{"id":"https://openalex.org/W7220868428","doi":"https://doi.org/10.64898/2026.10.03.755596","title":"Monkeypox virus M2 rewires nucleocytoplasmic transport to coordinate host translation suppression and immune evasion","display_name":"Monkeypox virus M2 rewires nucleocytoplasmic transport to coordinate host translation suppression and immune evasion","publication_year":2026,"publication_date":"2026-10-06","ids":{"openalex":"https://openalex.org/W7220868428","doi":"https://doi.org/10.64898/2026.10.03.755596"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.03.755596","doi":"https://doi.org/10.64898/2026.10.03.755596","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.03.755596","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.03.755596.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.03.755596.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102726934","display_name":"Xin Huang","orcid":"https://orcid.org/0000-0002-6247-1946","observed_orcids":["https://orcid.org/0000-0002-6247-1946","https://orcid.org/0009-0006-0461-1716"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Huang","raw_affiliation_strings":["Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Fudan University, Shanghai 200032, China"],"raw_orcid":"https://orcid.org/0009-0006-0461-1716","affiliations":[{"raw_affiliation_string":"Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157811098","display_name":"Yilin Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yilin Yang","raw_affiliation_strings":["Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157820849","display_name":"Wei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106882","display_name":"Wuhan Institute of Virology","ror":"https://ror.org/01jxjav08","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106882"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391768268","display_name":"State Key Laboratory of Virology","ror":"https://ror.org/05sqd2v93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I37461747","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China","University of the Chinese Academy of Sciences, Beijing 100049, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]},{"raw_affiliation_string":"University of the Chinese Academy of Sciences, Beijing 100049, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068243367","display_name":"Wuyuan Lu","orcid":"https://orcid.org/0000-0003-1318-9968","observed_orcids":["https://orcid.org/0000-0003-1318-9968"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wuyuan Lu","raw_affiliation_strings":["Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Fudan University, Shanghai 200032, China"],"raw_orcid":"https://orcid.org/0000-0003-1318-9968","affiliations":[{"raw_affiliation_string":"Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5068243367"],"corresponding_institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monkeypox-virus","display_name":"monkeypox virus","score":0.9929999709129333},{"id":"https://openalex.org/keywords/m2-protein","display_name":"M2 protein","score":0.9300000071525574},{"id":"https://openalex.org/keywords/host-shutoff","display_name":"host shutoff","score":0.9089999794960022},{"id":"https://openalex.org/keywords/nuclear-transport","display_name":"nuclear transport","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nuclear-envelope","display_name":"nuclear envelope","score":0.7749999761581421},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cap-dependent-translation","display_name":"cap-dependent translation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.6320000290870667},{"id":"https://openalex.org/keywords/orthopoxvirus","display_name":"orthopoxvirus","score":0.7789999842643738},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.7400000095367432},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.5699999928474426},{"id":"https://openalex.org/keywords/antiviral-drug-targets","display_name":"antiviral drug targets","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7670000195503235},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6430000066757202},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.570900022983551},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5647000074386597},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5303999781608582},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4948999881744385},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.4925999939441681},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4921000003814697},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.4408999979496002},{"id":"https://openalex.org/C2781251061","wikidata":"https://www.wikidata.org/wiki/Q5416089","display_name":"Evasion (ethics)","level":3,"score":0.4278999865055084},{"id":"https://openalex.org/C140933497","wikidata":"https://www.wikidata.org/wiki/Q7933606","display_name":"Viral pathogenesis","level":4,"score":0.4250999987125397},{"id":"https://openalex.org/C25897203","wikidata":"https://www.wikidata.org/wiki/Q3241872","display_name":"Viral life cycle","level":4,"score":0.41780000925064087},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.39959999918937683},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35830000042915344},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.34860000014305115},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3465999960899353},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.3264000117778778},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.30880001187324524},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.30630001425743103},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.29750001430511475},{"id":"https://openalex.org/C2777245867","wikidata":"https://www.wikidata.org/wiki/Q46305","display_name":"Filoviridae","level":5,"score":0.2930000126361847},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2904999852180481},{"id":"https://openalex.org/C2779758228","wikidata":"https://www.wikidata.org/wiki/Q858790","display_name":"DNA virus","level":4,"score":0.2881999909877777},{"id":"https://openalex.org/C2778011067","wikidata":"https://www.wikidata.org/wiki/Q382370","display_name":"Monkeypox","level":5,"score":0.28780001401901245},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2851000130176544},{"id":"https://openalex.org/C15224491","wikidata":"https://www.wikidata.org/wiki/Q7169338","display_name":"Permissive","level":2,"score":0.2721000015735626},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.271699994802475},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.2703000009059906},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.2605000138282776},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.25679999589920044}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.03.755596","doi":"https://doi.org/10.64898/2026.10.03.755596","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.03.755596","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.03.755596.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.03.755596","doi":"https://doi.org/10.64898/2026.10.03.755596","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.03.755596","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.03.755596.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.6226999759674072,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1359662343","display_name":null,"funder_award_id":"ZD2021CY001","funder_id":"https://openalex.org/F4320321851","funder_display_name":"Fudan University"},{"id":"https://openalex.org/G1856013897","display_name":null,"funder_award_id":"32571391","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8116276879","display_name":null,"funder_award_id":"82030062","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321851","display_name":"Fudan University","ror":"https://ror.org/013q1eq08"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220868428.pdf","grobid_xml":"https://content.openalex.org/works/W7220868428.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1784712937","https://openalex.org/W1863953228","https://openalex.org/W1953665670","https://openalex.org/W1966510211","https://openalex.org/W1977883755","https://openalex.org/W1991404926","https://openalex.org/W1997971074","https://openalex.org/W2002226709","https://openalex.org/W2008938739","https://openalex.org/W2009707997","https://openalex.org/W2020996714","https://openalex.org/W2025343024","https://openalex.org/W2050674793","https://openalex.org/W2065305397","https://openalex.org/W2079838847","https://openalex.org/W2087181210","https://openalex.org/W2088307305","https://openalex.org/W2097102109","https://openalex.org/W2115668602","https://openalex.org/W2117319524","https://openalex.org/W2120161238","https://openalex.org/W2137729139","https://openalex.org/W2150249493","https://openalex.org/W2150456529","https://openalex.org/W2163409779","https://openalex.org/W2397395972","https://openalex.org/W2697918121","https://openalex.org/W2770168610","https://openalex.org/W2775529910","https://openalex.org/W2808130319","https://openalex.org/W2887556102","https://openalex.org/W2898708852","https://openalex.org/W2939668119","https://openalex.org/W2981903711","https://openalex.org/W3028104079","https://openalex.org/W3091285461","https://openalex.org/W3092296275","https://openalex.org/W3094558943","https://openalex.org/W3111222233","https://openalex.org/W3127173946","https://openalex.org/W3172681111","https://openalex.org/W3208232492","https://openalex.org/W4212770368","https://openalex.org/W4286210426","https://openalex.org/W4294637087","https://openalex.org/W4308207588","https://openalex.org/W4313217507","https://openalex.org/W4391349211","https://openalex.org/W7096186325","https://openalex.org/W7130315184"],"related_works":["https://openalex.org/W2128633905","https://openalex.org/W4398177301","https://openalex.org/W7131124340","https://openalex.org/W4391513602","https://openalex.org/W4400004342","https://openalex.org/W3028104079","https://openalex.org/W4396795925","https://openalex.org/W7170220320","https://openalex.org/W7095350133","https://openalex.org/W7111154265"],"abstract_inverted_index":{"Abstract":[0],"Host":[1],"shutoff":[2],"is":[3,89],"a":[4,24,38,44,79,108,113,184],"conserved":[5],"viral":[6,139,179],"strategy":[7],"to":[8,63,70,100,151,164,193],"dismantle":[9],"cellular":[10],"defenses,":[11],"yet":[12],"the":[13,29,56,64,71,169],"molecular":[14,80],"orchestrators":[15],"in":[16,141,182],"large":[17],"DNA":[18],"viruses":[19],"remain":[20],"poorly":[21],"defined.":[22],"Through":[23],"systematic":[25],"functional":[26],"screen":[27],"of":[28,47,119],"monkeypox":[30],"virus":[31,130],"(MPXV)":[32],"proteome,":[33],"we":[34,132],"identify":[35],"M2":[36,59,87,105,136,148],"as":[37,78],"potent,":[39],"multifunctional":[40],"effector":[41],"that":[42,123,135,147],"executes":[43],"global":[45],"blockade":[46],"host":[48,153,196],"gene":[49],"expression.":[50],"Unlike":[51],"its":[52],"assembly-centric":[53],"homologs":[54],"across":[55],"orthopoxvirus":[57],"genus,":[58],"localizes":[60],"not":[61],"only":[62],"well-characterized":[65],"endoplasmic":[66],"reticulum":[67],"but":[68,115],"also":[69,90],"nuclear":[72],"envelope,":[73],"where":[74],"it":[75],"may":[76,98,106,149],"function":[77],"chokepoint,":[81],"obstructing":[82],"bidirectional":[83],"nucleocytoplasmic":[84],"transport.":[85],"Concurrently,":[86],"expression":[88,137],"associated":[91],"with":[92],"altered":[93],"Akt/mTOR/4EBP1":[94],"signaling":[95],"axis,":[96],"which":[97,183],"contribute":[99,150],"reduced":[101],"cap-dependent":[102],"translation.":[103,127],"Intriguingly,":[104],"induce":[107],"\u2018transcriptional":[109],"trap\u2019":[110],"\u2014":[111],"triggering":[112],"robust":[114],"futile":[116],"ERK-dependent":[117],"activation":[118],"AP-1-mediated":[120],"stress":[121],"responses":[122],"are":[124,162],"decoupled":[125],"from":[126],"Using":[128],"recombinant":[129],"engineering,":[131],"provide":[133],"evidence":[134],"augments":[138],"replication":[140],"cell":[142],"culture.":[143],"These":[144],"findings":[145],"suggest":[146],"MPXV-mediated":[152],"shutoff,":[154],"although":[155],"further":[156],"studies":[157],"under":[158],"authentic":[159],"infection":[160],"conditions":[161],"required":[163],"establish":[165],"causality":[166],"and":[167,190],"define":[168],"underlying":[170],"mechanism.":[171],"Our":[172],"study":[173],"preliminarily":[174],"reveals":[175],"an":[176],"paradigm":[177],"for":[178,202],"niche":[180],"adaptation,":[181],"single":[185],"protein":[186],"coordinates":[187],"spatial":[188],"sequestration":[189],"biochemical":[191],"suppression":[192],"enact":[194],"multi-layered":[195],"suppression,":[197],"providing":[198],"critical":[199],"candidate":[200],"targets":[201],"therapeutic":[203],"intervention":[204],"against":[205],"emerging":[206],"orthopoxviruses.":[207]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-08T00:00:00"}
