{"id":"https://openalex.org/W7220882133","doi":null,"title":"Nuevos an\u00e1logos de isotiocianatos naturales basados en carbohidratos: dise\u00f1o, s\u00edntesis y evaluaci\u00f3n biol\u00f3gica","display_name":"Nuevos an\u00e1logos de isotiocianatos naturales basados en carbohidratos: dise\u00f1o, s\u00edntesis y evaluaci\u00f3n biol\u00f3gica","publication_year":2026,"publication_date":"2026-07-24","ids":{"openalex":"https://openalex.org/W7220882133"},"language":"es","primary_location":{"id":"pmh:oai:idus.us.es:11441/190111","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11441/190111","pdf_url":"https://idus.us.es/bitstreams/11985109-8d0f-44f9-a217-65bfb1e622da/download","source":{"id":"https://openalex.org/S4306401665","display_name":"Deposito de Investigacion Universidad de Sevilla (University of Seville)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79238269","host_organization_name":"Universidad de Sevilla","host_organization_lineage":["https://openalex.org/I79238269"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://idus.us.es/bitstreams/11985109-8d0f-44f9-a217-65bfb1e622da/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157876583","display_name":"Luis Alberto Prieto Ram\u00edrez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Prieto Ram\u00edrez, Luis Alberto","raw_affiliation_strings":["Facultad de Ciencias de la Universidad Aut\u00f3noma de Madrid ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Ciencias de la Universidad Aut\u00f3noma de Madrid ,","institution_ids":["https://openalex.org/I63634437"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5157876583"],"corresponding_institution_ids":["https://openalex.org/I63634437"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.7548999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.7548999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.14249999821186066,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.03579999879002571,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycoconjugates","display_name":"glycoconjugates","score":0.824999988079071},{"id":"https://openalex.org/keywords/glucosinolates","display_name":"glucosinolates","score":0.8360000252723694},{"id":"https://openalex.org/keywords/myrosinase","display_name":"myrosinase","score":0.890999972820282},{"id":"https://openalex.org/keywords/sulforaphane","display_name":"sulforaphane","score":0.8330000042915344},{"id":"https://openalex.org/keywords/moringin","display_name":"moringin","score":0.9330000281333923},{"id":"https://openalex.org/keywords/nrf2-activation","display_name":"Nrf2 activation","score":0.49399998784065247},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7020000219345093},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9879999756813049},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.6510000228881836},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8360000252723694},{"id":"https://openalex.org/keywords/adme-prediction","display_name":"ADME prediction","score":0.5580000281333923},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.39399999380111694},{"id":"https://openalex.org/keywords/glut-transporters","display_name":"GLUT transporters","score":0.375}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.5188000202178955},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.37209999561309814},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.351500004529953},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.311599999666214},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.31150001287460327},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.16410000622272491},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.13819999992847443},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.11919999867677689},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.1145000010728836},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.10159999877214432}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:idus.us.es:11441/190111","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11441/190111","pdf_url":"https://idus.us.es/bitstreams/11985109-8d0f-44f9-a217-65bfb1e622da/download","source":{"id":"https://openalex.org/S4306401665","display_name":"Deposito de Investigacion Universidad de Sevilla (University of Seville)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79238269","host_organization_name":"Universidad de Sevilla","host_organization_lineage":["https://openalex.org/I79238269"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"}],"best_oa_location":{"id":"pmh:oai:idus.us.es:11441/190111","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11441/190111","pdf_url":"https://idus.us.es/bitstreams/11985109-8d0f-44f9-a217-65bfb1e622da/download","source":{"id":"https://openalex.org/S4306401665","display_name":"Deposito de Investigacion Universidad de Sevilla (University of Seville)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79238269","host_organization_name":"Universidad de Sevilla","host_organization_lineage":["https://openalex.org/I79238269"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220882133.pdf","grobid_xml":"https://content.openalex.org/works/W7220882133.grobid-xml"},"referenced_works_count":222,"referenced_works":["https://openalex.org/W248383993","https://openalex.org/W1491051499","https://openalex.org/W1552939846","https://openalex.org/W1652692682","https://openalex.org/W1805149125","https://openalex.org/W1830031167","https://openalex.org/W1849819493","https://openalex.org/W1863861988","https://openalex.org/W1954514489","https://openalex.org/W1959511032","https://openalex.org/W1963406380","https://openalex.org/W1963552434","https://openalex.org/W1968984443","https://openalex.org/W1969189143","https://openalex.org/W1969237028","https://openalex.org/W1976261027","https://openalex.org/W1976436763","https://openalex.org/W1976499671","https://openalex.org/W1978159078","https://openalex.org/W1978293942","https://openalex.org/W1980425523","https://openalex.org/W1981225934","https://openalex.org/W1981745234","https://openalex.org/W1981883819","https://openalex.org/W1985942574","https://openalex.org/W1986257539","https://openalex.org/W1988495712","https://openalex.org/W1990802251","https://openalex.org/W1991161477","https://openalex.org/W1991201692","https://openalex.org/W1991631628","https://openalex.org/W1996521867","https://openalex.org/W1996600333","https://openalex.org/W2002015567","https://openalex.org/W2002801265","https://openalex.org/W2005877813","https://openalex.org/W2007784708","https://openalex.org/W2007969837","https://openalex.org/W2010993054","https://openalex.org/W2011826815","https://openalex.org/W2012182437","https://openalex.org/W2014215280","https://openalex.org/W2018339027","https://openalex.org/W2019730745","https://openalex.org/W2021270662","https://openalex.org/W2022533018","https://openalex.org/W2027542963","https://openalex.org/W2027605855","https://openalex.org/W2028046413","https://openalex.org/W2028980499","https://openalex.org/W2029275361","https://openalex.org/W2030898736","https://openalex.org/W2033495141","https://openalex.org/W2034006021","https://openalex.org/W2034224169","https://openalex.org/W2035522088","https://openalex.org/W2035676834","https://openalex.org/W2039005183","https://openalex.org/W2040333421","https://openalex.org/W2040340034","https://openalex.org/W2041550216","https://openalex.org/W2043716459","https://openalex.org/W2044227662","https://openalex.org/W2048561636","https://openalex.org/W2049864289","https://openalex.org/W2050273205","https://openalex.org/W2051090019","https://openalex.org/W2053281570","https://openalex.org/W2055455897","https://openalex.org/W2059944694","https://openalex.org/W2062898287","https://openalex.org/W2067174909","https://openalex.org/W2071004159","https://openalex.org/W2071811020","https://openalex.org/W2073643570","https://openalex.org/W2075534480","https://openalex.org/W2075859346","https://openalex.org/W2076498053","https://openalex.org/W2078086437","https://openalex.org/W2078532650","https://openalex.org/W2079391392","https://openalex.org/W2082926347","https://openalex.org/W2086101155","https://openalex.org/W2088990040","https://openalex.org/W2091240011","https://openalex.org/W2094389169","https://openalex.org/W2098462984","https://openalex.org/W2101937547","https://openalex.org/W2103325328","https://openalex.org/W2105668062","https://openalex.org/W2106140689","https://openalex.org/W2109689528","https://openalex.org/W2114163388","https://openalex.org/W2115153703","https://openalex.org/W2115643252","https://openalex.org/W2118233996","https://openalex.org/W2121229452","https://openalex.org/W2121358285","https://openalex.org/W2122497259","https://openalex.org/W2126012382","https://openalex.org/W2126635195","https://openalex.org/W2129569411","https://openalex.org/W2130029858","https://openalex.org/W2131059541","https://openalex.org/W2132525235","https://openalex.org/W2135732933","https://openalex.org/W2137622838","https://openalex.org/W2137991354","https://openalex.org/W2143981217","https://openalex.org/W2146558971","https://openalex.org/W2147993766","https://openalex.org/W2148284063","https://openalex.org/W2151614363","https://openalex.org/W2154062229","https://openalex.org/W2154385453","https://openalex.org/W2155324869","https://openalex.org/W2156283242","https://openalex.org/W2160724016","https://openalex.org/W2168395641","https://openalex.org/W2176317606","https://openalex.org/W2187442906","https://openalex.org/W2291387770","https://openalex.org/W2297382745","https://openalex.org/W2313968233","https://openalex.org/W2323714638","https://openalex.org/W2333867322","https://openalex.org/W2337118882","https://openalex.org/W2426209056","https://openalex.org/W2474588061","https://openalex.org/W2486034701","https://openalex.org/W2520091754","https://openalex.org/W2559862100","https://openalex.org/W2560747746","https://openalex.org/W2568189309","https://openalex.org/W2593436234","https://openalex.org/W2744472379","https://openalex.org/W2770748248","https://openalex.org/W2774336664","https://openalex.org/W2781001843","https://openalex.org/W2782514497","https://openalex.org/W2786987313","https://openalex.org/W2793085429","https://openalex.org/W2793589433","https://openalex.org/W2803731604","https://openalex.org/W2804332880","https://openalex.org/W2807365771","https://openalex.org/W2808739227","https://openalex.org/W2809382515","https://openalex.org/W2820530002","https://openalex.org/W2884964182","https://openalex.org/W2899433532","https://openalex.org/W2900935596","https://openalex.org/W2901842078","https://openalex.org/W2902069072","https://openalex.org/W2908230192","https://openalex.org/W2949121428","https://openalex.org/W2951394153","https://openalex.org/W2958025173","https://openalex.org/W2968074063","https://openalex.org/W2971582004","https://openalex.org/W2972892167","https://openalex.org/W2985988211","https://openalex.org/W2987102360","https://openalex.org/W2989052455","https://openalex.org/W2992092023","https://openalex.org/W2996107378","https://openalex.org/W2999159548","https://openalex.org/W3012392756","https://openalex.org/W3014043866","https://openalex.org/W3023388601","https://openalex.org/W3025447533","https://openalex.org/W3025801371","https://openalex.org/W3032984656","https://openalex.org/W3034310241","https://openalex.org/W3035050134","https://openalex.org/W3045540118","https://openalex.org/W3049559440","https://openalex.org/W3087992083","https://openalex.org/W3092126466","https://openalex.org/W3107923066","https://openalex.org/W3108385798","https://openalex.org/W3127454645","https://openalex.org/W3139512624","https://openalex.org/W3169545953","https://openalex.org/W3171021949","https://openalex.org/W3187643350","https://openalex.org/W3203622089","https://openalex.org/W3213275622","https://openalex.org/W4210694998","https://openalex.org/W4210734847","https://openalex.org/W4211115520","https://openalex.org/W4211223138","https://openalex.org/W4212944329","https://openalex.org/W4221060738","https://openalex.org/W4235752331","https://openalex.org/W4241938123","https://openalex.org/W4289939586","https://openalex.org/W4293084539","https://openalex.org/W4311684292","https://openalex.org/W4311724886","https://openalex.org/W4327716322","https://openalex.org/W4362558489","https://openalex.org/W4384820525","https://openalex.org/W4387440676","https://openalex.org/W4389509770","https://openalex.org/W4391781128","https://openalex.org/W4393935425","https://openalex.org/W4398202647","https://openalex.org/W4403320429","https://openalex.org/W4403820364","https://openalex.org/W4403844349","https://openalex.org/W4404061126","https://openalex.org/W4404813541","https://openalex.org/W4405207286","https://openalex.org/W4405992770","https://openalex.org/W4406466424","https://openalex.org/W4409510914","https://openalex.org/W4412013811","https://openalex.org/W4412727451","https://openalex.org/W4414678046","https://openalex.org/W4415764614","https://openalex.org/W4416738474"],"related_works":["https://openalex.org/W3014788329","https://openalex.org/W7071745220","https://openalex.org/W2896324078","https://openalex.org/W7148671793","https://openalex.org/W1990280750","https://openalex.org/W4394956289","https://openalex.org/W3124152334","https://openalex.org/W117798217","https://openalex.org/W2916438522","https://openalex.org/W3016158261"],"abstract_inverted_index":{"Los":[0,218,257],"isotiocianatos":[1],"(ITCs)":[2],"naturales,":[3],"tales":[4],"como":[5,86,118,135,167,206,237,284,331],"el":[6,105,122,142,160,187,288,348],"sulforafano,":[7],"la":[8,11,26,29,36,72,136,139,181,245,252,285,296,299,305,314,338],"iberina":[9],"y":[10,62,83,88,141,177,190,210,216,229,250,272,287,304],"moringina,":[12],"son":[13],"compuestos":[14,219,319],"presentes":[15],"en":[16,81,199,240,267,337,342],"diversas":[17],"especies":[18],"vegetales,":[19],"liberados":[20],"por":[21,35],"hidr\u00f3lisis":[22],"de":[23,28,38,47,53,78,92,100,107,124,126,145,155,162,164,170,193,196,204,225,244,251,262,269,277,290,294,307,311,317,333,351],"glucosinolatos":[24],"mediante":[25,212],"acci\u00f3n":[27],"enzima":[30],"mirosinasa.":[31],"Estructuralmente,":[32],"se":[33,64,185,221],"caracterizan":[34],"presencia":[37,306],"un":[39,45],"grupo":[40,248,302],"ITC":[41,249],"(\u00e2\u20ac\u201cNCS)":[42],"unido":[43],"a":[44,51,129,227],"\u00e1tomo":[46,293],"azufre":[48],"u":[49],"ox\u00edgeno":[50],"trav\u00e9s":[52],"una":[54,152,238,264,326,344],"cadena":[55],"alif\u00e1tica.":[56],"Sus":[57],"importantes":[58],"propiedades":[59,134,355],"antioxidantes,":[60],"antiinflamatorias":[61],"antitumorales":[63],"relacionan":[65],"principalmente":[66],"con":[67,223,329,354],"su":[68,93,130,149,175],"capacidad":[69,131],"para":[70,121,132,347],"activar":[71],"v\u00eda":[73],"NRF2":[74],"e":[75],"inhibir":[76],"factores":[77,283],"transcripci\u00f3n":[79],"implicados":[80,336],"inflamaci\u00f3n":[82,271],"proliferaci\u00f3n":[84],"celular,":[85],"NF-\u00ce\u00baB":[87],"STAT3.":[89],"A":[90],"pesar":[91],"elevado":[94],"potencial":[95],"terap\u00e9utico,":[96],"las":[97],"limitaciones":[98],"farmacocin\u00e9ticas":[99],"los":[101,114,168,275,318,322,334],"ITCs":[102,197],"naturales":[103],"justifican":[104],"desarrollo":[106],"nuevos":[108,352],"an\u00e1logos":[109],"estructurales.":[110],"En":[111,180],"este":[112],"contexto,":[113],"carbohidratos":[115],"han":[116],"surgido":[117],"plataformas":[119],"prometedoras":[120],"dise\u00f1o":[123,156,349],"derivados":[125,203,353],"ITCs,":[127],"debido":[128],"modular":[133],"estabilidad":[137,239],"qu\u00edmica,":[138],"solubilidad":[140],"perfil":[143],"farmacocin\u00e9tico":[144],"estas":[146],"mol\u00e9culas.":[147],"Adem\u00e1s,":[148],"utilizaci\u00f3n":[150],"constituye":[151],"estrategia":[153],"racional":[154,350],"que":[157,282],"podr\u00eda":[158],"favorecer":[159],"aprovechamiento":[161],"sistemas":[163,308],"transporte":[165],"end\u00f3genos,":[166],"transportadores":[169],"glucosa":[171],"(GLUT),":[172],"mejorando":[173],"potencialmente":[174],"biodisponibilidad":[176],"selectividad":[178],"celular.":[179],"presente":[182],"Tesis":[183],"Doctoral":[184],"aborda":[186],"dise\u00f1o,":[188],"s\u00edntesis":[189],"evaluaci\u00f3n":[191],"biol\u00f3gica":[192,316],"diferentes":[194],"familias":[195],"basados":[198],"carbohidratos,":[200],"incluyendo":[201],"glicoconjugados":[202],"monosac\u00e1ridos":[205],"D-glucosa,":[207],"D-galactosa,":[208],"D-manosa":[209],"L-ramnosa":[211],"rutas":[213],"sint\u00e9ticas":[214],"convergentes":[215],"eficientes.":[217],"sintetizados":[220],"obtuvieron":[222],"rendimientos":[224],"moderados":[226],"excelentes":[228],"mostraron":[230],"perfiles":[231],"ADME":[232],"in":[233],"silico":[234],"favorables,":[235],"as\u00ed":[236],"medio":[241],"acuoso":[242],"dependiente":[243],"posici\u00f3n":[246,300],"del":[247,255,292,301],"arquitectura":[253],"molecular":[254],"derivado.":[256],"ensayos":[258],"biol\u00f3gicos":[259],"realizados":[260],"pusieron":[261],"manifiesto":[263],"relevante":[265],"actividad":[266,315,339],"modelos":[268],"neuroprotecci\u00f3n,":[270],"c\u00e1ncer.":[273],"Asimismo,":[274],"estudios":[276,323],"relaci\u00f3n":[278],"estructura-actividad":[279],"(SAR)":[280],"revelaron":[281],"naturaleza":[286],"estado":[289],"oxidaci\u00f3n":[291],"azufre,":[295],"configuraci\u00f3n":[297],"anom\u00e9rica,":[298],"funcional":[303],"divalentes":[309],"modulan":[310],"forma":[312],"significativa":[313],"sintetizados.":[320],"Finalmente,":[321],"computacionales":[324],"sugieren":[325],"posible":[327],"interacci\u00f3n":[328],"STAT3":[330],"uno":[332],"mecanismos":[335],"observada,":[340],"proporcionando":[341],"conjunto":[343],"base":[345],"s\u00f3lida":[346],"optimizadas.":[356]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-10-08T00:00:00"}