{"id":"https://openalex.org/W7220847541","doi":"https://doi.org/10.64898/2026.10.05.756676","title":"C3a receptor signalling in ObRb-expressing neurons promotes leptin resistance and obesity-associated cardiac remodelling","display_name":"C3a receptor signalling in ObRb-expressing neurons promotes leptin resistance and obesity-associated cardiac remodelling","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220847541","doi":"https://doi.org/10.64898/2026.10.05.756676"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.05.756676","doi":"https://doi.org/10.64898/2026.10.05.756676","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.756676","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.05.756676.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.05.756676.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064522009","display_name":"Elias Rawish","orcid":"https://orcid.org/0000-0002-7919-4113","observed_orcids":["https://orcid.org/0000-0002-7919-4113"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Elias Rawish","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7919-4113","affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119315798","display_name":"Carolin Gragoll","orcid":"https://orcid.org/0009-0006-7893-8367","observed_orcids":["https://orcid.org/0009-0006-7893-8367"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carolin Gragoll","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany"],"raw_orcid":"https://orcid.org/0009-0006-7893-8367","affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149190993","display_name":"Michael Schneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Schneider","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157857472","display_name":"Timo Rusack","orcid":"https://orcid.org/0009-0005-0886-7471","observed_orcids":["https://orcid.org/0009-0005-0886-7471"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Timo Rusack","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany"],"raw_orcid":"https://orcid.org/0009-0005-0886-7471","affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041780654","display_name":"Katharina Kurz","orcid":"https://orcid.org/0000-0003-4958-9541","observed_orcids":["https://orcid.org/0000-0003-4958-9541","https://orcid.org/0009-0002-6080-7060"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katharina Kurz","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany"],"raw_orcid":"https://orcid.org/0009-0002-6080-7060","affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029593870","display_name":"Violetta Pilorz","orcid":"https://orcid.org/0000-0002-8478-1734","observed_orcids":["https://orcid.org/0000-0002-8478-1734","https://orcid.org/0000-0003-0474-8975"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Violetta Pilorz","raw_affiliation_strings":["Institute of Neurobiology, Center of Brain Behavior and Metabolism, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurobiology, Center of Brain Behavior and Metabolism, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157866312","display_name":"Sophia Marie Reiners","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sophia Marie Reiners","raw_affiliation_strings":["Institute of Neurobiology, Center of Brain Behavior and Metabolism, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurobiology, Center of Brain Behavior and Metabolism, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062534408","display_name":"Sven Geisler","orcid":"https://orcid.org/0000-0002-5128-4467","observed_orcids":["https://orcid.org/0000-0002-5128-4467"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sven Geisler","raw_affiliation_strings":["Cell Analysis Core Facility, University of L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Analysis Core Facility, University of L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157793166","display_name":"Janti HajAhmad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Janti HajAhmad","raw_affiliation_strings":["Institute for Systemic Inflammation Research, University of L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systemic Inflammation Research, University of L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062966830","display_name":"Nuria L\u00f3pez\u2010Alc\u00e1ntara","orcid":"https://orcid.org/0000-0002-3384-3093","observed_orcids":["https://orcid.org/0000-0002-3384-3093"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nuria Lopez-Alcantara","raw_affiliation_strings":["Institute for Experimental Endocrinology, Center of Brain Behavior and Metabolism, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Experimental Endocrinology, Center of Brain Behavior and Metabolism, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148227093","display_name":"Nada Alnaggar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nada Alnaggar","raw_affiliation_strings":["Cardiology, Angiology, Haemostaseology, and Medical Intensive Care, Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany","Cardiovascular Systems Biology, Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology, Angiology, Haemostaseology, and Medical Intensive Care, Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450","https://openalex.org/I4387153978"]},{"raw_affiliation_string":"Cardiovascular Systems Biology, Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157868419","display_name":"Andreas Teufel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Teufel","raw_affiliation_strings":["Division of Hepatology, Division of Clinical Bioinformatics, Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatology, Division of Clinical Bioinformatics, Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030993211","display_name":"Mirko Otto","orcid":"https://orcid.org/0000-0002-8131-7397","observed_orcids":["https://orcid.org/0000-0002-8131-7397"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mirko Otto","raw_affiliation_strings":["Department of Surgery, University Medicine Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University Medicine Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157831705","display_name":"Jorge Duque Escobar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jorge Duque Escobar","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","Institute for Cardiogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute for Cardiogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038605040","display_name":"Thomas Stiermaier","orcid":"https://orcid.org/0000-0003-1957-3741","observed_orcids":["https://orcid.org/0000-0003-1957-3741"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Stiermaier","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157869286","display_name":"Sven G. Meuth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089242","display_name":"D\u00fcsseldorf University Hospital","ror":"https://ror.org/006k2kk72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089242"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sven G. Meuth","raw_affiliation_strings":["Department of Neurology, Medical Faculty, University Hospital Duesseldorf, Heinrich-Heine-University D\u00fcsseldorf, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical Faculty, University Hospital Duesseldorf, Heinrich-Heine-University D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I4210089242","https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021301101","display_name":"Zouhair Aherrahrou","orcid":"https://orcid.org/0000-0002-1241-8733","observed_orcids":["https://orcid.org/0000-0002-1241-8733"]},"institutions":[{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Zouhair Aherrahrou","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","Institute for Cardiogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute for Cardiogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157844532","display_name":"Henrik Oster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Henrik Oster","raw_affiliation_strings":["Institute of Neurobiology, Center of Brain Behavior and Metabolism, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurobiology, Center of Brain Behavior and Metabolism, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048849091","display_name":"Walter Raasch","orcid":"https://orcid.org/0000-0002-8781-2997","observed_orcids":["https://orcid.org/0000-0002-8781-2997"]},"institutions":[{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Walter Raasch","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","Institute for Experimental and Clinical Pharmacology and Toxicology, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute for Experimental and Clinical Pharmacology and Toxicology, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046127730","display_name":"Tanja Zeller","orcid":"https://orcid.org/0000-0003-3379-2641","observed_orcids":["https://orcid.org/0000-0003-3379-2641"]},"institutions":[{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tanja Zeller","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","Institute for Cardiogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute for Cardiogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152534573","display_name":"Harald Langer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Harald Langer","raw_affiliation_strings":["Cardiology, Angiology, Haemostaseology, and Medical Intensive Care, Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany","Cardiovascular Systems Biology, Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","European Center for AngioScience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","German Center for Cardiovascular Research (DZHK) partner site Heidelberg/Mannheim, Germany","Helmholtz-Institute for Translational AngioCardioScience (HI-TAC), Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology, Angiology, Haemostaseology, and Medical Intensive Care, Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450","https://openalex.org/I4387153978"]},{"raw_affiliation_string":"Cardiovascular Systems Biology, Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450","https://openalex.org/I4387153978"]},{"raw_affiliation_string":"European Center for AngioScience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]},{"raw_affiliation_string":"German Center for Cardiovascular Research (DZHK) partner site Heidelberg/Mannheim, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Helmholtz-Institute for Translational AngioCardioScience (HI-TAC), Mannheim, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005325608","display_name":"Joerg Koehl","orcid":"https://orcid.org/0000-0003-1121-3178","observed_orcids":["https://orcid.org/0000-0003-1121-3178"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00f6rg K\u00f6hl","raw_affiliation_strings":["Institute for Systemic Inflammation Research, University of L\u00fcbeck, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1121-3178","affiliations":[{"raw_affiliation_string":"Institute for Systemic Inflammation Research, University of L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157843785","display_name":"Ingo Eitel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ingo Eitel","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5064522009"],"corresponding_institution_ids":["https://openalex.org/I4210112713","https://openalex.org/I4210127591","https://openalex.org/I9341345"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.8036999702453613,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.8036999702453613,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.19269999861717224,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c3a-receptor","display_name":"C3a receptor","score":0.949999988079071},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/leptin-resistance","display_name":"leptin resistance","score":0.9179999828338623},{"id":"https://openalex.org/keywords/leptin-receptor-neurons","display_name":"leptin receptor neurons","score":0.7480000257492065},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9039999842643738},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.8870000243186951},{"id":"https://openalex.org/keywords/diastolic-dysfunction","display_name":"diastolic dysfunction","score":0.8960000276565552},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cardiac-sympathetic-innervation","display_name":"cardiac sympathetic innervation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/bariatric-surgery","display_name":"bariatric surgery","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cardiometabolic-disease","display_name":"cardiometabolic disease","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.9007999897003174},{"id":"https://openalex.org/C14372207","wikidata":"https://www.wikidata.org/wiki/Q7072306","display_name":"Leptin receptor","level":4,"score":0.7781000137329102},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5705999732017517},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5652999877929688},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5496000051498413},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.44620001316070557},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.43140000104904175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42410001158714294},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41920000314712524},{"id":"https://openalex.org/C90582226","wikidata":"https://www.wikidata.org/wiki/Q424292","display_name":"Anaphylatoxin","level":4,"score":0.36980000138282776},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.3677000105381012},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.34929999709129333},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.33869999647140503},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.29589998722076416},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.26190000772476196},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.2558000087738037},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.25060001015663147}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.05.756676","doi":"https://doi.org/10.64898/2026.10.05.756676","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.756676","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.05.756676.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.05.756676","doi":"https://doi.org/10.64898/2026.10.05.756676","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.756676","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.05.756676.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2637971011","display_name":null,"funder_award_id":"394046768","funder_id":"https://openalex.org/F4320312069","funder_display_name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung"},{"id":"https://openalex.org/G2867604408","display_name":null,"funder_award_id":"SFB 1366","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8330628523","display_name":"SFB 1366: Vaskul\u00e4re Kontrolle der Organfunktion","funder_award_id":"394046768","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G9000844750","display_name":null,"funder_award_id":"81Z0700107","funder_id":"https://openalex.org/F4320312069","funder_display_name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung"}],"funders":[{"id":"https://openalex.org/F4320312069","display_name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","ror":"https://ror.org/031t5w623"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320322414","display_name":"Universit\u00e4t zu L\u00fcbeck","ror":"https://ror.org/00t3r8h32"},{"id":"https://openalex.org/F4320326500","display_name":"Deutsche Gesellschaft f\u00fcr Kardiologie-Herz und Kreislaufforschung.","ror":"https://ror.org/02p22ad51"},{"id":"https://openalex.org/F4320334322","display_name":"HORIZON EUROPE Framework Programme","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220847541.pdf","grobid_xml":"https://content.openalex.org/works/W7220847541.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1585045992","https://openalex.org/W1916876466","https://openalex.org/W1964562779","https://openalex.org/W1986385659","https://openalex.org/W2021127134","https://openalex.org/W2029999922","https://openalex.org/W2040930644","https://openalex.org/W2041710499","https://openalex.org/W2041872947","https://openalex.org/W2044722821","https://openalex.org/W2077033935","https://openalex.org/W2077335475","https://openalex.org/W2091795452","https://openalex.org/W2093249614","https://openalex.org/W2097954820","https://openalex.org/W2103581424","https://openalex.org/W2117007075","https://openalex.org/W2120790798","https://openalex.org/W2134070809","https://openalex.org/W2137601030","https://openalex.org/W2139223838","https://openalex.org/W2150790437","https://openalex.org/W2154696002","https://openalex.org/W2160447524","https://openalex.org/W2160824260","https://openalex.org/W2168344829","https://openalex.org/W2567620261","https://openalex.org/W2625982645","https://openalex.org/W2727793071","https://openalex.org/W2767013543","https://openalex.org/W2804727859","https://openalex.org/W2922528877","https://openalex.org/W2937229868","https://openalex.org/W2966964832","https://openalex.org/W2981562683","https://openalex.org/W3000176126","https://openalex.org/W3091416909","https://openalex.org/W3118623772","https://openalex.org/W3169929588","https://openalex.org/W3198439879","https://openalex.org/W3208416565","https://openalex.org/W4306766297","https://openalex.org/W4318038341","https://openalex.org/W4327549443","https://openalex.org/W4377227292","https://openalex.org/W4386154055","https://openalex.org/W4389386888","https://openalex.org/W4393255879","https://openalex.org/W4394875155","https://openalex.org/W4399057077","https://openalex.org/W4406205125","https://openalex.org/W4409290969","https://openalex.org/W4412743232","https://openalex.org/W7125521586"],"related_works":["https://openalex.org/W4413236408","https://openalex.org/W2123597656","https://openalex.org/W2578450913","https://openalex.org/W4404437848","https://openalex.org/W7097917950","https://openalex.org/W3016759415","https://openalex.org/W2564191131","https://openalex.org/W4315784394","https://openalex.org/W4318953329","https://openalex.org/W2044170861"],"abstract_inverted_index":{"Abstract":[0],"Obesity":[1],"is":[2,32],"associated":[3,123],"with":[4,124],"hypothalamic":[5,159],"inflammation,":[6],"leptin":[7,53,59,68,92,160],"resistance":[8,161],"and":[9,57,73,76,90,107,139,162],"increased":[10],"cardiometabolic":[11,175],"risk,":[12],"but":[13],"the":[14,39],"neuroimmune":[15,155],"signals":[16,47],"linking":[17],"nutrient":[18],"excess":[19],"to":[20,43,158],"these":[21],"outcomes":[22],"remain":[23],"incompletely":[24],"defined.":[25],"Here":[26],"we":[27],"show":[28],"that":[29,46],"diet-induced":[30],"obesity":[31,138],"accompanied":[33],"by":[34],"local":[35],"complement":[36,132,167],"activation":[37,133],"in":[38,64,94,137,150,174],"mouse":[40],"hypothalamus,":[41],"leading":[42],"C3a":[44,49],"generation":[45],"through":[48],"receptor":[50,54],"(C3aR)":[51],"on":[52],"(ObRb)-expressing":[55],"neurons":[56,66,152],"blunts":[58],"signaling.":[60],"Deletion":[61],"of":[62,116],"C3aR":[63,85,100,148],"ObRb-expressing":[65,151],"preserves":[67],"responsiveness,":[69],"reduces":[70],"food":[71],"intake":[72],"weight":[74,88,121],"gain,":[75,122],"improves":[77,91],"glucose":[78],"homeostasis":[79],"during":[80],"dietary":[81],"challenge.":[82],"Systemic":[83],"pharmacological":[84,99],"targeting":[86,101],"induces":[87],"loss":[89],"responsiveness":[93],"established":[95],"obesity.":[96],"Genetic":[97],"or":[98],"also":[102],"attenuates":[103],"obesity-associated":[104,163],"diastolic":[105],"dysfunction":[106],"myocardial":[108],"fibrosis;":[109],"pair-feeding":[110],"experiments":[111],"reveal":[112],"an":[113],"additional":[114],"component":[115],"cardiac":[117,126,164],"protection":[118],"beyond":[119],"reduced":[120],"lower":[125],"sympathetic":[127],"innervation.":[128],"In":[129],"humans,":[130],"circulating":[131],"markers":[134],"are":[135],"elevated":[136],"decline":[140],"after":[141],"bariatric":[142],"surgery.":[143],"Together,":[144],"our":[145],"findings":[146],"identify":[147],"signaling":[149,168],"as":[153,169],"a":[154,170],"pathway":[156],"contributing":[157],"remodeling,":[165],"highlighting":[166],"potential":[171],"therapeutic":[172],"target":[173],"disease.":[176]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-08T00:00:00"}
