{"id":"https://openalex.org/W7220896641","doi":"https://doi.org/10.1080/17501911.2026.2744072","title":"ATP1A2 as a subtype-associated candidate prognostic biomarker in breast cancer: an integrated transcriptomic, epigenetic and in vitro analysis","display_name":"ATP1A2 as a subtype-associated candidate prognostic biomarker in breast cancer: an integrated transcriptomic, epigenetic and in vitro analysis","publication_year":2026,"publication_date":"2026-10-08","ids":{"openalex":"https://openalex.org/W7220896641","doi":"https://doi.org/10.1080/17501911.2026.2744072","pmid":"https://pubmed.ncbi.nlm.nih.gov/42847739"},"language":"en","primary_location":{"id":"doi:10.1080/17501911.2026.2744072","doi":"https://doi.org/10.1080/17501911.2026.2744072","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17501911.2026.2744072","pdf_url":null,"source":{"id":"https://openalex.org/S42283280","display_name":"Epigenomics","issn_l":"1750-192X","issn":["1750-192X","1750-1911"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6084/m9.figshare.34242361","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033933243","display_name":"Daniel Rodrigues de Bastos","orcid":"https://orcid.org/0000-0001-7091-1959","observed_orcids":["https://orcid.org/0000-0001-7091-1959"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210157743","display_name":"Universidad Privada del Este","ror":"https://ror.org/05azpw996","country_code":"PY","type":"education","lineage":["https://openalex.org/I4210157743"]}],"countries":["BR","PY"],"is_corresponding":true,"raw_author_name":"Daniel Rodrigues de Bastos","raw_affiliation_strings":["Universidad Privada del Este","Universidade de S\u00e3o Paulo"],"raw_orcid":"https://orcid.org/0000-0001-7091-1959","affiliations":[{"raw_affiliation_string":"Universidad Privada del Este","institution_ids":["https://openalex.org/I4210157743"]},{"raw_affiliation_string":"Universidade de S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078490852","display_name":"Renan Gomes do Nascimento","orcid":"https://orcid.org/0000-0002-7579-0671","observed_orcids":["https://orcid.org/0000-0002-7579-0671"]},"institutions":[{"id":"https://openalex.org/I4210130229","display_name":"Associa\u00e7\u00e3o Paulista para o Desenvolvimento da Medicina","ror":"https://ror.org/02qvzqk75","country_code":"BR","type":"nonprofit","lineage":["https://openalex.org/I4210130229"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Renan Gomes do Nascimento","raw_affiliation_strings":["Associa\u00e7\u00e3o Paulista para o Desenvolvimento da Medicina (SPDM)"],"raw_orcid":"https://orcid.org/0000-0002-7579-0671","affiliations":[{"raw_affiliation_string":"Associa\u00e7\u00e3o Paulista para o Desenvolvimento da Medicina (SPDM)","institution_ids":["https://openalex.org/I4210130229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107459732","display_name":"Maiza Vitoria Aguiar Silva Oliveira","orcid":"https://orcid.org/0009-0007-8319-0207","observed_orcids":["https://orcid.org/0009-0007-8319-0207"]},"institutions":[{"id":"https://openalex.org/I4210157743","display_name":"Universidad Privada del Este","ror":"https://ror.org/05azpw996","country_code":"PY","type":"education","lineage":["https://openalex.org/I4210157743"]}],"countries":["PY"],"is_corresponding":false,"raw_author_name":"Maiza Vitoria Aguiar Silva Oliveira","raw_affiliation_strings":["Universidad Privada del Este"],"raw_orcid":"https://orcid.org/0009-0007-8319-0207","affiliations":[{"raw_affiliation_string":"Universidad Privada del Este","institution_ids":["https://openalex.org/I4210157743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157933096","display_name":"Sandra Gonzalez L.","orcid":"https://orcid.org/0009-0003-9851-7867","observed_orcids":["https://orcid.org/0009-0003-9851-7867"]},"institutions":[{"id":"https://openalex.org/I4210157743","display_name":"Universidad Privada del Este","ror":"https://ror.org/05azpw996","country_code":"PY","type":"education","lineage":["https://openalex.org/I4210157743"]}],"countries":["PY"],"is_corresponding":false,"raw_author_name":"Sandra Gonzalez L.","raw_affiliation_strings":["Universidad Privada del Este"],"raw_orcid":"https://orcid.org/0009-0003-9851-7867","affiliations":[{"raw_affiliation_string":"Universidad Privada del Este","institution_ids":["https://openalex.org/I4210157743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147325690","display_name":"Marilaura Chamorro","orcid":"https://orcid.org/0009-0004-7262-2535","observed_orcids":["https://orcid.org/0009-0004-7262-2535"]},"institutions":[{"id":"https://openalex.org/I4210157743","display_name":"Universidad Privada del Este","ror":"https://ror.org/05azpw996","country_code":"PY","type":"education","lineage":["https://openalex.org/I4210157743"]}],"countries":["PY"],"is_corresponding":false,"raw_author_name":"Marilaura Chamorro","raw_affiliation_strings":["Universidad Privada del Este"],"raw_orcid":"https://orcid.org/0009-0004-7262-2535","affiliations":[{"raw_affiliation_string":"Universidad Privada del Este","institution_ids":["https://openalex.org/I4210157743"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036910755","display_name":"Ricardo Cesar Cintra","orcid":"https://orcid.org/0000-0002-5374-5319","observed_orcids":["https://orcid.org/0000-0002-5374-5319"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ricardo Cesar Cintra","raw_affiliation_strings":["Faculdade de Medicina da Universidade de S\u00e3o Paulo","Hospital das Clinicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo FMUSP HC","Universidade de S\u00e3o Paulo"],"raw_orcid":"https://orcid.org/0000-0002-5374-5319","affiliations":[{"raw_affiliation_string":"Faculdade de Medicina da Universidade de S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Hospital das Clinicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo FMUSP HC","institution_ids":["https://openalex.org/I4210145268"]},{"raw_affiliation_string":"Universidade de S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5033933243"],"corresponding_institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210157743"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atp1a2","display_name":"ATP1A2","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9789999723434448},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.996999979019165},{"id":"https://openalex.org/keywords/breast-cancer-subtypes","display_name":"breast cancer subtypes","score":0.7850000262260437},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.875},{"id":"https://openalex.org/keywords/cpg-sites","display_name":"CpG sites","score":0.8029999732971191},{"id":"https://openalex.org/keywords/passenger-genes","display_name":"passenger genes","score":0.7360000014305115},{"id":"https://openalex.org/keywords/basal-like-breast-cancer","display_name":"basal-like breast cancer","score":0.8529999852180481},{"id":"https://openalex.org/keywords/luminal-a-subtype","display_name":"luminal A","score":0.7910000085830688},{"id":"https://openalex.org/keywords/her2-enriched-breast-cancer","display_name":"HER2-enriched breast cancer","score":0.9020000100135803},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9589999914169312},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.8100000023841858},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6790000200271606},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.7570000290870667},{"id":"https://openalex.org/keywords/breast-cancer-cell-lines","display_name":"breast cancer cell lines","score":0.7360000014305115},{"id":"https://openalex.org/keywords/drug-response","display_name":"drug response","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.713699996471405},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7053999900817871},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.536899983882904},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5148000121116638},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.4325000047683716},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.399399995803833},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3691999912261963},{"id":"https://openalex.org/C2780737395","wikidata":"https://www.wikidata.org/wiki/Q18353741","display_name":"Epigenetic therapy","level":5,"score":0.32030001282691956},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31299999356269836},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.31279999017715454},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.2531000077724457}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1080/17501911.2026.2744072","doi":"https://doi.org/10.1080/17501911.2026.2744072","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17501911.2026.2744072","pdf_url":null,"source":{"id":"https://openalex.org/S42283280","display_name":"Epigenomics","issn_l":"1750-192X","issn":["1750-192X","1750-1911"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenomics","raw_type":"journal-article"},{"id":"pmid:42847739","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42847739","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenomics","raw_type":"Journal Article"},{"id":"doi:10.6084/m9.figshare.34242361","doi":"https://doi.org/10.6084/m9.figshare.34242361","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34242361","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.6084/m9.figshare.34242361.v1","doi":"https://doi.org/10.6084/m9.figshare.34242361.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34242361.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.6084/m9.figshare.34242361","doi":"https://doi.org/10.6084/m9.figshare.34242361","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34242361","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W812288956","https://openalex.org/W2005895632","https://openalex.org/W2123032740","https://openalex.org/W2141414987","https://openalex.org/W2142911989","https://openalex.org/W2153056550","https://openalex.org/W2157796307","https://openalex.org/W2185207072","https://openalex.org/W2291767163","https://openalex.org/W2336200579","https://openalex.org/W2463239901","https://openalex.org/W2569283191","https://openalex.org/W2758252083","https://openalex.org/W2765224588","https://openalex.org/W2800852522","https://openalex.org/W2912033166","https://openalex.org/W2943472942","https://openalex.org/W2953381975","https://openalex.org/W3015279038","https://openalex.org/W3023752815","https://openalex.org/W3028304854","https://openalex.org/W3042670097","https://openalex.org/W3116977338","https://openalex.org/W3133549624","https://openalex.org/W3147649493","https://openalex.org/W4206036024","https://openalex.org/W4211156615","https://openalex.org/W4220813890","https://openalex.org/W4224264061","https://openalex.org/W4244074209","https://openalex.org/W4296625120","https://openalex.org/W4301159569","https://openalex.org/W4388698764","https://openalex.org/W4393935425","https://openalex.org/W4405679778","https://openalex.org/W4413994469"],"related_works":["https://openalex.org/W7117291382","https://openalex.org/W3158473353","https://openalex.org/W2012488194","https://openalex.org/W2616697549","https://openalex.org/W4224981723","https://openalex.org/W2995164729","https://openalex.org/W3173074919","https://openalex.org/W4280609582","https://openalex.org/W1973767578","https://openalex.org/W2333354211"],"abstract_inverted_index":{"Background":[0],"To":[1],"evaluate":[2],"ATP1A2":[3,27,51,76,111,128,146,177],"as":[4],"a":[5,91],"subtype-associated":[6],"candidate":[7],"prognostic":[8],"biomarker":[9],"in":[10,20,58,80,98,104,170],"breast":[11,59,81,87,181],"cancer":[12,60,182],"by":[13],"integrating":[14],"transcriptomic,":[15],"epigenetic,":[16],"immune,":[17],"survival,":[18,188],"and":[19,25,38,42,54,66,72,89,101,107,124,133,136,161,166,184],"vitro":[21,171],"expression":[22,29,77,112,129],"analyses.Research":[23],"design":[24],"methods":[26],"mRNA":[28,150],"was":[30,47,56,78,113],"analyzed":[31],"using":[32],"TCGA-BRCA":[33],"data":[34],"from":[35],"1,087":[36],"patients":[37],"compared":[39,83],"across":[40,49],"clinicopathological":[41,117],"molecular":[43],"features.":[44],"DNA":[45],"methylation":[46],"evaluated":[48],"twelve":[50],"CpG":[52],"sites,":[53],"RT-qPCR":[55],"performed":[57],"cell":[61],"lines":[62],"representing":[63],"luminal,":[64],"HER2-enriched,":[65],"triple-negative":[67],"models":[68],"under":[69],"basal":[70],"conditions":[71],"after":[73],"therapeutic":[74],"exposure.Results":[75],"reduced":[79,149],"tumors":[82,100,144],"with":[84,94,115,140,180],"tumor-adjacent":[85],"normal":[86],"tissue":[88],"followed":[90],"subtype-dependent":[92],"pattern,":[93],"the":[95,102,157],"lowest":[96],"levels":[97],"basal-like":[99],"highest":[103],"luminal":[105],"A":[106],"normal-like":[108],"tumors.":[109],"Low":[110],"associated":[114,139,179],"aggressive":[116],"features,":[118],"hormone":[119],"receptor":[120],"negativity,":[121],"HER2":[122],"positivity,":[123],"non-luminal":[125],"subtypes.":[126],"High":[127],"predicted":[130],"improved":[131],"overall":[132,141,187],"disease-free":[134],"survival":[135],"remained":[137],"independently":[138,185],"survival.":[142],"Basal-like":[143],"displayed":[145],"amplification":[147],"despite":[148],"expression,":[151],"suggesting":[152],"possible":[153],"passenger-gene":[154],"behavior":[155],"within":[156],"1q21-q23":[158],"amplicon.":[159],"Methylation":[160],"immune":[162],"analyses":[163],"suggested":[164],"epigenetic":[165],"microenvironmental":[167],"influences,":[168],"whereas":[169],"assays":[172],"showed":[173],"treatment-associated":[174],"transcriptional":[175],"modulation.Conclusions":[176],"s":[178],"subtype":[183],"predicts":[186],"warranting":[189],"further":[190],"independent":[191],"validation.":[192]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-10-09T00:00:00"}