{"id":"https://openalex.org/W7220841505","doi":"https://doi.org/10.64898/2026.10.06.757084","title":"Lipid acyl chain remodeling governs KRAS nanoclustering and oncogenic functions through membrane composition control","display_name":"Lipid acyl chain remodeling governs KRAS nanoclustering and oncogenic functions through membrane composition control","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220841505","doi":"https://doi.org/10.64898/2026.10.06.757084","pmid":"https://pubmed.ncbi.nlm.nih.gov/42926664","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13692196"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.06.757084","doi":"https://doi.org/10.64898/2026.10.06.757084","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.757084","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.06.757084.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.06.757084.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040281214","display_name":"Neha Arora","orcid":"https://orcid.org/0000-0001-9198-8744","observed_orcids":["https://orcid.org/0000-0001-9198-8744"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Neha Arora","raw_affiliation_strings":["Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center, Houston, Texas, USA"],"raw_orcid":"https://orcid.org/0000-0001-9198-8744","affiliations":[{"raw_affiliation_string":"Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009296454","display_name":"Rafael Bravo","orcid":"https://orcid.org/0000-0001-6732-2205","observed_orcids":["https://orcid.org/0000-0001-6732-2205"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rafael S. Bravo","raw_affiliation_strings":["The Institute for Clinical Research & Learning Health Care, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA"],"raw_orcid":"https://orcid.org/0000-0001-6732-2205","affiliations":[{"raw_affiliation_string":"The Institute for Clinical Research & Learning Health Care, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157859503","display_name":"Hong Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Liang","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004242684","display_name":"Jeffrey T. Chang","orcid":"https://orcid.org/0000-0002-4578-5636","observed_orcids":["https://orcid.org/0000-0002-4578-5636"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey T. Chang","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA","Graduate School of Biological Sciences, MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"Graduate School of Biological Sciences, MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157858789","display_name":"Alex Reed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Reed","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, La Jolla, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, La Jolla, San Diego, California, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157885524","display_name":"Junchen Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junchen Liu","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157835316","display_name":"Benjamin Cravatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin F. Cravatt","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, La Jolla, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, La Jolla, San Diego, California, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078004886","display_name":"Haoqiang Ying","orcid":"https://orcid.org/0000-0003-0616-2310","observed_orcids":["https://orcid.org/0000-0003-0616-2310"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haoqiang Ying","raw_affiliation_strings":["Department of Molecular and Cellular Oncology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Oncology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062460881","display_name":"Claudia Pedroza","orcid":"https://orcid.org/0000-0003-4235-1282","observed_orcids":["https://orcid.org/0000-0003-4235-1282"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudia Pedroza","raw_affiliation_strings":["The Institute for Clinical Research & Learning Health Care, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute for Clinical Research & Learning Health Care, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007222475","display_name":"Yong Zhou","orcid":"https://orcid.org/0000-0002-0214-8151","observed_orcids":["https://orcid.org/0000-0002-0214-8151"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Zhou","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA","Graduate School of Biological Sciences, MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas, USA"],"raw_orcid":"https://orcid.org/0000-0002-0214-8151","affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"Graduate School of Biological Sciences, MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040281214"],"corresponding_institution_ids":["https://openalex.org/I919571938"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6747999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6747999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.22179999947547913,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.056699998676776886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.9150000214576721},{"id":"https://openalex.org/keywords/nanoclustering","display_name":"nanoclustering","score":0.7459999918937683},{"id":"https://openalex.org/keywords/membrane-composition","display_name":"membrane composition","score":0.6359999775886536},{"id":"https://openalex.org/keywords/lpcat3","display_name":"LPCAT3","score":0.8450000286102295},{"id":"https://openalex.org/keywords/phosphatidylserine","display_name":"phosphatidylserine","score":0.8479999899864197},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.8640000224113464},{"id":"https://openalex.org/keywords/anionic-phospholipids","display_name":"anionic phospholipids","score":0.7870000004768372},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8140000104904175},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6284999847412109},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.5358999967575073},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5307000279426575},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5090000033378601},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5044000148773193},{"id":"https://openalex.org/C2780241833","wikidata":"https://www.wikidata.org/wiki/Q6556375","display_name":"Lipidome","level":3,"score":0.49559998512268066},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.4575999975204468},{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.45750001072883606},{"id":"https://openalex.org/C58017582","wikidata":"https://www.wikidata.org/wiki/Q6556376","display_name":"Lipidomics","level":2,"score":0.4327000081539154},{"id":"https://openalex.org/C2775970874","wikidata":"https://www.wikidata.org/wiki/Q2609152","display_name":"Acyltransferase","level":3,"score":0.4284000098705292},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4205000102519989},{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.41670000553131104},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.3840000033378601},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.36910000443458557},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.34869998693466187},{"id":"https://openalex.org/C146727910","wikidata":"https://www.wikidata.org/wiki/Q501620","display_name":"Palmitoylation","level":4,"score":0.33059999346733093},{"id":"https://openalex.org/C2779637612","wikidata":"https://www.wikidata.org/wiki/Q2354337","display_name":"Phosphatidylserine","level":4,"score":0.3147999942302704},{"id":"https://openalex.org/C2779403975","wikidata":"https://www.wikidata.org/wiki/Q24724230","display_name":"Caveolin","level":4,"score":0.3043999969959259},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.27250000834465027},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.2624000012874603}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.10.06.757084","doi":"https://doi.org/10.64898/2026.10.06.757084","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.757084","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.06.757084.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13692196","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13692196/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13692196/pdf/nihpp-2026.10.06.757084v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42926664","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42926664","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.10.06.757084","doi":"https://doi.org/10.64898/2026.10.06.757084","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.757084","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.06.757084.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1342469590","display_name":"Phosphatidylserine acyl chain remodeling regulates KRAS spatial distribution and function on the plasma membrane.","funder_award_id":"R01GM138668","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220841505.pdf","grobid_xml":"https://content.openalex.org/works/W7220841505.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1774371590","https://openalex.org/W1935919210","https://openalex.org/W1966981268","https://openalex.org/W1968075591","https://openalex.org/W1974083452","https://openalex.org/W1997183854","https://openalex.org/W2001090712","https://openalex.org/W2002490399","https://openalex.org/W2009718333","https://openalex.org/W2057632732","https://openalex.org/W2069269337","https://openalex.org/W2081990599","https://openalex.org/W2092973995","https://openalex.org/W2114138419","https://openalex.org/W2129653056","https://openalex.org/W2172885745","https://openalex.org/W2509677031","https://openalex.org/W2561607790","https://openalex.org/W2767424120","https://openalex.org/W2769577802","https://openalex.org/W2810715232","https://openalex.org/W2945161487","https://openalex.org/W2945901473","https://openalex.org/W2960060221","https://openalex.org/W3013377779","https://openalex.org/W3122102409","https://openalex.org/W3127157041","https://openalex.org/W3160230590","https://openalex.org/W3215191746","https://openalex.org/W4200340850","https://openalex.org/W4221112683","https://openalex.org/W4281794414","https://openalex.org/W4307637711","https://openalex.org/W4313455186","https://openalex.org/W4318338003","https://openalex.org/W4319310796","https://openalex.org/W4361204964","https://openalex.org/W4384664389","https://openalex.org/W4385830709","https://openalex.org/W4391684970","https://openalex.org/W4400606027","https://openalex.org/W4414183296","https://openalex.org/W4414183311","https://openalex.org/W4414321603","https://openalex.org/W7164896456"],"related_works":["https://openalex.org/W4399275933","https://openalex.org/W7164896456","https://openalex.org/W4393092329","https://openalex.org/W3171335757","https://openalex.org/W2791097681","https://openalex.org/W3203874650","https://openalex.org/W4417321508","https://openalex.org/W1968075591","https://openalex.org/W4214507957","https://openalex.org/W7095764142"],"abstract_inverted_index":{"KRAS":[0,43,96,111,123,152,171,198],"signaling":[1,105,153,187],"is":[2],"spatially":[3],"organized":[4],"within":[5],"the":[6,11,21,79],"dynamic":[7],"proteolipid":[8,148],"nanoclusters":[9],"on":[10],"plasma":[12],"membrane":[13,74,140,190],"(PM)":[14],"that":[15,62,71,150],"selectively":[16,161],"concentrate":[17],"anionic":[18],"phospholipids,":[19,68],"yet":[20],"molecular":[22],"determinants":[23],"governing":[24],"this":[25,157,174],"lipid":[26,130,177],"sorting":[27],"remain":[28],"incompletely":[29],"defined.":[30],"Here":[31],"we":[32,69],"identify":[33],"phospholipid":[34],"acyl":[35,75,141,178],"chain":[36,76,142,179],"composition":[37,143,191],"as":[38,144,181,192],"a":[39,59,126,145,182],"critical":[40],"regulator":[41,184],"of":[42,54,73,89,116,147,185],"spatial":[44],"organization":[45,149],"and":[46,51,99,101,106,165,188],"signal":[47],"output.":[48],"Using":[49],"genetic":[50],"pharmacological":[52],"perturbation":[53],"lysophosphatidylcholine":[55],"acyltransferase":[56],"3":[57],"(LPCAT3),":[58],"key":[60],"enzyme":[61],"incorporates":[63],"polyunsaturated":[64,92],"fatty":[65],"acids":[66],"into":[67],"demonstrate":[70],"remodeling":[72,180],"unsaturation":[77,131],"alters":[78],"phosphatidylserine":[80],"(PS)":[81],"lipidome":[82],"without":[83],"changing":[84],"total":[85],"PS":[86,93],"abundance.":[87],"Loss":[88],"LPCAT3":[90,159],"depletes":[91],"species,":[94],"disrupts":[95],"PM":[97],"association":[98],"nanoclustering,":[100,124],"attenuates":[102],"downstream":[103],"MAPK":[104],"oncogenic":[107,197],"activity":[108],"across":[109],"multiple":[110],"mutant":[112],"contexts.":[113],"Acute":[114],"restoration":[115],"polyunsaturated,":[117],"but":[118],"not":[119],"saturated,":[120],"lipids":[121],"rescue":[122],"establishing":[125],"direct":[127,170],"requirement":[128],"for":[129],"in":[132,196],"sustaining":[133],"signaling-competent":[134],"assemblies.":[135],"Mechanistically,":[136],"these":[137],"findings":[138],"define":[139],"determinant":[146],"encodes":[151],"capacity.":[154],"Consistent":[155],"with":[156],"model,":[158],"inhibition":[160],"impairs":[162],"KRAS-dependent":[163],"proliferation":[164],"sensitizes":[166],"tumor":[167],"cells":[168],"to":[169],"inhibition.":[172],"Together,":[173],"work":[175],"uncovers":[176],"fundamental":[183],"membrane-associated":[186],"identifies":[189],"an":[193],"exploitable":[194],"vulnerability":[195],"systems.":[199]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-08T00:00:00"}
