{"id":"https://openalex.org/W7220854119","doi":"https://doi.org/10.3389/fneur.2026.1867021","title":"Interpretable model using serum biomarkers and intra-/peri-aneurysmal CTA radiomics for discriminating ruptured from unruptured intracranial aneurysms: an external validation retrospective study","display_name":"Interpretable model using serum biomarkers and intra-/peri-aneurysmal CTA radiomics for discriminating ruptured from unruptured intracranial aneurysms: an external validation retrospective study","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220854119","doi":"https://doi.org/10.3389/fneur.2026.1867021","pmid":"https://pubmed.ncbi.nlm.nih.gov/42908583","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13683125"},"language":"en","primary_location":{"id":"doi:10.3389/fneur.2026.1867021","doi":"https://doi.org/10.3389/fneur.2026.1867021","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1867021","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1867021/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1867021/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100446338","display_name":"Juan Liu","orcid":"https://orcid.org/0000-0003-3568-0889","observed_orcids":["https://orcid.org/0000-0003-3568-0889"]},"institutions":[{"id":"https://openalex.org/I4210086248","display_name":"Affiliated Hospital of Southwest Medical University","ror":"https://ror.org/0014a0n68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Liu","raw_affiliation_strings":["Department of Interventional Medicine, The Affiliated Hospital of Southwest Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Medicine, The Affiliated Hospital of Southwest Medical University","institution_ids":["https://openalex.org/I4210086248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100325083","display_name":"Zhipeng Chen","orcid":"https://orcid.org/0000-0002-7546-6740","observed_orcids":["https://orcid.org/0000-0002-7546-6740","https://orcid.org/0009-0004-1585-2123"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhipeng Chen","raw_affiliation_strings":["Department of Radiology, Luzhou People's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Luzhou People's Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157802663","display_name":"Kun Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kun Wang","raw_affiliation_strings":["Department of Radiology, Luzhou People's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Luzhou People's Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150883420","display_name":"Chunyue Yan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chunyue Yan","raw_affiliation_strings":["Department of Emergency Medicine, Luzhou People's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Luzhou People's Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157803562","display_name":"Fei Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fei Wang","raw_affiliation_strings":["Department of Radiology, Luzhou People's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Luzhou People's Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5129764684","display_name":"Xiaolei Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210086248","display_name":"Affiliated Hospital of Southwest Medical University","ror":"https://ror.org/0014a0n68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086248"]},{"id":"https://openalex.org/I4210096200","display_name":"Fourth People's Hospital of Sichuan Province","ror":"https://ror.org/00vva8g89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096200"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaolei Sun","raw_affiliation_strings":["Department of General Surgery (Vascular Surgery), The Affiliated Hospital of Southwest Medical University","Department of Interventional Medicine, The Affiliated Hospital of Southwest Medical University","The Fourth People\u2019s Hospital of Sichuan Province, West China Chunxi Hospital of Sichuan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery (Vascular Surgery), The Affiliated Hospital of Southwest Medical University","institution_ids":["https://openalex.org/I4210086248"]},{"raw_affiliation_string":"Department of Interventional Medicine, The Affiliated Hospital of Southwest Medical University","institution_ids":["https://openalex.org/I4210086248"]},{"raw_affiliation_string":"The Fourth People\u2019s Hospital of Sichuan Province, West China Chunxi Hospital of Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210096200"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5129764684","https://openalex.org/A5157803562"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210086248","https://openalex.org/I4210096200"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.75141766,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1867021","last_page":"1867021"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ruptured-intracranial-aneurysm","display_name":"ruptured intracranial aneurysm","score":0.8930000066757202},{"id":"https://openalex.org/keywords/aneurysm-rupture-prediction","display_name":"aneurysm rupture prediction","score":0.9419999718666077},{"id":"https://openalex.org/keywords/radiomics","display_name":"radiomics","score":0.6169999837875366},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.8539999723434448},{"id":"https://openalex.org/keywords/ct-angiography","display_name":"CT angiography","score":0.6029999852180481},{"id":"https://openalex.org/keywords/model-interpretability","display_name":"model interpretability","score":0.7850000262260437},{"id":"https://openalex.org/keywords/classifier-combination","display_name":"classifier combination","score":0.6430000066757202},{"id":"https://openalex.org/keywords/shap","display_name":"SHAP","score":0.6729999780654907},{"id":"https://openalex.org/keywords/external-validation","display_name":"external validation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/nonlinear-dose-response-relationship","display_name":"nonlinear dose-response relationship","score":0.5210000276565552},{"id":"https://openalex.org/keywords/aneurysm-size","display_name":"aneurysm size","score":0.4519999921321869},{"id":"https://openalex.org/keywords/aneurysm-neck-diameter","display_name":"aneurysm neck width","score":0.5109999775886536},{"id":"https://openalex.org/keywords/aneurysm-location","display_name":"aneurysm location","score":0.4959999918937683},{"id":"https://openalex.org/keywords/aneurysm-morphology","display_name":"aneurysm morphology","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C2778559731","wikidata":"https://www.wikidata.org/wiki/Q23808793","display_name":"Radiomics","level":2,"score":0.7656000256538391},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7382000088691711},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6029000282287598},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5677000284194946},{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.5537999868392944},{"id":"https://openalex.org/C35405484","wikidata":"https://www.wikidata.org/wiki/Q4967066","display_name":"Brier score","level":2,"score":0.5371000170707703},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5098999738693237},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.4465999901294708},{"id":"https://openalex.org/C3020225094","wikidata":"https://www.wikidata.org/wiki/Q80091","display_name":"Area under curve","level":3,"score":0.4343999922275543},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.43160000443458557},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4108000099658966},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.3334999978542328},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.3197000026702881},{"id":"https://openalex.org/C137345334","wikidata":"https://www.wikidata.org/wiki/Q7303350","display_name":"Recursive partitioning","level":2,"score":0.2840999960899353},{"id":"https://openalex.org/C2777389994","wikidata":"https://www.wikidata.org/wiki/Q17012884","display_name":"Appropriate Use Criteria","level":2,"score":0.2831000089645386},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.27129998803138733},{"id":"https://openalex.org/C2781347138","wikidata":"https://www.wikidata.org/wiki/Q1024492","display_name":"Computed tomography angiography","level":3,"score":0.2694999873638153},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.2556999921798706},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.25380000472068787},{"id":"https://openalex.org/C2780073493","wikidata":"https://www.wikidata.org/wiki/Q7523837","display_name":"Single Center","level":2,"score":0.25290000438690186},{"id":"https://openalex.org/C71472368","wikidata":"https://www.wikidata.org/wiki/Q676880","display_name":"Text mining","level":2,"score":0.2515999972820282}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072226","descriptor_name":"Computed Tomography Angiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000097188","descriptor_name":"Radiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002532","descriptor_name":"Intracranial Aneurysm","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D002532","descriptor_name":"Intracranial Aneurysm","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017542","descriptor_name":"Aneurysm, Ruptured","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D017542","descriptor_name":"Aneurysm, Ruptured","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fneur.2026.1867021","doi":"https://doi.org/10.3389/fneur.2026.1867021","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1867021","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1867021/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13683125","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13683125/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13683125/pdf/fneur-17-1867021.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurol","raw_type":"Text"},{"id":"pmid:42908583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42908583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neurology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1275de66d5c04a959fa622c59f6e51a5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1275de66d5c04a959fa622c59f6e51a5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neurology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fneur.2026.1867021","doi":"https://doi.org/10.3389/fneur.2026.1867021","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1867021","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1867021/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3576713021","display_name":null,"funder_award_id":"82470430","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8837662388","display_name":null,"funder_award_id":"KeyME-2024-07","funder_id":"https://openalex.org/F4320328652","funder_display_name":"Southwest Medical University"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320328652","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220854119.pdf","grobid_xml":"https://content.openalex.org/works/W7220854119.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1975430056","https://openalex.org/W2109284659","https://openalex.org/W2155524664","https://openalex.org/W2547066587","https://openalex.org/W2804961811","https://openalex.org/W2805973760","https://openalex.org/W2996705655","https://openalex.org/W2999466503","https://openalex.org/W3092342649","https://openalex.org/W3096603491","https://openalex.org/W3113619380","https://openalex.org/W3133925340","https://openalex.org/W3193349619","https://openalex.org/W4220811181","https://openalex.org/W4223652309","https://openalex.org/W4280579527","https://openalex.org/W4292833494","https://openalex.org/W4307551227","https://openalex.org/W4368342562","https://openalex.org/W4386592099","https://openalex.org/W4390665549","https://openalex.org/W4390746311","https://openalex.org/W4399374622","https://openalex.org/W4404065761","https://openalex.org/W4404234893","https://openalex.org/W4404597613","https://openalex.org/W4406329891","https://openalex.org/W4410894746","https://openalex.org/W4412505523","https://openalex.org/W4412690437","https://openalex.org/W7117363397","https://openalex.org/W7118628392","https://openalex.org/W7128950906","https://openalex.org/W7136807798","https://openalex.org/W7140759348"],"related_works":["https://openalex.org/W7142170604","https://openalex.org/W7128950906","https://openalex.org/W4385707672","https://openalex.org/W7207827176","https://openalex.org/W7156143003","https://openalex.org/W7133000850","https://openalex.org/W3130376355","https://openalex.org/W4292833494","https://openalex.org/W4405209933","https://openalex.org/W4413063972"],"abstract_inverted_index":{"Objective":[0],"To":[1],"develop":[2,107],"an":[3,175,275],"interpretable":[4],"model":[5,113,299,302,307,325],"that":[6],"integrates":[7],"diverse":[8],"machine":[9,101],"learning":[10,102],"algorithms,":[11],"fusion":[12,112,298],"strategies,":[13],"intra\u2212/perianeurysmal":[14,241],"CTA":[15,46],"radiomics,":[16],"and":[17,28,63,85,109,127,142,154,190,217,226,243,251,269,274,300,326],"serum":[18,91,98],"biomarkers":[19],"to":[20,29,106,296],"differentiate":[21],"ruptured":[22,314],"from":[23,51,65,315],"unruptured":[24,316],"intracranial":[25],"aneurysms":[26],"(IAs),":[27],"investigate":[30],"the":[31,60,74,110,136,139,162,170,240,266,297,321,324],"underlying":[32],"biological":[33],"features":[34,220,273,294],"associated":[35],"with":[36,179],"rupture":[37,280],"status.":[38],"Methods":[39],"Totally,":[40],"744":[41],"IAs":[42,279],"patients":[43],"who":[44],"underwent":[45],"were":[47,81,104],"retrospectively":[48],"enrolled.":[49],"Data":[50],"Center":[52,66],"1":[53,87],"(":[54,68],"N":[55,69],"=":[56,70,223,247],"423)":[57],"served":[58,72],"as":[59,73,233,235],"training":[61],"set,":[62,173],"data":[64],"2":[67],"321)":[71],"external":[75,171],"validation":[76,172,336],"set.":[77],"Volumes":[78],"of":[79,177,205,278,323],"interest":[80],"delineated":[82],"in":[83,169,329],"intra-aneurysmal":[84,216,267],"peri-aneurysmal":[86,218,270],"mm":[88],"regions.":[89],"The":[90,305],"inflammation":[92],"score":[93,194],"(SIS)":[94],"was":[95,114,133,149],"constructed":[96],"using":[97,120],"biomarkers.":[99],"Seven":[100],"classifiers":[103,119],"employed":[105],"models,":[108,164],"optimal":[111],"developed":[115],"by":[116,135],"combining":[117],"all":[118,229,253],"arithmetic":[121],"mean,":[122,124,126],"geometric":[123],"weighted":[125],"logistic":[128],"regression":[129],"(LRSLM).":[130],"Model":[131],"performance":[132,168,311],"assessed":[134],"area":[137],"under":[138],"curve":[140,144],"(AUC)":[141],"decision":[143],"analysis":[145,258,290,319],"(DCA),":[146],"while":[147],"interpretability":[148,322],"evaluated":[150],"via":[151],"SHAP,":[152],"correlation,":[153],"restricted":[155],"cubic":[156],"spline":[157],"(RCS)":[158],"analyses.":[159],"Results":[160],"Among":[161],"11":[163],"LRSLM":[165,306],"exhibited":[166],"robust":[167,309],"achieving":[174],"AUC":[176],"0.9177":[178],"good":[180],"calibration.":[181],"It":[182],"also":[183],"demonstrated":[184,260],"high":[185],"accuracy":[186],"(0.8847),":[187],"recall":[188],"(0.8171),":[189],"a":[191,202,261],"low":[192],"Brier":[193],"(0.0999),":[195],"alongside":[196],"greater":[197],"clinical":[198,341],"net":[199],"benefit":[200],"across":[201],"wide":[203],"range":[204],"threshold":[206],"probabilities":[207],"(10\u201385%).":[208],"Correlation":[209],"analyses":[210],"revealed":[211],"strong":[212],"positive":[213,237],"associations":[214],"between":[215,239,265],"radiomic":[219,272],"(Spearman\u2019s":[221,245],"r":[222,246],"0.62,":[224],"0.72,":[225],"0.84,":[227],"respectively;":[228],"p":[230,254,282,286],"<":[231,255,283,287],"0.001),":[232],"well":[234],"significant":[236,262],"correlations":[238],"radiomics":[242,293],"SIS":[244],"0.32,":[248,250],"0.29,":[249],"0.34;":[252],"0.001).":[256],"RCS":[257],"further":[259],"non-linear":[263],"relationship":[264],"(IRSIAs)":[268],"(PRSIAs)":[271],"increased":[276],"incidence":[277],"(Non-linear":[281],"0.05;":[284],"Overall":[285],"0.05).":[288],"SHAP":[289,318],"highlighted":[291],"key":[292],"contributors":[295],"supported":[301],"interpretability.":[303],"Conclusion":[304],"achieves":[308],"discriminative":[310],"for":[312],"differentiating":[313],"IAs.":[317],"enhances":[320],"may":[327],"assist":[328],"identifying":[330],"high-risk":[331],"phenotypic":[332],"features,":[333],"although":[334],"prospective":[335],"is":[337],"required":[338],"before":[339],"predictive":[340],"application":[342],"can":[343],"be":[344],"considered.":[345]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-08T00:00:00"}
