{"id":"https://openalex.org/W7220860209","doi":"https://doi.org/10.64898/2026.10.06.757079","title":"Prenatal Alcohol Exposure Downregulates Focal Adhesion Molecules Tensin 1 and Tensin 2 Contributing to Cerebrovascular Dysfunction","display_name":"Prenatal Alcohol Exposure Downregulates Focal Adhesion Molecules Tensin 1 and Tensin 2 Contributing to Cerebrovascular Dysfunction","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220860209","doi":"https://doi.org/10.64898/2026.10.06.757079"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.06.757079","doi":"https://doi.org/10.64898/2026.10.06.757079","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.757079","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.06.757079.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.06.757079.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157856024","display_name":"Richard J Justice","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Justice","raw_affiliation_strings":["Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM 87131 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM 87131 USA","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033254684","display_name":"Amy S. Gardiner","orcid":"https://orcid.org/0000-0002-8179-4919","observed_orcids":["https://orcid.org/0000-0002-8179-4919"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amy S. Gardiner","raw_affiliation_strings":["Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM 87131 USA"],"raw_orcid":"https://orcid.org/0000-0002-8179-4919","affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM 87131 USA","institution_ids":["https://openalex.org/I169521973"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033254684"],"corresponding_institution_ids":["https://openalex.org/I169521973"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.031199999153614044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.027799999341368675,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prenatal-alcohol-exposure","display_name":"prenatal alcohol exposure","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fetal-alcohol-spectrum-disorders","display_name":"fetal alcohol spectrum disorders","score":0.9649999737739563},{"id":"https://openalex.org/keywords/mir-150-5p","display_name":"miR-150-5p","score":0.9480000138282776},{"id":"https://openalex.org/keywords/brain-microvascular-endothelial-cells","display_name":"brain microvascular endothelial cells","score":0.8679999709129333},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/endothelial-sprouting","display_name":"endothelial sprouting","score":0.7929999828338623},{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.5080000162124634},{"id":"https://openalex.org/keywords/cerebrovascular-development","display_name":"cerebrovascular development","score":0.953000009059906},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.6039999723434448},{"id":"https://openalex.org/keywords/3-utr-binding","display_name":"3' UTR binding","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2779549131","wikidata":"https://www.wikidata.org/wiki/Q83167294","display_name":"Tensin","level":5,"score":0.9056000113487244},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.694100022315979},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5253000259399414},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5094000101089478},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.4507000148296356},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43790000677108765},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.41440001130104065},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.3785000145435333},{"id":"https://openalex.org/C2778241760","wikidata":"https://www.wikidata.org/wiki/Q1057052","display_name":"Sprouting","level":2,"score":0.3643999993801117},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.36309999227523804},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34299999475479126},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33320000767707825},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3276999890804291},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.322299987077713},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3052000105381012},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.301800012588501},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.27079999446868896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2590000033378601},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.25699999928474426},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.2554999887943268},{"id":"https://openalex.org/C122871604","wikidata":"https://www.wikidata.org/wiki/Q2248886","display_name":"Neural cell adhesion molecule","level":4,"score":0.25290000438690186},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.2506999969482422}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.06.757079","doi":"https://doi.org/10.64898/2026.10.06.757079","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.757079","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.06.757079.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.06.757079","doi":"https://doi.org/10.64898/2026.10.06.757079","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.757079","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.06.757079.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220860209.pdf","grobid_xml":"https://content.openalex.org/works/W7220860209.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1787824584","https://openalex.org/W2010461414","https://openalex.org/W2029315212","https://openalex.org/W2076413918","https://openalex.org/W2100932663","https://openalex.org/W2104435626","https://openalex.org/W2156815304","https://openalex.org/W2275015992","https://openalex.org/W2279076193","https://openalex.org/W2433700089","https://openalex.org/W2792288381","https://openalex.org/W2947856544","https://openalex.org/W3010192928","https://openalex.org/W3038535900","https://openalex.org/W3088793929","https://openalex.org/W3110398655","https://openalex.org/W3127251697","https://openalex.org/W3132514097","https://openalex.org/W3211739860","https://openalex.org/W4200564084","https://openalex.org/W4210705575","https://openalex.org/W4295910775","https://openalex.org/W4307292494","https://openalex.org/W4307776780","https://openalex.org/W4309452252","https://openalex.org/W4321598769","https://openalex.org/W4327905879","https://openalex.org/W4362578146","https://openalex.org/W4380077490","https://openalex.org/W4382400397","https://openalex.org/W4387020789","https://openalex.org/W4393032128","https://openalex.org/W4393902835","https://openalex.org/W4400409852","https://openalex.org/W4401281555","https://openalex.org/W4401537341","https://openalex.org/W4404578957","https://openalex.org/W4412152226","https://openalex.org/W7161128668","https://openalex.org/W7207661139"],"related_works":["https://openalex.org/W3166096714","https://openalex.org/W4295910775","https://openalex.org/W7048910431","https://openalex.org/W4398166683","https://openalex.org/W7167657379","https://openalex.org/W7222922160","https://openalex.org/W7061309770","https://openalex.org/W7039420322","https://openalex.org/W2104435626","https://openalex.org/W4309452252"],"abstract_inverted_index":{"Abstract":[0],"Fetal":[1],"alcohol":[2,10,60],"spectrum":[3],"disorders":[4],"(FASD)":[5],"are":[6],"caused":[7],"by":[8,59,79],"prenatal":[9],"exposure":[11,61],"(PAE),":[12],"which":[13,73],"leads":[14],"to":[15,95,109,116],"developmental":[16],"defects":[17],"during":[18,30,178],"embryogenesis.":[19],"Angiogenesis":[20],"is":[21,27,36],"one":[22],"facet":[23],"of":[24,45,84,93,98,167],"development":[25],"that":[26,42,71,146,156],"heavily":[28],"dysregulated":[29],"PAE":[31],"and":[32,52,86,100,120,132,137,151,155,159,169],"where":[33],"such":[34],"impairment":[35],"poorly":[37],"understood.":[38],"Here":[39],"we":[40,74,103,144],"found":[41,70,76,145],"expression":[43,83,161],"levels":[44],"focal":[46],"adhesion":[47],"molecules":[48],"Tensin":[49,53],"1":[50],"(Tns1)":[51],"2":[54],"(Tns2)":[55],"were":[56],"significantly":[57],"reduced":[58],"in":[62,114,140,153],"brain":[63],"microvascular":[64],"endothelial":[65,111,175],"cells":[66],"(BMVECs).":[67],"We":[68],"also":[69],"miR-150-5p,":[72],"previously":[75],"was":[77],"increased":[78],"PAE,":[80],"regulates":[81,149],"the":[82,96,164],"Tns1":[85,99,122,131,150,158],"Tns2.":[87,101],"Dual-luciferase":[88],"assays":[89,108],"demonstrated":[90],"direct":[91],"binding":[92],"miR-150-5p":[94,129,147,171],"3\u2019UTRs":[97],"Additionally,":[102],"utilized":[104],"sprouting":[105,113,141,177],"angiogenesis":[106],"bead":[107],"evaluate":[110],"cell":[112,176],"response":[115],"ethanol":[117],"(EtOH)":[118],"treatment":[119],"following":[121],"and/or":[123],"Tns2":[124,133,152,160],"overexpression":[125],"as":[126,128],"well":[127],"modulation.":[130],"rescued":[134],"both":[135],"EtOH-":[136],"miR-150-5p-mediated":[138],"deficits":[139],"angiogenesis.":[142],"Overall,":[143],"negatively":[148],"BMVECs":[154],"augmenting":[157],"may":[162],"reverse":[163],"negative":[165],"effects":[166],"EtOH,":[168],"subsequent":[170],"elevation,":[172],"thus":[173],"improving":[174],"cerebrovascular":[179],"development.":[180]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-08T00:00:00"}