{"id":"https://openalex.org/W7220852179","doi":"https://doi.org/10.1038/s42003-026-11091-1","title":"IFN-dependent Gsdmd priming induces pyroptosis in coronavirus-infected healthy cells","display_name":"IFN-dependent Gsdmd priming induces pyroptosis in coronavirus-infected healthy cells","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220852179","doi":"https://doi.org/10.1038/s42003-026-11091-1"},"language":"en","primary_location":{"id":"doi:10.1038/s42003-026-11091-1","doi":"https://doi.org/10.1038/s42003-026-11091-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-026-11091-1","pdf_url":"https://www.nature.com/articles/s42003-026-11091-1_reference.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s42003-026-11091-1_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157811974","display_name":"Cheng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2802608112","display_name":"Shanghai Chest Hospital","ror":"https://ror.org/03fjc3817","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802608112"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Li","raw_affiliation_strings":["Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2802608112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157810552","display_name":"Yiman Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiman Han","raw_affiliation_strings":["Department of Anesthesiology, Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital), Shanghai, 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital), Shanghai, 200433, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157879166","display_name":"Jianwen Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2802608112","display_name":"Shanghai Chest Hospital","ror":"https://ror.org/03fjc3817","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802608112"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianwen Zhou","raw_affiliation_strings":["Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2802608112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157879968","display_name":"Liyuan Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyuan Zhao","raw_affiliation_strings":["National Key Laboratory of Immunity & Inflammation, Naval Medical University, Shanghai, 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Key Laboratory of Immunity & Inflammation, Naval Medical University, Shanghai, 200433, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157818385","display_name":"Yuanyuan Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2802608112","display_name":"Shanghai Chest Hospital","ror":"https://ror.org/03fjc3817","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802608112"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Zou","raw_affiliation_strings":["Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2802608112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157813754","display_name":"Hongwei Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2802608112","display_name":"Shanghai Chest Hospital","ror":"https://ror.org/03fjc3817","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802608112"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongwei Zhu","raw_affiliation_strings":["Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2802608112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157815974","display_name":"Chunfu Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Chunfu Zheng","raw_affiliation_strings":["Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, T2N 4N1, AB, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, T2N 4N1, AB, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157881641","display_name":"Yonghua Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yonghua Li","raw_affiliation_strings":["Department of Anesthesiology, Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital), Shanghai, 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital), Shanghai, 200433, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157812048","display_name":"Jingxiang Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2802608112","display_name":"Shanghai Chest Hospital","ror":"https://ror.org/03fjc3817","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802608112"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jingxiang Wu","raw_affiliation_strings":["Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2802608112"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5157812048","https://openalex.org/A5157815974","https://openalex.org/A5157881641"],"corresponding_institution_ids":["https://openalex.org/I168635309","https://openalex.org/I177933477","https://openalex.org/I183067930","https://openalex.org/I2802608112","https://openalex.org/I4210099558"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6343163,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.6679999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.6679999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.32839998602867126,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.7350000143051147},{"id":"https://openalex.org/keywords/gasdermin-d","display_name":"gasdermin D","score":0.8389999866485596},{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/coronavirus-infection","display_name":"coronavirus infection","score":0.7990000247955322},{"id":"https://openalex.org/keywords/normal-cells","display_name":"normal cells","score":0.6499999761581421},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.5360000133514404},{"id":"https://openalex.org/keywords/inflammasome","display_name":"inflammasome","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5845999717712402},{"id":"https://openalex.org/C17172800","wikidata":"https://www.wikidata.org/wiki/Q7263707","display_name":"Pyroptosis","level":4,"score":0.578000009059906},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5220999717712402},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.4519999921321869},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34459999203681946},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.32190001010894775},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.31299999356269836},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29120001196861267},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2676999866962433},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.24369999766349792}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s42003-026-11091-1","doi":"https://doi.org/10.1038/s42003-026-11091-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-026-11091-1","pdf_url":"https://www.nature.com/articles/s42003-026-11091-1_reference.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s42003-026-11091-1","doi":"https://doi.org/10.1038/s42003-026-11091-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-026-11091-1","pdf_url":"https://www.nature.com/articles/s42003-026-11091-1_reference.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G337981651","display_name":null,"funder_award_id":"YG2024LC10","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"}],"funders":[{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220852179.pdf","grobid_xml":"https://content.openalex.org/works/W7220852179.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1864325817","https://openalex.org/W1882905539","https://openalex.org/W2024591203","https://openalex.org/W2091129202","https://openalex.org/W2099866950","https://openalex.org/W2517547699","https://openalex.org/W2945002892","https://openalex.org/W2965379348","https://openalex.org/W2965599961","https://openalex.org/W3030537287","https://openalex.org/W3045220852","https://openalex.org/W3096510866","https://openalex.org/W3099753556","https://openalex.org/W3105908160","https://openalex.org/W3142080073","https://openalex.org/W3157263169","https://openalex.org/W3170744214","https://openalex.org/W3191470838","https://openalex.org/W3191928958","https://openalex.org/W3198304310","https://openalex.org/W4210988908","https://openalex.org/W4295706093","https://openalex.org/W4307846899","https://openalex.org/W4321478362","https://openalex.org/W4323660073","https://openalex.org/W4379518562","https://openalex.org/W4387740087","https://openalex.org/W4388339287","https://openalex.org/W4399830390","https://openalex.org/W4403882203","https://openalex.org/W4404679088","https://openalex.org/W4406682540","https://openalex.org/W4411241008"],"related_works":["https://openalex.org/W4210718716","https://openalex.org/W4411241008","https://openalex.org/W3047876262","https://openalex.org/W4281401914","https://openalex.org/W3217656885","https://openalex.org/W3185357835","https://openalex.org/W4408008708","https://openalex.org/W4313305840","https://openalex.org/W4311985923","https://openalex.org/W7124870590"],"abstract_inverted_index":{"Dysregulated":[0],"pyroptosis":[1,47,58,101],"in":[2,78,92,130],"coronavirus-associated":[3],"acute":[4],"respiratory":[5],"distress":[6],"syndrome":[7],"(ARDS)":[8],"involves":[9],"intricate":[10],"crosstalk":[11],"between":[12],"viral":[13,124],"infection":[14,56],"and":[15,102,116,126,143,177],"host":[16],"inflammatory":[17,180],"cascades;":[18],"however,":[19],"the":[20,74,84,93],"detailed":[21],"mechanism":[22,165],"of":[23,63,95,157,175],"gasdermin-mediated":[24],"tissue":[25],"damage":[26,182],"remains":[27],"poorly":[28],"defined.":[29],"Here,":[30],"using":[31],"a":[32,45,96,109,136,145,154,163],"porcine":[33],"deltacoronavirus":[34],"(PDCoV)":[35],"murine":[36],"model":[37,156],"that":[38,50,99,172],"faithfully":[39],"recapitulates":[40],"human":[41],"disease,":[42],"we":[43,161],"report":[44],"dual-layered":[46],"amplification":[48],"circuit":[49],"drives":[51],"ARDS":[52,142],"pathology.":[53],"Mechanistically,":[54],"PDCoV":[55],"triggers":[57],"via":[59],"Nlrp3":[60,117],"inflammasome-dependent":[61],"cleavage":[62],"Gsdmd,":[64],"while":[65],"IFN-\u03b2":[66],"acts":[67],"as":[68],"an":[69],"intercellular":[70],"messenger":[71],"to":[72,87,148],"induce":[73],"transcription":[75],"factor":[76],"Irf2":[77,81,113],"bystander":[79],"cells.":[80],"directly":[82],"binds":[83],"Gsdmd":[85],"promoter":[86],"upregulate":[88],"its":[89],"transcription,":[90],"resulting":[91],"formation":[94],"feedforward":[97],"loop":[98],"amplifies":[100],"exacerbates":[103],"alveolar":[104],"injury.":[105],"We":[106,170],"further":[107],"developed":[108],"combination":[110],"therapy":[111],"targeting":[112],"(via":[114,118],"siRNA)":[115],"MCC950),":[119],"which":[120],"synergistically":[121],"reduced":[122],"pulmonary":[123],"loads":[125],"suppressed":[127],"IL-1\u03b2/IL-18":[128],"release":[129],"infected":[131],"mice.":[132],"Our":[133],"findings":[134],"reveal":[135],"coordinated":[137],"transcriptional-proteolytic":[138],"axis":[139],"underlying":[140],"coronavirus-induced":[141,158],"validate":[144],"host-directed":[146],"strategy":[147],"mitigate":[149],"pyroptosis-associated":[150],"lung":[151,159,181],"damage.":[152],"Using":[153],"mouse":[155],"injury,":[160],"identify":[162],"two-tier":[164],"controlling":[166],"pyroptotic":[167],"cell":[168],"death.":[169],"show":[171],"combined":[173],"inhibition":[174],"NLRP3":[176],"IRF2":[178],"reduces":[179],"more":[183],"effectively":[184],"than":[185],"single":[186],"target":[187],"treatment.":[188]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-08T00:00:00"}