https://doi.org/10.64898/2026.10.06.757088","title":"Benchmarking longitudinal local centiles for radiographic knee osteoarthritis prognosis","display_name":"Benchmarking longitudinal local centiles for radiographic knee osteoarthritis prognosis","publication_year":2026,"publication_date":"2026-10-08","ids":{"openalex":"https://openalex.org/W7220919113","doi":"https://doi.org/10.64898/2026.10.06.757088","pmid":"https://pubmed.ncbi.nlm.nih.gov/42926486","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13692169"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.06.757088","doi":"https://doi.org/10.64898/2026.10.06.757088","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.757088","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/08/2026.10.06.757088.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/08/2026.10.06.757088.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100398874","display_name":"Tengfei Li","orcid":"https://orcid.org/0000-0001-6142-3865","observed_orcids":["https://orcid.org/0000-0001-6142-3865"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tengfei Li","raw_affiliation_strings":["University of North Carolina at Chapel Hill;"],"raw_orcid":"https://orcid.org/0000-0001-6142-3865","affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill;","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157893485","display_name":"Tianyou Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianyou Luo","raw_affiliation_strings":["Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599;","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014096938","display_name":"Boqi Chen","orcid":"https://orcid.org/0000-0002-1451-3603","observed_orcids":["https://orcid.org/0000-0002-1451-3603"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boqi Chen","raw_affiliation_strings":["Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599;","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048322244","display_name":"Chao Huang","orcid":"https://orcid.org/0000-0002-1157-4291","observed_orcids":["https://orcid.org/0000-0002-1157-4291"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chao Huang","raw_affiliation_strings":["Department of Epidemiology & Biostatistics, University of Georgia, Athens, GA, USA, 30606;"],"raw_orcid":"https://orcid.org/0000-0002-1157-4291","affiliations":[{"raw_affiliation_string":"Department of Epidemiology & Biostatistics, University of Georgia, Athens, GA, USA, 30606;","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102848878","display_name":"Zhengyang Shen","orcid":"https://orcid.org/0000-0003-3442-6344","observed_orcids":["https://orcid.org/0000-0003-3442-6344"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhengyang Shen","raw_affiliation_strings":["Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599;","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157925631","display_name":"Zhenlin Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhenlin Xu","raw_affiliation_strings":["Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599;","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081537144","display_name":"Daniel Nissman","orcid":"https://orcid.org/0000-0002-6022-7288","observed_orcids":["https://orcid.org/0000-0002-6022-7288"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Nissman","raw_affiliation_strings":["Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599;"],"raw_orcid":"https://orcid.org/0000-0002-6022-7288","affiliations":[{"raw_affiliation_string":"Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599;","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006415209","display_name":"Yvonne M. Golightly","orcid":"https://orcid.org/0000-0003-1205-2759","observed_orcids":["https://orcid.org/0000-0003-1205-2759"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yvonne M. Golightly","raw_affiliation_strings":["Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599; College of Allied Health Professions, Unive;"],"raw_orcid":"https://orcid.org/0000-0003-1205-2759","affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599; College of Allied Health Professions, Unive;","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088835363","display_name":"Amanda E. Nelson","orcid":"https://orcid.org/0000-0002-9344-7877","observed_orcids":["https://orcid.org/0000-0002-9344-7877"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda E. Nelson","raw_affiliation_strings":["Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599;"],"raw_orcid":"https://orcid.org/0000-0002-9344-7877","affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599;","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013188944","display_name":"Gandikota Girish","orcid":"https://orcid.org/0000-0002-6311-1213","observed_orcids":["https://orcid.org/0000-0002-6311-1213"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Girish Gandikota","raw_affiliation_strings":["Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599;"],"raw_orcid":"https://orcid.org/0000-0002-6311-1213","affiliations":[{"raw_affiliation_string":"Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599;","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108610850","display_name":"Marc Niethammer","orcid":"https://orcid.org/0009-0003-7340-9050","observed_orcids":["https://orcid.org/0009-0003-7340-9050"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Niethammer","raw_affiliation_strings":["Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599; Department of Computer Science and Engineering and Department of Neurological Surgery, University of California San Diego, La Jolla, CA, USA, 92093"],"raw_orcid":"https://orcid.org/0009-0003-7340-9050","affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599; Department of Computer Science and Engineering and Department of Neurological Surgery, University of California San Diego, La Jolla, CA, USA, 92093","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077961759","display_name":"Hongtu Zhu B","orcid":"https://orcid.org/0000-0002-6781-2690","observed_orcids":["https://orcid.org/0000-0002-6781-2690"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hongtu Zhu","raw_affiliation_strings":["Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599;"],"raw_orcid":"https://orcid.org/0000-0002-6781-2690","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599;","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5077961759"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.823199987411499,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.823199987411499,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.027400000020861626,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14510","display_name":"Medical Imaging and Analysis","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cartilage-thickness","display_name":"cartilage thickness","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cartilage-thinning","display_name":"cartilage thinning","score":0.5559999942779541},{"id":"https://openalex.org/keywords/deep-features","display_name":"deep features","score":0.5820000171661377},{"id":"https://openalex.org/keywords/radiomics","display_name":"radiomics","score":0.6119999885559082},{"id":"https://openalex.org/keywords/osteoarthritis-initiative","display_name":"Osteoarthritis Initiative","score":0.875},{"id":"https://openalex.org/keywords/early-osteoarthritis-detection","display_name":"early osteoarthritis detection","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7659000158309937},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7562999725341797},{"id":"https://openalex.org/C36454342","wikidata":"https://www.wikidata.org/wiki/Q245341","display_name":"Radiography","level":2,"score":0.6643999814987183},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.5127999782562256},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4991999864578247},{"id":"https://openalex.org/C86251818","wikidata":"https://www.wikidata.org/wiki/Q816754","display_name":"Benchmarking","level":2,"score":0.38100001215934753},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.37470000982284546},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.3564999997615814},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.35199999809265137},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3434999883174896},{"id":"https://openalex.org/C3020672099","wikidata":"https://www.wikidata.org/wiki/Q857354","display_name":"Longitudinal data","level":2,"score":0.326200008392334},{"id":"https://openalex.org/C3018143345","wikidata":"https://www.wikidata.org/wiki/Q37425","display_name":"Knee cartilage","level":5,"score":0.28600001335144043},{"id":"https://openalex.org/C29694066","wikidata":"https://www.wikidata.org/wiki/Q118301","display_name":"Orthodontics","level":1,"score":0.2549999952316284},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.25270000100135803},{"id":"https://openalex.org/C120934525","wikidata":"https://www.wikidata.org/wiki/Q849149","display_name":"Absolute deviation","level":2,"score":0.2515000104904175}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.10.06.757088","doi":"https://doi.org/10.64898/2026.10.06.757088","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.757088","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/08/2026.10.06.757088.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13692169","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13692169/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13692169/pdf/nihpp-2026.10.06.757088v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42926486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42926486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.10.06.757088","doi":"https://doi.org/10.64898/2026.10.06.757088","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.757088","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/08/2026.10.06.757088.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1158108047","display_name":null,"funder_award_id":"N01 \u2010 AR \u2010 2 \u2010 2261","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G166592988","display_name":null,"funder_award_id":"N01\u2010AR\u20102\u20102260","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G400178218","display_name":null,"funder_award_id":"N01 \u2010 AR \u2010 2 \u2010 2258","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G482432850","display_name":null,"funder_award_id":"N01-AR-2- 2262","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4866043667","display_name":null,"funder_award_id":"R01AR082684","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G724008290","display_name":null,"funder_award_id":"N01AR22259","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000857838","display_name":"Integrative Predictors of Temporomandibular Degenerative Joint Disease","funder_award_id":"R01DE024450","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G9000879569","display_name":"Shared neural basis and genetic architecture of psychiatric disorders","funder_award_id":"R01MH136055","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000918007","display_name":"UNC Core Center for Clinical Research","funder_award_id":"P30AR072580","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220919113.pdf","grobid_xml":"https://content.openalex.org/works/W7220919113.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1523800615","https://openalex.org/W1869625801","https://openalex.org/W1963796570","https://openalex.org/W1967057044","https://openalex.org/W1979024706","https://openalex.org/W1988774578","https://openalex.org/W1996796871","https://openalex.org/W2005931143","https://openalex.org/W2024492637","https://openalex.org/W2031247908","https://openalex.org/W2031416591","https://openalex.org/W2046945713","https://openalex.org/W2064363744","https://openalex.org/W2109005911","https://openalex.org/W2118529444","https://openalex.org/W2119160928","https://openalex.org/W2128650484","https://openalex.org/W2132697886","https://openalex.org/W2136326182","https://openalex.org/W2154065358","https://openalex.org/W2166136140","https://openalex.org/W2187638581","https://openalex.org/W2229782077","https://openalex.org/W2744099886","https://openalex.org/W2748169532","https://openalex.org/W2767128594","https://openalex.org/W2770553236","https://openalex.org/W2896481393","https://openalex.org/W2942238494","https://openalex.org/W2945976633","https://openalex.org/W2952396505","https://openalex.org/W2980134306","https://openalex.org/W2998789541","https://openalex.org/W2999615587","https://openalex.org/W3005507917","https://openalex.org/W3006698055","https://openalex.org/W3028355634","https://openalex.org/W3036485623","https://openalex.org/W3084251109","https://openalex.org/W3100004368","https://openalex.org/W3112717819","https://openalex.org/W3135376722","https://openalex.org/W3155312544","https://openalex.org/W3171095855","https://openalex.org/W3197325932","https://openalex.org/W3206139074","https://openalex.org/W3212228145","https://openalex.org/W3213058594","https://openalex.org/W4205170763","https://openalex.org/W4211067786","https://openalex.org/W4225246927","https://openalex.org/W4281649266","https://openalex.org/W4282927968","https://openalex.org/W4304690545","https://openalex.org/W4306931962","https://openalex.org/W4311583297","https://openalex.org/W4367315262","https://openalex.org/W4367597246","https://openalex.org/W4385805479","https://openalex.org/W4386042200","https://openalex.org/W4392011062","https://openalex.org/W4396232518","https://openalex.org/W4400769217","https://openalex.org/W7123764682"],"related_works":["https://openalex.org/W4386698988","https://openalex.org/W2023055815","https://openalex.org/W2914472922","https://openalex.org/W3213058594","https://openalex.org/W3113396289","https://openalex.org/W2142757990","https://openalex.org/W3164137725","https://openalex.org/W2024492637","https://openalex.org/W2887031790","https://openalex.org/W2582544766"],"abstract_inverted_index":{"Cartilage":[0],"thickness":[1,175],"on":[2],"MRI":[3],"is":[4,52],"a":[5,44],"structural":[6],"biomarker":[7],"of":[8,66],"osteoarthritis":[9],"(OA),":[10],"yet":[11],"anatomical":[12],"variation":[13],"and":[14,42,86,101,118,140,149,151],"aging":[15],"can":[16],"mask":[17],"early":[18],"disease,":[19],"including":[20],"changes":[21],"occurring":[22],"12-36":[23],"months":[24,139],"before":[25],"incident":[26,91],"OA.":[27],"We":[28,58],"propose":[29],"longitudinal":[30,80,124,182,192],"local":[31],"centile":[32,81,99,116,127,183,193],"maps":[33,176],"that":[34,51],"use":[35],"normative":[36],"growth":[37],"charts":[38,62],"as":[39],"prior":[40],"information":[41],"integrate":[43],"knee's":[45],"earlier":[46],"scans":[47,65],"to":[48],"identify":[49],"cartilage":[50,174],"thinner":[53],"or":[54],"thicker":[55],"than":[56,94],"expected.":[57],"built":[59],"the":[60,73,130,186,199],"reference":[61],"from":[63],"5,045":[64],"957":[67],"persistently":[68],"radiographically":[69],"normal":[70],"knees":[71],"in":[72,156],"Osteoarthritis":[74],"Initiative.":[75],"Under":[76],"participant-separated":[77],"nested":[78],"cross-validation,":[79],"profiles":[82,194],"achieved":[83,129],"higher":[84],"12-":[85],"24-month":[87],"AUCs":[88,132],"for":[89,162],"predicting":[90],"radiographic":[92],"OA":[93],"regional":[95,191],"PCA,":[96],"radiomics,":[97],"cross-sectional":[98,119],"features,":[100],"raw-map":[102,153],"deep":[103,154,181],"features":[104,128,155,184],"across":[105],"most":[106],"classifiers.":[107],"These":[108],"conventional":[109],"descriptors":[110],"added":[111,121],"little":[112,122],"when":[113],"combined":[114],"with":[115,198],"profiles,":[117],"centiles":[120,172],"beyond":[123],"centiles.":[125],"Deep":[126],"best":[131],"(0.954":[133],"[95%":[134],"CI":[135],"0.931-0.974]":[136],"at":[137,143],"12":[138,158],"0.969":[141],"[0.949-0.985]":[142],"24":[144],"months;":[145],"balanced":[146],"accuracy":[147],"0.917":[148],"0.931)":[150],"outperformed":[152],"all":[157],"classifiers":[159],"after":[160],"correction":[161],"multiple":[163],"comparisons.":[164],"No":[165],"representation":[166],"consistently":[167],"improved":[168],"36-month":[169],"prediction.":[170],"Longitudinal":[171],"transform":[173],"into":[177],"reference-based":[178],"deviation":[179],"maps:":[180],"provide":[185,195],"highest":[187],"predictive":[188],"accuracy,":[189],"while":[190],"interpretable":[196],"prognosis":[197],"second-highest":[200],"accuracy.":[201]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-09T00:00:00"}