{"id":"https://openalex.org/W7220855355","doi":"https://doi.org/10.3389/fncel.2026.1966983","title":"Astrocyte maturation creates a stage-specific niche that instructs hippocampal neurogenesis","display_name":"Astrocyte maturation creates a stage-specific niche that instructs hippocampal neurogenesis","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220855355","doi":"https://doi.org/10.3389/fncel.2026.1966983","pmid":"https://pubmed.ncbi.nlm.nih.gov/42908519","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13682960"},"language":"en","primary_location":{"id":"doi:10.3389/fncel.2026.1966983","doi":"https://doi.org/10.3389/fncel.2026.1966983","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2026.1966983","pdf_url":"https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2026.1966983/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2026.1966983/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093654031","display_name":"Evangelia Masouti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Evangelia Masouti","raw_affiliation_strings":["Department of Neurosurgery, University Hospital Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","Institute of Biochemistry, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University Hospital Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","institution_ids":["https://openalex.org/I181369854","https://openalex.org/I4210088053"]},{"raw_affiliation_string":"Institute of Biochemistry, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073003890","display_name":"Luc\u00eda Casares-Crespo","orcid":"https://orcid.org/0000-0003-3854-3636","observed_orcids":["https://orcid.org/0000-0003-3854-3636"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210148788","display_name":"Instituto de Biomedicina de Valencia","ror":"https://ror.org/05pq8vh42","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210148788"]},{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luc\u00eda Casares-Crespo","raw_affiliation_strings":["Centro de Investigaci\u00f3n Pr\u00edncipe Felipe (CIPF)-Associated Unit to the Instituto de Biomedicina de Valencia (IBV), Valencia Biomedical Research Foundation","Instituto de Biomedicina de Valencia (IBV), CSIC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Pr\u00edncipe Felipe (CIPF)-Associated Unit to the Instituto de Biomedicina de Valencia (IBV), Valencia Biomedical Research Foundation","institution_ids":["https://openalex.org/I4210148788","https://openalex.org/I4210165109"]},{"raw_affiliation_string":"Instituto de Biomedicina de Valencia (IBV), CSIC","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210148788"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009750508","display_name":"Andreas Sagner","orcid":"https://orcid.org/0000-0001-5698-8191","observed_orcids":["https://orcid.org/0000-0001-5698-8191"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Sagner","raw_affiliation_strings":["Department of Neurosurgery, University Hospital Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University Hospital Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","institution_ids":["https://openalex.org/I181369854","https://openalex.org/I4210088053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031041451","display_name":"Arne Gessner","orcid":"https://orcid.org/0000-0002-1729-4231","observed_orcids":["https://orcid.org/0000-0002-1729-4231"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Arne Gessner","raw_affiliation_strings":["Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157819085","display_name":"Martin F. Fromm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin F. Fromm","raw_affiliation_strings":["Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024073308","display_name":"Helena Mira","orcid":"https://orcid.org/0000-0001-8574-9544","observed_orcids":["https://orcid.org/0000-0001-8574-9544"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210148788","display_name":"Instituto de Biomedicina de Valencia","ror":"https://ror.org/05pq8vh42","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210148788"]},{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Helena Mira","raw_affiliation_strings":["Centro de Investigaci\u00f3n Pr\u00edncipe Felipe (CIPF)-Associated Unit to the Instituto de Biomedicina de Valencia (IBV), Valencia Biomedical Research Foundation","Instituto de Biomedicina de Valencia (IBV), CSIC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Pr\u00edncipe Felipe (CIPF)-Associated Unit to the Instituto de Biomedicina de Valencia (IBV), Valencia Biomedical Research Foundation","institution_ids":["https://openalex.org/I4210148788","https://openalex.org/I4210165109"]},{"raw_affiliation_string":"Instituto de Biomedicina de Valencia (IBV), CSIC","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210148788"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041040280","display_name":"Ruth Beckervordersandforth","orcid":"https://orcid.org/0000-0002-3617-7567","observed_orcids":["https://orcid.org/0000-0002-3617-7567"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ruth Beckervordersandforth","raw_affiliation_strings":["Department of Neurosurgery, University Hospital Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","Institute of Biochemistry, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University Hospital Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","institution_ids":["https://openalex.org/I181369854","https://openalex.org/I4210088053"]},{"raw_affiliation_string":"Institute of Biochemistry, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","institution_ids":["https://openalex.org/I181369854"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5041040280"],"corresponding_institution_ids":["https://openalex.org/I181369854","https://openalex.org/I4210088053"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.77334679,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":null,"first_page":"1966983","last_page":"1966983"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astrocyte-maturation","display_name":"astrocyte maturation","score":0.984000027179718},{"id":"https://openalex.org/keywords/astrocyte-conditioned-medium","display_name":"astrocyte-conditioned medium","score":0.8489999771118164},{"id":"https://openalex.org/keywords/hippocampal-neurogenesis","display_name":"hippocampal neurogenesis","score":0.921999990940094},{"id":"https://openalex.org/keywords/neural-stem-cell-niche","display_name":"neural stem cell niche","score":0.7570000290870667},{"id":"https://openalex.org/keywords/astrocyte-secretome","display_name":"astrocyte secretome","score":0.8190000057220459},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/gliogenesis","display_name":"gliogenesis","score":0.6700000166893005},{"id":"https://openalex.org/keywords/postnatal-development","display_name":"postnatal development","score":0.7310000061988831},{"id":"https://openalex.org/keywords/stem-cell-fate-specification","display_name":"stem cell fate specification","score":0.5849999785423279},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.4580000042915344},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.9079999923706055}],"concepts":[{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.8876000046730042},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.8009999990463257},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7541000247001648},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.7421000003814697},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.6428999900817871},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5965999960899353},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5835999846458435},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.5040000081062317},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44839999079704285},{"id":"https://openalex.org/C124964019","wikidata":"https://www.wikidata.org/wiki/Q11616062","display_name":"Precursor cell","level":3,"score":0.41119998693466187},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.41100001335144043},{"id":"https://openalex.org/C2780884517","wikidata":"https://www.wikidata.org/wiki/Q177105","display_name":"Neuroglia","level":3,"score":0.37290000915527344},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.33320000767707825},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.32420000433921814},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.3206000030040741},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.3192000091075897},{"id":"https://openalex.org/C162746124","wikidata":"https://www.wikidata.org/wiki/Q7002675","display_name":"Neurosphere","level":5,"score":0.3165000081062317},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2782999873161316},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.26910001039505005},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.26460000872612},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2533999979496002}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fncel.2026.1966983","doi":"https://doi.org/10.3389/fncel.2026.1966983","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2026.1966983","pdf_url":"https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2026.1966983/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13682960","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13682960/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13682960/pdf/fncel-20-1966983.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Neurosci","raw_type":"Text"},{"id":"pmid:42908519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42908519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:765ae04ceef442af88e21b19d367e27f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/765ae04ceef442af88e21b19d367e27f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular Neuroscience, Vol 20 (2026)","raw_type":"article"},{"id":"pmh:oai:open.fau.de:openfau/42037","doi":null,"is_oa":true,"landing_page_url":"https://open.fau.de/handle/openfau/42037","pdf_url":null,"source":{"id":"https://openalex.org/S4306402340","display_name":"OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universit\u00e4tsbibliothek Erlangen-N\u00fcrnberg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fncel.2026.1966983","doi":"https://doi.org/10.3389/fncel.2026.1966983","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2026.1966983","pdf_url":"https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2026.1966983/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2310932336","display_name":null,"funder_award_id":"BE5136/6-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3062626360","display_name":null,"funder_award_id":"INST90/1048-1 FUGG","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G329789726","display_name":null,"funder_award_id":"DFG GRK 2162/1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4676144778","display_name":null,"funder_award_id":"GRK2162/1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5188208403","display_name":null,"funder_award_id":"GRK 2162","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6303037346","display_name":null,"funder_award_id":"DFG GRK2162","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6410513913","display_name":null,"funder_award_id":"BE5136","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220855355.pdf","grobid_xml":"https://content.openalex.org/works/W7220855355.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1485665912","https://openalex.org/W1543151032","https://openalex.org/W1562967551","https://openalex.org/W1567926261","https://openalex.org/W1797578063","https://openalex.org/W1965976131","https://openalex.org/W1968379123","https://openalex.org/W1973565031","https://openalex.org/W1976325242","https://openalex.org/W1988452935","https://openalex.org/W1988976106","https://openalex.org/W1993629125","https://openalex.org/W2004191360","https://openalex.org/W2011331227","https://openalex.org/W2012935976","https://openalex.org/W2026147918","https://openalex.org/W2031611126","https://openalex.org/W2032928022","https://openalex.org/W2044654185","https://openalex.org/W2054275187","https://openalex.org/W2089204174","https://openalex.org/W2092635505","https://openalex.org/W2098622411","https://openalex.org/W2109963281","https://openalex.org/W2117523148","https://openalex.org/W2124940469","https://openalex.org/W2135046848","https://openalex.org/W2141351251","https://openalex.org/W2154641154","https://openalex.org/W2163958669","https://openalex.org/W2165302236","https://openalex.org/W2236139809","https://openalex.org/W2611496024","https://openalex.org/W2750665224","https://openalex.org/W2790863694","https://openalex.org/W2804479495","https://openalex.org/W2897300390","https://openalex.org/W2909403876","https://openalex.org/W2925077238","https://openalex.org/W2957051172","https://openalex.org/W2967829978","https://openalex.org/W3009790191","https://openalex.org/W3011286936","https://openalex.org/W3107540174","https://openalex.org/W3153009118","https://openalex.org/W3178979628","https://openalex.org/W4214951962","https://openalex.org/W4224229212","https://openalex.org/W4293582032","https://openalex.org/W4310157868","https://openalex.org/W4360982985","https://openalex.org/W4384561818","https://openalex.org/W4385564443","https://openalex.org/W4390589601","https://openalex.org/W7118072247"],"related_works":["https://openalex.org/W2386873808","https://openalex.org/W2221605826","https://openalex.org/W1965976131","https://openalex.org/W2945700975","https://openalex.org/W2339493840","https://openalex.org/W2130293902","https://openalex.org/W2117523148","https://openalex.org/W4410125609","https://openalex.org/W4403005128","https://openalex.org/W2021000905"],"abstract_inverted_index":{"Astrocytes":[0],"are":[1],"a":[2,85,98,189,213],"major":[3],"part":[4],"of":[5,19,34,80,127,135,168,191,203],"the":[6,30,38,77,81,88,121,125],"hippocampal":[7,51,105],"stem":[8,23],"cell":[9,26],"niche":[10,219],"and":[11,24,32,59,61,112,142,173,183,198,215,224],"have":[12],"been":[13],"shown":[14],"to":[15,29,40,103],"control":[16],"several":[17],"steps":[18],"neurogenesis,":[20,48],"from":[21,93,110,171],"neural":[22],"precursor":[25],"(NSPC)":[27],"proliferation":[28],"differentiation":[31],"maturation":[33,211],"newborn":[35],"neurons.":[36],"With":[37],"aim":[39],"identify":[41],"new":[42],"factors":[43],"by":[44],"which":[45],"astrocytes":[46,52,96,114,136,147,175,196],"promote":[47],"we":[49,83,131,187],"isolated":[50,138,148],"across":[53],"key":[54],"postnatal":[55],"stages":[56,151],"(p3,":[57],"p10,":[58],"p14)":[60],"collected":[62],"astrocyte":[63,89,210],"conditioned":[64],"medium":[65],"(ACM)":[66],"while":[67,107],"keeping":[68],"them":[69],"for":[70,157,181],"1":[71],"week":[72],"in":[73,87,155],"culture.":[74],"Depending":[75],"on":[76],"developmental":[78],"stage":[79],"astrocytes,":[82],"uncovered":[84],"shift":[86],"secretome.":[90],"Specifically,":[91],"ACM":[92,108],"p3":[94,172],"progenitor-like":[95],"promoted":[97],"gliogenic":[99],"program":[100],"when":[101],"applied":[102],"adult":[104],"NSPCs,":[106],"derived":[109],"p10":[111,141],"p14":[113,143,174],"exhibited":[115],"potent":[116,201],"neurogenic":[117,129],"properties.":[118],"To":[119],"define":[120],"molecular":[122],"basis":[123],"underlying":[124],"acquisition":[126],"these":[128,150],"properties,":[130],"performed":[132],"transcriptomic":[133],"profiling":[134],"directly":[137],"at":[139,149],"p3,":[140],"as":[144,146,195,200],"well":[145],"that":[152,193,209,220],"were":[153,163],"kept":[154],"culture":[156],"7":[158],"days.":[159],"These":[160],"data":[161],"sets":[162],"integrated":[164],"with":[165],"metabolomic":[166],"analysis":[167],"astrocyte-conditioned":[169],"media":[170],"revealing":[176],"distinct":[177],"stage-specific":[178,218],"programs":[179],"enriched":[180],"secretory":[182],"metabolic":[184],"pathways.":[185],"Notably,":[186],"identified":[188],"combination":[190],"metabolites":[192],"accumulates":[194],"mature":[197],"act":[199],"drivers":[202],"neuronal":[204],"differentiation.":[205],"Our":[206],"findings":[207],"demonstrate":[208],"establishes":[212],"metabolically":[214],"transcriptionally":[216],"defined,":[217],"instructs":[221],"NSPC":[222],"fate":[223],"drives":[225],"neurogenesis.":[226]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-08T00:00:00"}
