{"id":"https://openalex.org/W7220846327","doi":"https://doi.org/10.64898/2026.10.05.756742","title":"Sex-Dependent Microbiome-Metabolome Remodeling Associated with Bacteroides acidifaciens Modulation of Acute Respiratory Distress Syndrome","display_name":"Sex-Dependent Microbiome-Metabolome Remodeling Associated with Bacteroides acidifaciens Modulation of Acute Respiratory Distress Syndrome","publication_year":2026,"publication_date":"2026-10-06","ids":{"openalex":"https://openalex.org/W7220846327","doi":"https://doi.org/10.64898/2026.10.05.756742","pmid":"https://pubmed.ncbi.nlm.nih.gov/42926492","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13692127"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.05.756742","doi":"https://doi.org/10.64898/2026.10.05.756742","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.756742","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.05.756742.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.05.756742.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053330338","display_name":"Shanieka Caroline Staley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shanieka Staley","raw_affiliation_strings":["University of South Carolina School of Medicine, Department of Pathology, Microbiology, and Immunology, Columbia, South Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Carolina School of Medicine, Department of Pathology, Microbiology, and Immunology, Columbia, South Carolina, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157843522","display_name":"Carly Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carly Cooper","raw_affiliation_strings":["University of South Carolina, Department of Biological Sciences, Columbia, South Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Carolina, Department of Biological Sciences, Columbia, South Carolina, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107058770","display_name":"Stacey Oxendine","orcid":"https://orcid.org/0009-0006-3789-4337","observed_orcids":["https://orcid.org/0009-0006-3789-4337"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacey Oxendine","raw_affiliation_strings":["University of South Carolina School of Medicine, Department of Pathology, Microbiology, and Immunology, Columbia, South Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Carolina School of Medicine, Department of Pathology, Microbiology, and Immunology, Columbia, South Carolina, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157829685","display_name":"Jordan Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan Williams","raw_affiliation_strings":["University of South Carolina School of Medicine, Department of Pathology, Microbiology, and Immunology, Columbia, South Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Carolina School of Medicine, Department of Pathology, Microbiology, and Immunology, Columbia, South Carolina, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157792631","display_name":"Alissa Armstrong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alissa Armstrong","raw_affiliation_strings":["University of South Carolina, Department of Biological Sciences, Columbia, South Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Carolina, Department of Biological Sciences, Columbia, South Carolina, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077705410","display_name":"Kiesha Maria Wilson","orcid":"https://orcid.org/0000-0001-8550-3739","observed_orcids":["https://orcid.org/0000-0001-8550-3739"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kiesha Wilson","raw_affiliation_strings":["University of South Carolina School of Medicine, Department of Pathology, Microbiology, and Immunology, Columbia, South Carolina, USA"],"raw_orcid":"https://orcid.org/0000-0001-8550-3739","affiliations":[{"raw_affiliation_string":"University of South Carolina School of Medicine, Department of Pathology, Microbiology, and Immunology, Columbia, South Carolina, USA","institution_ids":["https://openalex.org/I155781252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5077705410"],"corresponding_institution_ids":["https://openalex.org/I155781252"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bacteroides-acidifaciens","display_name":"Bacteroides acidifaciens","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8889999985694885},{"id":"https://openalex.org/keywords/gut-lung-axis","display_name":"gut-lung axis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9760000109672546},{"id":"https://openalex.org/keywords/gut-metabolome","display_name":"gut metabolome","score":0.7360000014305115},{"id":"https://openalex.org/keywords/staphylococcal-enterotoxin-b","display_name":"staphylococcal enterotoxin B","score":0.9739999771118164},{"id":"https://openalex.org/keywords/lipid-mediators","display_name":"lipid mediators","score":0.7689999938011169},{"id":"https://openalex.org/keywords/bile-acids","display_name":"bile acids","score":0.7080000042915344},{"id":"https://openalex.org/keywords/redox-metabolism","display_name":"redox metabolism","score":0.8330000042915344},{"id":"https://openalex.org/keywords/butyrate","display_name":"butyrate","score":0.871999979019165},{"id":"https://openalex.org/keywords/sphingolipids","display_name":"sphingolipids","score":0.9160000085830688},{"id":"https://openalex.org/keywords/akkermansia","display_name":"Akkermansia","score":0.9259999990463257},{"id":"https://openalex.org/keywords/lachnospiraceae","display_name":"Lachnospiraceae","score":0.9480000138282776},{"id":"https://openalex.org/keywords/commensal-bacteria","display_name":"commensal bacteria","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C2778168646","wikidata":"https://www.wikidata.org/wiki/Q133186","display_name":"Bacteroides","level":3,"score":0.6090999841690063},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5534999966621399},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5516999959945679},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5379999876022339},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5210000276565552},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5090000033378601},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.48080000281333923},{"id":"https://openalex.org/C2776357993","wikidata":"https://www.wikidata.org/wiki/Q4840030","display_name":"Bacteroidaceae","level":3,"score":0.45170000195503235},{"id":"https://openalex.org/C2776979534","wikidata":"https://www.wikidata.org/wiki/Q193213","display_name":"Butyrate","level":3,"score":0.384799987077713},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.37059998512268066},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.3610000014305115},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.3508000075817108},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.34529998898506165},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3319000005722046},{"id":"https://openalex.org/C2780027724","wikidata":"https://www.wikidata.org/wiki/Q288892","display_name":"Ruminococcus","level":3,"score":0.32429999113082886},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.3158000111579895},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.31470000743865967},{"id":"https://openalex.org/C66999527","wikidata":"https://www.wikidata.org/wiki/Q421978","display_name":"Enterotoxin","level":4,"score":0.30970001220703125},{"id":"https://openalex.org/C2775941767","wikidata":"https://www.wikidata.org/wiki/Q15020908","display_name":"Akkermansia muciniphila","level":3,"score":0.29899999499320984},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.29809999465942383},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2913999855518341},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.29010000824928284},{"id":"https://openalex.org/C2781092032","wikidata":"https://www.wikidata.org/wiki/Q327663","display_name":"Clostridium","level":3,"score":0.28929999470710754},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.28600001335144043},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.28519999980926514},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.2849999964237213},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.28439998626708984},{"id":"https://openalex.org/C2779704485","wikidata":"https://www.wikidata.org/wiki/Q3825240","display_name":"Lachnospiraceae","level":5,"score":0.263700008392334},{"id":"https://openalex.org/C2780960513","wikidata":"https://www.wikidata.org/wiki/Q2720082","display_name":"Fusobacterium","level":4,"score":0.2597000002861023},{"id":"https://openalex.org/C2993183539","wikidata":"https://www.wikidata.org/wiki/Q754447","display_name":"Respiratory infection","level":3,"score":0.2500999867916107}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.10.05.756742","doi":"https://doi.org/10.64898/2026.10.05.756742","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.756742","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.05.756742.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13692127","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42926492/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13692127/pdf/nihpp-2026.10.05.756742v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42926492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42926492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.10.05.756742","doi":"https://doi.org/10.64898/2026.10.05.756742","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.756742","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.05.756742.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4790470846","display_name":"Dietary Supplements and Inflammation Phase-2","funder_award_id":"P20GM103641","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220846327.pdf","grobid_xml":"https://content.openalex.org/works/W7220846327.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1611854178","https://openalex.org/W1966452335","https://openalex.org/W1999906527","https://openalex.org/W2004806399","https://openalex.org/W2044216294","https://openalex.org/W2048469790","https://openalex.org/W2049506766","https://openalex.org/W2147243248","https://openalex.org/W2172560158","https://openalex.org/W2203446178","https://openalex.org/W2262277611","https://openalex.org/W2343917624","https://openalex.org/W2517943671","https://openalex.org/W2640475594","https://openalex.org/W2735904471","https://openalex.org/W2757397722","https://openalex.org/W2799932150","https://openalex.org/W2887026479","https://openalex.org/W2921966151","https://openalex.org/W2936757566","https://openalex.org/W3173264701","https://openalex.org/W3203151570","https://openalex.org/W4365136893","https://openalex.org/W4382813147","https://openalex.org/W4385216881","https://openalex.org/W4389199433","https://openalex.org/W4390587464","https://openalex.org/W4391880427","https://openalex.org/W4409886207","https://openalex.org/W4414397946"],"related_works":["https://openalex.org/W4414397946","https://openalex.org/W4311446918","https://openalex.org/W4410274017","https://openalex.org/W4221113016","https://openalex.org/W3217556680","https://openalex.org/W4408874750","https://openalex.org/W7161560487","https://openalex.org/W4206062543","https://openalex.org/W4413832583","https://openalex.org/W4313503887"],"abstract_inverted_index":{"Abstract":[0],"Acute":[1],"respiratory":[2],"distress":[3],"syndrome":[4],"(ARDS)":[5],"is":[6,219],"a":[7,150,203,220,240,312],"severe":[8],"lung":[9,208],"disorder":[10],"influenced":[11],"by":[12,154],"the":[13,16,41,65,236,263],"interplay":[14],"between":[15],"intestinal":[17,66,138,277],"microbiome,":[18],"host":[19,199],"metabolism,":[20],"and":[21,68,86,99,112,127,134,145,157,164,173,181,188,210,227,257,265,279,284,289,319,333],"immune":[22,247,266],"function.":[23],"We":[24],"previously":[25],"found":[26],"that":[27,198,244],"Bacteroides":[28,80,271],"acidifaciens":[29,81,272],"(BA)":[30],"has":[31,233],"opposing":[32],"effects":[33],"on":[34],"staphylococcal":[35],"enterotoxin":[36],"B":[37],"(SEB)-induced":[38],"ARDS,":[39,288],"worsening":[40],"condition":[42],"in":[43,49,64,131,142,159,184,193,282,305,330],"female":[44,283],"mice":[45,72,286],"while":[46,309],"alleviating":[47],"it":[48],"males.":[50,194],"This":[51],"study":[52],"aimed":[53],"to":[54,61,212,235],"examine":[55],"whether":[56],"these":[57],"outcomes":[58,332],"are":[59],"linked":[60],"sex-dependent":[62,110],"changes":[63,141],"microbiome":[67,139,264],"gut-lung":[69,237],"metabolome.":[70],"C3H/HeJ":[71],"of":[73,179,242,293],"both":[74,262,295],"sexes":[75],"were":[76,91],"orally":[77],"colonized":[78],"with":[79,120,224,316],"before":[82],"SEB":[83],"exposure.":[84],"Stool":[85],"bronchoalveolar":[87],"lavage":[88],"fluid":[89],"(BALF)":[90],"collected":[92],"for":[93,214,326,334],"analysis":[94],"using":[95],"16S":[96],"rRNA":[97],"sequencing":[98],"untargeted":[100],"liquid":[101],"chromatography":[102],"mass":[103],"spectrometry":[104],"metabolomics.":[105],"Our":[106],"findings":[107,323],"revealed":[108],"distinct":[109,177],"metabolic":[111,280,313],"microbial":[113,171,278],"responses.":[114,248],"In":[115],"females,":[116],"disease":[117],"exacerbation":[118],"correlated":[119],"elevated":[121],"lipid":[122,180,307],"mediators":[123],"(leukotriene":[124],"B4,":[125],"13-oxoODE,":[126],"13S-HODE)":[128],"alongside":[129],"shifts":[130],"bile":[132],"acid":[133,191],"redox":[135,182],"metabolism.":[136],"The":[137],"showed":[140,149],"Bacteroides,":[143],"Akkermansia,":[144],"Lachnospiraceae.":[146],"Conversely,":[147],"males":[148,310],"protective":[151],"phenotype":[152],"characterized":[153],"increased":[155],"butyrate":[156],"alterations":[158],"sphingolipid,":[160],"amino":[161],"acid,":[162],"redox,":[163],"nucleotide":[165],"pathways.":[166],"Integrated":[167],"analyses":[168],"identified":[169],"sex-associated":[170],"communities":[172],"metabolomic":[174],"profiles,":[175],"highlighting":[176],"patterns":[178,192],"associations":[183],"females":[185],"versus":[186],"sphingolipid":[187],"short-chain":[189],"fatty":[190],"These":[195,322],"results":[196],"suggest":[197],"sex":[200,260],"influences":[201],"how":[202,250,258,294],"commensal":[204,252],"bacterium":[205],"affects":[206],"inflammatory":[207,222,306],"injury":[209],"point":[211],"pathways":[213],"future":[215],"research.":[216],"Importance":[217],"ARDS":[218,298,331],"fatal":[221],"response":[223,267],"high":[225],"mortality":[226],"limited":[228],"targeted":[229],"therapies.":[230],"Emerging":[231],"evidence":[232,292],"pointed":[234],"axis":[238],"as":[239],"source":[241],"inflammation":[243],"shapes":[245],"pulmonary":[246],"Yet,":[249],"individual":[251],"bacteria":[253],"influence":[254],"this":[255],"axis,":[256],"biological":[259],"alters":[261],"remains":[268],"poorly":[269],"understood.":[270],",":[273],"drives":[274],"fundamentally":[275],"different":[276],"states":[281],"male":[285],"during":[287],"provides":[290],"some":[291],"can":[296],"impact":[297],"outcomes.":[299],"Females":[300],"develop":[301],"an":[302],"environment":[303],"enriched":[304],"mediators,":[308],"exhibit":[311],"profile":[314],"associated":[315],"barrier":[317],"support":[318],"reduced":[320],"inflammation.":[321],"have":[324],"implications":[325],"understanding":[327],"sex-based":[328],"differences":[329],"identifying":[335],"microbiome-targeted":[336],"therapeutic":[337],"strategies.":[338]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-08T00:00:00"}