{"id":"https://openalex.org/W7220903804","doi":"https://doi.org/10.1080/15384047.2026.2746137","title":"ARHGAP40 suppresses clear cell renal cell carcinoma progression and is associated with altered glutamine-related metabolism and redox balance","display_name":"ARHGAP40 suppresses clear cell renal cell carcinoma progression and is associated with altered glutamine-related metabolism and redox balance","publication_year":2026,"publication_date":"2026-10-08","ids":{"openalex":"https://openalex.org/W7220903804","doi":"https://doi.org/10.1080/15384047.2026.2746137","pmid":"https://pubmed.ncbi.nlm.nih.gov/42848714","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13652080"},"language":"en","primary_location":{"id":"doi:10.1080/15384047.2026.2746137","doi":"https://doi.org/10.1080/15384047.2026.2746137","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15384047.2026.2746137","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15384047.2026.2746137?needAccess=true","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/15384047.2026.2746137?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068318065","display_name":"Na Young You","orcid":"https://orcid.org/0000-0003-1816-2959","observed_orcids":["https://orcid.org/0000-0003-1816-2959"]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na You","raw_affiliation_strings":["Guangzhou Huayin Health Group Co., Ltd","Guangzhou Huayin Medical Laboratory Center Co, Ltd","School of Biology and Biological Engineering, South China University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Huayin Health Group Co., Ltd","institution_ids":[]},{"raw_affiliation_string":"Guangzhou Huayin Medical Laboratory Center Co, Ltd","institution_ids":[]},{"raw_affiliation_string":"School of Biology and Biological Engineering, South China University of Technology","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157828740","display_name":"Xiaoxia Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799773085","display_name":"Nanjing General Hospital of Nanjing Military Command","ror":"https://ror.org/04kmpyd03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2799773085"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoxia Wang","raw_affiliation_strings":["Department of Pathology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University","institution_ids":["https://openalex.org/I2799773085","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157893868","display_name":"Caizhu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Caizhu Wang","raw_affiliation_strings":["Guangzhou Huayin Health Group Co., Ltd","Guangzhou Huayin Medical Laboratory Center Co, Ltd","School of Biology and Biological Engineering, South China University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Huayin Health Group Co., Ltd","institution_ids":[]},{"raw_affiliation_string":"Guangzhou Huayin Medical Laboratory Center Co, Ltd","institution_ids":[]},{"raw_affiliation_string":"School of Biology and Biological Engineering, South China University of Technology","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088278644","display_name":"Long Ma","orcid":"https://orcid.org/0000-0001-8479-2663","observed_orcids":["https://orcid.org/0000-0001-8479-2663"]},"institutions":[{"id":"https://openalex.org/I2799773085","display_name":"Nanjing General Hospital of Nanjing Military Command","ror":"https://ror.org/04kmpyd03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2799773085"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Long Ma","raw_affiliation_strings":["Department of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University","institution_ids":["https://openalex.org/I2799773085","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107706109","display_name":"Lyu Yanli","orcid":"https://orcid.org/0009-0006-1642-7190","observed_orcids":["https://orcid.org/0009-0006-1642-7190"]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanli Lyu","raw_affiliation_strings":["School of Life Sciences, Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University","institution_ids":["https://openalex.org/I152031979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144648106","display_name":"Han Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Liu","raw_affiliation_strings":["School of Life Sciences, Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University","institution_ids":["https://openalex.org/I152031979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101488857","display_name":"Fan Yang","orcid":"https://orcid.org/0000-0002-0411-7391","observed_orcids":["https://orcid.org/0000-0002-0411-7391","https://orcid.org/0009-0000-4130-3946"]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Yang","raw_affiliation_strings":["School of Life Sciences, Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University","institution_ids":["https://openalex.org/I152031979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157982606","display_name":"Jiandong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799773085","display_name":"Nanjing General Hospital of Nanjing Military Command","ror":"https://ror.org/04kmpyd03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2799773085"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]},{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiandong Wang","raw_affiliation_strings":["Department of Pathology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University","School of Biology and Biological Engineering, South China University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University","institution_ids":["https://openalex.org/I2799773085","https://openalex.org/I881766915"]},{"raw_affiliation_string":"School of Biology and Biological Engineering, South China University of Technology","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035010235","display_name":"\u5f20\u9f99\u6c5f","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799773085","display_name":"Nanjing General Hospital of Nanjing Military Command","ror":"https://ror.org/04kmpyd03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2799773085"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Longjiang Zhang","raw_affiliation_strings":["Department of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University","institution_ids":["https://openalex.org/I2799773085","https://openalex.org/I881766915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5158026485","display_name":"Jufang Wang","orcid":"https://orcid.org/0000-0002-9908-1001","observed_orcids":["https://orcid.org/0000-0002-9908-1001"]},"institutions":[{"id":"https://openalex.org/I2799773085","display_name":"Nanjing General Hospital of Nanjing Military Command","ror":"https://ror.org/04kmpyd03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2799773085"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]},{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jufang Wang","raw_affiliation_strings":["Department of Pathology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University","School of Biology and Biological Engineering, South China University of Technology"],"raw_orcid":"https://orcid.org/0000-0002-9908-1001","affiliations":[{"raw_affiliation_string":"Department of Pathology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University","institution_ids":["https://openalex.org/I2799773085","https://openalex.org/I881766915"]},{"raw_affiliation_string":"School of Biology and Biological Engineering, South China University of Technology","institution_ids":["https://openalex.org/I90610280"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5035010235","https://openalex.org/A5158026485"],"corresponding_institution_ids":["https://openalex.org/I2799773085","https://openalex.org/I881766915","https://openalex.org/I90610280"],"apc_list":{"value":2710,"currency":"EUR","value_usd":2970},"apc_paid":{"value":2710,"currency":"EUR","value_usd":2970},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72997512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"1","first_page":"2746137","last_page":"2746137"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.7749000191688538,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.7749000191688538,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.14669999480247498,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9610000252723694},{"id":"https://openalex.org/keywords/rhoa","display_name":"RhoA","score":0.9409999847412109},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9959999918937683},{"id":"https://openalex.org/keywords/glutamine-metabolism","display_name":"glutamine metabolism","score":0.9959999918937683},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.7689999938011169},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.6769999861717224},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.906000018119812},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9829999804496765},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9039999842643738},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cell-proliferation-and-invasion","display_name":"cell proliferation and invasion","score":0.5899999737739563},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.7727000117301941},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6747999787330627},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6274999976158142},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5698000192642212},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.44110000133514404},{"id":"https://openalex.org/C2778560582","wikidata":"https://www.wikidata.org/wiki/Q18347894","display_name":"Clear cell","level":3,"score":0.43459999561309814},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42719998955726624},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.42340001463890076},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4090999960899353},{"id":"https://openalex.org/C168031717","wikidata":"https://www.wikidata.org/wiki/Q1530280","display_name":"Balance (ability)","level":2,"score":0.33709999918937683},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3280999958515167},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.31940001249313354},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3059999942779541},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.29679998755455017},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.27790001034736633},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.27619999647140503},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.273499995470047},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2621999979019165},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.25189998745918274},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.2515999972820282}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020742","descriptor_name":"rhoA GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/15384047.2026.2746137","doi":"https://doi.org/10.1080/15384047.2026.2746137","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15384047.2026.2746137","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15384047.2026.2746137?needAccess=true","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13652080","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13652080/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13652080/pdf/KCBT_27_2746137.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biol Ther","raw_type":"Text"},{"id":"pmid:42848714","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42848714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer biology & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6dbe91478a264e158c5712b490584906","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6dbe91478a264e158c5712b490584906","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Biology & Therapy, Vol 27, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/15384047.2026.2746137","doi":"https://doi.org/10.1080/15384047.2026.2746137","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15384047.2026.2746137","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15384047.2026.2746137?needAccess=true","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220903804.pdf","grobid_xml":"https://content.openalex.org/works/W7220903804.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W2052926928","https://openalex.org/W2130410032","https://openalex.org/W2146512944","https://openalex.org/W2168420558","https://openalex.org/W2764252414","https://openalex.org/W2806219344","https://openalex.org/W3175752499","https://openalex.org/W3186505039","https://openalex.org/W4224210227","https://openalex.org/W4236357753","https://openalex.org/W4291782152","https://openalex.org/W4310874089","https://openalex.org/W4313306358","https://openalex.org/W4379385717","https://openalex.org/W4387563672","https://openalex.org/W4390732330","https://openalex.org/W4391840598","https://openalex.org/W4401948805","https://openalex.org/W4402526482","https://openalex.org/W4404389028","https://openalex.org/W4405890873","https://openalex.org/W4407911510","https://openalex.org/W4408661714","https://openalex.org/W4409591625","https://openalex.org/W4409736934","https://openalex.org/W4410561314","https://openalex.org/W4411921755","https://openalex.org/W4414571103","https://openalex.org/W4415601587","https://openalex.org/W4416334506"],"related_works":["https://openalex.org/W7154310282","https://openalex.org/W7202345259","https://openalex.org/W4321261345","https://openalex.org/W4296328403","https://openalex.org/W4283213889","https://openalex.org/W7135202669","https://openalex.org/W4283367581","https://openalex.org/W2062863565","https://openalex.org/W2398126789","https://openalex.org/W2946215758"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Clear":[1],"cell":[2,4,95],"renal":[3],"carcinoma":[5],"(ccRCC)":[6],"is":[7],"characterized":[8],"by":[9,126,165],"marked":[10],"molecular":[11],"and":[12,25,28,37,49,56,65,77,85,100,106,121,130,139,142,150,155,161,195],"metabolic":[13,29],"heterogeneity.":[14],"This":[15],"study":[16],"investigated":[17],"the":[18,112,147,159,171],"functional":[19,187],"role":[20],"of":[21],"ARHGAP40":[22,33,80,92,109,116,133,166,175],"in":[23,83,181],"ccRCC":[24,84],"examined":[26],"signaling":[27],"changes":[30],"associated":[31,87,118],"with":[32,88,119],"expression.":[34],"METHODS:":[35],",":[36],"an":[38],"ARHGAP40-overexpression":[39],"xenograft":[40,101],"model":[41],"was":[42,81,86,117,124],"used":[43],"to":[44],"assess":[45],"tumor":[46,179],"growth.":[47],"Co-immunoprecipitation":[48],"RhoA":[50,57,128],"activity":[51,129],"assays":[52],"assessed":[53],"ARHGAP40-RhoA":[54],"interaction":[55],"activation,":[58],"while":[59,103],"PI3K/AKT":[60,131],"signaling,":[61,192],"glutamine":[62,138,144],"metabolism,":[63,194],"GSH/GSSG,":[64],"ROS":[66,152],"levels":[67,141],"were":[68,72],"examined.":[69],"Rescue":[70],"experiments":[71],"performed":[73],"using":[74],"SC79,":[75],"RhoA-Q63L,":[76],"NAC.":[78],"RESULTS:":[79],"downregulated":[82],"increased":[89,151],"promoter":[90],"methylation.":[91],"overexpression":[93,123,134],"suppressed":[94],"proliferation,":[96],"migration,":[97],"invasion,":[98],"EMT,":[99],"growth,":[102],"promoting":[104],"apoptosis":[105],"G1-phase":[107],"arrest;":[108],"knockdown":[110],"produced":[111],"opposite":[113],"effects.":[114],"Mechanistically,":[115],"RhoA,":[120],"its":[122],"accompanied":[125],"reduced":[127,136],"phosphorylation.":[132],"also":[135],"intracellular":[137],"glutamate":[140],"net":[143],"consumption,":[145],"decreased":[146],"GSH/GSSG":[148],"ratio,":[149],"levels.":[153],"SC79":[154],"RhoA-Q63L":[156],"partially":[157],"reversed":[158,170],"biological":[160],"redox":[162,172,197],"effects":[163],"induced":[164],"overexpression,":[167],"whereas":[168],"NAC":[169],"changes.":[173],"CONCLUSION:":[174],"acts":[176],"as":[177],"a":[178,186],"suppressor":[180],"ccRCC.":[182],"Our":[183],"findings":[184],"support":[185],"link":[188],"between":[189],"ARHGAP40,":[190],"RhoA-PI3K/AKT":[191],"glutamine-related":[193],"cellular":[196],"balance.":[198]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-09T00:00:00"}
