{"id":"https://openalex.org/W7220859187","doi":"https://doi.org/10.4274/thoracrespract.2026.2026-5-9","title":"Pretransplant Small-airway Dysfunction is Associated with Posttransplant Complications in Adult HSCT Recipients","display_name":"Pretransplant Small-airway Dysfunction is Associated with Posttransplant Complications in Adult HSCT Recipients","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220859187","doi":"https://doi.org/10.4274/thoracrespract.2026.2026-5-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/42840756","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13687692"},"language":"en","primary_location":{"id":"doi:10.4274/thoracrespract.2026.2026-5-9","doi":"https://doi.org/10.4274/thoracrespract.2026.2026-5-9","is_oa":true,"landing_page_url":"https://doi.org/10.4274/thoracrespract.2026.2026-5-9","pdf_url":"https://thoracrespract.org/pdf/68ab204c-182b-49da-b227-bc7efe058632/articles/ThoracResPract.2026.2026-5-9/5-2026.2026-5-9.pdf","source":{"id":"https://openalex.org/S4393920162","display_name":"Thoracic research and practice","issn_l":"2979-9139","issn":["2979-9139"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thoracic Research and Practice","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://thoracrespract.org/pdf/68ab204c-182b-49da-b227-bc7efe058632/articles/ThoracResPract.2026.2026-5-9/5-2026.2026-5-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112927595","display_name":"Caner \u00c7\u0131nar","orcid":"https://orcid.org/0000-0003-3284-3945","observed_orcids":["https://orcid.org/0000-0003-3284-3945"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Caner \u00c7\u0131nar","raw_affiliation_strings":["Division of Pulmonary Medicine, Marmara University Faculty of Medicine, \u0130stanbul, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Medicine, Marmara University Faculty of Medicine, \u0130stanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090281542","display_name":"Ahmet Mert Yan\u0131k","orcid":"https://orcid.org/0000-0002-1908-0149","observed_orcids":["https://orcid.org/0000-0002-1908-0149","https://orcid.org/0000-0003-3488-5372"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ahmet Mert Yan\u0131k","raw_affiliation_strings":["Division of Hematology, Marmara University Faculty of Medicine, \u0130stanbul, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Marmara University Faculty of Medicine, \u0130stanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059562767","display_name":"Zeynep Mercanci","orcid":"https://orcid.org/0000-0003-3689-6550","observed_orcids":["https://orcid.org/0000-0003-3689-6550"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Zeynep Mercanc\u0131","raw_affiliation_strings":["Division of Pulmonary Medicine, Marmara University Faculty of Medicine, \u0130stanbul, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Medicine, Marmara University Faculty of Medicine, \u0130stanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157809056","display_name":"Cansu Y\u0131ld\u0131z","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Cansu Y\u0131ld\u0131z","raw_affiliation_strings":["Division of Pulmonary Medicine, Marmara University Faculty of Medicine, \u0130stanbul, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Medicine, Marmara University Faculty of Medicine, \u0130stanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019334532","display_name":"Tayfur Topta\u015f","orcid":"https://orcid.org/0000-0002-2690-8581","observed_orcids":["https://orcid.org/0000-0002-2690-8581"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tayfur Topta\u015f","raw_affiliation_strings":["Division of Hematology, Marmara University Faculty of Medicine, \u0130stanbul, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Marmara University Faculty of Medicine, \u0130stanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127248471","display_name":"I\u015eIK ATAG\u00dcND\u00dcZ","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"I\u015f\u0131k Atag\u00fcnd\u00fcz","raw_affiliation_strings":["Division of Hematology, Marmara University Faculty of Medicine, \u0130stanbul, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Marmara University Faculty of Medicine, \u0130stanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127081671","display_name":"SEM\u0130HA EMEL ERY\u00dcKSEL","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Semiha Emel Ery\u00fcksel","raw_affiliation_strings":["Division of Pulmonary Medicine, Marmara University Faculty of Medicine, \u0130stanbul, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Medicine, Marmara University Faculty of Medicine, \u0130stanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028663989","display_name":"Sait Karakurt","orcid":"https://orcid.org/0000-0002-6699-5798","observed_orcids":["https://orcid.org/0000-0002-6699-5798"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sait Karakurt","raw_affiliation_strings":["Division of Pulmonary Medicine, Marmara University Faculty of Medicine, \u0130stanbul, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Medicine, Marmara University Faculty of Medicine, \u0130stanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I74897591"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112927595"],"corresponding_institution_ids":["https://openalex.org/I74897591"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7296465,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"Spec Issue 1","first_page":"20","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.1177000030875206,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/small-airway-dysfunction","display_name":"small airway dysfunction","score":0.9319999814033508},{"id":"https://openalex.org/keywords/fef25-75","display_name":"FEF25-75","score":0.8669999837875366},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8927000164985657},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49079999327659607},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.33480000495910645},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3319999873638153},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.31850001215934753},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.30469998717308044},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3010999858379364},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.2809999883174896},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2694000005722046},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2313999980688095}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4274/thoracrespract.2026.2026-5-9","doi":"https://doi.org/10.4274/thoracrespract.2026.2026-5-9","is_oa":true,"landing_page_url":"https://doi.org/10.4274/thoracrespract.2026.2026-5-9","pdf_url":"https://thoracrespract.org/pdf/68ab204c-182b-49da-b227-bc7efe058632/articles/ThoracResPract.2026.2026-5-9/5-2026.2026-5-9.pdf","source":{"id":"https://openalex.org/S4393920162","display_name":"Thoracic research and practice","issn_l":"2979-9139","issn":["2979-9139"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thoracic Research and Practice","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13687692","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13687692/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13687692/pdf/ThoracResPract-27-S1-20.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorac Res Pract","raw_type":"Text"},{"id":"pmid:42840756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42840756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thoracic research and practice","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f7ceea2656564732b061537ce197c336","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f7ceea2656564732b061537ce197c336","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Thoracic Research and Practice, Vol 27, Iss sI1, Pp 20-26 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4274/thoracrespract.2026.2026-5-9","doi":"https://doi.org/10.4274/thoracrespract.2026.2026-5-9","is_oa":true,"landing_page_url":"https://doi.org/10.4274/thoracrespract.2026.2026-5-9","pdf_url":"https://thoracrespract.org/pdf/68ab204c-182b-49da-b227-bc7efe058632/articles/ThoracResPract.2026.2026-5-9/5-2026.2026-5-9.pdf","source":{"id":"https://openalex.org/S4393920162","display_name":"Thoracic research and practice","issn_l":"2979-9139","issn":["2979-9139"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thoracic Research and Practice","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320325078","display_name":"Marmara \u00dcniversitesi","ror":"https://ror.org/02kswqa67"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220859187.pdf","grobid_xml":"https://content.openalex.org/works/W7220859187.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1994120040","https://openalex.org/W2001595976","https://openalex.org/W2317123883","https://openalex.org/W2163605464","https://openalex.org/W2553303553","https://openalex.org/W4387268736","https://openalex.org/W2081211494","https://openalex.org/W2591931516","https://openalex.org/W2906684411","https://openalex.org/W2138359066"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Pulmonary":[1],"function":[2],"testing":[3],"is":[4],"routinely":[5],"performed":[6],"before":[7],"hematopoietic":[8],"stem":[9],"cell":[10],"transplantation":[11],"(HSCT),":[12],"but":[13,193,212],"conventional":[14],"parameters":[15],"may":[16,204],"not":[17,215],"capture":[18],"subtle":[19],"airway":[20],"abnormalities.This":[21],"study":[22],"evaluated":[23],"the":[24,177],"association":[25,162],"of":[26,35,75,118,126,144],"pretransplant":[27,184],"forced":[28,36,92],"expiratory":[29,93],"flow":[30],"between":[31,59],"25%":[32],"and":[33,61,90],"75%":[34],"vital":[37],"capacity":[38],"(FEF":[39],"25-75":[40,64,123,130,137,170,186,203],")":[41],"with":[42,120,128,141,190],"post-HSCT":[43,76,113,191],"complications":[44,145],"in":[45,95,116],"adults.":[46],"MATERIAL":[47],"AND":[48],"METHODS:This":[49],"retrospective":[50],"single-center":[51],"cohort":[52],"included":[53],"83":[54],"adults":[55],"who":[56],"underwent":[57],"HSCT":[58,88],"2016":[60],"2023.Reduced":[62],"FEF":[63,122,129,136,185,202],"was":[65,72,101,138,187],"defined":[66],"as":[67,219],"<75%":[68],"predicted.The":[69],"primary":[70],"outcome":[71],"a":[73],"composite":[74],"complications.Multivariable":[77],"logistic":[78],"regression":[79],"models":[80],"were":[81],"adjusted":[82],"for":[83],"age,":[84],"sex,":[85],"ever-smoking":[86],"status,":[87],"type,":[89],"reduced":[91,121],"volume":[94],"1":[96,99,158,210],"second":[97],"(FEV":[98],").Discrimination":[100],"assessed":[102],"using":[103],"receiver":[104],"operating":[105],"characteristic":[106],"analysis.":[107],"RESULTS:Overall,":[108],"32":[109],"patients":[110,119],"(38.6%)":[111],"experienced":[112],"complications.Complications":[114],"occurred":[115],"50.0%":[117],"versus":[124],"28.9%":[125],"those":[127],"\u226575%":[131],"predicted":[132],"(P":[133],"=":[134,155,168],"0.049).Reduced":[135],"independently":[139,188],"associated":[140,189],"higher":[142],"odds":[143],"[odds":[146],"ratio":[147],"(OR):":[148],"3.58,":[149],"95%":[150,165,180],"confidence":[151],"interval":[152],"(CI):":[153],"1.28-10.04;P":[154],"0.015].Reduced":[156],"FEV":[157,209],"showed":[159,171,194],"an":[160,220],"inverse":[161],"(OR:":[163],"0.12,":[164],"CI:":[166,181],"0.02-0.71;P":[167],"0.019).FEF":[169],"poor":[172,195],"standalone":[173,196],"discrimination":[174],"(area":[175],"under":[176],"curve:":[178],"0.578,":[179],"0.450-0.705).":[182],"CONCLUSION:Reduced":[183],"complications,":[192],"discrimination.These":[197],"hypothesis-generating":[198],"findings":[199],"suggest":[200],"that":[201],"provide":[205],"information":[206],"complementary":[207],"to":[208],",":[211],"they":[213],"do":[214],"support":[216],"its":[217],"use":[218],"independent":[221],"predictive":[222],"test.Larger":[223],"prospective":[224],"studies":[225],"are":[226],"required.":[227]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-08T00:00:00"}