{"id":"https://openalex.org/W7220860311","doi":"https://doi.org/10.36660/abc.20250854","title":"Astragalus Polysaccharide Enhances Mitochondrial Biogenesis and Function in Cardiomyocytes Through AMPK Activation","display_name":"Astragalus Polysaccharide Enhances Mitochondrial Biogenesis and Function in Cardiomyocytes Through AMPK Activation","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7220860311","doi":"https://doi.org/10.36660/abc.20250854","pmid":"https://pubmed.ncbi.nlm.nih.gov/42848624","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13671154"},"language":"pt","primary_location":{"id":"doi:10.36660/abc.20250854","doi":"https://doi.org/10.36660/abc.20250854","is_oa":true,"landing_page_url":"https://doi.org/10.36660/abc.20250854","pdf_url":null,"source":{"id":"https://openalex.org/S67004851","display_name":"Arquivos Brasileiros de Cardiologia","issn_l":"0066-782X","issn":["0066-782X","1678-4170"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310312504","host_organization_name":"Sociedade Brasileira de Cardiologia (SBC)","host_organization_lineage":["https://openalex.org/P4310312504"],"host_organization_lineage_names":["Sociedade Brasileira de Cardiologia (SBC)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Cardiologia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.36660/abc.20250854","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157825903","display_name":"Chengbin Wang","orcid":"https://orcid.org/0009-0009-8475-9447","observed_orcids":["https://orcid.org/0009-0009-8475-9447"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chengbin Wang","raw_affiliation_strings":["Guizhou University of Traditional Chinese Medicine"],"raw_orcid":"https://orcid.org/0009-0009-8475-9447","affiliations":[{"raw_affiliation_string":"Guizhou University of Traditional Chinese Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116870780","display_name":"Shuhan Lv","orcid":"https://orcid.org/0009-0006-0613-962X","observed_orcids":["https://orcid.org/0009-0006-0613-962X","https://orcid.org/0009-0000-7772-5200"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuhan Lv","raw_affiliation_strings":["Guizhou University of Traditional Chinese Medicine"],"raw_orcid":"https://orcid.org/0009-0000-7772-5200","affiliations":[{"raw_affiliation_string":"Guizhou University of Traditional Chinese Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157804728","display_name":"Xingde Liu","orcid":"https://orcid.org/0009-0002-5613-7033","observed_orcids":["https://orcid.org/0009-0002-5613-7033"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xingde Liu","raw_affiliation_strings":["Guizhou University of Traditional Chinese Medicine"],"raw_orcid":"https://orcid.org/0009-0002-5613-7033","affiliations":[{"raw_affiliation_string":"Guizhou University of Traditional Chinese Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66125606,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"123","issue":"8","first_page":"e20250854","last_page":"e20250854"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8779000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8779000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.03779999911785126,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astragalus-polysaccharide","display_name":"Astragalus polysaccharide","score":0.968999981880188},{"id":"https://openalex.org/keywords/astragalus-membranaceus","display_name":"Astragalus membranaceus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8450000286102295},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.8899999856948853},{"id":"https://openalex.org/keywords/ampk-signaling","display_name":"AMPK signaling","score":0.8100000023841858},{"id":"https://openalex.org/keywords/pgc-1alpha","display_name":"PGC-1\u03b1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cardiac-mitochondrial-dysfunction","display_name":"cardiac mitochondrial dysfunction","score":0.5849999785423279},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8650000095367432},{"id":"https://openalex.org/keywords/mitochondrial-dna","display_name":"mitochondrial DNA","score":0.41600000858306885},{"id":"https://openalex.org/keywords/complex-iv-activity","display_name":"complex IV activity","score":0.5440000295639038},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.6610000133514404},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.593999981880188},{"id":"https://openalex.org/keywords/tfam","display_name":"TFAM","score":0.9459999799728394},{"id":"https://openalex.org/keywords/ucp2","display_name":"UCP2","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hl-1-cells","display_name":"HL-1 cells","score":0.7239999771118164},{"id":"https://openalex.org/keywords/compound-c","display_name":"compound C","score":0.5550000071525574},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.3050000071525574}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6712999939918518},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4966000020503998},{"id":"https://openalex.org/C169415338","wikidata":"https://www.wikidata.org/wiki/Q18031951","display_name":"TFAM","level":4,"score":0.3190999925136566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3188999891281128},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.2759000062942505},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.2694000005722046},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.22579999268054962},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21979999542236328},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20569999516010284},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.19169999659061432}],"mesh":[{"descriptor_ui":"D000071248","descriptor_name":"Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001678","descriptor_name":"Organelle Biogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D027883","descriptor_name":"Astragalus Plant","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D063269","descriptor_name":"Mitochondrial Turnover","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.36660/abc.20250854","doi":"https://doi.org/10.36660/abc.20250854","is_oa":true,"landing_page_url":"https://doi.org/10.36660/abc.20250854","pdf_url":null,"source":{"id":"https://openalex.org/S67004851","display_name":"Arquivos Brasileiros de Cardiologia","issn_l":"0066-782X","issn":["0066-782X","1678-4170"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310312504","host_organization_name":"Sociedade Brasileira de Cardiologia (SBC)","host_organization_lineage":["https://openalex.org/P4310312504"],"host_organization_lineage_names":["Sociedade Brasileira de Cardiologia (SBC)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Cardiologia","raw_type":"journal-article"},{"id":"doi:10.36660/abc.20250854i","doi":"https://doi.org/10.36660/abc.20250854i","is_oa":true,"landing_page_url":"https://doi.org/10.36660/abc.20250854i","pdf_url":"https://abccardiol.org/wp-content/uploads/articles_xml/0066-782x-abc-123-8-e20250854/0066-782x-abc-123-8-e20250854.pdf","source":{"id":"https://openalex.org/S67004851","display_name":"Arquivos Brasileiros de Cardiologia","issn_l":"0066-782X","issn":["0066-782X","1678-4170"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310312504","host_organization_name":"Sociedade Brasileira de Cardiologia (SBC)","host_organization_lineage":["https://openalex.org/P4310312504"],"host_organization_lineage_names":["Sociedade Brasileira de Cardiologia (SBC)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Cardiologia","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13671154","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13671154/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13671154/pdf/0066-782x-abc-123-8-e20250854.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arq Bras Cardiol","raw_type":"Text"},{"id":"pmid:42848624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42848624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos brasileiros de cardiologia","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e7b1e8cdebd04c539f97e1e879971015","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e7b1e8cdebd04c539f97e1e879971015","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arquivos Brasileiros de Cardiologia, Vol 123, Iss 8 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.36660/abc.20250854","doi":"https://doi.org/10.36660/abc.20250854","is_oa":true,"landing_page_url":"https://doi.org/10.36660/abc.20250854","pdf_url":null,"source":{"id":"https://openalex.org/S67004851","display_name":"Arquivos Brasileiros de Cardiologia","issn_l":"0066-782X","issn":["0066-782X","1678-4170"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310312504","host_organization_name":"Sociedade Brasileira de Cardiologia (SBC)","host_organization_lineage":["https://openalex.org/P4310312504"],"host_organization_lineage_names":["Sociedade Brasileira de Cardiologia (SBC)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Cardiologia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220860311.pdf","grobid_xml":"https://content.openalex.org/works/W7220860311.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2388378698","https://openalex.org/W4416782792","https://openalex.org/W589551010","https://openalex.org/W7056248009","https://openalex.org/W2930690443","https://openalex.org/W2365945653","https://openalex.org/W2960293062","https://openalex.org/W7156348884","https://openalex.org/W2765209161","https://openalex.org/W2783567687"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mitochondrial":[1,97,117],"dysfunction":[2],"is":[3],"a":[4,24,248],"key":[5],"driver":[6],"of":[7,53,68,90,207,240],"heart":[8],"failure,":[9],"underscoring":[10],"the":[11,51,66,69,175,205,241],"need":[12],"for":[13,94,252],"therapies":[14],"that":[15],"promote":[16],"mitochondrial":[17,39,56,122,133,146,183,193,201,232,257],"biogenesis":[18,59,118,233],"and":[19,58,63,111,132,137,155,164,187,200,211,213,234],"function.":[20],"Astragalus":[21,28],"polysaccharide":[22],"(APS),":[23],"bioactive":[25],"compound":[26],"from":[27],"membranaceus,":[29],"has":[30],"demonstrated":[31],"cardioprotective":[32],"properties,":[33],"but":[34],"its":[35],"direct":[36],"effects":[37,52,220],"on":[38,55],"homeostasis":[40],"in":[41,60,236],"cardiomyocytes":[42,62,84,237],"remain":[43],"unclear.":[44],"OBJECTIVES:":[45],"This":[46],"study":[47],"aimed":[48],"to":[49,64,173],"investigate":[50],"APS":[54,91,179,203,230],"function":[57,235],"HL-1":[61,83],"elucidate":[65],"involvement":[67],"AMP-activated":[70],"protein":[71,152],"kinase":[72],"(AMPK)/peroxisome":[73],"proliferator-activated":[74],"receptor":[75],"gamma":[76],"coactivator":[77],"1-alpha":[78],"(PGC-1\u03b1)":[79],"signaling":[80,243],"pathway.":[81],"METHODS:":[82],"were":[85,109,159,221],"treated":[86],"with":[87,226,256],"non-toxic":[88],"concentrations":[89],"(1.25-2.5":[92],"g/L)":[93],"48":[95],"hours.":[96],"respiration":[98],"was":[99,115,119,171],"assessed":[100],"via":[101],"Seahorse":[102],"XF":[103],"Analyzer,":[104],"adenosine":[105],"triphosphate":[106],"(ATP)":[107],"levels":[108],"quantified,":[110],"Complex":[112,188],"IV":[113,189],"activity":[114],"measured.":[116],"evaluated":[120],"by":[121,161,196,223],"DNA":[123,126],"(mtDNA)/":[124],"nuclear":[125,141],"(nDNA)":[127],"ratio,":[128],"cytochrome":[129],"B":[130],"levels,":[131],"mass.":[134,202],"Key":[135],"proteins":[136],"genes,":[138],"including":[139],"PGC-1\u03b1,":[140,208],"respiratory":[142],"factor":[143,148],"2":[144,153],"(NRF2),":[145],"transcription":[147],"A":[149],"(TFAM),":[150],"uncoupling":[151],"(UCP2),":[154],"phosphorylated":[156],"AMPK":[157,167,215,224],"(p-AMPK),":[158],"analyzed":[160],"Western":[162],"blot":[163],"qPCR.":[165],"The":[166],"inhibitor":[168],"Compound":[169,227],"C":[170],"used":[172],"confirm":[174],"pathway's":[176],"role.":[177],"RESULTS:":[178],"treatment":[180],"significantly":[181],"enhanced":[182],"respiration,":[184],"ATP":[185],"production,":[186],"activity.":[190],"It":[191],"promoted":[192],"biogenesis,":[194],"evidenced":[195],"increased":[197],"mtDNA/nDNA":[198],"ratio":[199],"upregulated":[204],"expression":[206],"NRF2,":[209],"TFAM,":[210],"UCP2,":[212],"activated":[214],"phosphorylation.":[216],"All":[217],"these":[218],"beneficial":[219],"abolished":[222],"inhibition":[225],"C.":[228],"CONCLUSIONS:":[229],"enhances":[231],"through":[238],"activation":[239],"AMPK/PGC-1\u03b1":[242],"pathway,":[244],"identifying":[245],"it":[246],"as":[247],"potential":[249],"therapeutic":[250],"agent":[251],"cardiac":[253],"diseases":[254],"associated":[255],"dysfunction.":[258]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-08T00:00:00"}