{"id":"https://openalex.org/W7220861750","doi":"https://doi.org/10.64898/2026.10.06.755294","title":"Artesunate Exploits Glutathione-Dependent Redox Vulnerability in Metastatic Lung Adenocarcinoma","display_name":"Artesunate Exploits Glutathione-Dependent Redox Vulnerability in Metastatic Lung Adenocarcinoma","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220861750","doi":"https://doi.org/10.64898/2026.10.06.755294"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.06.755294","doi":"https://doi.org/10.64898/2026.10.06.755294","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.755294","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.06.755294.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.06.755294.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5130598224","display_name":"Patricia Munteanu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Patricia Munteanu","raw_affiliation_strings":["Department of Medical Oncology, Cell Plasticity and Metastasis, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Cell Plasticity and Metastasis, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032975611","display_name":"Sophia Neuhaus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sophia Neuhaus","raw_affiliation_strings":["Department of Medical Oncology, Cell Plasticity and Metastasis, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Cell Plasticity and Metastasis, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157810853","display_name":"Paula Feldt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Paula Feldt","raw_affiliation_strings":["Department of Medical Oncology, Cell Plasticity and Metastasis, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Cell Plasticity and Metastasis, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005618683","display_name":"Vahan Serobyan","orcid":"https://orcid.org/0000-0001-5055-8422","observed_orcids":["https://orcid.org/0000-0001-5055-8422"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vahan Serobyan","raw_affiliation_strings":["German Cancer Research Centre (DKFZ), Heidelberg, Germany","Translational Skin Cancer Research, German Cancer Consortium (DKTK), University Medicine Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Cancer Research Centre (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Translational Skin Cancer Research, German Cancer Consortium (DKTK), University Medicine Essen, Essen, Germany","institution_ids":["https://openalex.org/I4391767962"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anna Baginska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anna Baginska","raw_affiliation_strings":["Department of Medical Oncology, Cell Plasticity and Metastasis, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Cell Plasticity and Metastasis, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065710911","display_name":"Jos\u00e9 Pedro Friedmann Angeli","orcid":"https://orcid.org/0000-0001-7706-1379","observed_orcids":["https://orcid.org/0000-0001-7706-1379"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jose Pedro Friedmann Angeli","raw_affiliation_strings":["Rudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7706-1379","affiliations":[{"raw_affiliation_string":"Rudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157815387","display_name":"J\u00fcrgen Becker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Becker","raw_affiliation_strings":["Department of Dermatology, University Hospital Essen, Essen, Germany","German Cancer Research Centre (DKFZ), Heidelberg, Germany","Translational Skin Cancer Research, German Cancer Consortium (DKTK), University Medicine Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"German Cancer Research Centre (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Translational Skin Cancer Research, German Cancer Consortium (DKTK), University Medicine Essen, Essen, Germany","institution_ids":["https://openalex.org/I4391767962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036367485","display_name":"Alexander Schramm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Schramm","raw_affiliation_strings":["Department of Medical Oncology, Molecular Oncology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Molecular Oncology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I62318514"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025856946","display_name":"Barbara M. Gr\u00fcner","orcid":"https://orcid.org/0000-0003-0974-4826","observed_orcids":["https://orcid.org/0000-0003-0974-4826"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Barbara M. Gr\u00fcner","raw_affiliation_strings":["Department of Medical Oncology, Cell Plasticity and Metastasis, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Germany","German Cancer Consortium (DKTK), partner site Essen/D\u00fcsseldorf, a partnership between DKFZ and University Hospital Essen, University of Duisburg-Essen, Essen, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0974-4826","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Cell Plasticity and Metastasis, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I62318514"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), partner site Essen/D\u00fcsseldorf, a partnership between DKFZ and University Hospital Essen, University of Duisburg-Essen, Essen, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I62318514"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5025856946"],"corresponding_institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4210119759","https://openalex.org/I62318514"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7929999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7929999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.13809999823570251,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artesunate","display_name":"artesunate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8029999732971191},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7950000166893005},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7720000147819519},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7770000100135803},{"id":"https://openalex.org/keywords/metabolic-vulnerability","display_name":"metabolic vulnerability","score":0.7070000171661377},{"id":"https://openalex.org/keywords/metastatic-seeding","display_name":"metastatic seeding","score":0.7509999871253967},{"id":"https://openalex.org/keywords/kras-g12d","display_name":"KRAS G12D","score":0.8939999938011169},{"id":"https://openalex.org/keywords/p53-knockout","display_name":"p53 knockout","score":0.9169999957084656},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6118999719619751},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5141000151634216},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.42980000376701355},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.40630000829696655},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.40139999985694885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39559999108314514},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.39410001039505005},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3822999894618988},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.37709999084472656},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.36719998717308044},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.36160001158714294},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3612000048160553},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36079999804496765},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3418000042438507},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.33730000257492065},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.3343000113964081},{"id":"https://openalex.org/C2778059366","wikidata":"https://www.wikidata.org/wiki/Q707939","display_name":"Artesunate","level":4,"score":0.3328000009059906},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.30979999899864197},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.3093999922275543},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.3025999963283539},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3021000027656555},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3003000020980835},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2948000133037567},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.2913999855518341},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.29109999537467957},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.29010000824928284},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.28349998593330383},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2824999988079071},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.27230000495910645},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.25279998779296875},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.250900000333786},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.06.755294","doi":"https://doi.org/10.64898/2026.10.06.755294","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.755294","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.06.755294.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.06.755294","doi":"https://doi.org/10.64898/2026.10.06.755294","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.755294","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.06.755294.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2335721336","display_name":null,"funder_award_id":"CRU337","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8665684607","display_name":"KFO 337: Ph\u00e4notypische Therapie und Immunresistenz in Krebs (PhenoTImE): Pr\u00e4klinischer und translationaler Fortschritt der KFO 337","funder_award_id":"405344257","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320323556","display_name":"Deutsche Krebshilfe","ror":"https://ror.org/01wxdd722"},{"id":"https://openalex.org/F4320327569","display_name":"Deutschen Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220861750.pdf","grobid_xml":"https://content.openalex.org/works/W7220861750.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1967596683","https://openalex.org/W1973840375","https://openalex.org/W2023405265","https://openalex.org/W2035618305","https://openalex.org/W2035676834","https://openalex.org/W2088055025","https://openalex.org/W2098131661","https://openalex.org/W2102186262","https://openalex.org/W2138207763","https://openalex.org/W2144316016","https://openalex.org/W2146040216","https://openalex.org/W2163182602","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2498090354","https://openalex.org/W2519825823","https://openalex.org/W2520894026","https://openalex.org/W2586407709","https://openalex.org/W2762087180","https://openalex.org/W2769635882","https://openalex.org/W2790217549","https://openalex.org/W2790769430","https://openalex.org/W2809281987","https://openalex.org/W2889721542","https://openalex.org/W2894188334","https://openalex.org/W3010323140","https://openalex.org/W3012307045","https://openalex.org/W3015802361","https://openalex.org/W3022968840","https://openalex.org/W3088753670","https://openalex.org/W3107515905","https://openalex.org/W3121611509","https://openalex.org/W3173942724","https://openalex.org/W3202100113","https://openalex.org/W3206088408","https://openalex.org/W3209079142","https://openalex.org/W3217189159","https://openalex.org/W4244949663","https://openalex.org/W4291170595","https://openalex.org/W4294216483","https://openalex.org/W4294542865","https://openalex.org/W4303859051","https://openalex.org/W4310595161","https://openalex.org/W4380576533","https://openalex.org/W4381489565","https://openalex.org/W4388742731","https://openalex.org/W4399544580","https://openalex.org/W4400850181","https://openalex.org/W4402886999","https://openalex.org/W4412756907","https://openalex.org/W4415026081","https://openalex.org/W4416422480"],"related_works":["https://openalex.org/W3002518739","https://openalex.org/W7135180437","https://openalex.org/W3004559986","https://openalex.org/W2147262287","https://openalex.org/W4400850181","https://openalex.org/W2360653956","https://openalex.org/W2239439128","https://openalex.org/W2059722530","https://openalex.org/W2209616468","https://openalex.org/W3043267993"],"abstract_inverted_index":{"SUMMARY":[0],"Metastatic":[1],"dissemination":[2],"remains":[3],"the":[4,29],"principal":[5],"cause":[6],"of":[7,39,51,70,113],"mortality":[8],"in":[9,42,48,76,109,123,143],"lung":[10],"adenocarcinoma.":[11],"To":[12],"identify":[13,135],"metabolic":[14,54,141],"vulnerabilities":[15],"associated":[16],"with":[17,23],"metastasis,":[18],"we":[19,45],"used":[20],"cell":[21,125],"lines":[22],"distinct":[24],"metastatic":[25,71,80,144],"abilities":[26],"derived":[27],"from":[28],"Kras":[30],"G12D":[31],";p53":[32],"KO":[33],"mouse":[34],"model.":[35],"Building":[36],"on":[37],"evidence":[38],"mitochondrial":[40],"dysfunction":[41],"metastasis-derived":[43,110],"cells,":[44],"performed":[46],"an":[47],"vivo":[49,77],"screen":[50],"a":[52,58,67,140],"focused":[53],"drug":[55],"library":[56],"using":[57,151],"multiplexed":[59],"DNA-barcoding":[60],"platform.":[61],"This":[62],"approach":[63],"identified":[64],"artesunate":[65,89],"as":[66,139],"selective":[68],"inhibitor":[69],"seeding,":[72],"which":[73],"was":[74],"validated":[75],"to":[78,120],"reduce":[79],"burden":[81],"while":[82],"leaving":[83],"primary":[84,128],"tumor":[85],"growth":[86],"unaffected.":[87],"Mechanistically,":[88],"induced":[90],"oxidative":[91],"stress,":[92],"characterized":[93],"by":[94],"reactive":[95],"oxygen":[96],"species":[97],"and":[98,102],"lipid":[99],"peroxidation.":[100],"Transcriptomic":[101],"mechanistic":[103],"profiling":[104],"revealed":[105],"altered":[106],"redox":[107,137],"homeostasis":[108,138],"cells.":[111],"Inhibition":[112],"glutathione":[114],"synthesis":[115],"specifically":[116,149],"sensitized":[117],"these":[118],"cells":[119,130,145],"artesunate,":[121],"resulting":[122],"extensive":[124],"death,":[126],"whereas":[127],"tumor-derived":[129],"remained":[131],"resistant.":[132],"These":[133],"findings":[134],"glutathione-dependent":[136],"vulnerability":[142],"that":[146],"can":[147],"be":[148],"targeted":[150],"artesunate.":[152]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-08T00:00:00"}
