{"id":"https://openalex.org/W7220852115","doi":"https://doi.org/10.3389/fonc.2026.1933438","title":"Overall survival after relapse in high-risk neuroblastoma: an adjusted indirect comparison of post-relapse dinutuximab beta, historical controls, and relapse after first-line dinutuximab beta maintenance","display_name":"Overall survival after relapse in high-risk neuroblastoma: an adjusted indirect comparison of post-relapse dinutuximab beta, historical controls, and relapse after first-line dinutuximab beta maintenance","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220852115","doi":"https://doi.org/10.3389/fonc.2026.1933438","pmid":"https://pubmed.ncbi.nlm.nih.gov/42908775","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13683140"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2026.1933438","doi":"https://doi.org/10.3389/fonc.2026.1933438","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1933438","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1933438/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1933438/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018970052","display_name":"Holger N. Lode","orcid":"https://orcid.org/0000-0002-1201-208X","observed_orcids":["https://orcid.org/0000-0002-1201-208X"]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Holger N. Lode","raw_affiliation_strings":["Department of Pediatric Hematology and Oncology, University Medicine Greifswald"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology and Oncology, University Medicine Greifswald","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037590703","display_name":"Przemys\u0142aw Holko","orcid":"https://orcid.org/0000-0002-6821-4078","observed_orcids":["https://orcid.org/0000-0002-6821-4078"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Przemys\u0142aw Holko","raw_affiliation_strings":["Department of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036855099","display_name":"Aleksandra Wieczorek","orcid":"https://orcid.org/0000-0001-6750-2628","observed_orcids":["https://orcid.org/0000-0001-6750-2628"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Aleksandra Wieczorek","raw_affiliation_strings":["Paediatric Haematology Oncology, Jagiellonian University Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paediatric Haematology Oncology, Jagiellonian University Medical College","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087863230","display_name":"Katarzyna \u015aladowska","orcid":"https://orcid.org/0000-0002-6633-0999","observed_orcids":["https://orcid.org/0000-0002-6633-0999"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Katarzyna \u015aladowska","raw_affiliation_strings":["Department of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022533249","display_name":"Nikolai Siebert","orcid":"https://orcid.org/0000-0001-6254-1302","observed_orcids":["https://orcid.org/0000-0001-6254-1302"]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nikolai Siebert","raw_affiliation_strings":["Department of Pediatric Hematology and Oncology, University Medicine Greifswald"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology and Oncology, University Medicine Greifswald","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017308862","display_name":"Dominique Valteau\u2010Couanet","orcid":"https://orcid.org/0009-0001-9880-2241","observed_orcids":["https://orcid.org/0009-0001-9880-2241"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dominique Valteau-Couanet","raw_affiliation_strings":["Children and Adolescent Oncology Department, Gustave Roussy, Paris-Sud University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children and Adolescent Oncology Department, Gustave Roussy, Paris-Sud University","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074834398","display_name":"Alberto Garaventa","orcid":"https://orcid.org/0000-0002-5368-6363","observed_orcids":["https://orcid.org/0000-0002-5368-6363"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Garaventa","raw_affiliation_strings":["Oncology Unit, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) Istituto Giannina Gaslini"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Unit, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) Istituto Giannina Gaslini","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132667874","display_name":"Adela Canete","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Adela Ca\u00f1ete","raw_affiliation_strings":["Hospital Universitario y Politecnico La Fe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario y Politecnico La Fe","institution_ids":["https://openalex.org/I3019010403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071510295","display_name":"John Anderson","orcid":"https://orcid.org/0000-0001-7509-3203","observed_orcids":["https://orcid.org/0000-0001-7509-3203"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Anderson","raw_affiliation_strings":["University College London (UCL) Great Ormond Street Institute of Child Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London (UCL) Great Ormond Street Institute of Child Health","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043164298","display_name":"Isaac Yaniv","orcid":"https://orcid.org/0009-0005-1063-5872","observed_orcids":["https://orcid.org/0009-0005-1063-5872"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I4210109312","display_name":"Schneider Children's Medical Center","ror":"https://ror.org/01z3j3n30","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210109312"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Isaac Yaniv","raw_affiliation_strings":["Schneider Children\u2019s Medical Center of Israel, Sackler Faculty of Medicine Tel Aviv University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schneider Children\u2019s Medical Center of Israel, Sackler Faculty of Medicine Tel Aviv University","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I4210109312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123179227","display_name":"Shifra Ash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109312","display_name":"Schneider Children's Medical Center","ror":"https://ror.org/01z3j3n30","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210109312"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Shifra Ash","raw_affiliation_strings":["Schneider Children's Medical Center of Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schneider Children's Medical Center of Israel","institution_ids":["https://openalex.org/I4210109312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103113623","display_name":"Lucas Moreno","orcid":"https://orcid.org/0000-0002-0708-1670","observed_orcids":["https://orcid.org/0000-0002-0708-1670"]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Lucas Moreno","raw_affiliation_strings":["Division of Pediatric Hematology & Oncology, Vall d\u2019Hebron Barcelona Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology & Oncology, Vall d\u2019Hebron Barcelona Hospital","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140695394","display_name":"Juliet Gray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Juliet Gray","raw_affiliation_strings":["Centre for Cancer Immunology, University of Southampton"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cancer Immunology, University of Southampton","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036969722","display_name":"Roberto Luksch","orcid":"https://orcid.org/0000-0002-7203-4176","observed_orcids":["https://orcid.org/0000-0002-7203-4176"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Luksch","raw_affiliation_strings":["Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123598117","display_name":"Genevieve Laureys","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Genevieve Laureys","raw_affiliation_strings":["Department of Pediatric Hematology/Oncology and Stem Cell Transplantation University Hospital Ghent"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology/Oncology and Stem Cell Transplantation University Hospital Ghent","institution_ids":["https://openalex.org/I2801227569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157887019","display_name":"Cormac Owens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cormac Owens","raw_affiliation_strings":["Department of Haematology and Oncology, Children's Health Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology and Oncology, Children's Health Ireland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066768474","display_name":"Carla Manzitti","orcid":"https://orcid.org/0000-0002-1501-5518","observed_orcids":["https://orcid.org/0000-0002-1501-5518"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carla Manzitti","raw_affiliation_strings":["Oncology Unit, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) Istituto Giannina Gaslini"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Unit, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) Istituto Giannina Gaslini","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043909136","display_name":"Sascha Troschke\u2010Meurer","orcid":"https://orcid.org/0000-0002-6185-462X","observed_orcids":["https://orcid.org/0000-0002-6185-462X"]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sascha Troschke-Meurer","raw_affiliation_strings":["Department of Pediatric Hematology and Oncology, University Medicine Greifswald"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology and Oncology, University Medicine Greifswald","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081766870","display_name":"Pawe\u0142 Kawalec","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Pawe\u0142 Kawalec","raw_affiliation_strings":["Centrum HTA Sp. z o.o","Department of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centrum HTA Sp. z o.o","institution_ids":[]},{"raw_affiliation_string":"Department of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157886273","display_name":"Ruth L. Ladenstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123554","display_name":"St Anna Children's Hospital","ror":"https://ror.org/02qb3f692","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210123554"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Ruth L. Ladenstein","raw_affiliation_strings":["Department of Paediatrics, Saint Anna Children\u2019s Hospital, Medical University","Department of Pediatrics, Medical University Vienna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Saint Anna Children\u2019s Hospital, Medical University","institution_ids":["https://openalex.org/I4210123554"]},{"raw_affiliation_string":"Department of Pediatrics, Medical University Vienna","institution_ids":["https://openalex.org/I76134821"]}]}],"institutions":[],"countries_distinct_count":9,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5018970052","https://openalex.org/A5081766870"],"corresponding_institution_ids":["https://openalex.org/I126596746","https://openalex.org/I2799318839"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72785362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"1933438","last_page":"1933438"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.8199999928474426},{"id":"https://openalex.org/keywords/relapsed-neuroblastoma","display_name":"relapsed neuroblastoma","score":0.8600000143051147},{"id":"https://openalex.org/keywords/dinutuximab-beta","display_name":"dinutuximab beta","score":0.9639999866485596},{"id":"https://openalex.org/keywords/anti-gd2-immunotherapy","display_name":"anti-GD2 immunotherapy","score":0.8410000205039978},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8339999914169312},{"id":"https://openalex.org/keywords/legacy-effects","display_name":"legacy effects","score":0.7680000066757202},{"id":"https://openalex.org/keywords/high-risk-neuroblastoma","display_name":"high-risk neuroblastoma","score":0.75},{"id":"https://openalex.org/keywords/historical-controls","display_name":"historical controls","score":0.48899999260902405},{"id":"https://openalex.org/keywords/time-to-relapse","display_name":"time to relapse","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8381999731063843},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6653000116348267},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.657800018787384},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6140000224113464},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.613099992275238},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5997999906539917},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.48559999465942383},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.37869998812675476},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.37790000438690186},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.37619999051094055},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.3269999921321869},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.29019999504089355},{"id":"https://openalex.org/C2778283404","wikidata":"https://www.wikidata.org/wiki/Q6736822","display_name":"Maintenance therapy","level":3,"score":0.289900004863739},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.2784000039100647},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.27480000257492065},{"id":"https://openalex.org/C2777382242","wikidata":"https://www.wikidata.org/wiki/Q6017816","display_name":"Index (typography)","level":2,"score":0.2685000002384186},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.2653000056743622},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2578999996185303}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.3389/fonc.2026.1933438","doi":"https://doi.org/10.3389/fonc.2026.1933438","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1933438","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1933438/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13683140","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13683140/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13683140/pdf/fonc-16-1933438.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:42908775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42908775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.soton.ac.uk:515867","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.3389/fonc.2026.1933438>).","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:archive.ugent.be:01M5ETV5W4R7HBMMZCMSHM5705","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1854/LU-01M5ETV5W4R7HBMMZCMSHM5705","pdf_url":"https://biblio.ugent.be/publication/01M5ETV5W4R7HBMMZCMSHM5705/file/01M5ETWHNPW02QYV80S5WPR478.pdf","source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 2234-943X","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ruj.uj.edu.pl:item/584055","doi":null,"is_oa":true,"landing_page_url":"https://ruj.uj.edu.pl/handle/item/584055","pdf_url":null,"source":{"id":"https://openalex.org/S4306401249","display_name":"Jagiellonian University Repository (Jagiellonian University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126596746","host_organization_name":"Jagiellonian University","host_organization_lineage":["https://openalex.org/I126596746"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:57dda50114bd4130aab8deadae1f23f6","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/57dda50114bd4130aab8deadae1f23f6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 16 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2026.1933438","doi":"https://doi.org/10.3389/fonc.2026.1933438","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1933438","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1933438/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G7920440635","display_name":null,"funder_award_id":"M2116","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320317461","display_name":"Recordati Rare Diseases","ror":"https://ror.org/00x68eg25"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220852115.pdf","grobid_xml":"https://content.openalex.org/works/W7220852115.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1985200617","https://openalex.org/W2066925870","https://openalex.org/W2142495742","https://openalex.org/W2767789735","https://openalex.org/W2900463817","https://openalex.org/W3018670999","https://openalex.org/W3172626823","https://openalex.org/W3205211596","https://openalex.org/W4213435533","https://openalex.org/W4224056643","https://openalex.org/W4225131937","https://openalex.org/W4283460025","https://openalex.org/W4285012742","https://openalex.org/W4285491244","https://openalex.org/W4319161361","https://openalex.org/W4322623407","https://openalex.org/W4385758531","https://openalex.org/W4387472932","https://openalex.org/W4392640282","https://openalex.org/W4407029981","https://openalex.org/W4407576339","https://openalex.org/W4407943506","https://openalex.org/W4410974800","https://openalex.org/W4413401697","https://openalex.org/W4417304576","https://openalex.org/W7125400801","https://openalex.org/W7126032203"],"related_works":["https://openalex.org/W7125400801","https://openalex.org/W4417482254","https://openalex.org/W4413431778","https://openalex.org/W7170159117","https://openalex.org/W4410974800","https://openalex.org/W4385758531","https://openalex.org/W4382402620","https://openalex.org/W7214718589","https://openalex.org/W4414409494","https://openalex.org/W4319161361"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"compare":[2],"overall":[3],"survival":[4,136,399],"(OS)":[5],"in":[6,49,215,221,380],"patients":[7,32,84,100,207,261,304,351],"with":[8,12,18,26,78,102,163,287,292,341,346,395],"relapsed":[9,34,51,86,263,306,353,382],"neuroblastoma":[10],"treated":[11,101],"dinutuximab":[13],"beta":[14],"(DB)":[15],"after":[16,35,87,104,240,264,283,307,337,354,408],"relapse":[17,105,190,284,338],"that":[19,334,386],"of":[20,47,60,193,205,210,244,248,362,366,378],"two":[21],"comparator":[22],"populations:":[23],"historical":[24,76,270,294,348],"controls":[25,77,271,295,349],"no":[27,79],"prior":[28,61,80,107,355,387,409],"anti-disialoganglioside-2":[29],"exposure":[30,108,251],"and":[31,53,92,99,117,146,151,157,171,230,269,303,327,350,384],"who":[33,85,262,305,352],"first-line":[36,62,88,249,265,308,356,367,388,410],"DB":[37,48,89,97,103,250,266,281,309,335,357,368,379,389,406],"maintenance":[38,90,267,310,358,390],"immunotherapy.":[39,359],"The":[40,401],"objectives":[41],"were":[42,113,129,208,213,237,321],"to":[43,54,191,196],"evaluate":[44,405],"the":[45,50,140,169,174,186,199,216,375,381],"effectiveness":[46],"setting":[52,383],"assess":[55],"a":[56,122,181,245,363,396],"potential":[57],"legacy":[58,246,364],"effect":[59,247,365],"therapy.":[63],"Methods:":[64],"This":[65,329],"unanchored":[66],"indirect":[67,331],"comparison":[68,332],"used":[69],"individual":[70],"patient":[71],"data":[72,197],"from":[73,139,188,198,226],"three":[74],"cohorts:":[75],"anti-GD2":[81],"therapy":[82],"(N/N),":[83],"immunotherapy":[91,268,311,369],"did":[93,256,403],"not":[94,257,393,404],"receive":[95],"subsequent":[96],"(DB/N),":[98],"without":[106],"(N/DB).":[109],"Harmonized":[110],"eligibility":[111],"criteria":[112],"applied":[114],"across":[115,323],"cohorts,":[116,173],"follow-up":[118],"was":[119,137,178,252,285,339,370,392],"aligned":[120],"using":[121,131,153,180],"common":[123],"post-relapse":[124,148,175,398],"index":[125,149,176],"date.":[126],"Adjusted":[127],"comparisons":[128],"performed":[130],"propensity":[132],"score":[133],"reweighting.":[134],"Overall":[135],"measured":[138],"observed":[141],"(N/DB)":[142],"or":[143],"imputed":[144,179],"(N/N":[145],"DB/N)":[147],"date":[150,177],"analyzed":[152],"weighted":[154,158,217],"Kaplan-Meier":[155],"methods":[156],"Cox":[159],"proportional":[160],"hazards":[161],"models,":[162],"hazard":[164],"ratios":[165],"(HR)":[166],"reported.":[167],"For":[168],"N/N":[170],"DB/N":[172],"quantile":[182],"regression":[183],"model":[184],"estimating":[185],"interval":[187],"first":[189],"initiation":[192],"DB,":[194],"fitted":[195],"N/DB":[200],"cohort.":[201],"Results:":[202],"A":[203],"total":[204],"329":[206],"assessed,":[209],"whom":[211],"266":[212],"included":[214],"analyses.":[218,325],"Baseline":[219],"imbalances":[220],"age":[222],"at":[223],"relapse,":[224],"time":[225],"diagnosis,":[227],"MYCN":[228],"status,":[229],"International":[231],"Neuroblastoma":[232],"Staging":[233],"System":[234],"(INSS)":[235],"stage":[236],"largely":[238],"resolved":[239],"weighting.":[241],"No":[242,360],"evidence":[243,361],"observed,":[253],"as":[254],"OS":[255,290,344],"differ":[258],"significantly":[259,288,342],"between":[260],"(HR":[272,296,312],"=":[273,297,313],"1.26,":[274],"95%":[275,299,315],"CI":[276,300,316],"0.70-2.26;":[277],"p=0.437).":[278],"In":[279],"contrast,":[280],"administered":[282,336],"associated":[286,340,394],"improved":[289,343],"compared":[291,345],"both":[293,347],"0.53,":[298],"0.35-0.81;":[301],"p=0.003)":[302],"0.42,":[314],"0.25-0.72;":[317],"p=0.001).":[318],"These":[319,372],"findings":[320,373],"consistent":[322],"sensitivity":[324],"Conclusion":[326],"limitations:":[328],"adjusted":[330],"demonstrated":[333],"identified.":[371],"support":[374],"clinical":[376],"relevance":[377],"indicate":[385],"alone":[391],"persistent":[397],"advantage.":[400],"study":[402],"retreatment":[407],"exposure.":[411]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-08T00:00:00"}