{"id":"https://openalex.org/W7220838731","doi":"https://doi.org/10.3389/fbioe.2026.1953510","title":"ZnPc(Lys)5-mediated photodynamic inactivation and reduction of Candida albicans biofilm-associated cells in vitro and in vivo","display_name":"ZnPc(Lys)5-mediated photodynamic inactivation and reduction of Candida albicans biofilm-associated cells in vitro and in vivo","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220838731","doi":"https://doi.org/10.3389/fbioe.2026.1953510","pmid":"https://pubmed.ncbi.nlm.nih.gov/42909076","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13683795"},"language":"en","primary_location":{"id":"doi:10.3389/fbioe.2026.1953510","doi":"https://doi.org/10.3389/fbioe.2026.1953510","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2026.1953510","pdf_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1953510/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1953510/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157859163","display_name":"Danlin Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Danlin Li","raw_affiliation_strings":["Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province and Fujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University","Institute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province and Fujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Institute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157799685","display_name":"Fang Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Yuan","raw_affiliation_strings":["Department of Stomatology, Cangshan Hospital, the 900Th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stomatology, Cangshan Hospital, the 900Th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001812456","display_name":"Yuchen Yang","orcid":"https://orcid.org/0000-0001-8122-3035","observed_orcids":["https://orcid.org/0000-0001-8122-3035"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuchen Yang","raw_affiliation_strings":["Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province and Fujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University","Institute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province and Fujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Institute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157838179","display_name":"Kangli Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kangli Zhou","raw_affiliation_strings":["Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province and Fujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University","Institute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province and Fujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Institute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157859174","display_name":"Fei Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Xie","raw_affiliation_strings":["Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province and Fujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University","Institute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province and Fujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Institute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157836773","display_name":"Zhiming Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiming Li","raw_affiliation_strings":["Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province and Fujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University","Institute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province and Fujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Institute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157799579","display_name":"Xiaoling Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoling Huang","raw_affiliation_strings":["College of Chemistry, Fuzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry, Fuzhou University","institution_ids":["https://openalex.org/I80947539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128885153","display_name":"Mingdong Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingdong Huang","raw_affiliation_strings":["College of Chemistry, Fuzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry, Fuzhou University","institution_ids":["https://openalex.org/I80947539"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157834271","display_name":"Minkui Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Minkui Lin","raw_affiliation_strings":["Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province and Fujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University","Institute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province and Fujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Institute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5128885153","https://openalex.org/A5157834271"],"corresponding_institution_ids":["https://openalex.org/I129708740","https://openalex.org/I80947539"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.68556677,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":"1953510","last_page":"1953510"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.02449999935925007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9150000214576721},{"id":"https://openalex.org/keywords/antimicrobial-photodynamic-therapy","display_name":"antimicrobial photodynamic therapy","score":0.8169999718666077},{"id":"https://openalex.org/keywords/candida-biofilms","display_name":"Candida biofilms","score":0.8009999990463257},{"id":"https://openalex.org/keywords/denture-base-materials","display_name":"denture base materials","score":0.6539999842643738},{"id":"https://openalex.org/keywords/stomatitis","display_name":"stomatitis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/antifungal-activity","display_name":"antifungal activity","score":0.7210000157356262},{"id":"https://openalex.org/keywords/photosensitizers","display_name":"photosensitizers","score":0.8259999752044678},{"id":"https://openalex.org/keywords/nystatin-comparison","display_name":"nystatin comparison","score":0.6129999756813049},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.49900001287460327},{"id":"https://openalex.org/keywords/epithelial-hyperplasia","display_name":"epithelial hyperplasia","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.8903999924659729},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7903000116348267},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.7749999761581421},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6585999727249146},{"id":"https://openalex.org/C2779051857","wikidata":"https://www.wikidata.org/wiki/Q911386","display_name":"Stomatitis","level":2,"score":0.6067000031471252},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6040999889373779},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.526199996471405},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.48559999465942383},{"id":"https://openalex.org/C2780941728","wikidata":"https://www.wikidata.org/wiki/Q17990675","display_name":"Cleanser","level":2,"score":0.4812000095844269},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.4171000123023987},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.3513999879360199},{"id":"https://openalex.org/C2777229883","wikidata":"https://www.wikidata.org/wiki/Q410534","display_name":"Miconazole","level":3,"score":0.30809998512268066},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2750000059604645},{"id":"https://openalex.org/C2780020223","wikidata":"https://www.wikidata.org/wiki/Q25323681","display_name":"Mucoadhesion","level":4,"score":0.271699994802475},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.26109999418258667},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.26080000400543213},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.2524000108242035}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbioe.2026.1953510","doi":"https://doi.org/10.3389/fbioe.2026.1953510","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2026.1953510","pdf_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1953510/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13683795","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13683795/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13683795/pdf/fbioe-14-1953510.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Bioeng Biotechnol","raw_type":"Text"},{"id":"pmid:42909076","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42909076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioengineering and biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:90bf5e94a11b4b7d981eaf0e0dd1cd9b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/90bf5e94a11b4b7d981eaf0e0dd1cd9b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioengineering and Biotechnology, Vol 14 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fbioe.2026.1953510","doi":"https://doi.org/10.3389/fbioe.2026.1953510","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2026.1953510","pdf_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1953510/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321878","display_name":"Natural Science Foundation of Fujian Province","ror":null},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"},{"id":"https://openalex.org/F4320336588","display_name":"Fujian Provincial Health Technology Project","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220838731.pdf","grobid_xml":"https://content.openalex.org/works/W7220838731.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1978958698","https://openalex.org/W1979896286","https://openalex.org/W1979953751","https://openalex.org/W2008706380","https://openalex.org/W2028297222","https://openalex.org/W2030759159","https://openalex.org/W2031201987","https://openalex.org/W2034836723","https://openalex.org/W2036704777","https://openalex.org/W2037591016","https://openalex.org/W2062374558","https://openalex.org/W2068081000","https://openalex.org/W2076994566","https://openalex.org/W2078566318","https://openalex.org/W2079214845","https://openalex.org/W2089855828","https://openalex.org/W2090865730","https://openalex.org/W2094417180","https://openalex.org/W2101493227","https://openalex.org/W2118992884","https://openalex.org/W2127002115","https://openalex.org/W2144322656","https://openalex.org/W2155908385","https://openalex.org/W2162335168","https://openalex.org/W2162773156","https://openalex.org/W2173327197","https://openalex.org/W2197205497","https://openalex.org/W2230608622","https://openalex.org/W2334096763","https://openalex.org/W2559941745","https://openalex.org/W2591084942","https://openalex.org/W2616603212","https://openalex.org/W2618896812","https://openalex.org/W2761342269","https://openalex.org/W2785933072","https://openalex.org/W2787578697","https://openalex.org/W2800142592","https://openalex.org/W2800208502","https://openalex.org/W2806055322","https://openalex.org/W2883082567","https://openalex.org/W2884145325","https://openalex.org/W2998934587","https://openalex.org/W3034483708","https://openalex.org/W3048763654","https://openalex.org/W3090533192","https://openalex.org/W3158193933","https://openalex.org/W3163647323","https://openalex.org/W3163952952","https://openalex.org/W3170933027","https://openalex.org/W3195743534","https://openalex.org/W4211024586","https://openalex.org/W4284883262","https://openalex.org/W4285732639","https://openalex.org/W4295185207","https://openalex.org/W4297905750","https://openalex.org/W4315853541","https://openalex.org/W4319758656","https://openalex.org/W4328102481","https://openalex.org/W4361296803","https://openalex.org/W4380082411","https://openalex.org/W4380088692","https://openalex.org/W4387459392","https://openalex.org/W4387898433","https://openalex.org/W4396625986","https://openalex.org/W4404054832","https://openalex.org/W4405082211","https://openalex.org/W4407156976","https://openalex.org/W4407909585","https://openalex.org/W4409523433","https://openalex.org/W4413971685"],"related_works":["https://openalex.org/W7216367262","https://openalex.org/W1994081232","https://openalex.org/W2015323254","https://openalex.org/W2954310156","https://openalex.org/W2773709097","https://openalex.org/W7070957318","https://openalex.org/W4406133272","https://openalex.org/W7140585942","https://openalex.org/W3217287396","https://openalex.org/W2897647667"],"abstract_inverted_index":{"Introduction":[0],"Candida-associated":[1,139],"stomatitis":[2,140],"is":[3,14,27],"a":[4,85,135,170,181,203,299],"common":[5,86],"oral":[6],"mucosal":[7,66,307],"condition,":[8],"particularly":[9],"among":[10],"denture":[11,23,87],"wearers,":[12],"and":[13,63,77,108,119,128,149,189,267,286,306],"closely":[15],"associated":[16,65],"with":[17,100,180],"persistent":[18],"Candida":[19,61,69,107],"albicans":[20,70,178],"biofilms":[21,62,78],"on":[22,81,122,175],"surfaces.":[24],"ZnPc(Lys)":[25,51,97,153,165,260,277,296],"5":[26,52,98,154,162,166,261,278,297],"an":[28],"amphiphilic":[29],"phthalocyanine\u2013peptide":[30],"nanomaterial":[31],"that":[32],"has":[33],"previously":[34],"been":[35],"shown":[36],"to":[37,143,219,274],"form":[38],"nanoscale":[39],"supramolecular":[40],"assemblies":[41],"in":[42,58,74,146,208,243,284,287],"aqueous":[43],"environments.":[44],"This":[45],"study":[46],"evaluated":[47],"the":[48,120,145,197,220,223],"efficacy":[49,151,221,272],"of":[50,93,96,138,152,186,205,222,236,259],"-mediated":[53,167],"antimicrobial":[54],"photodynamic":[55],"therapy":[56],"(aPDT)":[57],"reducing":[59],"denture-associated":[60],"alleviating":[64],"inflammation.":[67],"Methods":[68],"suspensions":[71],"were":[72,79,102,113,132,249],"cultured":[73],"vitro":[75,285],",":[76,179,256],"formed":[80],"polymethyl":[82],"methacrylate":[83],"(PMMA),":[84],"base":[88],"material.":[89],"The":[90],"antifungal":[91,150,282],"effects":[92,121],"different":[94],"concentrations":[95],"combined":[99],"aPDT":[101,168,200],"assessed":[103],"against":[104],"both":[105],"planktonic":[106,176],"biofilms.":[109],"Biofilm":[110],"structural":[111],"changes":[112],"observed":[114,191,250],"by":[115],"scanning":[116],"electron":[117,231],"microscopy,":[118],"PMMA":[123,244,291],"physical":[124],"properties":[125],"(microhardness":[126],"[HV]":[127],"surface":[129,247],"roughness":[130,248],"[Ra])":[131],"analyzed.":[133],"Additionally,":[134],"mouse":[136],"model":[137],"was":[141,217],"used":[142],"evaluate":[144],"vivo":[147,255,288],"anti-inflammatory":[148],"-aPDT":[155,262,279],"following":[156],"repeated":[157,257],"applications":[158,258],"(three":[159],"treatments":[160],"over":[161],"days).":[163],"Results":[164],"exerted":[169],"significant":[171,234,241,281],"concentration-dependent":[172],"fungicidal":[173],"effect":[174],"C.":[177],"minimum":[182],"effective":[183],"concentration":[184],"(MEC)":[185],"25":[187],"\u03bcM":[188,199],"no":[190,240],"dark":[192],"toxicity.":[193],"Against":[194],"mature":[195],"biofilms,":[196],"50":[198],"treatment":[201],"achieved":[202],"reduction":[204],"approximately":[206],"96%":[207],"recoverable":[209],"viable":[210],"biofilm-associated":[211],"cells":[212],"(P":[213,227,251],"<":[214],"0.0001),":[215],"which":[216],"comparable":[218,273],"commercial":[224],"cleanser":[225],"Polident":[226],">":[228,252],"0.05).":[229,253],"Scanning":[230],"microscopy":[232],"confirmed":[233],"disruption":[235],"biofilm":[237,304],"architecture,":[238],"while":[239],"alterations":[242],"microhardness":[245],"or":[246,315],"In":[254],"significantly":[263],"reduced":[264],"epithelial":[265],"hyperplasia":[266],"inflammatory":[268],"infiltration,":[269],"demonstrating":[270],"therapeutic":[271],"nystatin.":[275],"Conclusion":[276],"demonstrated":[280],"activity":[283],"without":[289],"compromising":[290],"integrity.":[292],"These":[293],"findings":[294],"support":[295],"as":[298],"promising":[300],"photosensitizer":[301],"for":[302],"denture-surface":[303],"control":[305],"inflammation":[308],"mitigation,":[309],"warranting":[310],"further":[311],"investigation":[312],"under":[313],"extended":[314],"multi-session":[316],"clinical":[317],"protocols.":[318]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-08T00:00:00"}