{"id":"https://openalex.org/W7220861816","doi":"https://doi.org/10.64898/2026.09.30.755598","title":"PKA disrupts adult ovarian identity circuits through direct inhibition of TRIM28-chromatin binding","display_name":"PKA disrupts adult ovarian identity circuits through direct inhibition of TRIM28-chromatin binding","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220861816","doi":"https://doi.org/10.64898/2026.09.30.755598"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.30.755598","doi":"https://doi.org/10.64898/2026.09.30.755598","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.30.755598","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.09.30.755598.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.09.30.755598.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092901274","display_name":"Florian Chaleil","orcid":"https://orcid.org/0009-0007-6969-5428","observed_orcids":["https://orcid.org/0009-0007-6969-5428"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Florian Chaleil","raw_affiliation_strings":["Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France"],"raw_orcid":"https://orcid.org/0009-0007-6969-5428","affiliations":[{"raw_affiliation_string":"Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043573055","display_name":"Lionel Le Gallic","orcid":"https://orcid.org/0000-0001-7147-9846","observed_orcids":["https://orcid.org/0000-0001-7147-9846"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lionel Le Gallic","raw_affiliation_strings":["Institute of Human Genetics (IGH), CNRS UMR9002, University of Montpellier"],"raw_orcid":"https://orcid.org/0000-0001-7147-9846","affiliations":[{"raw_affiliation_string":"Institute of Human Genetics (IGH), CNRS UMR9002, University of Montpellier","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210163339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043106965","display_name":"Isabelle Sahut\u2010Barnola","orcid":"https://orcid.org/0000-0001-7004-8577","observed_orcids":["https://orcid.org/0000-0001-7004-8577"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Isabelle Sahut-Barnola","raw_affiliation_strings":["Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003880247","display_name":"Joris Mordier","orcid":"https://orcid.org/0000-0003-1179-7660","observed_orcids":["https://orcid.org/0000-0003-1179-7660"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Joris Mordier","raw_affiliation_strings":["Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France"],"raw_orcid":"https://orcid.org/0000-0003-1179-7660","affiliations":[{"raw_affiliation_string":"Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063813463","display_name":"St\u00e9phanie Le Gras","orcid":"https://orcid.org/0000-0001-6293-6507","observed_orcids":["https://orcid.org/0000-0001-6293-6507"]},"institutions":[{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phanie Le Gras","raw_affiliation_strings":["Institute of Genetics and molecular and cellular biology, Illkirch-Graffenstaden"],"raw_orcid":"https://orcid.org/0000-0001-6293-6507","affiliations":[{"raw_affiliation_string":"Institute of Genetics and molecular and cellular biology, Illkirch-Graffenstaden","institution_ids":["https://openalex.org/I4210086872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113410965","display_name":"Sylvain Roumeau","orcid":"https://orcid.org/0000-0003-2855-5414","observed_orcids":["https://orcid.org/0000-0003-2855-5414"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210128870","display_name":"Centre Hospitalier Universitaire de Clermont-Ferrand","ror":"https://ror.org/02tcf7a68","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210128870"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvain Roumeau","raw_affiliation_strings":["Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France","Service d\u2019Endocrinologie, Centre Hospitalier Universitaire Gabriel Montpied, Clermont-Ferrand, France"],"raw_orcid":"https://orcid.org/0000-0003-2855-5414","affiliations":[{"raw_affiliation_string":"Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]},{"raw_affiliation_string":"Service d\u2019Endocrinologie, Centre Hospitalier Universitaire Gabriel Montpied, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I4210128870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056295276","display_name":"C\u00e9line Keime","orcid":"https://orcid.org/0000-0001-7604-3814","observed_orcids":["https://orcid.org/0000-0001-7604-3814"]},"institutions":[{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9line Keime","raw_affiliation_strings":["Institute of Genetics and molecular and cellular biology, Illkirch-Graffenstaden"],"raw_orcid":"https://orcid.org/0000-0001-7604-3814","affiliations":[{"raw_affiliation_string":"Institute of Genetics and molecular and cellular biology, Illkirch-Graffenstaden","institution_ids":["https://openalex.org/I4210086872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074608051","display_name":"Cyril Djari","orcid":"https://orcid.org/0000-0001-7666-9024","observed_orcids":["https://orcid.org/0000-0001-7666-9024"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210128870","display_name":"Centre Hospitalier Universitaire de Clermont-Ferrand","ror":"https://ror.org/02tcf7a68","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210128870"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["CH","FR"],"is_corresponding":false,"raw_author_name":"Cyril Djari","raw_affiliation_strings":["Department of Genetic Medicine and Development, University of Geneva, 1211 Geneva, Switzerland","Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France","Institute of Human Genetics (IGH), CNRS UMR9002, University of Montpellier","Service d\u2019Endocrinologie, Centre Hospitalier Universitaire Gabriel Montpied, Clermont-Ferrand, France"],"raw_orcid":"https://orcid.org/0000-0001-7666-9024","affiliations":[{"raw_affiliation_string":"Department of Genetic Medicine and Development, University of Geneva, 1211 Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]},{"raw_affiliation_string":"Institute of Human Genetics (IGH), CNRS UMR9002, University of Montpellier","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210163339"]},{"raw_affiliation_string":"Service d\u2019Endocrinologie, Centre Hospitalier Universitaire Gabriel Montpied, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I4210128870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153625830","display_name":"Antoine Vigier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I4210128870","display_name":"Centre Hospitalier Universitaire de Clermont-Ferrand","ror":"https://ror.org/02tcf7a68","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210128870"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["CH","FR"],"is_corresponding":false,"raw_author_name":"Antoine Vigier","raw_affiliation_strings":["Department of Genetic Medicine and Development, University of Geneva, 1211 Geneva, Switzerland","Institute of Genetics and molecular and cellular biology, Illkirch-Graffenstaden","Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France","Institute of Human Genetics (IGH), CNRS UMR9002, University of Montpellier","Service d\u2019Endocrinologie, Centre Hospitalier Universitaire Gabriel Montpied, Clermont-Ferrand, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Medicine and Development, University of Geneva, 1211 Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Institute of Genetics and molecular and cellular biology, Illkirch-Graffenstaden","institution_ids":["https://openalex.org/I4210086872"]},{"raw_affiliation_string":"Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]},{"raw_affiliation_string":"Institute of Human Genetics (IGH), CNRS UMR9002, University of Montpellier","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210163339"]},{"raw_affiliation_string":"Service d\u2019Endocrinologie, Centre Hospitalier Universitaire Gabriel Montpied, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I4210128870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153560579","display_name":"L. Badoil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L\u00e9na Badoil","raw_affiliation_strings":["Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004076862","display_name":"Pierre Val","orcid":"https://orcid.org/0000-0001-7648-5567","observed_orcids":["https://orcid.org/0000-0001-7648-5567"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Val","raw_affiliation_strings":["Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France"],"raw_orcid":"https://orcid.org/0000-0001-7648-5567","affiliations":[{"raw_affiliation_string":"Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110249176","display_name":"Jean\u2010Christophe Pointud","orcid":"https://orcid.org/0009-0004-3014-1012","observed_orcids":["https://orcid.org/0009-0004-3014-1012"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Christophe Pointud","raw_affiliation_strings":["Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France"],"raw_orcid":"https://orcid.org/0009-0004-3014-1012","affiliations":[{"raw_affiliation_string":"Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031897654","display_name":"Constantine A. Stratakis","orcid":"https://orcid.org/0000-0002-4058-5520","observed_orcids":["https://orcid.org/0000-0002-4058-5520"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I2801024494","display_name":"HCA Healthcare","ror":"https://ror.org/0237c2m81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801024494"]},{"id":"https://openalex.org/I4210105723","display_name":"FORTH Institute of Molecular Biology and Biotechnology","ror":"https://ror.org/01gzszr18","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210105723","https://openalex.org/I8901234"]},{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR","US"],"is_corresponding":false,"raw_author_name":"Constantine A. Stratakis","raw_affiliation_strings":["Department of Pediatrics, University of Athens Medical School, Athens, Greece","Hospital for Endocrine Surgery Research Center, HCA Florida Healthcare, HCA Healthcare Research Institute, Tampa, Florida, USA","Human Genetics & Precision Medicine, IMBB, FORTH, Heraklion, Greece"],"raw_orcid":"https://orcid.org/0000-0002-4058-5520","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Athens Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"Hospital for Endocrine Surgery Research Center, HCA Florida Healthcare, HCA Healthcare Research Institute, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2801024494"]},{"raw_affiliation_string":"Human Genetics & Precision Medicine, IMBB, FORTH, Heraklion, Greece","institution_ids":["https://openalex.org/I4210105723","https://openalex.org/I8901234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051495906","display_name":"Florence M. Cammas","orcid":"https://orcid.org/0000-0003-4117-8182","observed_orcids":["https://orcid.org/0000-0003-4117-8182"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Florence Cammas","raw_affiliation_strings":["Institute of Human Genetics (IGH), CNRS UMR9002, University of Montpellier"],"raw_orcid":"https://orcid.org/0000-0003-4117-8182","affiliations":[{"raw_affiliation_string":"Institute of Human Genetics (IGH), CNRS UMR9002, University of Montpellier","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210163339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028122717","display_name":"Antoine Martinez","orcid":"https://orcid.org/0000-0001-9304-5061","observed_orcids":["https://orcid.org/0000-0001-9304-5061"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Antoine Martinez","raw_affiliation_strings":["Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France"],"raw_orcid":"https://orcid.org/0000-0001-9304-5061","affiliations":[{"raw_affiliation_string":"Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006014020","display_name":"Fran\u00e7is Poulat","orcid":"https://orcid.org/0000-0003-2070-1296","observed_orcids":["https://orcid.org/0000-0003-2070-1296"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Francis Poulat","raw_affiliation_strings":["Institute of Human Genetics (IGH), CNRS UMR9002, University of Montpellier"],"raw_orcid":"https://orcid.org/0000-0003-2070-1296","affiliations":[{"raw_affiliation_string":"Institute of Human Genetics (IGH), CNRS UMR9002, University of Montpellier","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210163339"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033156431","display_name":"Anne\u2010Marie Lefran\u00e7ois\u2010Martinez","orcid":"https://orcid.org/0000-0003-2021-2548","observed_orcids":["https://orcid.org/0000-0003-2021-2548"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Anne Marie Lefran\u00e7ois-Martinez","raw_affiliation_strings":["Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France"],"raw_orcid":"https://orcid.org/0000-0003-2021-2548","affiliations":[{"raw_affiliation_string":"Institute of Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5033156431"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.5038999915122986,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.5038999915122986,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.420199990272522,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9210000038146973},{"id":"https://openalex.org/keywords/trim28","display_name":"TRIM28","score":0.9959999918937683},{"id":"https://openalex.org/keywords/foxl2","display_name":"FOXL2","score":0.8339999914169312},{"id":"https://openalex.org/keywords/sumoylation","display_name":"SUMOylation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/granulosa-cells","display_name":"granulosa cells","score":0.9150000214576721},{"id":"https://openalex.org/keywords/gonadotropin-signaling","display_name":"gonadotropin signaling","score":0.7360000014305115},{"id":"https://openalex.org/keywords/chromatin-binding","display_name":"chromatin binding","score":0.8140000104904175},{"id":"https://openalex.org/keywords/carney-complex","display_name":"Carney complex","score":0.6980000138282776},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.734000027179718},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C171350616","wikidata":"https://www.wikidata.org/wiki/Q61506","display_name":"SUMO protein","level":4,"score":0.6424000263214111},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5669000148773193},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5649999976158142},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5561000108718872},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4661000072956085},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.4634000062942505},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4174000024795532},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3540000021457672},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3393000066280365},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.32690000534057617},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.299699991941452},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.29840001463890076},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.29660001397132874},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.29440000653266907},{"id":"https://openalex.org/C2776888042","wikidata":"https://www.wikidata.org/wiki/Q422137","display_name":"Steroid hormone","level":3,"score":0.28780001401901245},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.28209999203681946},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2791999876499176},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2612000107765198},{"id":"https://openalex.org/C2779122487","wikidata":"https://www.wikidata.org/wiki/Q281579","display_name":"Germ cell","level":3,"score":0.2554999887943268}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.30.755598","doi":"https://doi.org/10.64898/2026.09.30.755598","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.30.755598","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.09.30.755598.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.30.755598","doi":"https://doi.org/10.64898/2026.09.30.755598","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.30.755598","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.09.30.755598.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G12037968","display_name":null,"funder_award_id":"CAP 2025","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G254877862","display_name":null,"funder_award_id":"CAP 20-25","funder_id":"https://openalex.org/F4320329116","funder_display_name":"Universit\u00e9 Clermont-Auvergne"},{"id":"https://openalex.org/G2845043987","display_name":"Interaction between PKA signalling and TRIM28 in ovarian maintenance and pathology","funder_award_id":"ANR-21-CE14-0061","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3812186825","display_name":"Sant\u00e9 des femmes, sant\u00e9 des couples","funder_award_id":"ANR-24-PESF-0001","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5128561041","display_name":"Sex-specific tissue homeostasis and its impact on adrenal diseases","funder_award_id":"ANR-18-CE14-0012","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320329116","display_name":"Universit\u00e9 Clermont-Auvergne","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220861816.pdf","grobid_xml":"https://content.openalex.org/works/W7220861816.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W2500326083","https://openalex.org/W7170856157"],"related_works":["https://openalex.org/W4386856404","https://openalex.org/W4288700137","https://openalex.org/W7170856157","https://openalex.org/W7134026341","https://openalex.org/W7152930706","https://openalex.org/W2605195274","https://openalex.org/W2801148568","https://openalex.org/W7171820637","https://openalex.org/W7134981512","https://openalex.org/W2125100570"],"abstract_inverted_index":{"SUMMARY":[0],"Functional":[1],"ovarian":[2,31,47,97,123,158],"plasticity":[3,32],"depends":[4,57],"on":[5,58,111,149,156],"the":[6,87,143,198],"granulosa":[7],"cell":[8,160],"(GC)":[9],"fate":[10],"determination,":[11],"differentiation,":[12],"oocyte":[13],"support":[14,165],"and":[15,50,93,104,138,153,180,193],"steroid":[16],"production.":[17],"After":[18],"birth,":[19],"GC":[20,65,78,98],"identity":[21,48,79,195],"must":[22],"be":[23,67,82],"maintained":[24],"in":[25,64,76,88,120,144,197],"differentiating":[26],"follicles,":[27],"while":[28],"from":[29,126,130],"puberty,":[30],"is":[33],"cyclically":[34],"challenged":[35],"by":[36,69],"gonadotropic":[37],"hormones.":[38],"TRIM28-FOXL2":[39],"interactions":[40],"form":[41],"a":[42],"key":[43],"chromatin":[44,151],"component":[45],"maintaining":[46],"programs":[49],"repressing":[51],"testis-specific":[52],"genes.":[53],"This":[54,113,183],"TRIM28":[55,102,177],"role":[56],"its":[59,154],"E3-SUMO-ligase":[60],"activity,":[61],"suggesting":[62],"SUMOylation":[63,118,185],"can":[66],"regulated":[68],"transient":[70,173],"hormonal":[71,74,191],"cues,":[72],"although":[73],"involvement":[75],"modulating":[77],"remains":[80],"to":[81,116],"established.":[83],"Here,":[84],"we":[85,141],"demonstrated":[86,106],"vivo":[89,145],"interplay":[90],"between":[91],"gonadotropic-PKA-signaling":[92],"hypo-SUMOylation":[94],"waves":[95],"underlying":[96],"plasticity.":[99],"In":[100],"vitro":[101],"mutagenesis":[103],"phospho-proteomics":[105],"direct":[107],"PKA":[108,128,146],"inhibitory":[109,147],"control":[110],"TRIM28.":[112],"prompted":[114],"us":[115],"highlight":[117],"alterations":[119],"Carney":[121],"Complex":[122],"lesions":[124],"resulting":[125],"chronic":[127],"activity":[129],"rare":[131],"genetic":[132],"mutations.":[133],"Using":[134],"mutant":[135],"models,":[136],"transcriptomics":[137],"TRIM28/FOXL2-ChIP-Seq":[139],"analyses,":[140],"specified":[142],"mechanisms":[148],"TRIM28/FOXL2":[150],"binding":[152],"consequences":[155],"adult":[157],"somatic":[159],"identity.":[161],"Together,":[162],"our":[163],"data":[164],"an":[166],"integrative":[167],"model":[168],"where":[169],"gonadotrophin":[170],"pulses":[171],"create":[172],"windows":[174],"of":[175,190],"PKA-mediated":[176],"phosphorylation,":[178],"hypo-SUMOylation,":[179],"FOXL2\u2013TRIM28":[181],"destabilization.":[182],"positions":[184],"dynamics":[186],"as":[187],"central":[188],"integrator":[189],"signaling":[192],"epigenetic":[194],"maintenance":[196],"ovary.":[199]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-08T00:00:00"}
