{"id":"https://openalex.org/W7220836726","doi":"https://doi.org/10.3389/fneur.2026.1870779","title":"Management of fragile X-associated tremor ataxia syndrome: a review for clinicians","display_name":"Management of fragile X-associated tremor ataxia syndrome: a review for clinicians","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220836726","doi":"https://doi.org/10.3389/fneur.2026.1870779","pmid":"https://pubmed.ncbi.nlm.nih.gov/42909313","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13684911"},"language":"en","primary_location":{"id":"doi:10.3389/fneur.2026.1870779","doi":"https://doi.org/10.3389/fneur.2026.1870779","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1870779","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1870779/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1870779/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101571010","display_name":"Deborah A. Hall","orcid":"https://orcid.org/0000-0003-2772-7851","observed_orcids":["https://orcid.org/0000-0003-2772-7851"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Deborah A. Hall","raw_affiliation_strings":["Department of Neurological Sciences, Rush University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical Center","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157858630","display_name":"David Andr\u00e9s Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Andr\u00e9s Gonz\u00e1lez","raw_affiliation_strings":["Department of Neurological Sciences, Rush University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical Center","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055780470","display_name":"Jessica Klusek","orcid":"https://orcid.org/0000-0002-2818-0344","observed_orcids":["https://orcid.org/0000-0002-2818-0344"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Klusek","raw_affiliation_strings":["Department of Communication Sciences and Disorders, University of South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Communication Sciences and Disorders, University of South Carolina","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001583322","display_name":"Peter K. Todd","orcid":"https://orcid.org/0000-0003-4781-6376","observed_orcids":["https://orcid.org/0000-0003-4781-6376"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210102099","display_name":"VA Ann Arbor Healthcare System","ror":"https://ror.org/018txrr13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210102099","https://openalex.org/I4210127612"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter K. Todd","raw_affiliation_strings":["Department of Neurology, University of Michigan","Veterans Administration Ann Arbor Healthcare System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Michigan","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Veterans Administration Ann Arbor Healthcare System","institution_ids":["https://openalex.org/I4210102099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056327011","display_name":"Joan A. O\u2019Keefe","orcid":"https://orcid.org/0000-0003-4018-7212","observed_orcids":["https://orcid.org/0000-0003-4018-7212"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan A. O\u2019Keefe","raw_affiliation_strings":["Department of Neurological Sciences, Rush University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical Center","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034582410","display_name":"Nell Maltman","orcid":"https://orcid.org/0000-0001-7874-9925","observed_orcids":["https://orcid.org/0000-0001-7874-9925"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nell Maltman","raw_affiliation_strings":["Department of Speech, Language and Hearing Sciences, University of Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Speech, Language and Hearing Sciences, University of Arizona","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041437511","display_name":"Federica Alice Maria Montanaro","orcid":"https://orcid.org/0000-0001-7293-2315","observed_orcids":["https://orcid.org/0000-0001-7293-2315"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Alice Maria Montanaro","raw_affiliation_strings":["Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari Aldo Moro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari Aldo Moro","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083677550","display_name":"Dragana D. Protic","orcid":"https://orcid.org/0000-0002-2137-5405","observed_orcids":["https://orcid.org/0000-0002-2137-5405"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Dragana Protic","raw_affiliation_strings":["Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade","institution_ids":["https://openalex.org/I4068193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055371991","display_name":"Laura Scorr","orcid":"https://orcid.org/0000-0002-4569-6393","observed_orcids":["https://orcid.org/0000-0002-4569-6393"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Scorr","raw_affiliation_strings":["Department of Neurology, Emory University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Emory University School of Medicine","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157836525","display_name":"Rabia Malik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rabia Malik","raw_affiliation_strings":["Department of Neurological Sciences, Rush University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical Center","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061582190","display_name":"Pierpaolo Turcano","orcid":"https://orcid.org/0000-0002-3240-8348","observed_orcids":["https://orcid.org/0000-0002-3240-8348"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pierpaolo Turcano","raw_affiliation_strings":["Department of Neurological Sciences, Rush University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical Center","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051376785","display_name":"Matthew S. Meyers","orcid":"https://orcid.org/0000-0002-1321-6850","observed_orcids":["https://orcid.org/0000-0002-1321-6850"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew S. Meyers","raw_affiliation_strings":["Department of Neurological Sciences, Rush University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical Center","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075173157","display_name":"Andreea L. Seritan","orcid":"https://orcid.org/0000-0001-9287-9056","observed_orcids":["https://orcid.org/0000-0001-9287-9056"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andreea Seritan","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, University of California, San Francisco","UCSF Weill Institute for Neurosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"UCSF Weill Institute for Neurosciences","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5101571010"],"corresponding_institution_ids":["https://openalex.org/I1285301757"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45626072,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1870779","last_page":"1870779"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.06300000101327896,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fragile-x-associated-tremor-ataxia-syndrome","display_name":"fragile X-associated tremor/ataxia syndrome","score":0.9819999933242798},{"id":"https://openalex.org/keywords/symptomatic-treatment","display_name":"symptomatic treatment","score":0.6769999861717224},{"id":"https://openalex.org/keywords/tremor","display_name":"tremor","score":0.699999988079071},{"id":"https://openalex.org/keywords/ataxia","display_name":"ataxia","score":0.8399999737739563},{"id":"https://openalex.org/keywords/parkinsonism","display_name":"parkinsonism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.9800000190734863},{"id":"https://openalex.org/keywords/psychiatric-symptoms","display_name":"psychiatric symptoms","score":0.906000018119812},{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"deep brain stimulation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/rehabilitation","display_name":"rehabilitation","score":0.5040000081062317},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.6710000038146973},{"id":"https://openalex.org/keywords/nutrition","display_name":"nutrition","score":0.6869999766349792},{"id":"https://openalex.org/keywords/multidisciplinary-care","display_name":"multidisciplinary care","score":0.8740000128746033},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7310000061988831},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.715399980545044},{"id":"https://openalex.org/C2780906641","wikidata":"https://www.wikidata.org/wiki/Q213373","display_name":"Ataxia","level":2,"score":0.5989000201225281},{"id":"https://openalex.org/C2778261627","wikidata":"https://www.wikidata.org/wiki/Q2608695","display_name":"Movement disorders","level":3,"score":0.5781999826431274},{"id":"https://openalex.org/C2908670167","wikidata":"https://www.wikidata.org/wiki/Q827017","display_name":"Gait Ataxia","level":3,"score":0.5412999987602234},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5349000096321106},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.5041000247001648},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4796000123023987},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.462799996137619},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45210000872612},{"id":"https://openalex.org/C2780112193","wikidata":"https://www.wikidata.org/wiki/Q693519","display_name":"Essential tremor","level":2,"score":0.4374000132083893},{"id":"https://openalex.org/C2780294739","wikidata":"https://www.wikidata.org/wiki/Q2149420","display_name":"Intention tremor","level":3,"score":0.39419999718666077},{"id":"https://openalex.org/C2780148635","wikidata":"https://www.wikidata.org/wiki/Q154709","display_name":"Cerebellar ataxia","level":3,"score":0.3935000002384186},{"id":"https://openalex.org/C2780317758","wikidata":"https://www.wikidata.org/wiki/Q3339235","display_name":"Neurological disorder","level":3,"score":0.38199999928474426},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.38190001249313354},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.34769999980926514},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.34040001034736633},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.33959999680519104},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2653999924659729},{"id":"https://openalex.org/C2780566141","wikidata":"https://www.wikidata.org/wiki/Q3065932","display_name":"Cognitive disorder","level":4,"score":0.2639999985694885},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2637999951839447},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.2619999945163727},{"id":"https://openalex.org/C2781265626","wikidata":"https://www.wikidata.org/wiki/Q1147152","display_name":"Cognitive behavioral therapy","level":3,"score":0.2603999972343445},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.2565000057220459},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.250900000333786}],"mesh":[{"descriptor_ui":"D001259","descriptor_name":"Ataxia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005600","descriptor_name":"Fragile X Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D005600","descriptor_name":"Fragile X Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014202","descriptor_name":"Tremor","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fneur.2026.1870779","doi":"https://doi.org/10.3389/fneur.2026.1870779","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1870779","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1870779/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13684911","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684911/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684911/pdf/fneur-17-1870779.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurol","raw_type":"Text"},{"id":"pmid:42909313","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42909313","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neurology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d4bf006ba12c402ea7e37e5a337e363e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d4bf006ba12c402ea7e37e5a337e363e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neurology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fneur.2026.1870779","doi":"https://doi.org/10.3389/fneur.2026.1870779","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1870779","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1870779/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4567570713","display_name":"Language as a Candidate Marker of FXTAS in FMR1 Premutation Carriers","funder_award_id":"R21DC020257","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G5798117841","display_name":"CGG repeat associated translation in Fragile X-associated Tremor/Ataxia Syndrome","funder_award_id":"R01NS086810","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000893209","display_name":"Fragile X Premutations, Mechanisms and Modifiers","funder_award_id":"1p50hd118707-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000903227","display_name":"Clinical Outcome Assessment and Treatment Monitoring Markers for Clinical Trial Readiness in FXTAS","funder_award_id":"1u01ns143225-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000907684","display_name":"Aging Symptom Trajectories in Mother Carriers of the FMR1 Premutation","funder_award_id":"R01AG073374","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000911735","display_name":"Translation of the FMR1 Premutation Phenotypes Across the Lifespan","funder_award_id":"1p50hd118708-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306136","display_name":"Michael J. Fox Foundation for Parkinson's Research","ror":"https://ror.org/03arq3225"},{"id":"https://openalex.org/F4320308687","display_name":"CHDI Foundation","ror":"https://ror.org/046eh8t80"},{"id":"https://openalex.org/F4320311600","display_name":"Regeneron Pharmaceuticals","ror":"https://ror.org/02f51rf24"},{"id":"https://openalex.org/F4320314430","display_name":"Ionis Pharmaceuticals","ror":"https://ror.org/00t8bew53"},{"id":"https://openalex.org/F4320317126","display_name":"Denali Therapeutics","ror":"https://ror.org/00pprn321"},{"id":"https://openalex.org/F4320319747","display_name":"Texas Alzheimer's Research and Care Consortium","ror":null},{"id":"https://openalex.org/F4320327918","display_name":"H. Lundbeck A/S","ror":"https://ror.org/0564cd633"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220836726.pdf","grobid_xml":"https://content.openalex.org/works/W7220836726.grobid-xml"},"referenced_works_count":173,"referenced_works":["https://openalex.org/W1493874225","https://openalex.org/W1557510885","https://openalex.org/W1596831436","https://openalex.org/W1759290616","https://openalex.org/W1857971518","https://openalex.org/W1873305365","https://openalex.org/W1893987280","https://openalex.org/W1975487229","https://openalex.org/W1977627907","https://openalex.org/W1980888470","https://openalex.org/W1988498459","https://openalex.org/W1990249516","https://openalex.org/W1997578140","https://openalex.org/W1999830666","https://openalex.org/W2001791299","https://openalex.org/W2006202040","https://openalex.org/W2007794787","https://openalex.org/W2010767833","https://openalex.org/W2018919386","https://openalex.org/W2023732231","https://openalex.org/W2027109785","https://openalex.org/W2029109276","https://openalex.org/W2041080802","https://openalex.org/W2042265424","https://openalex.org/W2043177024","https://openalex.org/W2043749004","https://openalex.org/W2048622395","https://openalex.org/W2048764982","https://openalex.org/W2072379598","https://openalex.org/W2072672031","https://openalex.org/W2073888157","https://openalex.org/W2074173662","https://openalex.org/W2076010357","https://openalex.org/W2076716839","https://openalex.org/W2077967214","https://openalex.org/W2079202551","https://openalex.org/W2081150767","https://openalex.org/W2081577013","https://openalex.org/W2081581737","https://openalex.org/W2083347748","https://openalex.org/W2087897679","https://openalex.org/W2090594222","https://openalex.org/W2092475629","https://openalex.org/W2095073167","https://openalex.org/W2099328792","https://openalex.org/W2102368782","https://openalex.org/W2102877608","https://openalex.org/W2110991424","https://openalex.org/W2115310431","https://openalex.org/W2115628281","https://openalex.org/W2116801942","https://openalex.org/W2123257432","https://openalex.org/W2133912210","https://openalex.org/W2136777136","https://openalex.org/W2138332753","https://openalex.org/W2144889654","https://openalex.org/W2145583517","https://openalex.org/W2153474936","https://openalex.org/W2154849846","https://openalex.org/W2157331971","https://openalex.org/W2159540630","https://openalex.org/W2162154612","https://openalex.org/W2343960803","https://openalex.org/W2462102436","https://openalex.org/W2498880326","https://openalex.org/W2514135285","https://openalex.org/W2522727107","https://openalex.org/W2603299701","https://openalex.org/W2621294751","https://openalex.org/W2734775196","https://openalex.org/W2774066971","https://openalex.org/W2783376871","https://openalex.org/W2786309249","https://openalex.org/W2789145681","https://openalex.org/W2790058988","https://openalex.org/W2802731759","https://openalex.org/W2803517711","https://openalex.org/W2889978352","https://openalex.org/W2901162074","https://openalex.org/W2902481475","https://openalex.org/W2922383807","https://openalex.org/W2943593955","https://openalex.org/W2944702832","https://openalex.org/W2995032041","https://openalex.org/W3005591847","https://openalex.org/W3006292903","https://openalex.org/W3008424837","https://openalex.org/W3020980741","https://openalex.org/W3036932455","https://openalex.org/W3037169653","https://openalex.org/W3037799335","https://openalex.org/W3040800398","https://openalex.org/W3042335505","https://openalex.org/W3048452503","https://openalex.org/W3048918161","https://openalex.org/W3093320036","https://openalex.org/W3095595037","https://openalex.org/W3120657362","https://openalex.org/W3126701236","https://openalex.org/W3135998545","https://openalex.org/W3138811377","https://openalex.org/W3160085287","https://openalex.org/W3160713960","https://openalex.org/W3161376722","https://openalex.org/W3162566439","https://openalex.org/W3170696603","https://openalex.org/W3184254488","https://openalex.org/W3192281797","https://openalex.org/W3195896909","https://openalex.org/W3201373770","https://openalex.org/W4206081940","https://openalex.org/W4206589490","https://openalex.org/W4206603969","https://openalex.org/W4214725482","https://openalex.org/W4220819244","https://openalex.org/W4221016088","https://openalex.org/W4238040070","https://openalex.org/W4247532636","https://openalex.org/W4280569520","https://openalex.org/W4283121701","https://openalex.org/W4285027629","https://openalex.org/W4293282428","https://openalex.org/W4297964858","https://openalex.org/W4310255124","https://openalex.org/W4378679194","https://openalex.org/W4378782604","https://openalex.org/W4379157483","https://openalex.org/W4386189495","https://openalex.org/W4386913147","https://openalex.org/W4389334291","https://openalex.org/W4389509149","https://openalex.org/W4390918689","https://openalex.org/W4390938216","https://openalex.org/W4391033348","https://openalex.org/W4391607593","https://openalex.org/W4391783202","https://openalex.org/W4394695153","https://openalex.org/W4394859447","https://openalex.org/W4394923625","https://openalex.org/W4396954720","https://openalex.org/W4397008852","https://openalex.org/W4399099913","https://openalex.org/W4399178615","https://openalex.org/W4400114698","https://openalex.org/W4401164874","https://openalex.org/W4401431027","https://openalex.org/W4402273148","https://openalex.org/W4402290624","https://openalex.org/W4402929123","https://openalex.org/W4403700159","https://openalex.org/W4405550934","https://openalex.org/W4406253938","https://openalex.org/W4406424017","https://openalex.org/W4408718204","https://openalex.org/W4408955753","https://openalex.org/W4409330157","https://openalex.org/W4409687338","https://openalex.org/W4410950448","https://openalex.org/W4411849592","https://openalex.org/W4412486229","https://openalex.org/W4413052195","https://openalex.org/W4413435216","https://openalex.org/W4414167830","https://openalex.org/W4415191989","https://openalex.org/W4415536088","https://openalex.org/W4415918728","https://openalex.org/W4416075736","https://openalex.org/W4416512425","https://openalex.org/W4416719810","https://openalex.org/W7121047648","https://openalex.org/W7137072418","https://openalex.org/W7157944237","https://openalex.org/W7164820120"],"related_works":["https://openalex.org/W2115628281","https://openalex.org/W1990249516","https://openalex.org/W2245070562","https://openalex.org/W4251420078","https://openalex.org/W7139064227","https://openalex.org/W4378679194","https://openalex.org/W1973667745","https://openalex.org/W2944264261","https://openalex.org/W7099979639","https://openalex.org/W2483196934"],"abstract_inverted_index":{"Fragile":[0],"X-associated":[1],"tremor":[2],"ataxia":[3,85],"syndrome":[4],"(FXTAS)":[5],"is":[6,31,50,97,160,221],"a":[7,44,61,212],"multi-faceted":[8],"and":[9,24,26,34,52,74,86,93,131,149,156,166,181,188,193,205,209],"progressive":[10],"neurodegenerative":[11,207],"disorder":[12,169],"that":[13,198],"manifests":[14],"clinically":[15],"with":[16,127,154,171],"action":[17],"tremor,":[18,84],"gait":[19],"ataxia,":[20],"parkinsonism,":[21],"peripheral":[22],"neuropathy,":[23],"cognitive":[25,118],"psychiatric":[27],"features.":[28],"The":[29],"disease":[30],"highly":[32],"heterogeneous":[33],"there":[35],"are":[36,196,199],"no":[37],"FDA":[38],"approved":[39],"medications":[40,92,114,122],"for":[41,71,116,137],"FXTAS":[42],"as":[43,83,104,177],"specific":[45,58],"indication.":[46],"As":[47],"such,":[48],"treatment":[49,69],"symptomatic":[51,91],"must":[53],"be":[54,111,135,152],"tailored":[55],"to":[56,90,113,162,201,223],"the":[57,72],"needs":[59],"of":[60,78,141,190,227],"given":[62],"patient.":[63],"This":[64],"review":[65],"provides":[66],"expert":[67],"opinion-based":[68],"recommendations":[70,197],"core":[73],"ancillary":[75],"clinical":[76,165],"features":[77,170],"FXTAS.":[79,228],"Movement":[80],"disorders,":[81,119],"such":[82,103,176],"parkinsonism":[87],"may":[88,210],"respond":[89],"therapies,":[94,175],"but":[95,120,158],"caution":[96,159],"required":[98,161],"when":[99,125],"considering":[100],"surgical":[101],"interventions":[102],"deep":[105],"brain":[106],"stimulation.":[107],"Cognitive":[108],"decline":[109],"can":[110,151],"responsive":[112],"developed":[115],"other":[117,138,202],"these":[121],"work":[123],"best":[124],"combined":[126],"non-medication":[128],"based":[129],"approaches":[130],"all":[132,225],"patients":[133],"should":[134],"screened":[136],"reversible":[139],"causes":[140],"memory":[142],"decline.":[143],"Psychiatric":[144],"symptoms,":[145],"including":[146],"anxiety,":[147],"depression,":[148],"psychosis,":[150],"treated":[153],"psychotherapy":[155],"medications;":[157],"avoid":[163],"exacerbating":[164],"subclinical":[167],"movement":[168],"psychotropic":[172],"medications.":[173],"Rehabilitative":[174],"speech":[178],"therapy,":[179,183],"occupational,":[180],"physical":[182],"often":[184],"enhance":[185],"patient":[186],"function":[187],"quality":[189],"life.":[191],"Exercise":[192],"good":[194],"nutrition":[195],"common":[200],"cerebellar":[203],"ataxias":[204],"adult":[206],"disorders":[208],"have":[211],"positive":[213],"impact":[214],"on":[215],"general":[216],"health.":[217],"A":[218],"multi-disciplinary":[219],"approach":[220],"recommended":[222],"address":[224],"components":[226]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-08T00:00:00"}
