{"id":"https://openalex.org/W7220834596","doi":"https://doi.org/10.64898/2026.10.07.757226","title":"Sphingolipid-Driven Lipotoxicity Promotes Calcific Aortic Valve Disease Through ER-Stress\u2013NF-\u03baB\u2013EndMT Signaling and Is Therapeutically Targetable Through Serine Palmitoyltransferase Inhibition","display_name":"Sphingolipid-Driven Lipotoxicity Promotes Calcific Aortic Valve Disease Through ER-Stress\u2013NF-\u03baB\u2013EndMT Signaling and Is Therapeutically Targetable Through Serine Palmitoyltransferase Inhibition","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220834596","doi":"https://doi.org/10.64898/2026.10.07.757226"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.07.757226","doi":"https://doi.org/10.64898/2026.10.07.757226","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.07.757226","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.07.757226.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.07.757226.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064522009","display_name":"Elias Rawish","orcid":"https://orcid.org/0000-0002-7919-4113","observed_orcids":["https://orcid.org/0000-0002-7919-4113"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"E. Rawish","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7919-4113","affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157857472","display_name":"Timo Rusack","orcid":"https://orcid.org/0009-0005-0886-7471","observed_orcids":["https://orcid.org/0009-0005-0886-7471"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Rusack","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157885684","display_name":"Peter Ruben Letsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Letsch","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089360501","display_name":"Julica Inderhees","orcid":"https://orcid.org/0000-0003-4523-3652","observed_orcids":["https://orcid.org/0000-0003-4523-3652"]},"institutions":[{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Inderhees","raw_affiliation_strings":["Bioanalytic Core Facility, Center of Brain, Behavior and Metabolism, University of L\u00fcbeck, L\u00fcbeck, Germany","DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioanalytic Core Facility, Center of Brain, Behavior and Metabolism, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111182487","display_name":"Kristian Haendler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. H\u00e4ndler","raw_affiliation_strings":["University Hospital Schleswig-Holstein, Institute of Human Genetics, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Institute of Human Genetics, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713","https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119315798","display_name":"Carolin Gragoll","orcid":"https://orcid.org/0009-0006-7893-8367","observed_orcids":["https://orcid.org/0009-0006-7893-8367"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Gragoll","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011767365","display_name":"Jakob Christoph Voran","orcid":"https://orcid.org/0009-0000-4547-9260","observed_orcids":["https://orcid.org/0009-0000-4547-9260"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J.C. Voran","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Department of Internal Medicine III, Cardiology and Critical Care, Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Department of Internal Medicine III, Cardiology and Critical Care, Kiel, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157837613","display_name":"Michael Schneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Schneider","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041780654","display_name":"Katharina Kurz","orcid":"https://orcid.org/0000-0003-4958-9541","observed_orcids":["https://orcid.org/0000-0003-4958-9541","https://orcid.org/0009-0002-6080-7060"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Kurz","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043218998","display_name":"Mohammed Rabiul Hosen","orcid":"https://orcid.org/0000-0003-2823-0628","observed_orcids":["https://orcid.org/0000-0003-2823-0628"]},"institutions":[{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M.R. Hosen","raw_affiliation_strings":["Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, Venusberg-Campus Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, Venusberg-Campus Germany","institution_ids":["https://openalex.org/I2799391451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045958405","display_name":"Maren Behrensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Behrensen","raw_affiliation_strings":["Institute for Cardiogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cardiogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105911615","display_name":"Svenja Denker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Denker","raw_affiliation_strings":["L\u00fcbeck Institute of Experimental Dermatology, Medical Systems Biology, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L\u00fcbeck Institute of Experimental Dermatology, Medical Systems Biology, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157860092","display_name":"Axel Kuenstner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. K\u00fcnstner","raw_affiliation_strings":["L\u00fcbeck Institute of Experimental Dermatology, Medical Systems Biology, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L\u00fcbeck Institute of Experimental Dermatology, Medical Systems Biology, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049422892","display_name":"Thorben Sauer","orcid":"https://orcid.org/0000-0002-4511-6037","observed_orcids":["https://orcid.org/0000-0002-4511-6037"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Sauer","raw_affiliation_strings":["University Hospital Schleswig-Holstein, Section for Translational Surgical Oncology and Biobanking, Department of Surgery, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Section for Translational Surgical Oncology and Biobanking, Department of Surgery, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713","https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157831705","display_name":"Jorge Duque Escobar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Duque-Escobar","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","Institute for Cardiogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute for Cardiogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143623039","display_name":"Tobias Schmidt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Schmidt","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157836543","display_name":"Derk Frank","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. Frank","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Department of Internal Medicine III, Cardiology and Critical Care, Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Department of Internal Medicine III, Cardiology and Critical Care, Kiel, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038605040","display_name":"Thomas Stiermaier","orcid":"https://orcid.org/0000-0003-1957-3741","observed_orcids":["https://orcid.org/0000-0003-1957-3741"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Stiermaier","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048849091","display_name":"Walter Raasch","orcid":"https://orcid.org/0000-0002-8781-2997","observed_orcids":["https://orcid.org/0000-0002-8781-2997"]},"institutions":[{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W. Raasch","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","Institute for Experimental and Clinical Pharmacology and Toxicology, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute for Experimental and Clinical Pharmacology and Toxicology, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122081365","display_name":"Oliver J. M\u00fcller","orcid":"https://orcid.org/0000-0001-8223-2638","observed_orcids":["https://orcid.org/0000-0001-8223-2638"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"O.J. M\u00fcller","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Department of Internal Medicine V, Angiology, Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Department of Internal Medicine V, Angiology, Kiel, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046127730","display_name":"Tanja Zeller","orcid":"https://orcid.org/0000-0003-3379-2641","observed_orcids":["https://orcid.org/0000-0003-3379-2641"]},"institutions":[{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Zeller","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","Institute for Cardiogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute for Cardiogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086749090","display_name":"Hauke S. Busch","orcid":"https://orcid.org/0000-0003-4763-4521","observed_orcids":["https://orcid.org/0000-0003-4763-4521"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. Busch","raw_affiliation_strings":["L\u00fcbeck Institute of Experimental Dermatology, Medical Systems Biology, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L\u00fcbeck Institute of Experimental Dermatology, Medical Systems Biology, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087941391","display_name":"Timo Gemoll","orcid":"https://orcid.org/0000-0001-7400-5240","observed_orcids":["https://orcid.org/0000-0001-7400-5240"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Gemoll","raw_affiliation_strings":["University Hospital Schleswig-Holstein, Section for Translational Surgical Oncology and Biobanking, Department of Surgery, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Section for Translational Surgical Oncology and Biobanking, Department of Surgery, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713","https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127176510","display_name":"Christoph Knosalla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210105663","display_name":"Deutsches Herzzentrum der Charit\u00e9","ror":"https://ror.org/01mmady97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210105663","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Knosalla","raw_affiliation_strings":["Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Germany","Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charit\u00e9 (DHZC), Berlin, Germany","German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charit\u00e9 (DHZC), Berlin, Germany","institution_ids":["https://openalex.org/I4210105663"]},{"raw_affiliation_string":"German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049446559","display_name":"Malte Spielmann","orcid":"https://orcid.org/0000-0002-0583-4683","observed_orcids":["https://orcid.org/0000-0002-0583-4683"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Spielmann","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Institute of Human Genetics, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Institute of Human Genetics, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713","https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157838294","display_name":"Zouhair Aherrharou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Z. Aherrharou","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","Institute for Cardiogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute for Cardiogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011083228","display_name":"Scott A. Summers","orcid":"https://orcid.org/0000-0002-4919-0592","observed_orcids":["https://orcid.org/0000-0002-4919-0592"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.A. Summers","raw_affiliation_strings":["Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157843785","display_name":"Ingo Eitel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"I. Eitel","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024507851","display_name":"Christian Frerker","orcid":"https://orcid.org/0000-0003-0226-0888","observed_orcids":["https://orcid.org/0000-0003-0226-0888"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Frerker","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site North, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Medical Clinic II, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5064522009"],"corresponding_institution_ids":["https://openalex.org/I4210112713","https://openalex.org/I4210127591","https://openalex.org/I9341345"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.5791000127792358,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.5791000127792358,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.30469998717308044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.03970000147819519,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcific-aortic-valve-disease","display_name":"calcific aortic valve disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ceramide-accumulation","display_name":"ceramide accumulation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/myriocin","display_name":"myriocin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/lipotoxicity","display_name":"lipotoxicity","score":0.753000020980835},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9039999842643738},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.8920000195503235},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9559999704360962},{"id":"https://openalex.org/keywords/endothelial-mesenchymal-transition","display_name":"endothelial-to-mesenchymal transition","score":1.0},{"id":"https://openalex.org/keywords/valvular-interstitial-cells","display_name":"valvular interstitial cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/valvular-calcification","display_name":"valve calcification","score":0.8489999771118164},{"id":"https://openalex.org/keywords/aortic-stenosis","display_name":"aortic stenosis","score":0.6240000128746033},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.6510000228881836},{"id":"https://openalex.org/keywords/grp78","display_name":"GRP78","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.8598999977111816},{"id":"https://openalex.org/C58017582","wikidata":"https://www.wikidata.org/wiki/Q6556376","display_name":"Lipidomics","level":2,"score":0.578499972820282},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.5720999836921692},{"id":"https://openalex.org/C2780714102","wikidata":"https://www.wikidata.org/wiki/Q616071","display_name":"Aortic valve","level":2,"score":0.4569999873638153},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4429999887943268},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4390000104904175},{"id":"https://openalex.org/C2781414266","wikidata":"https://www.wikidata.org/wiki/Q531019","display_name":"Aortic valve stenosis","level":3,"score":0.41179999709129333},{"id":"https://openalex.org/C44353895","wikidata":"https://www.wikidata.org/wiki/Q6556772","display_name":"Lipotoxicity","level":4,"score":0.3750999867916107},{"id":"https://openalex.org/C2776931407","wikidata":"https://www.wikidata.org/wiki/Q418892","display_name":"Glycosphingolipid","level":2,"score":0.3734999895095825},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3700999915599823},{"id":"https://openalex.org/C2779736815","wikidata":"https://www.wikidata.org/wiki/Q1130519","display_name":"valvular heart disease","level":2,"score":0.36039999127388},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34929999709129333},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3465000092983246},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33649998903274536},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.3215999901294708},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.2985999882221222},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.29809999465942383},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.28679999709129333},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2759000062942505},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.26489999890327454},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.26260000467300415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26019999384880066},{"id":"https://openalex.org/C2780545995","wikidata":"https://www.wikidata.org/wiki/Q18030421","display_name":"PDGFB","level":5,"score":0.2590999901294708},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.25519999861717224}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.07.757226","doi":"https://doi.org/10.64898/2026.10.07.757226","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.07.757226","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.07.757226.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.07.757226","doi":"https://doi.org/10.64898/2026.10.07.757226","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.07.757226","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.10.07.757226.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220834596.pdf","grobid_xml":"https://content.openalex.org/works/W7220834596.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1555669240","https://openalex.org/W1965381743","https://openalex.org/W1972433143","https://openalex.org/W1972564818","https://openalex.org/W1972900673","https://openalex.org/W2014959138","https://openalex.org/W2043353709","https://openalex.org/W2057131420","https://openalex.org/W2070197168","https://openalex.org/W2105924650","https://openalex.org/W2116181016","https://openalex.org/W2117055361","https://openalex.org/W2122497790","https://openalex.org/W2148093271","https://openalex.org/W2158589283","https://openalex.org/W2167045683","https://openalex.org/W2287556634","https://openalex.org/W2403974914","https://openalex.org/W2564181903","https://openalex.org/W2767748723","https://openalex.org/W2768617092","https://openalex.org/W2771175433","https://openalex.org/W2787469326","https://openalex.org/W2790345314","https://openalex.org/W2978092687","https://openalex.org/W3006898627","https://openalex.org/W3027524647","https://openalex.org/W3093893074","https://openalex.org/W3097883702","https://openalex.org/W3136668199","https://openalex.org/W3157706141","https://openalex.org/W4220909370","https://openalex.org/W4223934831","https://openalex.org/W4281748724","https://openalex.org/W4296185277","https://openalex.org/W4321790500","https://openalex.org/W4386661160","https://openalex.org/W4388596245","https://openalex.org/W4390904368","https://openalex.org/W4393278169","https://openalex.org/W4399564202","https://openalex.org/W4405873562","https://openalex.org/W4407884229","https://openalex.org/W4410980478"],"related_works":["https://openalex.org/W4403818648","https://openalex.org/W3215076242","https://openalex.org/W4281786641","https://openalex.org/W7127652009","https://openalex.org/W7202391206","https://openalex.org/W7223103803","https://openalex.org/W1990328408","https://openalex.org/W2945756679","https://openalex.org/W3184135465","https://openalex.org/W2790345314"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Calcific":[2],"aortic":[3,48,108,312,425],"valve":[4,109,113,259],"disease":[5,294,403],"(CAVD)":[6],"lacks":[7,329],"disease-modifying":[8],"therapy.":[9,306],"LDL-cholesterol":[10],"lowering":[11,197],"does":[12],"not":[13,156],"attenuate":[14],"valvular":[15,62,182,345],"calcification,":[16],"suggesting":[17],"cholesterol-independent":[18],"drivers.":[19],"Thus,":[20],"we":[21],"tested":[22,58,103],"whether":[23,29],"ceramide":[24,162,317,335,389],"accumulation":[25],"drives":[26],"CAVD":[27,227,305,375,384],"and":[28,41,45,92,117,126,145,166,170,187,189,193,246,249,261,323,339],"inhibiting":[30],"sphingolipid":[31,220,282,332,362],"de":[32,218,280,360],"novo":[33,219,281,361],"synthesis":[34,221,283],"is":[35,284,308,352],"therapeutic.":[36],"Methods":[37],"We":[38],"integrated":[39],"lipidomics":[40,260],"proteomics":[42],"of":[43,55,68,136,271,290,359,374],"calcified":[44],"non-calcified":[46],"human":[47,61,132,262,311,344],"valves":[49,133,313],"with":[50,73,81,179],"matched":[51,152,327],"plasma.":[52],"Mechanistic":[53],"effects":[54],"ceramides":[56,138],"were":[57,120,155],"in":[59,77,104,229,237,275,342,376],"primary":[60,343],"interstitial":[63,346],"cells":[64],"(VICs).":[65],"Therapeutic":[66],"efficacy":[67],"serine":[69],"palmitoyltransferase":[70],"(SPT)":[71],"inhibition":[72,178,298,358,397],"Myriocin":[74,100,180,208,232],"was":[75,101],"evaluated":[76],"ApoE":[78],"\u2212/\u2212":[79],"mice":[80],"PCSK9":[82],"DY":[83],"-AAV\u2013driven":[84],"hyperlipidemia":[85],"on":[86],"Western":[87],"diet":[88],"using":[89],"preventive":[90],"treatment":[91],"therapeutic":[93,202],"initiation":[94],"after":[95,205,225,365],"echocardiographically":[96,366],"verified":[97,367],"gradient":[98,206,368],"elevation.":[99],"additionally":[102],"a":[105,201,269,300,330],"normolipidemic":[106,238],"wild-type":[107],"wire-injury":[110],"model.":[111],"Hemodynamics,":[112],"structure,":[114],"lipid":[115],"composition,":[116],"cell-state":[118],"transitions":[119],"assessed":[121],"by":[122],"echocardiography,":[123],"histology,":[124],"lipidomics,":[125],"single-cell":[127],"RNA":[128,241],"sequencing.":[129],"Results\\":[130],"Calcified":[131,310],"showed":[134,243],"enrichment":[135,318],"long-chain":[137,160,316],"linked":[139,319],"to":[140,320,422],"NF-\u03baB,":[141,169,321],"endothelial-to-mesenchymal":[142],"transition":[143],"(EndMT),":[144],"ER-stress/unfolded":[146],"protein":[147],"response":[148],"(UPR)":[149],"programs,":[150,325],"whereas":[151,326],"plasma":[153,198,328],"sphingolipids":[154],"elevated.":[157],"In":[158,174,200,277],"hVICs,":[159],"C18":[161,334],"induced":[163],"GRP78/BiP,":[164],"CHOP,":[165],"ATF4,":[167],"activated":[168],"promoted":[171],"dose-dependent":[172],"calcification.":[173],"vivo":[175,230,278,377],",":[176,279],"SPT":[177,297,396,411],"lowered":[181],"ceramides,":[183],"reduced":[184,244],"leaflet":[185],"inflammation":[186],"mineralization,":[188],"improved":[190],"cusp":[191],"separation":[192],"transvalvular":[194],"hemodynamics":[195],"without":[196],"LDL-cholesterol.":[199],"protocol":[203],"initiated":[204,364],"elevation,":[207,369],"halted":[209],"further":[210,371],"hemodynamic":[211,293,372,407],"progression,":[212,295],"providing":[213],"the":[214,353,381],"first":[215,354],"evidence":[216],"that":[217,356],"can":[222],"be":[223],"targeted":[224,414],"established":[226,292,406],"onset":[228],".":[231,378],"also":[233],"attenuated":[234],"injury-induced":[235],"stenosis":[236,426],"mice.":[239],"Single-cell":[240],"sequencing":[242],"NF-\u03baB/EndMT":[245],"ER-stress":[247],"signatures":[248],"shifted":[250],"VIC":[251,263],"states":[252],"away":[253],"from":[254],"osteogenic":[255],"phenotypes.":[256],"Conclusions":[257],"Human":[258],"experiments":[264],"identify":[265],"ceramide-driven":[266],"lipotoxicity":[267,390],"as":[268,299,419],"driver":[270],"an":[272,285],"ER-stress\u2013NF-\u03baB\u2013EndMT":[273],"axis":[274],"CAVD.":[276],"actionable,":[286],"LDL-independent":[287,402],"target":[288],"capable":[289],"modifying":[291],"supporting":[296],"tractable":[301],"strategy":[302],"for":[303,401],"medical":[304,420],"What":[307,379],"new?":[309],"show":[314],"local":[315],"EndMT,":[322],"ER-stress/UPR":[324],"corresponding":[331],"increase.":[333],"directly":[336],"promotes":[337],"ER-stress\u2013":[338],"NF-\u03baB-dependent":[340],"calcification":[341],"cells.":[347],"To":[348],"our":[349],"knowledge,":[350],"this":[351],"demonstration":[355],"pharmacologic":[357],"synthesis,":[363],"attenuates":[370],"progression":[373,385],"are":[380],"clinical":[382],"implications?":[383],"may":[386],"involve":[387],"valve-local":[388],"rather":[391],"than":[392],"LDL":[393],"cholesterol":[394],"alone.":[395],"provides":[398],"preclinical":[399],"proof-of-concept":[400],"modification,":[404],"including":[405],"disease.":[408],"Clinically":[409],"translatable":[410],"inhibitors":[412],"or":[413],"delivery":[415],"strategies":[416],"warrant":[417],"evaluation":[418],"approaches":[421],"slow":[423],"calcific":[424],"progression.":[427]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-08T00:00:00"}
