{"id":"https://openalex.org/W7220846206","doi":"https://doi.org/10.3389/fsysb.2026.1903662","title":"Addressing biomedical complexity using the energy systems language","display_name":"Addressing biomedical complexity using the energy systems language","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220846206","doi":"https://doi.org/10.3389/fsysb.2026.1903662","pmid":"https://pubmed.ncbi.nlm.nih.gov/42908843","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13683192"},"language":"en","primary_location":{"id":"doi:10.3389/fsysb.2026.1903662","doi":"https://doi.org/10.3389/fsysb.2026.1903662","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fsysb.2026.1903662","pdf_url":"https://www.frontiersin.org/journals/systems-biology/articles/10.3389/fsysb.2026.1903662/pdf","source":{"id":"https://openalex.org/S4386621871","display_name":"Frontiers in Systems Biology","issn_l":"2674-0702","issn":["2674-0702"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Systems Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/systems-biology/articles/10.3389/fsysb.2026.1903662/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117692937","display_name":"Federico Surra","orcid":"https://orcid.org/0009-0001-8685-2284","observed_orcids":["https://orcid.org/0009-0001-8685-2284"]},"institutions":[{"id":"https://openalex.org/I149461666","display_name":"Ca' Foscari University of Venice","ror":"https://ror.org/04yzxz566","country_code":"IT","type":"education","lineage":["https://openalex.org/I149461666"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Federico Surra","raw_affiliation_strings":["DMSN-Department of Molecular Sciences and Nanosystems, Ca\u2019 Foscari University of Venice","NICHE-Centre for Environmental Humanities, Ca\u2019 Foscari University of Venice","SMAC-Centre for the Study of the Systemic Dynamics of Complex Diseases, Ca\u2019 Foscari University of Venice"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DMSN-Department of Molecular Sciences and Nanosystems, Ca\u2019 Foscari University of Venice","institution_ids":["https://openalex.org/I149461666"]},{"raw_affiliation_string":"NICHE-Centre for Environmental Humanities, Ca\u2019 Foscari University of Venice","institution_ids":["https://openalex.org/I149461666"]},{"raw_affiliation_string":"SMAC-Centre for the Study of the Systemic Dynamics of Complex Diseases, Ca\u2019 Foscari University of Venice","institution_ids":["https://openalex.org/I149461666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009338340","display_name":"Francesco Gonella","orcid":"https://orcid.org/0000-0001-8504-5301","observed_orcids":["https://orcid.org/0000-0001-8504-5301"]},"institutions":[{"id":"https://openalex.org/I149461666","display_name":"Ca' Foscari University of Venice","ror":"https://ror.org/04yzxz566","country_code":"IT","type":"education","lineage":["https://openalex.org/I149461666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Gonella","raw_affiliation_strings":["DMSN-Department of Molecular Sciences and Nanosystems, Ca\u2019 Foscari University of Venice","NICHE-Centre for Environmental Humanities, Ca\u2019 Foscari University of Venice","SMAC-Centre for the Study of the Systemic Dynamics of Complex Diseases, Ca\u2019 Foscari University of Venice"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DMSN-Department of Molecular Sciences and Nanosystems, Ca\u2019 Foscari University of Venice","institution_ids":["https://openalex.org/I149461666"]},{"raw_affiliation_string":"NICHE-Centre for Environmental Humanities, Ca\u2019 Foscari University of Venice","institution_ids":["https://openalex.org/I149461666"]},{"raw_affiliation_string":"SMAC-Centre for the Study of the Systemic Dynamics of Complex Diseases, Ca\u2019 Foscari University of Venice","institution_ids":["https://openalex.org/I149461666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052428074","display_name":"Luigi Conte","orcid":"https://orcid.org/0000-0001-7284-7524","observed_orcids":["https://orcid.org/0000-0001-7284-7524"]},"institutions":[{"id":"https://openalex.org/I149461666","display_name":"Ca' Foscari University of Venice","ror":"https://ror.org/04yzxz566","country_code":"IT","type":"education","lineage":["https://openalex.org/I149461666"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Luigi Conte","raw_affiliation_strings":["DAIS-Department of Environmental Sciences, Informatics and Statistics, Ca\u2019 Foscari University of Venice","NICHE-Centre for Environmental Humanities, Ca\u2019 Foscari University of Venice"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DAIS-Department of Environmental Sciences, Informatics and Statistics, Ca\u2019 Foscari University of Venice","institution_ids":["https://openalex.org/I149461666"]},{"raw_affiliation_string":"NICHE-Centre for Environmental Humanities, Ca\u2019 Foscari University of Venice","institution_ids":["https://openalex.org/I149461666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018769545","display_name":"Alessandra Romano","orcid":"https://orcid.org/0000-0002-6333-4433","observed_orcids":["https://orcid.org/0000-0002-6333-4433"]},"institutions":[{"id":"https://openalex.org/I149461666","display_name":"Ca' Foscari University of Venice","ror":"https://ror.org/04yzxz566","country_code":"IT","type":"education","lineage":["https://openalex.org/I149461666"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Romano","raw_affiliation_strings":["Department of General Surgery and Medical\u2010Surgical Specialties, University of Catania","NICHE-Centre for Environmental Humanities, Ca\u2019 Foscari University of Venice"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery and Medical\u2010Surgical Specialties, University of Catania","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"NICHE-Centre for Environmental Humanities, Ca\u2019 Foscari University of Venice","institution_ids":["https://openalex.org/I149461666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052428074","https://openalex.org/A5117692937"],"corresponding_institution_ids":["https://openalex.org/I149461666"],"apc_list":{"value":1950,"currency":"CHF","value_usd":2353},"apc_paid":{"value":1950,"currency":"CHF","value_usd":2353},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.70247868,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":null,"first_page":"1903662","last_page":"1903662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14299","display_name":"Complex Systems and Dynamics","score":0.24120000004768372,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14299","display_name":"Complex Systems and Dynamics","score":0.24120000004768372,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.18700000643730164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12391","display_name":"Artificial Immune Systems Applications","score":0.17499999701976776,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adaptive-immune-response","display_name":"adaptive immune response","score":0.7829999923706055},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.9829999804496765},{"id":"https://openalex.org/keywords/long-lived-plasma-cells","display_name":"long-lived plasma cells","score":0.902999997138977},{"id":"https://openalex.org/keywords/antibody-secretion","display_name":"immunoglobulin secretion","score":0.9700000286102295},{"id":"https://openalex.org/keywords/immunoinformatics","display_name":"immunoinformatics","score":0.492000013589859},{"id":"https://openalex.org/keywords/carrying-capacity","display_name":"carrying capacity","score":0.5550000071525574},{"id":"https://openalex.org/keywords/resource-availability","display_name":"resource availability","score":0.6240000128746033},{"id":"https://openalex.org/keywords/lymphoid-malignancies","display_name":"lymphoid malignancies","score":0.8349999785423279},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.8149999976158142},{"id":"https://openalex.org/keywords/patient-specific-therapy","display_name":"patient-specific therapy","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6589999794960022},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.459199994802475},{"id":"https://openalex.org/C186370098","wikidata":"https://www.wikidata.org/wiki/Q442787","display_name":"Energy (signal processing)","level":2,"score":0.45739999413490295},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.4343000054359436},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.4318999946117401},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.40709999203681946},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.36390000581741333},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.3560999929904938},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.3384999930858612},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.30250000953674316},{"id":"https://openalex.org/C77405623","wikidata":"https://www.wikidata.org/wiki/Q598451","display_name":"System dynamics","level":2,"score":0.29120001196861267},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.28690001368522644},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.2809000015258789},{"id":"https://openalex.org/C47822265","wikidata":"https://www.wikidata.org/wiki/Q854457","display_name":"Complex system","level":2,"score":0.27619999647140503},{"id":"https://openalex.org/C179603123","wikidata":"https://www.wikidata.org/wiki/Q1941921","display_name":"Modeling language","level":3,"score":0.2720000147819519},{"id":"https://openalex.org/C107457646","wikidata":"https://www.wikidata.org/wiki/Q207434","display_name":"Human\u2013computer interaction","level":1,"score":0.26840001344680786},{"id":"https://openalex.org/C141218545","wikidata":"https://www.wikidata.org/wiki/Q7521336","display_name":"Simulation language","level":2,"score":0.2597000002861023},{"id":"https://openalex.org/C63108463","wikidata":"https://www.wikidata.org/wiki/Q581233","display_name":"Complex adaptive system","level":2,"score":0.2565999925136566}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fsysb.2026.1903662","doi":"https://doi.org/10.3389/fsysb.2026.1903662","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fsysb.2026.1903662","pdf_url":"https://www.frontiersin.org/journals/systems-biology/articles/10.3389/fsysb.2026.1903662/pdf","source":{"id":"https://openalex.org/S4386621871","display_name":"Frontiers in Systems Biology","issn_l":"2674-0702","issn":["2674-0702"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Systems Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13683192","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13683192/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13683192/pdf/fsysb-06-1903662.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Syst Biol","raw_type":"Text"},{"id":"pmid:42908843","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42908843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in systems biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0dfe4e07e6bb457887b039e7a5a4f570","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0dfe4e07e6bb457887b039e7a5a4f570","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Systems Biology, Vol 6 (2026)","raw_type":"article"},{"id":"pmh:oai:freidok.uni-freiburg.de:288927","doi":null,"is_oa":false,"landing_page_url":"https://freidok.uni-freiburg.de/data/288927","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Systems Biology. - 6 (2026) , ISSN: 2674-0702","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fsysb.2026.1903662","doi":"https://doi.org/10.3389/fsysb.2026.1903662","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fsysb.2026.1903662","pdf_url":"https://www.frontiersin.org/journals/systems-biology/articles/10.3389/fsysb.2026.1903662/pdf","source":{"id":"https://openalex.org/S4386621871","display_name":"Frontiers in Systems Biology","issn_l":"2674-0702","issn":["2674-0702"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220846206.pdf","grobid_xml":"https://content.openalex.org/works/W7220846206.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1507160172","https://openalex.org/W1571190010","https://openalex.org/W1577444491","https://openalex.org/W1874198475","https://openalex.org/W1967874296","https://openalex.org/W1977738976","https://openalex.org/W1980207416","https://openalex.org/W1986024900","https://openalex.org/W1994965846","https://openalex.org/W2002116790","https://openalex.org/W2012344554","https://openalex.org/W2025808088","https://openalex.org/W2033760933","https://openalex.org/W2034832824","https://openalex.org/W2043044267","https://openalex.org/W2048463061","https://openalex.org/W2059214352","https://openalex.org/W2060467993","https://openalex.org/W2062533676","https://openalex.org/W2068907790","https://openalex.org/W2096296714","https://openalex.org/W2106353254","https://openalex.org/W2114003068","https://openalex.org/W2128395962","https://openalex.org/W2155581408","https://openalex.org/W2232841288","https://openalex.org/W2763006513","https://openalex.org/W2901823815","https://openalex.org/W3118815801","https://openalex.org/W3189727915","https://openalex.org/W4210796579","https://openalex.org/W4211058750","https://openalex.org/W4244360209","https://openalex.org/W4254358219","https://openalex.org/W4385791029","https://openalex.org/W4388487446","https://openalex.org/W4390541499","https://openalex.org/W4401487594","https://openalex.org/W4412107901","https://openalex.org/W4413447918","https://openalex.org/W4413972726","https://openalex.org/W7128639265","https://openalex.org/W7152208679"],"related_works":["https://openalex.org/W7099738117","https://openalex.org/W23955172","https://openalex.org/W18669975","https://openalex.org/W2401967367","https://openalex.org/W194276096","https://openalex.org/W2102179751","https://openalex.org/W2147703845","https://openalex.org/W2239196911","https://openalex.org/W2054684559","https://openalex.org/W7208714765"],"abstract_inverted_index":{"Biological":[0],"complex":[1,162],"systems":[2,53],"self-organize":[3],"and":[4,41,79,113,134,147,167],"evolve":[5],"through":[6],"feedback-driven":[7],"interactions":[8],"not":[9],"adequately":[10],"captured":[11],"by":[12,76],"linear":[13],"cause-effect":[14],"models.":[15],"To":[16],"address":[17,85],"this":[18,92,157],"gap,":[19],"we":[20],"propose":[21],"a":[22,33,101,122],"novel":[23],"approach":[24,93],"grounded":[25],"in":[26,51,150],"Energy":[27],"Systems":[28],"Language":[29],"(ESL).":[30],"It":[31],"provides":[32],"description":[34],"of":[35,61,103,128,141,153,161],"how":[36],"resource":[37],"availability,":[38],"carrying":[39],"capacity":[40],"feedback":[42],"networks":[43],"shape":[44],"the":[45,56,59,95,104,151],"system":[46],"trajectories.":[47],"ESL":[48],"is":[49],"rooted":[50],"open":[52],"Thermodynamics,":[54],"shifting":[55],"focus":[57],"from":[58],"biology":[60],"events":[62],"to":[63,94,107,116],"their":[64],"systemic":[65],"structure.":[66],"Models":[67],"are":[68],"built":[69],"on":[70,179],"biomedical":[71],"knowledge,":[72],"with":[73],"parameters":[74],"determined":[75],"empirical":[77],"observation":[78],"biophysical":[80],"constraints,":[81],"producing":[82],"simulators":[83],"that":[84],"\"what":[86],"if\"":[87],"exploratory":[88],"questions.":[89],"We":[90,120],"applied":[91],"antigen-specific":[96],"adaptive":[97],"immune":[98],"response":[99,115],"as":[100],"proof-of-concept":[102],"framework":[105],"designed":[106],"investigate":[108],"system-level":[109],"dynamic":[110],"regime":[111],"stability":[112],"qualitative":[114],"external":[117],"driving":[118],"forces.":[119],"developed":[121],"computational":[123,174],"simulator":[124],"reproducing":[125],"hallmark":[126],"features":[127],"humoral":[129],"immunity":[130],"at":[131],"daily,":[132],"monthly":[133],"decadal":[135],"time-scales,":[136],"including":[137],"germinal-center":[138],"dynamics,":[139],"establishment":[140],"long-lived":[142],"plasma":[143],"cells,":[144],"antibody":[145],"secretion,":[146],"long-term":[148],"decline":[149],"absence":[152],"antigen":[154],"re-exposure.":[155],"Using":[156],"approach,":[158],"future":[159],"investigations":[160],"pathologies,":[163],"e.g.,":[164],"lymphoid":[165],"malignancies":[166],"autoimmune":[168],"diseases,":[169],"can":[170],"be":[171],"developed,":[172],"providing":[173],"tools":[175],"for":[176],"testing":[177],"hypotheses":[178],"patient-specific":[180],"therapeutic":[181],"strategies.":[182]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-08T00:00:00"}