{"id":"https://openalex.org/W7220856226","doi":"https://doi.org/10.64898/2026.10.01.756006","title":"Mesaconic acid delivery via biomaterials and engineered probiotics to the gut reduces inflammation in Crohn\u2019s Diseases mouse models","display_name":"Mesaconic acid delivery via biomaterials and engineered probiotics to the gut reduces inflammation in Crohn\u2019s Diseases mouse models","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220856226","doi":"https://doi.org/10.64898/2026.10.01.756006"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.01.756006","doi":"https://doi.org/10.64898/2026.10.01.756006","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.01.756006","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.01.756006.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.01.756006.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001707431","display_name":"Huikang Qian","orcid":"https://orcid.org/0000-0002-4502-196X","observed_orcids":["https://orcid.org/0000-0002-4502-196X"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huikang Qian","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA, 44106"],"raw_orcid":"https://orcid.org/0000-0002-4502-196X","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA, 44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088024944","display_name":"Drishtant Singh","orcid":"https://orcid.org/0000-0003-0179-2057","observed_orcids":["https://orcid.org/0000-0003-0179-2057"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Drishtant Singh","raw_affiliation_strings":["Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074209837","display_name":"Zixuan Chen","orcid":"https://orcid.org/0009-0000-8505-0733","observed_orcids":["https://orcid.org/0009-0000-8505-0733"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zixuan Cheng","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA, 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA, 44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157856058","display_name":"Wenfei Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenfei Zhao","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA, 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA, 44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104148983","display_name":"Bo Zhang","orcid":"https://orcid.org/0009-0000-7452-5510","observed_orcids":["https://orcid.org/0009-0000-7452-5510","https://orcid.org/0000-0002-9324-7074"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bo Zhang","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, Case Western Reserve University, Cleveland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Case Western Reserve University, Cleveland, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157816394","display_name":"Taravat Knodaei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taravat Khodaei","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA, 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA, 44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002449336","display_name":"Abhirami Thumsi","orcid":"https://orcid.org/0000-0002-6111-1009","observed_orcids":["https://orcid.org/0000-0002-6111-1009"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhirami Thumsi","raw_affiliation_strings":["Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA, 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA, 44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056324813","display_name":"Sanmoy Pathak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanmoy Pathak","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA, 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA, 44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157775915","display_name":"Abhirami Suresh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhirami P. Suresh","raw_affiliation_strings":["Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA, 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA, 44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078403705","display_name":"Paola Menghini","orcid":"https://orcid.org/0000-0002-8779-088X","observed_orcids":["https://orcid.org/0000-0002-8779-088X"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paola Menghini","raw_affiliation_strings":["Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157810387","display_name":"Julia Schiek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Schiek","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA, 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA, 44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157877863","display_name":"Viveka Rabara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Viveka Rabara","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA, 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA, 44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024204727","display_name":"Carlo De Salvo","orcid":"https://orcid.org/0000-0002-1523-1915","observed_orcids":["https://orcid.org/0000-0002-1523-1915"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlo De Salvo","raw_affiliation_strings":["Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA, 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA, 44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032047731","display_name":"Harihara Baskaran","orcid":"https://orcid.org/0000-0001-9966-9799","observed_orcids":["https://orcid.org/0000-0001-9966-9799"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harihara Baskaran","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, Case Western Reserve University, Cleveland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Case Western Reserve University, Cleveland, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035160783","display_name":"Yuji Aso","orcid":"https://orcid.org/0000-0003-0235-6724","observed_orcids":["https://orcid.org/0000-0003-0235-6724"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuji Aso","raw_affiliation_strings":["Division of Gastroenterology & Liver Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology & Liver Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089808127","display_name":"Madhan Mohan Chandra Sekhar Jaggarapu","orcid":"https://orcid.org/0000-0002-1437-6311","observed_orcids":["https://orcid.org/0000-0002-1437-6311"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madhan Mohan Chandra Sekhar Jaggarapu","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA, 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA, 44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087977422","display_name":"Abigail Raffner Basson","orcid":"https://orcid.org/0000-0002-8369-919X","observed_orcids":["https://orcid.org/0000-0002-8369-919X"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abigail Raffner Basson","raw_affiliation_strings":["Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA","Digestive Health Research Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Digestive Health Research Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059638560","display_name":"Abhinav P. Acharya","orcid":"https://orcid.org/0000-0002-9361-2764","observed_orcids":["https://orcid.org/0000-0002-9361-2764"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Abhinav P. Acharya","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA, 44106"],"raw_orcid":"https://orcid.org/0000-0002-9361-2764","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA, 44106","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059638560"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesaconic-acid","display_name":"mesaconic acid","score":0.8059999942779541},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9269999861717224},{"id":"https://openalex.org/keywords/engineered-probiotics","display_name":"engineered probiotics","score":0.7940000295639038},{"id":"https://openalex.org/keywords/escherichia-coli-nissle-1917","display_name":"Escherichia coli Nissle 1917","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cis-aconitate-decarboxylase","display_name":"cis-aconitate decarboxylase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/itaconic-acid","display_name":"itaconic acid","score":0.9610000252723694},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.8149999976158142},{"id":"https://openalex.org/keywords/rorgammat","display_name":"ROR\u03b3t","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mitochondrial-activity","display_name":"mitochondrial activity","score":0.5410000085830688},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.5320000052452087},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9509999752044678}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7254999876022339},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5175999999046326},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.45899999141693115},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.4465999901294708},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42829999327659607},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.4260999858379364},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.41609999537467957},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.41179999709129333},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3833000063896179},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.3828999996185303},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3684999942779541},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.35989999771118164},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.3497999906539917},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34860000014305115},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.3474000096321106},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.3458999991416931},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3449000120162964},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.3434000015258789},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3167000114917755},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.30970001220703125},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2944999933242798},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.2904999852180481},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.28760001063346863},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.28630000352859497},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2696000039577484},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2646999955177307},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.26179999113082886},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.2612999975681305},{"id":"https://openalex.org/C2993711000","wikidata":"https://www.wikidata.org/wiki/Q5058184","display_name":"Cell injury","level":3,"score":0.2583000063896179},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.25029999017715454},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.25}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.01.756006","doi":"https://doi.org/10.64898/2026.10.01.756006","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.01.756006","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.01.756006.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.01.756006","doi":"https://doi.org/10.64898/2026.10.01.756006","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.01.756006","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.01.756006.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309680","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83"},{"id":"https://openalex.org/F4320310281","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220856226.pdf","grobid_xml":"https://content.openalex.org/works/W7220856226.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W3137742875"],"related_works":["https://openalex.org/W4390442348","https://openalex.org/W3138363170","https://openalex.org/W4282002886","https://openalex.org/W2731037477","https://openalex.org/W4282937730","https://openalex.org/W4417486561","https://openalex.org/W4295700836","https://openalex.org/W4382931732","https://openalex.org/W2263794537","https://openalex.org/W7125474645"],"abstract_inverted_index":{"Abstract":[0],"Mesaconate":[1],"(MES,":[2],"an":[3,55,119],"immunosuppressive":[4],"metabolite)":[5],"but":[6],"not":[7],"itaconate":[8],"is":[9,26,72],"upregulated":[10],"in":[11,131,143,166],"stool":[12],"of":[13,31],"Crohn\u2019s":[14],"Disease":[15],"(CD)":[16],"patients,":[17],"albeit":[18],"below":[19],"therapeutic":[20,38],"levels..":[21],"However,":[22],"colonic":[23],"MES":[24,49,84,152,161],"level":[25,50],"difficult":[27],"to":[28,74,113,124],"maintain":[29],"because":[30],"its":[32,37],"high":[33],"absorption":[34],"rate,":[35],"limiting":[36],"potential":[39],"for":[40],"CD.":[41],"Herein,":[42],"we":[43],"developed":[44],"two":[45],"strategies":[46],"that":[47,63,71,159],"elevate":[48],"and":[51,76,92,95,104,115,134,141,147,157],"suppress":[52],"inflammation:":[53],"EcN-CAD,":[54],"engineered":[56],"probiotic":[57],"Escherichia":[58],"coli":[59],"Nissle":[60],"1917":[61],"(EcN)":[62],"overexpresses":[64],"cis-aconitate":[65],"decarboxylase":[66],"(CAD,":[67],"produces":[68],"itaconic":[69],"acid":[70],"converted":[73],"MES);":[75],"MES+Zn,":[77],"a":[78],"Zinc-MES":[79],"ionically":[80],"crosslinked":[81],"formulation.":[82],"Mechanistically,":[83],"modulates":[85],"T":[86,137,154],"cell":[87,155],"function":[88],"by":[89],"downregulating":[90],"glycolytic":[91],"mitochondrial":[93],"activity":[94],"decrease":[96],"ROR\u03b3t":[97,129],"expression.":[98],"In":[99],"preclinical":[100],"SAMP1/YitFC":[101,145,148],"dexamethasone-withdrawal":[102,149],"model":[103],"TNFDARE":[105],"model,":[106,146],"MES+Zn":[107],"decreased":[108,128],"gut":[109,139],"permeability":[110,140],"significantly":[111],"compared":[112,123],"controls":[114],"reduced":[116],"myeloperoxidase":[117],"(MPO,":[118],"inflammatory":[120,168],"marker)":[121],"1000-fold":[122],"controls.":[125],"EcN-CAD":[126],"probiotics":[127],"expression":[130],"CD4":[132],"+":[133,136],"CD8":[135],"cells,":[138],"inflammation":[142],"preventive":[144],"model.":[150],"Overall,":[151],"rewires":[153],"responses":[156],"technologies":[158],"enhance":[160],"levels":[162],"can":[163],"be":[164],"effective":[165],"gut-related":[167],"diseases.":[169]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-08T00:00:00"}