{"id":"https://openalex.org/W7220916337","doi":"https://doi.org/10.64898/2026.10.05.756899","title":"Programmable antigen-presenting scaffolds expand rare tumor-antigen-specific T cells from peripheral blood","display_name":"Programmable antigen-presenting scaffolds expand rare tumor-antigen-specific T cells from peripheral blood","publication_year":2026,"publication_date":"2026-10-08","ids":{"openalex":"https://openalex.org/W7220916337","doi":"https://doi.org/10.64898/2026.10.05.756899","pmid":"https://pubmed.ncbi.nlm.nih.gov/42926516","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13692185"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.05.756899","doi":"https://doi.org/10.64898/2026.10.05.756899","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.756899","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.05.756899.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.05.756899.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157894393","display_name":"Jessica Nicole DeVilla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica DeVilla","raw_affiliation_strings":["Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA","Program in Health Sciences and Technology, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA","The Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Program in Health Sciences and Technology, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I63966007"]},{"raw_affiliation_string":"The Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024242268","display_name":"Yoav Binenbaum","orcid":"https://orcid.org/0000-0001-9901-7782","observed_orcids":["https://orcid.org/0000-0001-9901-7782"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoav Binenbaum","raw_affiliation_strings":["Dana-Farber/Boston Children\u2019s Cancer and Blood Disorders Center, Boston, MA, USA","Harvard Medical School, Boston, MA, USA","The Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, USA"],"raw_orcid":"https://orcid.org/0000-0001-9901-7782","affiliations":[{"raw_affiliation_string":"Dana-Farber/Boston Children\u2019s Cancer and Blood Disorders Center, Boston, MA, USA","institution_ids":["https://openalex.org/I4210166317"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"The Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081486903","display_name":"Nicoletta Cieri","orcid":"https://orcid.org/0000-0003-1340-6272","observed_orcids":["https://orcid.org/0000-0003-1340-6272"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicoletta Cieri","raw_affiliation_strings":["Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA","Dana-Farber/Boston Children\u2019s Cancer and Blood Disorders Center, Boston, MA, USA","Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Dana-Farber/Boston Children\u2019s Cancer and Blood Disorders Center, Boston, MA, USA","institution_ids":["https://openalex.org/I4210166317"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157951187","display_name":"David KY Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Zhang","raw_affiliation_strings":["John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA","The Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"The Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102964861","display_name":"Helen Ji","orcid":"https://orcid.org/0009-0008-9121-1116","observed_orcids":["https://orcid.org/0009-0008-9121-1116"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen Ji","raw_affiliation_strings":["Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092772463","display_name":"Vittoria Martinolli D\u2019Arcy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vittoria Martinolli D\u2019Arcy","raw_affiliation_strings":["The Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006906416","display_name":"Giacomo Oliveira","orcid":"https://orcid.org/0000-0001-7435-5603","observed_orcids":["https://orcid.org/0000-0001-7435-5603"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giacomo Oliveira","raw_affiliation_strings":["Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA","Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157942911","display_name":"Michael Manos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Manos","raw_affiliation_strings":["Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003947352","display_name":"Donna S Neuberg","orcid":"https://orcid.org/0000-0003-2566-3145","observed_orcids":["https://orcid.org/0000-0003-2566-3145"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donna Neuberg","raw_affiliation_strings":["Dana-Farber Cancer Institute, Department of Data Science. I, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Department of Data Science. I, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008718116","display_name":"Jerome Ritz","orcid":"https://orcid.org/0000-0001-5526-4669","observed_orcids":["https://orcid.org/0000-0001-5526-4669"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerome Ritz","raw_affiliation_strings":["Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA","Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041066193","display_name":"Patrick Alexander Ott","orcid":"https://orcid.org/0000-0002-4253-943X","observed_orcids":["https://orcid.org/0000-0002-4253-943X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick A. Ott","raw_affiliation_strings":["Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA","Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001336137","display_name":"David J. Mooney","orcid":"https://orcid.org/0000-0001-6299-1194","observed_orcids":["https://orcid.org/0000-0001-6299-1194"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Mooney","raw_affiliation_strings":["John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA","The Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"The Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5147507492","display_name":"Catherine J. Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Catherine J. Wu","raw_affiliation_strings":["Broad Institute of MIT and Harvard, Cambridge, MA US","Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA","Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of MIT and Harvard, Cambridge, MA US","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5147507492"],"corresponding_institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I4210117453"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-expansion","display_name":"T cell expansion","score":0.7459999918937683},{"id":"https://openalex.org/keywords/melan-a","display_name":"Melan-A","score":0.6620000004768372},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9399999976158142},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.7559999823570251},{"id":"https://openalex.org/keywords/lipid-bilayers","display_name":"lipid bilayers","score":0.5609999895095825},{"id":"https://openalex.org/keywords/hla-a-0201","display_name":"HLA-A*0201","score":0.8989999890327454},{"id":"https://openalex.org/keywords/neoantigens","display_name":"neoantigens","score":0.6859999895095825},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7369999885559082},{"id":"https://openalex.org/keywords/t-cell-functional-avidity","display_name":"T cell functional avidity","score":0.625}],"concepts":[{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.503600001335144},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4668000042438507},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.4422000050544739},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.4352000057697296},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4350000023841858},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4000000059604645},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.3982999920845032},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.36640000343322754},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35830000042915344},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3538999855518341},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.3458999991416931},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3427000045776367},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.32829999923706055},{"id":"https://openalex.org/C179223381","wikidata":"https://www.wikidata.org/wiki/Q419425","display_name":"Avidity","level":3,"score":0.3203999996185303},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.31290000677108765},{"id":"https://openalex.org/C139563560","wikidata":"https://www.wikidata.org/wiki/Q224930","display_name":"Natural killer T cell","level":4,"score":0.31200000643730164},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.30379998683929443},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3003999888896942},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.29679998755455017},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.2937000095844269},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29190000891685486},{"id":"https://openalex.org/C2777016536","wikidata":"https://www.wikidata.org/wiki/Q7168713","display_name":"Peripheral tolerance","level":4,"score":0.2856999933719635},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.2851000130176544},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.2822999954223633},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.28200000524520874},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.273499995470047},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.2734000086784363},{"id":"https://openalex.org/C8840205","wikidata":"https://www.wikidata.org/wiki/Q7623301","display_name":"Streptamer","level":5,"score":0.27309998869895935},{"id":"https://openalex.org/C2779234475","wikidata":"https://www.wikidata.org/wiki/Q14897851","display_name":"CD154","level":5,"score":0.27059999108314514},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.25060001015663147}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.10.05.756899","doi":"https://doi.org/10.64898/2026.10.05.756899","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.756899","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.05.756899.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42926516","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42926516","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13692185","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13692185/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.10.05.756899","doi":"https://doi.org/10.64898/2026.10.05.756899","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.756899","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.05.756899.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2265262903","display_name":null,"funder_award_id":"U54 CA244726","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5409208129","display_name":"Research Training in Pediatric Oncology","funder_award_id":"T32CA136432","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309622","display_name":"Harvard University","ror":"https://ror.org/03vek6s52"},{"id":"https://openalex.org/F4320315119","display_name":"Parker Institute for Cancer Immunotherapy","ror":"https://ror.org/0184qbg02"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333979","display_name":"Hansj\u00f6rg Wyss Institute for Biologically Inspired Engineering, Harvard University","ror":"https://ror.org/008cfmj78"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220916337.pdf","grobid_xml":"https://content.openalex.org/works/W7220916337.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4385872063","https://openalex.org/W2996635610","https://openalex.org/W2980841377","https://openalex.org/W3014954266","https://openalex.org/W2431286612","https://openalex.org/W2571548840","https://openalex.org/W2998937323","https://openalex.org/W3198344807","https://openalex.org/W4388042465","https://openalex.org/W3037391321"],"abstract_inverted_index":{"Abstract":[0],"Adoptive":[1],"cellular":[2],"therapies":[3],"can":[4],"be":[5],"effective":[6],"against":[7],"solid":[8],"tumors":[9],"but":[10],"rely":[11],"on":[12,41],"the":[13,186],"identification":[14],"and":[15,38,62,111,118,202],"expansion":[16,102],"of":[17,58,76,83,103,113,123,128,143,145,172,188],"rare":[18,49,189],"tumor-reactive":[19],"T":[20,51,71,79,105,138,157],"cells":[21,52,72,80,106,139,148,158],"(TRTs).":[22],"Here,":[23],"we":[24],"utilize":[25],"antigen-presenting":[26],"cell-mimetic":[27],"scaffolds":[28],"(APC-ms),":[29],"a":[30,42,66,120,141,173,182],"modular":[31],"biomaterial":[32],"platform":[33,184],"that":[34,68,165],"presents":[35],"defined":[36,65],"peptide-HLA":[37],"co-stimulatory":[39,60],"ligands":[40],"fluid":[43],"lipid":[44],"bilayer":[45],"to":[46,73,140],"selectively":[47],"recover":[48],"antigen-specific":[50],"from":[53,89,191],"peripheral":[54,170,192],"blood.":[55],"Independent":[56],"variation":[57],"peptide-HLA,":[59],"ligands,":[61],"cytokine":[63],"support":[64],"formulation":[67],"enriched":[69],"MART-1-specific":[70,104,124,137],"above":[74],"2%":[75],"CD8":[77,146],"+":[78,86,147],"in":[81,169],"35":[82],"50":[84],"HLA-A*02:01":[85],"healthy":[87],"donors":[88],"low":[90],"or":[91],"undetectable":[92,168],"baseline":[93],"frequencies.":[94],"Compared":[95],"with":[96,107,131,175],"mo-DCs,":[97],"APC-ms":[98,134,154,180],"achieved":[99],"greater":[100],"fold":[101],"increased":[108],"functional":[109],"avidity":[110],"preservation":[112],"an":[114,161],"early":[115],"differentiation":[116],"phenotype,":[117],"generated":[119],"higher":[121],"number":[122],"clonotypes.":[125],"In":[126],"five":[127],"eight":[129],"patients":[130],"treatment-na\u00efve":[132],"melanoma,":[133],"could":[135,155],"enrich":[136],"median":[142],"13.7%":[144],"(range":[149],"0.30":[150],"\u2013":[151],"57.2%)":[152],"Moreover,":[153],"expand":[156],"specific":[159],"for":[160,185,198],"HLA-A*24:01-restricted":[162],"personal":[163],"neoantigen":[164],"were":[166],"previously":[167],"blood":[171],"patient":[174],"melanoma.":[176],"These":[177],"findings":[178],"establish":[179],"as":[181],"tunable":[183],"recovery":[187],"TRTs":[190],"blood,":[193],"supporting":[194],"its":[195],"further":[196],"development":[197],"therapeutic":[199],"TCR":[200],"discovery":[201],"personalized":[203],"adoptive":[204],"cell":[205],"therapy.":[206]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-09T00:00:00"}