{"id":"https://openalex.org/W7220834359","doi":"https://doi.org/10.1016/j.mtbio.2026.103732","title":"An intrascrotal bioadhesive nanoplatform for sustained hydrogen delivery ameliorates age-associated testicular dysfunction","display_name":"An intrascrotal bioadhesive nanoplatform for sustained hydrogen delivery ameliorates age-associated testicular dysfunction","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220834359","doi":"https://doi.org/10.1016/j.mtbio.2026.103732","pmid":"https://pubmed.ncbi.nlm.nih.gov/42898181","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13677336"},"language":"en","primary_location":{"id":"doi:10.1016/j.mtbio.2026.103732","doi":"https://doi.org/10.1016/j.mtbio.2026.103732","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mtbio.2026.103732","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2590006426009774/pdf","source":{"id":"https://openalex.org/S4210219546","display_name":"Materials Today Bio","issn_l":"2590-0064","issn":["2590-0064"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Today Bio","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2590006426009774/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157815210","display_name":"Shu Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37987034","display_name":"Guangzhou University","ror":"https://ror.org/05ar8rn06","country_code":"CN","type":"education","lineage":["https://openalex.org/I37987034"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu Liang","raw_affiliation_strings":["Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I37987034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117421470","display_name":"Jiawei Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37987034","display_name":"Guangzhou University","ror":"https://ror.org/05ar8rn06","country_code":"CN","type":"education","lineage":["https://openalex.org/I37987034"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiawei Lv","raw_affiliation_strings":["Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I37987034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101674350","display_name":"Zun Li","orcid":"https://orcid.org/0000-0003-0914-7116","observed_orcids":["https://orcid.org/0000-0003-0914-7116"]},"institutions":[{"id":"https://openalex.org/I37987034","display_name":"Guangzhou University","ror":"https://ror.org/05ar8rn06","country_code":"CN","type":"education","lineage":["https://openalex.org/I37987034"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zun Li","raw_affiliation_strings":["Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I37987034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157815551","display_name":"Zheng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37987034","display_name":"Guangzhou University","ror":"https://ror.org/05ar8rn06","country_code":"CN","type":"education","lineage":["https://openalex.org/I37987034"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Li","raw_affiliation_strings":["Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I37987034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100583842","display_name":"Jiachun Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37987034","display_name":"Guangzhou University","ror":"https://ror.org/05ar8rn06","country_code":"CN","type":"education","lineage":["https://openalex.org/I37987034"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiachun Jiang","raw_affiliation_strings":["Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I37987034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027339124","display_name":"Shaoqing Yu","orcid":"https://orcid.org/0000-0003-2208-4535","observed_orcids":["https://orcid.org/0000-0003-2208-4535"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shaoqing Yu","raw_affiliation_strings":["Allergy and Cancer Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergy and Cancer Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157821174","display_name":"Cheng Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37987034","display_name":"Guangzhou University","ror":"https://ror.org/05ar8rn06","country_code":"CN","type":"education","lineage":["https://openalex.org/I37987034"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cheng Wang","raw_affiliation_strings":["Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I37987034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157812628","display_name":"Xiongjun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37987034","display_name":"Guangzhou University","ror":"https://ror.org/05ar8rn06","country_code":"CN","type":"education","lineage":["https://openalex.org/I37987034"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiongjun Wang","raw_affiliation_strings":["Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I37987034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117421471","display_name":"Lingyun Xiao","orcid":"https://orcid.org/0009-0000-7101-0933","observed_orcids":["https://orcid.org/0009-0000-7101-0933"]},"institutions":[{"id":"https://openalex.org/I37987034","display_name":"Guangzhou University","ror":"https://ror.org/05ar8rn06","country_code":"CN","type":"education","lineage":["https://openalex.org/I37987034"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lingyun Xiao","raw_affiliation_strings":["Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China"],"raw_orcid":"https://orcid.org/0009-0000-7101-0933","affiliations":[{"raw_affiliation_string":"Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I37987034"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157878046","display_name":"Guanzhen Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guanzhen Yu","raw_affiliation_strings":["Allergy and Cancer Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergy and Cancer Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China","institution_ids":["https://openalex.org/I116953780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027339124","https://openalex.org/A5117421471","https://openalex.org/A5157812628","https://openalex.org/A5157821174","https://openalex.org/A5157878046"],"corresponding_institution_ids":["https://openalex.org/I116953780","https://openalex.org/I37987034"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":{"value":3400,"currency":"USD","value_usd":3400},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.81891613,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":null,"first_page":"103732","last_page":"103732"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.03779999911785126,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-hydrogen","display_name":"molecular hydrogen","score":0.8050000071525574},{"id":"https://openalex.org/keywords/testicular-aging","display_name":"testicular aging","score":0.8399999737739563},{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.7689999938011169},{"id":"https://openalex.org/keywords/sertoli-cells","display_name":"Sertoli cells","score":0.9589999914169312},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.7710000276565552},{"id":"https://openalex.org/keywords/phd1","display_name":"PHD1","score":0.7369999885559082},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.777999997138977},{"id":"https://openalex.org/keywords/lactic-acid-production","display_name":"lactic acid production","score":0.7799999713897705},{"id":"https://openalex.org/keywords/male-reproductive-aging","display_name":"male reproductive aging","score":0.7929999828338623},{"id":"https://openalex.org/keywords/seminiferous-epithelium","display_name":"seminiferous epithelium","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C2781068068","wikidata":"https://www.wikidata.org/wiki/Q195614","display_name":"Sertoli cell","level":3,"score":0.7731999754905701},{"id":"https://openalex.org/C2776634624","wikidata":"https://www.wikidata.org/wiki/Q4914690","display_name":"Bioadhesive","level":3,"score":0.7580000162124634},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.7404000163078308},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.5824999809265137},{"id":"https://openalex.org/C2994278967","wikidata":"https://www.wikidata.org/wiki/Q7314318","display_name":"Reproductive technology","level":4,"score":0.49309998750686646},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4634000062942505},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39590001106262207},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.390500009059906},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.388700008392334},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.374099999666214},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3628999888896942},{"id":"https://openalex.org/C2779066085","wikidata":"https://www.wikidata.org/wiki/Q9384","display_name":"Testicle","level":2,"score":0.34529998898506165},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.3328999876976013},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3109000027179718},{"id":"https://openalex.org/C2781245343","wikidata":"https://www.wikidata.org/wiki/Q7314311","display_name":"Reproductive immunology","level":5,"score":0.3019999861717224},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2955999970436096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29510000348091125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2921000123023987},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.29159998893737793},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.29120001196861267},{"id":"https://openalex.org/C2636012","wikidata":"https://www.wikidata.org/wiki/Q489842","display_name":"Blood\u2013testis barrier","level":4,"score":0.2872999906539917},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2833000123500824},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.26510000228881836},{"id":"https://openalex.org/C2776231299","wikidata":"https://www.wikidata.org/wiki/Q245489","display_name":"Trolox","level":4,"score":0.26100000739097595},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.2547999918460846},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.25429999828338623},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.2531000077724457},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.2506999969482422}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.mtbio.2026.103732","doi":"https://doi.org/10.1016/j.mtbio.2026.103732","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mtbio.2026.103732","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2590006426009774/pdf","source":{"id":"https://openalex.org/S4210219546","display_name":"Materials Today Bio","issn_l":"2590-0064","issn":["2590-0064"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Today Bio","raw_type":"journal-article"},{"id":"pmid:42898181","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42898181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials today. Bio","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13677336","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13677336/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mater Today Bio","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:20f147e03d824611887739200215b8e5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/20f147e03d824611887739200215b8e5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Materials Today Bio, Vol 41, Iss , Pp 103732- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.mtbio.2026.103732","doi":"https://doi.org/10.1016/j.mtbio.2026.103732","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mtbio.2026.103732","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2590006426009774/pdf","source":{"id":"https://openalex.org/S4210219546","display_name":"Materials Today Bio","issn_l":"2590-0064","issn":["2590-0064"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Today Bio","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5430672694","display_name":null,"funder_award_id":"2025A1515012020","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G7437123496","display_name":null,"funder_award_id":"81903914","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8178889368","display_name":null,"funder_award_id":"82473085","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220834359.pdf","grobid_xml":"https://content.openalex.org/works/W7220834359.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1983748546","https://openalex.org/W1987693668","https://openalex.org/W1994313430","https://openalex.org/W2014872152","https://openalex.org/W2035983112","https://openalex.org/W2065622784","https://openalex.org/W2077775407","https://openalex.org/W2079634965","https://openalex.org/W2082002945","https://openalex.org/W2083618601","https://openalex.org/W2083650284","https://openalex.org/W2085280452","https://openalex.org/W2109520380","https://openalex.org/W2111406982","https://openalex.org/W2149188107","https://openalex.org/W2157611444","https://openalex.org/W2160243612","https://openalex.org/W2160866228","https://openalex.org/W2165494231","https://openalex.org/W2166446009","https://openalex.org/W2169657429","https://openalex.org/W2171748049","https://openalex.org/W2490895295","https://openalex.org/W2521517273","https://openalex.org/W2533790379","https://openalex.org/W2615039571","https://openalex.org/W2892001132","https://openalex.org/W2953560178","https://openalex.org/W2962938520","https://openalex.org/W2964596167","https://openalex.org/W3000665150","https://openalex.org/W3014784053","https://openalex.org/W3038559729","https://openalex.org/W3049023870","https://openalex.org/W3089739802","https://openalex.org/W3102016493","https://openalex.org/W3110494535","https://openalex.org/W3135546729","https://openalex.org/W3169592085","https://openalex.org/W3177562296","https://openalex.org/W3186226233","https://openalex.org/W4210737485","https://openalex.org/W4220892878","https://openalex.org/W4225002645","https://openalex.org/W4230897640","https://openalex.org/W4281914060","https://openalex.org/W4283691281","https://openalex.org/W4285087820","https://openalex.org/W4302011997","https://openalex.org/W4310969218","https://openalex.org/W4311764037","https://openalex.org/W4313164451","https://openalex.org/W4321373217","https://openalex.org/W4385778810","https://openalex.org/W4387328467","https://openalex.org/W4389461378","https://openalex.org/W4389936339","https://openalex.org/W4396920496","https://openalex.org/W4400659839","https://openalex.org/W4401214747","https://openalex.org/W4403424952","https://openalex.org/W4407236307","https://openalex.org/W4410594758","https://openalex.org/W4412522334","https://openalex.org/W4412710404","https://openalex.org/W4412764818","https://openalex.org/W4413452747","https://openalex.org/W4416943258","https://openalex.org/W7118961680","https://openalex.org/W7128299514","https://openalex.org/W7154474488"],"related_works":["https://openalex.org/W4412764818","https://openalex.org/W1952545634","https://openalex.org/W1973636376","https://openalex.org/W7214900163","https://openalex.org/W2131245652","https://openalex.org/W2620184255","https://openalex.org/W4414379483","https://openalex.org/W4404461258","https://openalex.org/W4395002538","https://openalex.org/W4413794598"],"abstract_inverted_index":{"Testicular":[0],"aging":[1,35],"is":[2,36],"characterized":[3],"by":[4,38],"progressive":[5],"spermatogenic":[6],"decline.":[7],"Accumulating":[8],"oxidative":[9],"injury":[10],"and":[11,84,101,115,136,145,160,199],"insufficient":[12],"metabolic":[13,171,202],"support":[14],"from":[15],"Sertoli":[16,121,164,205],"cells":[17,122,206],"may":[18,177,207],"contribute":[19,208],"to":[20,74,180,209],"this":[21,45,186],"process.":[22],"Although":[23],"molecular":[24],"hydrogen":[25,87,95,191],"has":[26],"shown":[27],"antioxidant":[28],"potential,":[29],"its":[30,147,210],"therapeutic":[31],"application":[32],"in":[33,104,119,163,204],"reproductive":[34,197],"limited":[37,137],"rapid":[39],"dissipation":[40],"after":[41],"administration.":[42],"To":[43],"overcome":[44],"barrier,":[46],"we":[47],"developed":[48],"the":[49],"localized":[50],"hydrogen-releasing":[51],"system":[52],"S-H/B.":[53],"This":[54,92],"platform":[55],"integrates":[56],"hydrogenated":[57],"silicon":[58],"nanosheets":[59],"(S-H)":[60],"with":[61],"a":[62,189],"bioadhesive":[63,190],"polymer,":[64],"aldehyde-functionalized":[65],"polylactic":[66],"acid-hyperbranched":[67],"polyglycerol":[68],"(PLA-HPG-al).":[69],"The":[70,173],"resulting":[71],"formulation":[72],"adhered":[73],"peritesticular":[75],"tissue":[76],"following":[77,123],"intrascrotal":[78],"injection,":[79],"showed":[80],"prolonged":[81],"local":[82,94],"retention,":[83],"enabled":[85],"sustained":[86,93],"release":[88],"under":[89],"physiological":[90],"conditions.":[91],"delivery":[96,192],"reduced":[97,132],"age-associated":[98,195],"testicular":[99],"degeneration":[100],"promoted":[102],"spermatogenesis":[103],"aged":[105,120],"mice.":[106],"Notably,":[107],"single-cell":[108],"RNA":[109],"sequencing":[110],"revealed":[111],"enhanced":[112],"HIF-1":[113],"signaling":[114],"glycolysis-related":[116],"transcriptional":[117],"programs":[118],"S-H/B":[124,131,151],"treatment.":[125],"Further":[126],"mechanistic":[127],"analyses":[128],"indicated":[129],"that":[130,201],"ONOO":[133],"\u2212":[134],"levels":[135],"PHD1-dependent":[138],"HIF-1\u03b1":[139,143,167],"hydroxylation,":[140],"thereby":[141],"slowing":[142],"degradation":[144],"promoting":[146],"nuclear":[148],"localization.":[149],"Consistently,":[150],"increased":[152,174],"glycolytic":[153,158],"enzyme":[154],"expression,":[155],"glucose":[156],"uptake,":[157],"flux,":[159],"lactate":[161,175],"production":[162,176],"cells,":[165],"whereas":[166],"inhibition":[168],"attenuated":[169],"these":[170],"changes.":[172],"have":[178],"contributed":[179],"improved":[181],"seminiferous":[182],"epithelial":[183],"function.":[184],"Overall,":[185],"work":[187],"presents":[188],"strategy":[193],"for":[194],"male":[196],"dysfunction":[198],"suggests":[200],"remodeling":[203],"beneficial":[211],"effects.":[212]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-08T00:00:00"}
