{"id":"https://openalex.org/W7220916145","doi":"https://doi.org/10.64898/2026.10.01.756068","title":"Self-Exciting Population Event Models Reveal Abnormal Temporal Amplification in MAPT-Mutant Human Brain Assembloids","display_name":"Self-Exciting Population Event Models Reveal Abnormal Temporal Amplification in MAPT-Mutant Human Brain Assembloids","publication_year":2026,"publication_date":"2026-10-08","ids":{"openalex":"https://openalex.org/W7220916145","doi":"https://doi.org/10.64898/2026.10.01.756068"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.01.756068","doi":"https://doi.org/10.64898/2026.10.01.756068","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.01.756068","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.01.756068.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.01.756068.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073661232","display_name":"Tonmoy Monsoor","orcid":"https://orcid.org/0009-0006-1858-9417","observed_orcids":["https://orcid.org/0009-0006-1858-9417"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tonmoy Monsoor","raw_affiliation_strings":["Dept. of Electrical and Computer Engineering, University of California, Los Angeles"],"raw_orcid":"https://orcid.org/0009-0006-1858-9417","affiliations":[{"raw_affiliation_string":"Dept. of Electrical and Computer Engineering, University of California, Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071307526","display_name":"Colin M. McCrimmon","orcid":"https://orcid.org/0009-0007-6057-3782","observed_orcids":["https://orcid.org/0009-0007-6057-3782","https://orcid.org/0000-0003-1157-9858"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colin M. McCrimmon","raw_affiliation_strings":["Dept. of Neurology, University of California, Los Angeles"],"raw_orcid":"https://orcid.org/0009-0007-6057-3782","affiliations":[{"raw_affiliation_string":"Dept. of Neurology, University of California, Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130688970","display_name":"Prateik Sinha","orcid":"https://orcid.org/0009-0007-6836-9268","observed_orcids":["https://orcid.org/0009-0007-6836-9268"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Prateik Sinha","raw_affiliation_strings":["Dept. of Mathematics, University of California, Los Angeles"],"raw_orcid":"https://orcid.org/0009-0007-6836-9268","affiliations":[{"raw_affiliation_string":"Dept. of Mathematics, University of California, Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100359621","display_name":"Lina Zhang","orcid":"https://orcid.org/0009-0001-1005-3400","observed_orcids":["https://orcid.org/0009-0001-1005-3400","https://orcid.org/0000-0002-0206-9883"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lina Zhang","raw_affiliation_strings":["Dept. of Electrical and Computer Engineering, University of California, Los Angeles"],"raw_orcid":"https://orcid.org/0009-0001-1005-3400","affiliations":[{"raw_affiliation_string":"Dept. of Electrical and Computer Engineering, University of California, Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073016900","display_name":"Manoj Reddy Dareddy","orcid":"https://orcid.org/0000-0003-2496-9476","observed_orcids":["https://orcid.org/0000-0003-2496-9476"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manoj Reddy Dareddy","raw_affiliation_strings":["Dept. of Electrical and Computer Engineering, University of California, Los Angeles"],"raw_orcid":"https://orcid.org/0000-0003-2496-9476","affiliations":[{"raw_affiliation_string":"Dept. of Electrical and Computer Engineering, University of California, Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093771048","display_name":"Mehmet E. Lorasdagi","orcid":"https://orcid.org/0009-0007-2796-4888","observed_orcids":["https://orcid.org/0009-0007-2796-4888"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehmet Efe Lorasdagi","raw_affiliation_strings":["Dept. of Electrical and Computer Engineering, University of California, Los Angeles"],"raw_orcid":"https://orcid.org/0009-0007-2796-4888","affiliations":[{"raw_affiliation_string":"Dept. of Electrical and Computer Engineering, University of California, Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084524168","display_name":"Ranmal Aloka Samarasinghe","orcid":"https://orcid.org/0000-0002-8637-6177","observed_orcids":["https://orcid.org/0000-0002-8637-6177"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ranmal A. Samarasinghe","raw_affiliation_strings":["Dept. of Neurology, University of California, Los Angeles","Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA","Intellectual and Developmental Disabilities Research Center, UCLA"],"raw_orcid":"https://orcid.org/0000-0002-8637-6177","affiliations":[{"raw_affiliation_string":"Dept. of Neurology, University of California, Los Angeles","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Intellectual and Developmental Disabilities Research Center, UCLA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043479061","display_name":"Vwani Roychowdhury","orcid":"https://orcid.org/0000-0003-0832-6489","observed_orcids":["https://orcid.org/0000-0003-0832-6489"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vwani Roychowdhury","raw_affiliation_strings":["Dept. of Electrical and Computer Engineering, University of California, Los Angeles"],"raw_orcid":"https://orcid.org/0000-0003-0832-6489","affiliations":[{"raw_affiliation_string":"Dept. of Electrical and Computer Engineering, University of California, Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5130688970"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.6840999722480774,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.6840999722480774,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.06499999761581421,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.03999999910593033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.6809999942779541},{"id":"https://openalex.org/keywords/memory-decay","display_name":"memory decay","score":0.6790000200271606},{"id":"https://openalex.org/keywords/isogenic-cell-models","display_name":"isogenic cell models","score":0.5509999990463257},{"id":"https://openalex.org/keywords/neural-network-dysfunction","display_name":"neural network dysfunction","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C2779662365","wikidata":"https://www.wikidata.org/wiki/Q5416694","display_name":"Event (particle physics)","level":2,"score":0.5708000063896179},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5663999915122986},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.5045999884605408},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5041000247001648},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.45910000801086426},{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.42480000853538513},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41839998960494995},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40939998626708984},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.4036000072956085},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38989999890327454},{"id":"https://openalex.org/C24574437","wikidata":"https://www.wikidata.org/wiki/Q7135228","display_name":"Parametric model","level":3,"score":0.3801000118255615},{"id":"https://openalex.org/C155512373","wikidata":"https://www.wikidata.org/wiki/Q287450","display_name":"Residual","level":2,"score":0.36399999260902405},{"id":"https://openalex.org/C100906024","wikidata":"https://www.wikidata.org/wiki/Q205692","display_name":"Poisson distribution","level":2,"score":0.33820000290870667},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.32749998569488525},{"id":"https://openalex.org/C166144826","wikidata":"https://www.wikidata.org/wiki/Q1145117","display_name":"Poisson process","level":3,"score":0.32690000534057617},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3086000084877014},{"id":"https://openalex.org/C88871306","wikidata":"https://www.wikidata.org/wiki/Q7208287","display_name":"Point process","level":2,"score":0.27070000767707825},{"id":"https://openalex.org/C134261354","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical inference","level":2,"score":0.2653999924659729},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.26440000534057617},{"id":"https://openalex.org/C52079815","wikidata":"https://www.wikidata.org/wiki/Q7229808","display_name":"Population model","level":3,"score":0.2615000009536743},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2549000084400177},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.25450000166893005},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.25380000472068787},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.2515999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.01.756068","doi":"https://doi.org/10.64898/2026.10.01.756068","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.01.756068","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.01.756068.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.01.756068","doi":"https://doi.org/10.64898/2026.10.01.756068","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.01.756068","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.01.756068.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320315928","display_name":"Rose Hills Foundation","ror":"https://ror.org/01nebar93"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220916145.pdf","grobid_xml":"https://content.openalex.org/works/W7220916145.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7155045122","https://openalex.org/W7067223406","https://openalex.org/W4384830093","https://openalex.org/W3160857349","https://openalex.org/W6920685443","https://openalex.org/W6958473967","https://openalex.org/W7033505826","https://openalex.org/W6996718295","https://openalex.org/W2156094522","https://openalex.org/W1977402215"],"abstract_inverted_index":{"ABSTRACT":[0],"Human":[1],"brain":[2],"assembloids":[3],"provide":[4],"a":[5,33,76,125,144],"tractable":[6],"platform":[7],"for":[8,39],"studying":[9],"mutation-specific":[10],"network":[11,147],"dysfunction,":[12],"but":[13],"most":[14],"studies":[15],"do":[16],"not":[17],"distinguish":[18],"whether":[19],"abnormal":[20],"activity":[21],"arises":[22],"from":[23,65],"increased":[24,96],"spontaneous":[25],"initiation":[26,46],"or":[27,69],"stronger":[28],"history-dependent":[29,51,140],"amplification.":[30],"We":[31],"introduce":[32],"low-dimensional":[34],"discrete-time":[35],"self-exciting":[36],"population":[37],"model":[38],"calcium-imaging":[40],"event":[41],"sequences":[42],"that":[43],"separates":[44],"baseline":[45,97],"(":[47,53,59],"\u00b5":[48],"),":[49,55,94],"integrated":[50],"gain":[52],"\u03b7":[54,80,118],"and":[56,107],"memory":[57],"decay":[58],"\u03c4":[60],").":[61],"Across":[62],"175":[63],"recordings":[64],"13":[66,121],"MAPT":[67],"p.R406W":[68],"CRISPR-corrected":[70],"isogenic":[71],"assembloids,":[72,123],"biological-unit":[73],"inference":[74],"identified":[75],"4.31-fold":[77],"increase":[78],"in":[79,81],"mutants":[82],"(95%":[83],"CI":[84],"3.20\u20135.84;":[85],"exact":[86],"p":[87],"=":[88],"7.8":[89],"\u00d7":[90],"10":[91],"\u2212":[92],"4":[93],"without":[95],"activity.":[98],"Parametric":[99],"predictive":[100],"checks":[101],"exposed":[102],"residual":[103],"Poisson":[104],"overdispersion;":[105],"fixed-decay":[106],"beta-binomial":[108],"sensitivity":[109],"analyses":[110],"nevertheless":[111],"preserved":[112],"the":[113],"mutant":[114],"history":[115],"effect.":[116],"Median":[117],"separated":[119],"all":[120],"held-out":[122],"while":[124],"multifeature":[126],"recording-level":[127],"RBF-SVM":[128],"achieved":[129],"AUC":[130],"0.816":[131],"under":[132],"nested":[133],"whole-assembloid":[134],"holdout.":[135],"These":[136],"results":[137],"identify":[138],"robust":[139],"temporal":[141],"amplification":[142],"as":[143],"functional":[145],"MAPT-mutant":[146],"phenotype.":[148]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-09T00:00:00"}
