{"id":"https://openalex.org/W7220864339","doi":"https://doi.org/10.3892/mmr.2026.14037","title":"Research progress in synergistic multimechanism of nanomaterial-mediated neuroinflammatory therapy (Review)","display_name":"Research progress in synergistic multimechanism of nanomaterial-mediated neuroinflammatory therapy (Review)","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220864339","doi":"https://doi.org/10.3892/mmr.2026.14037","pmid":"https://pubmed.ncbi.nlm.nih.gov/42852620","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13691584"},"language":"en","primary_location":{"id":"doi:10.3892/mmr.2026.14037","doi":"https://doi.org/10.3892/mmr.2026.14037","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2026.14037","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2026.14037/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.spandidos-publications.com/10.3892/mmr.2026.14037/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100453940","display_name":"Heng Wang","orcid":"https://orcid.org/0000-0001-8471-6337","observed_orcids":["https://orcid.org/0000-0001-8471-6337"]},"institutions":[{"id":"https://openalex.org/I4405280798","display_name":"Gansu Medical College","ror":"https://ror.org/03f2w8r10","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Heng Wang","raw_affiliation_strings":["Department of Human Anatomy, Gansu Medical College, Pinliang, Gansu 744000, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Gansu Medical College, Pinliang, Gansu 744000, P.R.\u00a0China","institution_ids":["https://openalex.org/I4405280798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157797886","display_name":"Pei Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405280798","display_name":"Gansu Medical College","ror":"https://ror.org/03f2w8r10","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pei Yang","raw_affiliation_strings":["Department of Human Anatomy, Gansu Medical College, Pinliang, Gansu 744000, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Gansu Medical College, Pinliang, Gansu 744000, P.R.\u00a0China","institution_ids":["https://openalex.org/I4405280798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157829333","display_name":"Wantao Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405280798","display_name":"Gansu Medical College","ror":"https://ror.org/03f2w8r10","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280798"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wantao Liu","raw_affiliation_strings":["Department of Human Anatomy, Gansu Medical College, Pinliang, Gansu 744000, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Gansu Medical College, Pinliang, Gansu 744000, P.R.\u00a0China","institution_ids":["https://openalex.org/I4405280798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5157829333"],"corresponding_institution_ids":["https://openalex.org/I4405280798"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.47192982,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"6","first_page":"1","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.06449999660253525,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.972000002861023},{"id":"https://openalex.org/keywords/nanomaterials","display_name":"nanomaterials","score":0.9549999833106995},{"id":"https://openalex.org/keywords/blood-brain-barrier-penetration","display_name":"blood-brain barrier penetration","score":0.8550000190734863},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.8360000252723694},{"id":"https://openalex.org/keywords/microglial-polarization","display_name":"microglial polarization","score":0.8479999899864197},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7239999771118164},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9399999976158142},{"id":"https://openalex.org/keywords/biosafety-evaluation","display_name":"biosafety evaluation","score":0.6930000185966492},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5450999736785889},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.438400000333786},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.3849000036716461},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.375900000333786},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3458000123500824},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3375999927520752},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3276999890804291},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.29649999737739563},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2806999981403351},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2745000123977661},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2615000009536743},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.25850000977516174},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.25690001249313354},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.2540999948978424},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2531999945640564}],"mesh":[{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3892/mmr.2026.14037","doi":"https://doi.org/10.3892/mmr.2026.14037","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2026.14037","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2026.14037/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},{"id":"pmid:42852620","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42852620","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular medicine reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13691584","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13691584/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Med Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3892/mmr.2026.14037","doi":"https://doi.org/10.3892/mmr.2026.14037","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2026.14037","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2026.14037/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220864339.pdf","grobid_xml":"https://content.openalex.org/works/W7220864339.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7164857863","https://openalex.org/W7135240852","https://openalex.org/W7119789852","https://openalex.org/W4403162344","https://openalex.org/W2091446333","https://openalex.org/W4413655561","https://openalex.org/W2885518311","https://openalex.org/W7128693882","https://openalex.org/W7165809725","https://openalex.org/W7153746871"],"abstract_inverted_index":{"Neuroinflammation":[0],"treatment":[1],"faces":[2],"notable":[3],"challenges":[4],"such":[5],"as":[6],"low":[7],"blood\u2011brain":[8],"barrier":[9],"(BBB)":[10],"penetration,":[11],"poor":[12],"targeting":[13],"and":[14,25,49,69,76,93],"systemic":[15],"toxicity,":[16],"limiting":[17],"traditional":[18],"therapies":[19],"due":[20],"to":[21,59],"inefficient":[22],"drug":[23],"delivery":[24],"bioavailability.":[26],"Nanomaterials":[27],"have":[28],"innovatively":[29],"reshaped":[30],"this":[31],"paradigm":[32],"through":[33],"multiple":[34],"mechanisms.":[35],"The":[36,79],"present":[37,80],"review":[38,81],"elaborates":[39],"core":[40],"strategies":[41],"in":[42,85],"immunocyte":[43],"phenotype":[44],"regulation,":[45],"oxidative":[46],"stress":[47],"intervention":[48],"targeted":[50],"delivery,":[51],"focusing":[52],"on":[53],"modulating":[54],"microglia":[55],"transition":[56],"from":[57],"pro\u2011inflammatory":[58],"repair":[60],"states,":[61],"constructing":[62],"systems":[63],"for":[64,73],"reactive":[65],"oxygen":[66],"species":[67],"regulation":[68],"developing":[70],"biomimetic":[71],"carriers":[72],"BBB":[74],"penetration":[75],"lesion":[77],"targeting.":[78],"highlights":[82],"technical":[83],"bottlenecks":[84],"long\u2011term":[86],"biosafety":[87],"evaluation,":[88],"cross\u2011organ":[89],"metabolic":[90],"mechanism":[91],"analysis":[92],"clinical":[94],"translation":[95],"standardization.":[96]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-08T00:00:00"}