{"id":"https://openalex.org/W7220847995","doi":"https://doi.org/10.64898/2026.10.06.757003","title":"A Ribosomal RNA modification regulates translation of PI3K/AKT activators in high-grade serous ovarian carcinoma","display_name":"A Ribosomal RNA modification regulates translation of PI3K/AKT activators in high-grade serous ovarian carcinoma","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220847995","doi":"https://doi.org/10.64898/2026.10.06.757003"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.06.757003","doi":"https://doi.org/10.64898/2026.10.06.757003","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.757003","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.06.757003.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.06.757003.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108659867","display_name":"Andrew Rivera","orcid":"https://orcid.org/0009-0001-6559-4060","observed_orcids":["https://orcid.org/0009-0001-6559-4060"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrea Rivera-Pizana","raw_affiliation_strings":["D\u00e9partement de microbiologie et d\u2019infectiologie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada"],"raw_orcid":"https://orcid.org/0009-0001-6559-4060","affiliations":[{"raw_affiliation_string":"D\u00e9partement de microbiologie et d\u2019infectiologie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada","institution_ids":["https://openalex.org/I135117807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056889414","display_name":"Laurence Faucher\u2010Gigu\u00e8re","orcid":"https://orcid.org/0000-0002-5726-6446","observed_orcids":["https://orcid.org/0000-0002-5726-6446"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Laurence Faucher-Gigu\u00e8re","raw_affiliation_strings":["D\u00e9partement de microbiologie et d\u2019infectiologie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada"],"raw_orcid":"https://orcid.org/0000-0002-5726-6446","affiliations":[{"raw_affiliation_string":"D\u00e9partement de microbiologie et d\u2019infectiologie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada","institution_ids":["https://openalex.org/I135117807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082027663","display_name":"Michelle S. Scott","orcid":"https://orcid.org/0000-0001-6231-7714","observed_orcids":["https://orcid.org/0000-0001-6231-7714","https://orcid.org/0000-0003-3982-1159"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michelle S. Scott","raw_affiliation_strings":["D\u00e9partement de biochimie et g\u00e9nomique fonctionnelle, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada"],"raw_orcid":"https://orcid.org/0000-0001-6231-7714","affiliations":[{"raw_affiliation_string":"D\u00e9partement de biochimie et g\u00e9nomique fonctionnelle, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada","institution_ids":["https://openalex.org/I135117807"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080232104","display_name":"Sherif Abou Elela","orcid":"https://orcid.org/0000-0002-0630-3294","observed_orcids":["https://orcid.org/0000-0002-0630-3294"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Sherif Abou Elela","raw_affiliation_strings":["D\u00e9partement de microbiologie et d\u2019infectiologie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada"],"raw_orcid":"https://orcid.org/0000-0002-0630-3294","affiliations":[{"raw_affiliation_string":"D\u00e9partement de microbiologie et d\u2019infectiologie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada","institution_ids":["https://openalex.org/I135117807"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080232104"],"corresponding_institution_ids":["https://openalex.org/I135117807"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.039799999445676804,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.030400000512599945,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribosomal-rna-modification","display_name":"ribosomal RNA modification","score":0.9100000262260437},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9549999833106995},{"id":"https://openalex.org/keywords/high-grade-serous-ovarian-carcinoma","display_name":"high-grade serous ovarian cancer","score":0.968999981880188},{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/polysome-profiling","display_name":"polysome profiling","score":0.8259999752044678},{"id":"https://openalex.org/keywords/integrin-beta-4","display_name":"ITGB4","score":0.9229999780654907},{"id":"https://openalex.org/keywords/rasgrp2","display_name":"RASGRP2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.7839999794960022},{"id":"https://openalex.org/keywords/fgf18","display_name":"FGF18","score":0.9940000176429749},{"id":"https://openalex.org/keywords/irak1","display_name":"IRAK1","score":0.968999981880188},{"id":"https://openalex.org/keywords/spc24","display_name":"SPC24","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ribosome-association","display_name":"ribosome association","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C65666806","wikidata":"https://www.wikidata.org/wiki/Q970614","display_name":"Polysome","level":5,"score":0.704200029373169},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.5956000089645386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5777999758720398},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5450000166893005},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.5277000069618225},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5254999995231628},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.5188000202178955},{"id":"https://openalex.org/C38062823","wikidata":"https://www.wikidata.org/wiki/Q3408228","display_name":"Ribosomal protein","level":5,"score":0.4499000012874603},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4255000054836273},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4146000146865845},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.41339999437332153},{"id":"https://openalex.org/C98098607","wikidata":"https://www.wikidata.org/wiki/Q4639691","display_name":"5.8S ribosomal RNA","level":5,"score":0.41040000319480896},{"id":"https://openalex.org/C39685955","wikidata":"https://www.wikidata.org/wiki/Q3455905","display_name":"Translational regulation","level":5,"score":0.40880000591278076},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4081999957561493},{"id":"https://openalex.org/C2779341050","wikidata":"https://www.wikidata.org/wiki/Q24287527","display_name":"Small RNA","level":4,"score":0.37139999866485596},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.3610000014305115},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.34049999713897705},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.33399999141693115},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3336000144481659},{"id":"https://openalex.org/C150173356","wikidata":"https://www.wikidata.org/wiki/Q6144101","display_name":"Serous fluid","level":2,"score":0.325300008058548},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.31369999051094055},{"id":"https://openalex.org/C77430603","wikidata":"https://www.wikidata.org/wiki/Q166992","display_name":"Internal ribosome entry site","level":5,"score":0.3000999987125397},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.2994000017642975},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2962999939918518},{"id":"https://openalex.org/C179255354","wikidata":"https://www.wikidata.org/wiki/Q284416","display_name":"Small nucleolar RNA","level":5,"score":0.29350000619888306},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29170000553131104},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.288100004196167},{"id":"https://openalex.org/C2780926556","wikidata":"https://www.wikidata.org/wiki/Q7322419","display_name":"Ribosomal protein s6","level":5,"score":0.28360000252723694},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.2815000116825104},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.28110000491142273},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.2752000093460083},{"id":"https://openalex.org/C25281209","wikidata":"https://www.wikidata.org/wiki/Q3502188","display_name":"RNA polymerase I","level":5,"score":0.2694000005722046},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.2630000114440918},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.25999999046325684},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2578999996185303},{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.2531000077724457}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.06.757003","doi":"https://doi.org/10.64898/2026.10.06.757003","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.757003","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.06.757003.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.06.757003","doi":"https://doi.org/10.64898/2026.10.06.757003","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.757003","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.06.757003.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311614","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320334618","display_name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","ror":"https://ror.org/02eqrsj93"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220847995.pdf","grobid_xml":"https://content.openalex.org/works/W7220847995.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7206188513","https://openalex.org/W4225845204","https://openalex.org/W4206524093","https://openalex.org/W2971413301","https://openalex.org/W2948211395","https://openalex.org/W7204141789","https://openalex.org/W4294379436","https://openalex.org/W4408244084","https://openalex.org/W1986436400","https://openalex.org/W3045459672"],"abstract_inverted_index":{"ABSTRACT":[0],"PI3K/AKT":[1,60,104,143,201],"signalling":[2,26,202],"is":[3,18,63],"a":[4,42,48,64,197],"key":[5],"driver":[6],"of":[7,37,47,56,76,84,100,133,137,150,200],"ovarian":[8,67,204],"cancer":[9],"progression":[10],"and":[11,24,115,140,154,157,160,165,183],"an":[12,34],"important":[13],"therapeutic":[14],"target.":[15],"Its":[16],"deregulation":[17],"usually":[19],"explained":[20],"by":[21],"genetic":[22],"changes":[23],"altered":[25,116,129],"at":[27,80],"the":[28,45,54],"cell":[29,112,181],"surface.":[30],"Here,":[31],"we":[32],"identify":[33,193],"additional":[35],"layer":[36],"pathway":[38],"control,":[39],"in":[40,44,203],"which":[41,134],"change":[43],"level":[46],"cancer-associated":[49],"ribosomal":[50,78],"RNA":[51,72,79,138,186],"modification":[52,195],"alters":[53],"translation":[55],"proteins":[57],"that":[58,73],"regulate":[59],"activity.":[61],"SNORA81":[62,106,123,145,189],"high-grade":[65],"serous":[66],"carcinoma-associated":[68],"H/ACA":[69],"small":[70],"nucleolar":[71],"directs":[74],"pseudouridylation":[75],"28S":[77],"position":[81],"U4636.":[82],"Integration":[83],"tumour":[85],"transcriptomes":[86],"with":[87,95,128],"independent":[88],"SNORA81-depletion":[89],"datasets":[90],"identified":[91,125],"22":[92],"SNORA81-linked":[93],"transcripts":[94],"reversed":[96],"disease-associated":[97],"expression,":[98],"19":[99],"them":[101],"linked":[102],"to":[103,173],"signalling.":[105],"depletion":[107,124,146],"reduced":[108,147,158],"AKT":[109],"phosphorylation,":[110],"impaired":[111],"growth,":[113],"migration,":[114],"cell-cycle":[117],"distribution.":[118],"Molecularly,":[119],"polysome":[120],"profiling":[121],"following":[122],"524":[126],"mRNAs":[127],"ribosome":[130,148],"association,":[131],"485":[132],"changed":[135],"independently":[136],"abundance":[139],"included":[141],"29":[142],"regulators.":[144],"association":[149],"ITGB4,":[151],"RASGRP2,":[152],"IGF1":[153],"FGF18":[155],"transcripts,":[156],"ITGB4":[159,177],"RASGRP2":[161],"protein":[162],"abundance.":[163],"IRAK1":[164],"SPC24":[166],"acted":[167],"as":[168,196],"downstream":[169,185],"RNA-response":[170],"genes":[171],"contributing":[172],"selected":[174],"SNORA81-associated":[175],"phenotypes.":[176],"expression":[178],"partially":[179],"restored":[180,184],"growth":[182],"responses":[187],"after":[188],"depletion.":[190],"These":[191],"findings":[192],"rRNA":[194],"translational":[198],"regulator":[199],"cancer.":[205]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-08T00:00:00"}
