{"id":"https://openalex.org/W7220848385","doi":"https://doi.org/10.1016/j.isci.2026.117746","title":"Loss of the Asn333 high-mannose N-glycan impairs ACP3 folding and drives disease-associated dysfunction","display_name":"Loss of the Asn333 high-mannose N-glycan impairs ACP3 folding and drives disease-associated dysfunction","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7220848385","doi":"https://doi.org/10.1016/j.isci.2026.117746","pmid":"https://pubmed.ncbi.nlm.nih.gov/42894579","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13676724"},"language":"en","primary_location":{"id":"doi:10.1016/j.isci.2026.117746","doi":"https://doi.org/10.1016/j.isci.2026.117746","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2026.117746","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.isci.2026.117746","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011203970","display_name":"Noriyoshi Manabe","orcid":"https://orcid.org/0000-0002-8866-0526","observed_orcids":["https://orcid.org/0000-0002-8866-0526"]},"institutions":[{"id":"https://openalex.org/I85324120","display_name":"Tohoku Medical and Pharmaceutical University","ror":"https://ror.org/0264zxa45","country_code":"JP","type":"education","lineage":["https://openalex.org/I85324120"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriyoshi Manabe","raw_affiliation_strings":["Division of Structural Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi 981-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Structural Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi 981-8558, Japan","institution_ids":["https://openalex.org/I85324120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048353638","display_name":"Kazuyoshi ITOH","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088637","display_name":"Soka University","ror":"https://ror.org/003qdfg20","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210088637"]},{"id":"https://openalex.org/I4405286241","display_name":"Glycan and Life Systems Integration Center","ror":"https://ror.org/01k72j319","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210088637","https://openalex.org/I4405286241"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuyoshi Itoh","raw_affiliation_strings":["Glycan and Life Systems Integration Center (GaLSIC), Soka University, Hachioji, Tokyo 192-8577, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glycan and Life Systems Integration Center (GaLSIC), Soka University, Hachioji, Tokyo 192-8577, Japan","institution_ids":["https://openalex.org/I4210088637","https://openalex.org/I4405286241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023016790","display_name":"Shiho Ohno","orcid":"https://orcid.org/0000-0002-4069-8744","observed_orcids":["https://orcid.org/0000-0002-4069-8744"]},"institutions":[{"id":"https://openalex.org/I85324120","display_name":"Tohoku Medical and Pharmaceutical University","ror":"https://ror.org/0264zxa45","country_code":"JP","type":"education","lineage":["https://openalex.org/I85324120"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shiho Ohno","raw_affiliation_strings":["Division of Structural Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi 981-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Structural Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi 981-8558, Japan","institution_ids":["https://openalex.org/I85324120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157879492","display_name":"Ayumi Miura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85324120","display_name":"Tohoku Medical and Pharmaceutical University","ror":"https://ror.org/0264zxa45","country_code":"JP","type":"education","lineage":["https://openalex.org/I85324120"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayumi Miura","raw_affiliation_strings":["Division of Structural Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi 981-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Structural Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi 981-8558, Japan","institution_ids":["https://openalex.org/I85324120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157882112","display_name":"Aika Miyata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85324120","display_name":"Tohoku Medical and Pharmaceutical University","ror":"https://ror.org/0264zxa45","country_code":"JP","type":"education","lineage":["https://openalex.org/I85324120"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aika Miyata","raw_affiliation_strings":["Division of Structural Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi 981-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Structural Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi 981-8558, Japan","institution_ids":["https://openalex.org/I85324120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157815000","display_name":"Sora Yashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85324120","display_name":"Tohoku Medical and Pharmaceutical University","ror":"https://ror.org/0264zxa45","country_code":"JP","type":"education","lineage":["https://openalex.org/I85324120"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sora Yashima","raw_affiliation_strings":["Division of Structural Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi 981-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Structural Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi 981-8558, Japan","institution_ids":["https://openalex.org/I85324120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069984246","display_name":"Sachiko Komatsu","orcid":"https://orcid.org/0000-0003-3209-6732","observed_orcids":["https://orcid.org/0000-0003-3209-6732"]},"institutions":[{"id":"https://openalex.org/I85324120","display_name":"Tohoku Medical and Pharmaceutical University","ror":"https://ror.org/0264zxa45","country_code":"JP","type":"education","lineage":["https://openalex.org/I85324120"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sachiko Komatsu","raw_affiliation_strings":["Division of Bioanalytical Chemistry, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi 981-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bioanalytical Chemistry, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi 981-8558, Japan","institution_ids":["https://openalex.org/I85324120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157813281","display_name":"Tsutomu Fujimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85324120","display_name":"Tohoku Medical and Pharmaceutical University","ror":"https://ror.org/0264zxa45","country_code":"JP","type":"education","lineage":["https://openalex.org/I85324120"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsutomu Fujimura","raw_affiliation_strings":["Division of Bioanalytical Chemistry, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi 981-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bioanalytical Chemistry, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi 981-8558, Japan","institution_ids":["https://openalex.org/I85324120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020078793","display_name":"Hisatoshi Hanamatsu","orcid":"https://orcid.org/0000-0002-8461-2164","observed_orcids":["https://orcid.org/0000-0002-8461-2164"]},"institutions":[{"id":"https://openalex.org/I4405286252","display_name":"Institute for Glyco-core Research","ror":"https://ror.org/01m1wg322","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286252"]},{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisatoshi Hanamatsu","raw_affiliation_strings":["Institute for Glyco-Core Research (iGCORE), Nagoya University, Nagoya 466-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Glyco-Core Research (iGCORE), Nagoya University, Nagoya 466-8550, Japan","institution_ids":["https://openalex.org/I4405286252","https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103270610","display_name":"Jun\u2010ichi Furukawa","orcid":"https://orcid.org/0000-0002-7284-2261","observed_orcids":["https://orcid.org/0000-0002-7284-2261"]},"institutions":[{"id":"https://openalex.org/I4405286252","display_name":"Institute for Glyco-core Research","ror":"https://ror.org/01m1wg322","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286252"]},{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun-ichi Furukawa","raw_affiliation_strings":["Institute for Glyco-Core Research (iGCORE), Nagoya University, Nagoya 466-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Glyco-Core Research (iGCORE), Nagoya University, Nagoya 466-8550, Japan","institution_ids":["https://openalex.org/I4405286252","https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018918465","display_name":"Kiyohiko Angata","orcid":"https://orcid.org/0000-0001-5561-1368","observed_orcids":["https://orcid.org/0000-0001-5561-1368"]},"institutions":[{"id":"https://openalex.org/I4210088637","display_name":"Soka University","ror":"https://ror.org/003qdfg20","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210088637"]},{"id":"https://openalex.org/I4405286241","display_name":"Glycan and Life Systems Integration Center","ror":"https://ror.org/01k72j319","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210088637","https://openalex.org/I4405286241"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyohiko Angata","raw_affiliation_strings":["Glycan and Life Systems Integration Center (GaLSIC), Soka University, Hachioji, Tokyo 192-8577, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glycan and Life Systems Integration Center (GaLSIC), Soka University, Hachioji, Tokyo 192-8577, Japan","institution_ids":["https://openalex.org/I4210088637","https://openalex.org/I4405286241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027664329","display_name":"Akira Togayachi","orcid":"https://orcid.org/0000-0003-3600-9149","observed_orcids":["https://orcid.org/0000-0003-3600-9149"]},"institutions":[{"id":"https://openalex.org/I4210088637","display_name":"Soka University","ror":"https://ror.org/003qdfg20","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210088637"]},{"id":"https://openalex.org/I4405286241","display_name":"Glycan and Life Systems Integration Center","ror":"https://ror.org/01k72j319","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210088637","https://openalex.org/I4405286241"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Togayachi","raw_affiliation_strings":["Glycan and Life Systems Integration Center (GaLSIC), Soka University, Hachioji, Tokyo 192-8577, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glycan and Life Systems Integration Center (GaLSIC), Soka University, Hachioji, Tokyo 192-8577, Japan","institution_ids":["https://openalex.org/I4210088637","https://openalex.org/I4405286241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042790078","display_name":"Kiyoko Flora Aoki-Kinoshita","orcid":"https://orcid.org/0000-0002-6662-8015","observed_orcids":["https://orcid.org/0000-0002-6662-8015"]},"institutions":[{"id":"https://openalex.org/I4210088637","display_name":"Soka University","ror":"https://ror.org/003qdfg20","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210088637"]},{"id":"https://openalex.org/I4405286241","display_name":"Glycan and Life Systems Integration Center","ror":"https://ror.org/01k72j319","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210088637","https://openalex.org/I4405286241"]},{"id":"https://openalex.org/I4405286252","display_name":"Institute for Glyco-core Research","ror":"https://ror.org/01m1wg322","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286252"]},{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoko F. Aoki-Kinoshita","raw_affiliation_strings":["Glycan and Life Systems Integration Center (GaLSIC), Soka University, Hachioji, Tokyo 192-8577, Japan","Institute for Glyco-Core Research (iGCORE), Nagoya University, Nagoya 466-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glycan and Life Systems Integration Center (GaLSIC), Soka University, Hachioji, Tokyo 192-8577, Japan","institution_ids":["https://openalex.org/I4210088637","https://openalex.org/I4405286241"]},{"raw_affiliation_string":"Institute for Glyco-Core Research (iGCORE), Nagoya University, Nagoya 466-8550, Japan","institution_ids":["https://openalex.org/I4405286252","https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065345187","display_name":"Yoshihiro Akimoto","orcid":"https://orcid.org/0000-0002-0281-4150","observed_orcids":["https://orcid.org/0000-0002-0281-4150"]},"institutions":[{"id":"https://openalex.org/I190930483","display_name":"Kyorin University","ror":"https://ror.org/0188yz413","country_code":"JP","type":"education","lineage":["https://openalex.org/I190930483"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Akimoto","raw_affiliation_strings":["Department of Microscopic Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo 181-8611, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microscopic Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo 181-8611, Japan","institution_ids":["https://openalex.org/I190930483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157821558","display_name":"Tadashi Kaname","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132193","display_name":"National Center For Child Health and Development","ror":"https://ror.org/03fvwxc59","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210132193"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Kaname","raw_affiliation_strings":["Department of Genome Medicine, National Center for Child Health and Development, Tokyo 157-8535, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genome Medicine, National Center for Child Health and Development, Tokyo 157-8535, Japan","institution_ids":["https://openalex.org/I4210132193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025429263","display_name":"Shoko Nishihara","orcid":"https://orcid.org/0000-0002-1668-2603","observed_orcids":["https://orcid.org/0000-0002-1668-2603"]},"institutions":[{"id":"https://openalex.org/I4210088637","display_name":"Soka University","ror":"https://ror.org/003qdfg20","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210088637"]},{"id":"https://openalex.org/I4405286241","display_name":"Glycan and Life Systems Integration Center","ror":"https://ror.org/01k72j319","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210088637","https://openalex.org/I4405286241"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoko Nishihara","raw_affiliation_strings":["Glycan and Life Systems Integration Center (GaLSIC), Soka University, Hachioji, Tokyo 192-8577, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glycan and Life Systems Integration Center (GaLSIC), Soka University, Hachioji, Tokyo 192-8577, Japan","institution_ids":["https://openalex.org/I4210088637","https://openalex.org/I4405286241"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052716791","display_name":"Yoshiki Yamaguchi","orcid":"https://orcid.org/0000-0003-0100-5439","observed_orcids":["https://orcid.org/0000-0003-0100-5439"]},"institutions":[{"id":"https://openalex.org/I85324120","display_name":"Tohoku Medical and Pharmaceutical University","ror":"https://ror.org/0264zxa45","country_code":"JP","type":"education","lineage":["https://openalex.org/I85324120"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshiki Yamaguchi","raw_affiliation_strings":["Division of Structural Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi 981-8558, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0100-5439","affiliations":[{"raw_affiliation_string":"Division of Structural Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi 981-8558, Japan","institution_ids":["https://openalex.org/I85324120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5052716791"],"corresponding_institution_ids":["https://openalex.org/I85324120"],"apc_list":{"value":3240,"currency":"USD","value_usd":3240},"apc_paid":{"value":3240,"currency":"USD","value_usd":3240},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6258507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"10","first_page":"117746","last_page":"117746"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostatic-acid-phosphatase","display_name":"prostatic acid phosphatase","score":0.9739999771118164},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/high-mannose-n-glycans","display_name":"high-mannose glycans","score":0.9049999713897705},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.8009999990463257},{"id":"https://openalex.org/keywords/protein-glycan-interactions","display_name":"glycan-protein interactions","score":0.6200000047683716},{"id":"https://openalex.org/keywords/er-retention","display_name":"endoplasmic reticulum retention","score":0.7639999985694885},{"id":"https://openalex.org/keywords/glycoproteomics","display_name":"glycoproteomics","score":0.5799999833106995},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.6759999990463257},{"id":"https://openalex.org/keywords/neurodevelopmental-abnormalities","display_name":"neurodevelopmental abnormalities","score":0.7110000252723694},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.7020000219345093},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.567799985408783},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.5443000197410583},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4957999885082245},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37869998812675476},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.3578999936580658},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31869998574256897},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.28040000796318054},{"id":"https://openalex.org/C191120209","wikidata":"https://www.wikidata.org/wiki/Q908902","display_name":"Structural biology","level":2,"score":0.2556000053882599},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21940000355243683},{"id":"https://openalex.org/C2986265897","wikidata":"https://www.wikidata.org/wiki/Q23852","display_name":"Human physiology","level":2,"score":0.20499999821186066}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.isci.2026.117746","doi":"https://doi.org/10.1016/j.isci.2026.117746","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2026.117746","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},{"id":"pmid:42894579","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42894579","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13676724","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13676724/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3e4e0de876684807be143d98187cdea3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3e4e0de876684807be143d98187cdea3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"iScience, Vol 29, Iss 10, Pp 117746- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.isci.2026.117746","doi":"https://doi.org/10.1016/j.isci.2026.117746","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2026.117746","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2640591243","display_name":"\u7cd6\u9396\u7570\u5e38\u75c7\u306e\u30b2\u30ce\u30e0\u30fb\u7cd6\u9396\u89e3\u6790\u4f53\u5236\u69cb\u7bc9\u306b\u3088\u308b\u5168\u4f53\u628a\u63e1\u3068\u8a3a\u65ad\u6cd5\u958b\u767a","funder_award_id":"25ek0109815h0001","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G2958496071","display_name":"\u7cd6\u9396\u7570\u5e38\u95a2\u9023\u75be\u60a3\u306e\u30ef\u30f3\u30b9\u30c8\u30c3\u30d7\u691c\u67fb\u4f53\u5236\u306e\u69cb\u7bc9\u3068\u7c21\u6613\u8a3a\u65ad\u6cd5\u306e\u958b\u767a","funder_award_id":"22ek0109446h0003","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G9000938242","display_name":null,"funder_award_id":"JP26ek0109886","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1508256447","https://openalex.org/W1561830401","https://openalex.org/W1963605778","https://openalex.org/W1964084275","https://openalex.org/W1967430693","https://openalex.org/W1968862404","https://openalex.org/W1971460260","https://openalex.org/W1976499671","https://openalex.org/W1977603207","https://openalex.org/W1985460055","https://openalex.org/W2002237241","https://openalex.org/W2002620715","https://openalex.org/W2014057707","https://openalex.org/W2021520922","https://openalex.org/W2029667189","https://openalex.org/W2035384001","https://openalex.org/W2045335556","https://openalex.org/W2056214920","https://openalex.org/W2061335040","https://openalex.org/W2078598194","https://openalex.org/W2094417597","https://openalex.org/W2099540110","https://openalex.org/W2104172318","https://openalex.org/W2104418929","https://openalex.org/W2109154308","https://openalex.org/W2111106575","https://openalex.org/W2112286580","https://openalex.org/W2129631700","https://openalex.org/W2148415233","https://openalex.org/W2150969350","https://openalex.org/W2152938368","https://openalex.org/W2162695817","https://openalex.org/W2287000090","https://openalex.org/W2288691049","https://openalex.org/W2593996111","https://openalex.org/W2737764894","https://openalex.org/W2745067258","https://openalex.org/W2896957184","https://openalex.org/W2913106502","https://openalex.org/W2953110573","https://openalex.org/W2954883623","https://openalex.org/W2999983166","https://openalex.org/W3033472818","https://openalex.org/W3080771184","https://openalex.org/W3136093501","https://openalex.org/W4285087816","https://openalex.org/W4389367121","https://openalex.org/W4389487302","https://openalex.org/W4389497298","https://openalex.org/W4391614752","https://openalex.org/W4404160922"],"related_works":["https://openalex.org/W3172011169","https://openalex.org/W2019877029","https://openalex.org/W2120693849","https://openalex.org/W2041378699","https://openalex.org/W2042732772","https://openalex.org/W2025489129","https://openalex.org/W3134325625","https://openalex.org/W2007698009","https://openalex.org/W1964277788","https://openalex.org/W1499178728"],"abstract_inverted_index":{"Missense":[0],"mutations":[1],"disrupting":[2],"N":[3,18,33,52],"-glycosylation":[4,34],"motifs":[5],"can":[6],"perturb":[7],"protein":[8],"folding":[9,147],"and":[10,47,63,69,75,83,103,148],"trafficking,":[11],"yet":[12],"the":[13,28,92],"site-specific":[14,138],"contributions":[15],"of":[16,31],"individual":[17],"-glycans":[19],"to":[20,128],"proteostasis":[21,129],"remain":[22],"poorly":[23],"defined.":[24],"Here,":[25],"we":[26],"delineated":[27],"functional":[29],"hierarchy":[30],"three":[32],"sites":[35],"in":[36,58,131,145],"human":[37,149],"prostatic":[38],"acid":[39],"phosphatase":[40,71],"(ACP3).":[41],"Glycoproteomic":[42],"analysis":[43],"showed":[44],"that":[45,91],"Asn94":[46],"Asn220":[48],"carry":[49],"predominantly":[50],"complex-type":[51],"-glycans,":[53],"whereas":[54,73],"Asn333":[55,93,125],"is":[56],"enriched":[57],"high-mannose":[59,94],"structures.":[60],"Glycan-deficient":[61],"N94Q":[62],"N220Q":[64],"variants":[65],"were":[66],"efficiently":[67],"secreted":[68],"retained":[70],"activity,":[72],"N333Q":[74],"T335M":[76],"accumulated":[77],"intracellularly,":[78],"formed":[79],"endoplasmic":[80],"reticulum":[81],"aggregates,":[82],"lacked":[84],"enzymatic":[85],"activity.":[86],"Molecular":[87],"dynamics":[88],"simulations":[89],"revealed":[90],"glycan":[95,126],"forms":[96],"persistent":[97],"hydrogen-bond":[98],"networks":[99],"with":[100,142],"surrounding":[101],"residues":[102],"exhibits":[104],"markedly":[105],"reduced":[106],"conformational":[107],"flexibility,":[108],"supporting":[109],"a":[110,116,137],"non-redundant":[111],"structural":[112],"role.":[113],"Individuals":[114],"harboring":[115],"heterozygous":[117],"p.T335M":[118],"variant":[119],"presented":[120],"severe":[121],"neurodevelopmental":[122],"abnormalities,":[123],"linking":[124],"loss":[127],"failure":[130],"vivo":[132],".":[133],"These":[134],"findings":[135],"establish":[136],"glycan-protein":[139],"stabilizing":[140],"mechanism":[141],"broad":[143],"implications":[144],"glycoprotein":[146],"disease.":[150]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-08T00:00:00"}