{"id":"https://openalex.org/W7220854060","doi":"https://doi.org/10.3892/ijo.2026.5944","title":"cGAS\u2011STING pathway in digestive tract cancer: From molecular mechanisms to therapeutic applications (Review)","display_name":"cGAS\u2011STING pathway in digestive tract cancer: From molecular mechanisms to therapeutic applications (Review)","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220854060","doi":"https://doi.org/10.3892/ijo.2026.5944","pmid":"https://pubmed.ncbi.nlm.nih.gov/42852635","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13713052"},"language":"en","primary_location":{"id":"doi:10.3892/ijo.2026.5944","doi":"https://doi.org/10.3892/ijo.2026.5944","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2026.5944","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.3892/ijo.2026.5944","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157798532","display_name":"Tangna Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tangna Chen","raw_affiliation_strings":["Queen Mary College, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330031, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen Mary College, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330031, P.R.\u00a0China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157793811","display_name":"Jingyi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyi Zhang","raw_affiliation_strings":["Queen Mary College, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330031, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen Mary College, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330031, P.R.\u00a0China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101333494","display_name":"Jinghan Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinghan Sun","raw_affiliation_strings":["Queen Mary College, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330031, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen Mary College, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330031, P.R.\u00a0China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147485186","display_name":"Hongyan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyan Zhang","raw_affiliation_strings":["Medical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330031, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330031, P.R.\u00a0China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109301461","display_name":"Deqiang Huang","orcid":"https://orcid.org/0009-0005-7154-9978","observed_orcids":["https://orcid.org/0009-0005-7154-9978"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Deqiang Huang","raw_affiliation_strings":["Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330031, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330031, P.R.\u00a0China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"last","author":{"id":null,"display_name":"Haifeng Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haifeng Ye","raw_affiliation_strings":["Medical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330031, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330031, P.R.\u00a0China","institution_ids":["https://openalex.org/I4210164024"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109301461"],"corresponding_institution_ids":["https://openalex.org/I4210164024"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.4631829,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"69","issue":"5","first_page":"1","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cgas-sting-pathway","display_name":"cGAS-STING pathway","score":0.9980000257492065},{"id":"https://openalex.org/keywords/digestive-tract-cancer","display_name":"digestive tract cancer","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cytosolic-dna-sensing","display_name":"cytosolic DNA sensing","score":0.9549999833106995},{"id":"https://openalex.org/keywords/immunosuppressive-tumor-microenvironment","display_name":"immunosuppressive tumor microenvironment","score":0.7820000052452087},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7770000100135803},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.7250000238418579},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/m2-macrophage-polarization","display_name":"M2 macrophage polarization","score":0.9150000214576721},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.546999990940094},{"id":"https://openalex.org/keywords/oral-cancer","display_name":"oral cancer","score":0.6589999794960022},{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":1.0},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":1.0},{"id":"https://openalex.org/keywords/hepatobiliary-cancer","display_name":"hepatobiliary cancer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":1.0},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0}],"concepts":[{"id":"https://openalex.org/C2992581678","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Digestive tract","level":2,"score":0.758400022983551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7264000177383423},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6234999895095825},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.6071000099182129},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.4237000048160553},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4196000099182129},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40299999713897705},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3952000141143799},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34459999203681946},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.32519999146461487},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31290000677108765},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.28949999809265137},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28519999980926514}],"mesh":[{"descriptor_ui":"D000099196","descriptor_name":"cGAS-STING Signaling Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099197","descriptor_name":"STING Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099235","descriptor_name":"Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009713","descriptor_name":"Nucleotidyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3892/ijo.2026.5944","doi":"https://doi.org/10.3892/ijo.2026.5944","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2026.5944","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13713052","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13713052/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13713052/pdf/ijo-69-05-05944.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Oncol","raw_type":"Text"},{"id":"pmid:42852635","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42852635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/ijo.2026.5944","doi":"https://doi.org/10.3892/ijo.2026.5944","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2026.5944","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G410386908","display_name":null,"funder_award_id":"82402919","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4304980474","display_name":null,"funder_award_id":"82360450","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220854060.pdf","grobid_xml":"https://content.openalex.org/works/W7220854060.grobid-xml"},"referenced_works_count":244,"referenced_works":["https://openalex.org/W1977925553","https://openalex.org/W2012855647","https://openalex.org/W2015310325","https://openalex.org/W2084785039","https://openalex.org/W2131878959","https://openalex.org/W2142450582","https://openalex.org/W2154171253","https://openalex.org/W2220279767","https://openalex.org/W2310715021","https://openalex.org/W2555712788","https://openalex.org/W2566399608","https://openalex.org/W2580868078","https://openalex.org/W2613953650","https://openalex.org/W2738136165","https://openalex.org/W2783667606","https://openalex.org/W2793797279","https://openalex.org/W2804407252","https://openalex.org/W2905027070","https://openalex.org/W2919692138","https://openalex.org/W2946008330","https://openalex.org/W2946302521","https://openalex.org/W2962838796","https://openalex.org/W2984002195","https://openalex.org/W2995171541","https://openalex.org/W2998643215","https://openalex.org/W3012207340","https://openalex.org/W3015575990","https://openalex.org/W3029836467","https://openalex.org/W3035510490","https://openalex.org/W3038007966","https://openalex.org/W3038995504","https://openalex.org/W3091949069","https://openalex.org/W3099463467","https://openalex.org/W3109643959","https://openalex.org/W3111020808","https://openalex.org/W3112599058","https://openalex.org/W3112754342","https://openalex.org/W3120743630","https://openalex.org/W3132968418","https://openalex.org/W3138737720","https://openalex.org/W3149871196","https://openalex.org/W3155729654","https://openalex.org/W3164020869","https://openalex.org/W3168903679","https://openalex.org/W3174458295","https://openalex.org/W3174959685","https://openalex.org/W3176998507","https://openalex.org/W3197279314","https://openalex.org/W3198267263","https://openalex.org/W3200256151","https://openalex.org/W3203953717","https://openalex.org/W3204202932","https://openalex.org/W3204512228","https://openalex.org/W3204628173","https://openalex.org/W3210892875","https://openalex.org/W3213253836","https://openalex.org/W4205385142","https://openalex.org/W4205981291","https://openalex.org/W4207082611","https://openalex.org/W4210694027","https://openalex.org/W4210857128","https://openalex.org/W4213435335","https://openalex.org/W4220693847","https://openalex.org/W4220927682","https://openalex.org/W4223955386","https://openalex.org/W4224921893","https://openalex.org/W4224995991","https://openalex.org/W4226396199","https://openalex.org/W4229445969","https://openalex.org/W4281673144","https://openalex.org/W4282975734","https://openalex.org/W4283379897","https://openalex.org/W4283734650","https://openalex.org/W4291912251","https://openalex.org/W4295106190","https://openalex.org/W4302010994","https://openalex.org/W4304630399","https://openalex.org/W4306746300","https://openalex.org/W4308188444","https://openalex.org/W4308582133","https://openalex.org/W4309656465","https://openalex.org/W4309922305","https://openalex.org/W4310065688","https://openalex.org/W4310076711","https://openalex.org/W4312129906","https://openalex.org/W4313409632","https://openalex.org/W4313423387","https://openalex.org/W4318217757","https://openalex.org/W4318940462","https://openalex.org/W4322719655","https://openalex.org/W4323295440","https://openalex.org/W4323568459","https://openalex.org/W4327560957","https://openalex.org/W4361191078","https://openalex.org/W4362458559","https://openalex.org/W4362732156","https://openalex.org/W4366090423","https://openalex.org/W4367835523","https://openalex.org/W4376872402","https://openalex.org/W4377097828","https://openalex.org/W4377565261","https://openalex.org/W4379745108","https://openalex.org/W4380854519","https://openalex.org/W4380883456","https://openalex.org/W4381839746","https://openalex.org/W4384207023","https://openalex.org/W4385295281","https://openalex.org/W4385330635","https://openalex.org/W4385607368","https://openalex.org/W4385613047","https://openalex.org/W4385697847","https://openalex.org/W4385841464","https://openalex.org/W4386035040","https://openalex.org/W4386090060","https://openalex.org/W4386134670","https://openalex.org/W4386136701","https://openalex.org/W4386558735","https://openalex.org/W4387008324","https://openalex.org/W4387022558","https://openalex.org/W4387296621","https://openalex.org/W4387642349","https://openalex.org/W4387965761","https://openalex.org/W4388672886","https://openalex.org/W4389171843","https://openalex.org/W4389280509","https://openalex.org/W4389371330","https://openalex.org/W4389489603","https://openalex.org/W4390509728","https://openalex.org/W4390587986","https://openalex.org/W4391526993","https://openalex.org/W4391613313","https://openalex.org/W4391615950","https://openalex.org/W4391995138","https://openalex.org/W4392133515","https://openalex.org/W4392159137","https://openalex.org/W4392360851","https://openalex.org/W4392886964","https://openalex.org/W4393086111","https://openalex.org/W4394615268","https://openalex.org/W4394620899","https://openalex.org/W4394688221","https://openalex.org/W4394769328","https://openalex.org/W4395009911","https://openalex.org/W4396221802","https://openalex.org/W4396808229","https://openalex.org/W4399020705","https://openalex.org/W4399245548","https://openalex.org/W4399285078","https://openalex.org/W4399470340","https://openalex.org/W4399528497","https://openalex.org/W4399700579","https://openalex.org/W4399782781","https://openalex.org/W4399865741","https://openalex.org/W4400654686","https://openalex.org/W4400783508","https://openalex.org/W4400846540","https://openalex.org/W4400990314","https://openalex.org/W4401357376","https://openalex.org/W4401374908","https://openalex.org/W4401573103","https://openalex.org/W4401775630","https://openalex.org/W4401793909","https://openalex.org/W4401949871","https://openalex.org/W4402228485","https://openalex.org/W4402281631","https://openalex.org/W4402307705","https://openalex.org/W4402321910","https://openalex.org/W4402327482","https://openalex.org/W4402400643","https://openalex.org/W4402581532","https://openalex.org/W4402693902","https://openalex.org/W4403038030","https://openalex.org/W4403131283","https://openalex.org/W4403252611","https://openalex.org/W4403258926","https://openalex.org/W4403472206","https://openalex.org/W4403653198","https://openalex.org/W4403691634","https://openalex.org/W4403705997","https://openalex.org/W4404227655","https://openalex.org/W4404418722","https://openalex.org/W4404867558","https://openalex.org/W4405247133","https://openalex.org/W4405796629","https://openalex.org/W4405804178","https://openalex.org/W4405871180","https://openalex.org/W4406856777","https://openalex.org/W4406864556","https://openalex.org/W4407269701","https://openalex.org/W4407565135","https://openalex.org/W4407762981","https://openalex.org/W4408244713","https://openalex.org/W4408407550","https://openalex.org/W4408465452","https://openalex.org/W4408575934","https://openalex.org/W4408626911","https://openalex.org/W4408705909","https://openalex.org/W4409034844","https://openalex.org/W4409316518","https://openalex.org/W4409681455","https://openalex.org/W4410220894","https://openalex.org/W4410246954","https://openalex.org/W4410274455","https://openalex.org/W4410284650","https://openalex.org/W4410521608","https://openalex.org/W4410521775","https://openalex.org/W4410804033","https://openalex.org/W4410805470","https://openalex.org/W4410933682","https://openalex.org/W4410962750","https://openalex.org/W4411121742","https://openalex.org/W4411132195","https://openalex.org/W4411188466","https://openalex.org/W4411195675","https://openalex.org/W4411199770","https://openalex.org/W4411399432","https://openalex.org/W4411417594","https://openalex.org/W4411557131","https://openalex.org/W4412457146","https://openalex.org/W4412548902","https://openalex.org/W4412699384","https://openalex.org/W4412825141","https://openalex.org/W4412868792","https://openalex.org/W4412988954","https://openalex.org/W4413108209","https://openalex.org/W4413118046","https://openalex.org/W4413138575","https://openalex.org/W4413257141","https://openalex.org/W4413408522","https://openalex.org/W4413453376","https://openalex.org/W4413682483","https://openalex.org/W4413795145","https://openalex.org/W4414479089","https://openalex.org/W4414845098","https://openalex.org/W4414994430","https://openalex.org/W4415285801","https://openalex.org/W4415660302","https://openalex.org/W4415691112","https://openalex.org/W4415900936","https://openalex.org/W4416261305","https://openalex.org/W7128783921","https://openalex.org/W7130613321","https://openalex.org/W7151861537","https://openalex.org/W7167824678"],"related_works":["https://openalex.org/W7128400709","https://openalex.org/W7168473196","https://openalex.org/W7202242990","https://openalex.org/W4404867558","https://openalex.org/W7172199519","https://openalex.org/W7147152635","https://openalex.org/W4220685386","https://openalex.org/W2995171541","https://openalex.org/W4312132334","https://openalex.org/W7136074631"],"abstract_inverted_index":{"As":[0],"a":[1,27],"classic":[2],"cytosolic":[3],"DNA":[4,194],"sensor,":[5],"the":[6,18,35,76,84,96,108,118,128,134,137,144,149,161,175,206,218,227],"cyclic":[7],"GMP\u2011AMP":[8],"synthase":[9],"(cGAS)\u2011stimulator":[10],"of":[11,20,37,78,86,98,110,136,154,160,231],"interferon":[12],"genes":[13],"(STING)":[14],"pathway":[15,39,71,92,139,156,188,220,233],"contributes":[16],"to":[17,51,68,185,210,221],"secretion":[19],"multiple":[21,66,99],"inflammatory":[22],"molecules":[23],"and":[24,82,113,152,171,182,200,214,229],"functions":[25],"as":[26,192],"suppressor":[28],"or":[29],"promoter":[30],"in":[31,55,61,117,140,234],"tumor":[32,119],"development.":[33],"Currently,":[34],"effect":[36],"this":[38,70,155,187,232],"on":[40],"digestive":[41,62,141,162,235],"tract":[42,236],"cancer":[43,63,142,237],"types":[44],"remains":[45],"unclear,":[46],"which":[47,73],"may":[48],"be":[49],"due":[50],"its":[52],"paradoxical":[53],"roles":[54,230],"different":[56,158],"cell":[57],"types.":[58,238],"Tumor":[59],"cells":[60,81,112,116],"often":[64],"employ":[65],"mechanisms":[67],"inhibit":[69],"activation,":[72],"then":[74],"restricts":[75],"infiltration":[77],"antitumor":[79,223],"immune":[80,100],"facilitates":[83],"formation":[85],"an":[87],"immunosuppressive":[88,129],"microenvironment.":[89],"However,":[90],"cGAS\u2011STING":[91,138,219],"activation":[93,202],"also":[94,123],"influences":[95],"function":[97,109],"cells.":[101],"For":[102],"example,":[103],"while":[104],"it":[105,121],"mainly":[106],"potentiates":[107],"dendritic":[111],"natural":[114],"killer":[115],"microenvironment,":[120],"can":[122],"promote":[124],"macrophage":[125],"polarization":[126],"into":[127],"M2":[130],"subset.":[131],"To":[132],"improve":[133],"understanding":[135],"types,":[143],"present":[145,176,207],"article":[146],"systematically":[147],"reviews":[148],"regulatory":[150],"mechanism":[151],"effects":[153,224],"across":[157],"malignancies":[159],"system,":[163],"including":[164],"oral":[165],"cavity,":[166],"esophageal,":[167],"gastric,":[168],"hepatobiliary,":[169],"pancreatic":[170],"colorectal":[172],"cancer.":[173],"Furthermore,":[174],"review":[177,208],"examines":[178],"potential":[179],"stimulatory":[180],"strategies":[181],"future":[183],"directions":[184],"utilize":[186],"against":[189],"tumors,":[190],"such":[191],"inducing":[193],"damage,":[195],"removing":[196],"cell\u2011intrinsic":[197],"inhibitory":[198],"signals":[199],"direct":[201],"by":[203,225],"agonists.":[204],"Overall,":[205],"aims":[209],"provide":[211],"new":[212],"perspectives":[213],"ideas":[215],"for":[216],"leveraging":[217],"exert":[222],"highlighting":[226],"changes":[228]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-08T00:00:00"}
