{"id":"https://openalex.org/W7220831990","doi":"https://doi.org/10.1038/s41467-026-78357-4","title":"The Wnt co-receptor Arrow-LRP5/6 is required for planar cell polarity establishment in Drosophila","display_name":"The Wnt co-receptor Arrow-LRP5/6 is required for planar cell polarity establishment in Drosophila","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220831990","doi":"https://doi.org/10.1038/s41467-026-78357-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/41040177","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12485699"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-026-78357-4","doi":"https://doi.org/10.1038/s41467-026-78357-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-78357-4","pdf_url":"https://www.nature.com/articles/s41467-026-78357-4_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-026-78357-4_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157828437","display_name":"Ursula Weber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ursula Weber","raw_affiliation_strings":["Department of Cell, Developmental, & Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Department of Stem Cell Biology & Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell, Developmental, & Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Stem Cell Biology & Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020168242","display_name":"Reza Farhadifar","orcid":"https://orcid.org/0000-0003-2792-5380","observed_orcids":["https://orcid.org/0000-0003-2792-5380"]},"institutions":[{"id":"https://openalex.org/I4210107338","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210107338"]},{"id":"https://openalex.org/I4387153999","display_name":"Flatiron Institute","ror":"https://ror.org/00sekdz59","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210107338","https://openalex.org/I4387153999"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reza Farhadifar","raw_affiliation_strings":["Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0003-2792-5380","affiliations":[{"raw_affiliation_string":"Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY, USA","institution_ids":["https://openalex.org/I4210107338","https://openalex.org/I4387153999"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022776643","display_name":"Marek Mlodzik","orcid":"https://orcid.org/0000-0002-0628-3465","observed_orcids":["https://orcid.org/0000-0002-0628-3465"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marek Mlodzik","raw_affiliation_strings":["Department of Cell, Developmental, & Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. marek.mlodzik@mssm.edu","Department of Stem Cell Biology & Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. marek.mlodzik@mssm.edu","Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. marek.mlodzik@mssm.edu"],"raw_orcid":"https://orcid.org/0000-0002-0628-3465","affiliations":[{"raw_affiliation_string":"Department of Cell, Developmental, & Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. marek.mlodzik@mssm.edu","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Stem Cell Biology & Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. marek.mlodzik@mssm.edu","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. marek.mlodzik@mssm.edu","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5022776643"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":2.9209,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.92618355,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"17","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arrow","display_name":"arrows","score":0.375},{"id":"https://openalex.org/keywords/lrp5-6","display_name":"LRP5/6","score":0.8920000195503235},{"id":"https://openalex.org/keywords/planar-cell-polarity","display_name":"planar cell polarity","score":0.8830000162124634},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9399999976158142},{"id":"https://openalex.org/keywords/frizzled-receptors","display_name":"Frizzled receptors","score":0.8309999704360962},{"id":"https://openalex.org/keywords/dishevelled","display_name":"Dishevelled","score":0.9800000190734863},{"id":"https://openalex.org/keywords/wnt4","display_name":"Wnt4","score":0.5070000290870667},{"id":"https://openalex.org/keywords/fmi","display_name":"FMI","score":0.574999988079071},{"id":"https://openalex.org/keywords/vang","display_name":"Vang","score":0.527999997138977},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.6800000071525574},{"id":"https://openalex.org/keywords/co-receptors","display_name":"co-receptors","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.7369999885559082},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7300000190734863},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.659600019454956},{"id":"https://openalex.org/C49353375","wikidata":"https://www.wikidata.org/wiki/Q189100","display_name":"Cell polarity","level":3,"score":0.5564000010490417},{"id":"https://openalex.org/C2777361361","wikidata":"https://www.wikidata.org/wiki/Q1112585","display_name":"Polarity (international relations)","level":3,"score":0.5357000231742859},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.508400022983551},{"id":"https://openalex.org/C136961756","wikidata":"https://www.wikidata.org/wiki/Q7431879","display_name":"Schneider 2 cells","level":5,"score":0.460099995136261},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4422000050544739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42820000648498535},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4271000027656555},{"id":"https://openalex.org/C2777379243","wikidata":"https://www.wikidata.org/wiki/Q1054318","display_name":"Drosophilidae","level":4,"score":0.3919000029563904},{"id":"https://openalex.org/C134786449","wikidata":"https://www.wikidata.org/wiki/Q3391255","display_name":"Planar","level":2,"score":0.35659998655319214},{"id":"https://openalex.org/C107300179","wikidata":"https://www.wikidata.org/wiki/Q41797887","display_name":"Frizzled","level":4,"score":0.301800012588501},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.27000001072883606},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2563000023365021}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1038/s41467-026-78357-4","doi":"https://doi.org/10.1038/s41467-026-78357-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-78357-4","pdf_url":"https://www.nature.com/articles/s41467-026-78357-4_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2025.09.22.677847","doi":"https://doi.org/10.1101/2025.09.22.677847","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.09.22.677847","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/09/22/2025.09.22.677847.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13737122","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13737122/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13737122/pdf/41467_2026_Article_78357.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:41040177","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41040177","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42982827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42982827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12485699","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12485699/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41467-026-78357-4","doi":"https://doi.org/10.1038/s41467-026-78357-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-78357-4","pdf_url":"https://www.nature.com/articles/s41467-026-78357-4_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1493670431","display_name":null,"funder_award_id":"P30CA196521","funder_id":"https://openalex.org/F4320309658","funder_display_name":"Icahn School of Medicine at Mount Sinai"},{"id":"https://openalex.org/G9000902349","display_name":"Wnt/Frizzled-PCP signaling in development and disease","funder_award_id":"R35GM127103","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000919019","display_name":"The Tisch Cancer Institute - Cancer Center Support Grant","funder_award_id":"P30CA196521","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000919467","display_name":"Retinal Patterning During Eye Development","funder_award_id":"R01EY013256","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320309658","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220831990.pdf","grobid_xml":"https://content.openalex.org/works/W7220831990.grobid-xml"},"referenced_works_count":102,"referenced_works":["https://openalex.org/W180685312","https://openalex.org/W191629038","https://openalex.org/W1504655784","https://openalex.org/W1508305548","https://openalex.org/W1532880128","https://openalex.org/W1639000772","https://openalex.org/W1895850272","https://openalex.org/W1925247458","https://openalex.org/W1964391716","https://openalex.org/W1965204519","https://openalex.org/W1967062108","https://openalex.org/W1969584971","https://openalex.org/W1972937465","https://openalex.org/W1973537879","https://openalex.org/W1974313494","https://openalex.org/W1974520977","https://openalex.org/W1974712344","https://openalex.org/W1978789471","https://openalex.org/W1981288139","https://openalex.org/W1982244603","https://openalex.org/W1994979890","https://openalex.org/W1996583924","https://openalex.org/W1997440450","https://openalex.org/W2003286575","https://openalex.org/W2004379183","https://openalex.org/W2005440429","https://openalex.org/W2013650195","https://openalex.org/W2013891209","https://openalex.org/W2016240460","https://openalex.org/W2016423968","https://openalex.org/W2017453813","https://openalex.org/W2020459782","https://openalex.org/W2022490526","https://openalex.org/W2025244901","https://openalex.org/W2027894846","https://openalex.org/W2037128138","https://openalex.org/W2037615799","https://openalex.org/W2045590006","https://openalex.org/W2045646256","https://openalex.org/W2047586015","https://openalex.org/W2048873522","https://openalex.org/W2055557491","https://openalex.org/W2059321472","https://openalex.org/W2067149878","https://openalex.org/W2067267062","https://openalex.org/W2070548790","https://openalex.org/W2082978552","https://openalex.org/W2084060837","https://openalex.org/W2090723435","https://openalex.org/W2091221784","https://openalex.org/W2092117239","https://openalex.org/W2098357545","https://openalex.org/W2102512027","https://openalex.org/W2103110972","https://openalex.org/W2105277147","https://openalex.org/W2113263838","https://openalex.org/W2115362868","https://openalex.org/W2115758207","https://openalex.org/W2117365121","https://openalex.org/W2117539897","https://openalex.org/W2120525124","https://openalex.org/W2120983879","https://openalex.org/W2120995883","https://openalex.org/W2126827442","https://openalex.org/W2127251425","https://openalex.org/W2135141227","https://openalex.org/W2140883347","https://openalex.org/W2146916662","https://openalex.org/W2147666645","https://openalex.org/W2148371810","https://openalex.org/W2150671475","https://openalex.org/W2158021558","https://openalex.org/W2158682440","https://openalex.org/W2163226407","https://openalex.org/W2166296674","https://openalex.org/W2168714984","https://openalex.org/W2181885838","https://openalex.org/W2182126747","https://openalex.org/W2183101660","https://openalex.org/W2186446143","https://openalex.org/W2363071306","https://openalex.org/W2412108038","https://openalex.org/W2560304181","https://openalex.org/W2738074786","https://openalex.org/W2756712429","https://openalex.org/W2779861385","https://openalex.org/W2946069141","https://openalex.org/W3006741484","https://openalex.org/W3050643703","https://openalex.org/W3081107588","https://openalex.org/W3081552745","https://openalex.org/W3084421525","https://openalex.org/W3127498961","https://openalex.org/W3159453404","https://openalex.org/W3216701260","https://openalex.org/W4301326813","https://openalex.org/W4360873894","https://openalex.org/W4384662859","https://openalex.org/W4388499952","https://openalex.org/W4404200305","https://openalex.org/W4406799240","https://openalex.org/W7099191931"],"related_works":["https://openalex.org/W4256095919","https://openalex.org/W2111113377","https://openalex.org/W4255935955","https://openalex.org/W1635607892","https://openalex.org/W3084421525","https://openalex.org/W3033118943","https://openalex.org/W1544465315","https://openalex.org/W1979775212","https://openalex.org/W3081552745","https://openalex.org/W2038556753"],"abstract_inverted_index":{"Wnt-signaling,":[0],"via":[1],"\u03b2-catenin":[2],"or":[3],"the":[4,26,116,155,161,165],"planar":[5],"cell":[6,132],"polarity":[7,84],"(PCP)":[8],"branch,":[9],"is":[10,25,52,63],"crucial":[11],"for":[12,45],"development,":[13],"tissue":[14,120],"homeostasis,":[15],"and":[16,41,50,81,104,127,130,142,164,170],"linked":[17],"to":[18,35,89,172],"many":[19],"diseases.":[20],"LRP5/6,":[21],"arrow/arr":[22],"in":[23,29,66,75,86,125,148,176],"Drosophila,":[24,70],"obligate":[27],"co-receptor":[28],"Wnt/\u03b2-catenin":[30],"signaling,":[31],"with":[32,94,110,123,160],"ligand":[33,156],"binding":[34],"a":[36,182],"Frizzled":[37],"(Fz)":[38],"family":[39],"member":[40],"LRP5/6.":[42],"Current":[43],"models":[44],"Wnt/PCP":[46,67],"signaling":[47,147],"omit":[48],"Arr-LRP5/6":[49],"PCP":[51,77,91,101,146,167,174,184],"presumed":[53],"functioning":[54],"without":[55],"these":[56],"co-receptors.":[57],"Here":[58],"we":[59],"show":[60],"that":[61,137],"arr-LRP5/6":[62,153],"fully":[64],"required":[65],"signaling.":[68],"In":[69,115],"loss":[71,82,98],"of":[72,83,99,107,186],"arr":[73,118],"results":[74],"aberrant":[76],"mediated":[78],"cellular":[79],"orientation":[80],"coordination":[85],"wings,":[87],"comparable":[88],"core":[90,166,183],"factors":[92,168],"mutations,":[93],"defects":[95,124,175],"manifest":[96],"as":[97],"asymmetric":[100],"factor":[102],"localization":[103],"reduced":[105],"levels":[106],"Dishevelled":[108],"(Dsh)":[109],"centrally":[111],"forming":[112],"wing":[113],"hairs.":[114],"eye,":[117],"mutant":[119],"displays":[121],"phenotypes":[122],"chirality":[126],"photoreceptors":[128],"R3":[129],"R4":[131],"fates.":[133],"Functional":[134],"interactions":[135],"indicate":[136],"Fz":[138],"can":[139],"recruit":[140],"Arr,":[141],"Arr":[143],"potentiates":[144],"Fz-Dsh":[145],"all":[149],"tissues":[150],"tested.":[151],"Furthermore,":[152],"sensitizes":[154],"pair":[157],"Wg,":[158],"Wnt4":[159],"receptor":[162],"fz,":[163],"fmi":[169],"Vang/stbm":[171],"cause":[173],"heterozygous":[177],"conditions.":[178],"Our":[179],"data":[180],"support":[181],"function":[185],"Arr-LRP5/6,":[187],"promoting":[188],"Wnt/Fz-Dsh":[189],"PCP-complex":[190],"activity.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-08T00:00:00"}
