{"id":"https://openalex.org/W7220831774","doi":"https://doi.org/10.3389/fmicb.2026.1948008","title":"SLA1 governs azole resistance in Candidozyma auris via mitochondrial ROS-driven efflux pump expression","display_name":"SLA1 governs azole resistance in Candidozyma auris via mitochondrial ROS-driven efflux pump expression","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220831774","doi":"https://doi.org/10.3389/fmicb.2026.1948008","pmid":"https://pubmed.ncbi.nlm.nih.gov/42908792","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13683593"},"language":"en","primary_location":{"id":"doi:10.3389/fmicb.2026.1948008","doi":"https://doi.org/10.3389/fmicb.2026.1948008","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1948008","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1948008/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1948008/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5151929657","display_name":"SUO Chenhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chenhao Suo","raw_affiliation_strings":["Department of Laboratory Animal Center, General Hospital of Northern Theater Command"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Animal Center, General Hospital of Northern Theater Command","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137349773","display_name":"Wanli Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanli Zhang","raw_affiliation_strings":["The State Key Laboratory of Pharmaceutical Biotechnology, Chemistry and Biomedicine Innovation Center (ChemBIC), Division of Immunology, Medical School, Nanjing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Pharmaceutical Biotechnology, Chemistry and Biomedicine Innovation Center (ChemBIC), Division of Immunology, Medical School, Nanjing University","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100332404","display_name":"Yuhan Li","orcid":"https://orcid.org/0000-0003-2277-8422","observed_orcids":["https://orcid.org/0000-0003-2277-8422"]},"institutions":[{"id":"https://openalex.org/I135836153","display_name":"Shenyang Agricultural University","ror":"https://ror.org/01n7x9n08","country_code":"CN","type":"education","lineage":["https://openalex.org/I135836153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhan Li","raw_affiliation_strings":["College of Animal Science and Veterinary Medicine, Shenyang Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Veterinary Medicine, Shenyang Agricultural University","institution_ids":["https://openalex.org/I135836153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157862993","display_name":"Chao Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Li","raw_affiliation_strings":["Department of Emergency Medicine, The Second Affiliated Hospital of Army Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, The Second Affiliated Hospital of Army Medical University","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157838827","display_name":"Yaning Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaning Cui","raw_affiliation_strings":["State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Hospital of China Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Hospital of China Medical University","institution_ids":["https://openalex.org/I4210140515","https://openalex.org/I4391768041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157838970","display_name":"Yuwei Xiao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuwei Xiao","raw_affiliation_strings":["Department of Laboratory Animal Center, General Hospital of Northern Theater Command"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Animal Center, General Hospital of Northern Theater Command","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157862713","display_name":"Jianjun Lei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianjun Lei","raw_affiliation_strings":["Department of Laboratory Animal Center, General Hospital of Northern Theater Command"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Animal Center, General Hospital of Northern Theater Command","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101311660","display_name":"Yiru Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]},{"id":"https://openalex.org/I9224756","display_name":"Northeastern University","ror":"https://ror.org/03awzbc87","country_code":"CN","type":"education","lineage":["https://openalex.org/I9224756"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Yiru Gao","raw_affiliation_strings":["College of Life and Health Science, Northeastern University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life and Health Science, Northeastern University","institution_ids":["https://openalex.org/I12912129","https://openalex.org/I9224756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157862447","display_name":"He Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"He Zhang","raw_affiliation_strings":["Department of Laboratory Animal Center, General Hospital of Northern Theater Command"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Animal Center, General Hospital of Northern Theater Command","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5101311660","https://openalex.org/A5157862447"],"corresponding_institution_ids":["https://openalex.org/I12912129","https://openalex.org/I9224756"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.75702801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1948008","last_page":"1948008"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11900","display_name":"Fungal Plant Pathogen Control","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-auris","display_name":"Candida auris","score":0.9649999737739563},{"id":"https://openalex.org/keywords/azole-resistance","display_name":"azole resistance","score":0.9179999828338623},{"id":"https://openalex.org/keywords/fluconazole-resistance","display_name":"fluconazole resistance","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.8040000200271606},{"id":"https://openalex.org/keywords/oxidative-stress-adaptation","display_name":"oxidative stress adaptation","score":0.828000009059906},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cell-envelope-integrity","display_name":"cell envelope integrity","score":0.75},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.7099999785423279},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.906000018119812},{"id":"https://openalex.org/keywords/antifungal-resistance","display_name":"antifungal resistance","score":0.6420000195503235},{"id":"https://openalex.org/keywords/cytoskeleton-organization","display_name":"cytoskeletal organization","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6687999963760376},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.6593000292778015},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6172000169754028},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.541100025177002},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5144000053405762},{"id":"https://openalex.org/C2780315139","wikidata":"https://www.wikidata.org/wiki/Q419639","display_name":"Azole","level":3,"score":0.49970000982284546},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.44760000705718994},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.4449000060558319},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4178999960422516},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.41749998927116394},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.38449999690055847},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.3804999887943268},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.3781000077724457},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.32580000162124634},{"id":"https://openalex.org/C2909786013","wikidata":"https://www.wikidata.org/wiki/Q26816853","display_name":"Candida auris","level":3,"score":0.3091000020503998},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.30799999833106995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2881999909877777},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.2685000002384186},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.26820001006126404},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2635999917984009},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.2605000138282776}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fmicb.2026.1948008","doi":"https://doi.org/10.3389/fmicb.2026.1948008","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1948008","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1948008/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13683593","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13683593/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13683593/pdf/fmicb-17-1948008.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Microbiol","raw_type":"Text"},{"id":"pmid:42908792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42908792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7c95174e991b44638ae18503e5aede96","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7c95174e991b44638ae18503e5aede96","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Microbiology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmicb.2026.1948008","doi":"https://doi.org/10.3389/fmicb.2026.1948008","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1948008","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1948008/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220831774.pdf","grobid_xml":"https://content.openalex.org/works/W7220831774.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W3213518945","https://openalex.org/W4206828264","https://openalex.org/W4210498051","https://openalex.org/W4210536773","https://openalex.org/W4211223844","https://openalex.org/W4283727654","https://openalex.org/W4283744632","https://openalex.org/W4292686138","https://openalex.org/W4308192662","https://openalex.org/W4323354595","https://openalex.org/W4384830561","https://openalex.org/W4388833028","https://openalex.org/W4389085493","https://openalex.org/W4389479375","https://openalex.org/W4390500402","https://openalex.org/W4391100789","https://openalex.org/W4391160543","https://openalex.org/W4393055189","https://openalex.org/W4399557644","https://openalex.org/W4400608832","https://openalex.org/W4401793964","https://openalex.org/W4401832357","https://openalex.org/W4402316504","https://openalex.org/W4403769442","https://openalex.org/W4403945393","https://openalex.org/W4404356483","https://openalex.org/W4404542595","https://openalex.org/W4404547554","https://openalex.org/W4405229927","https://openalex.org/W4409290644","https://openalex.org/W4410521054","https://openalex.org/W4410562342","https://openalex.org/W4411306614","https://openalex.org/W4411886860","https://openalex.org/W4412165109","https://openalex.org/W4412491511","https://openalex.org/W4412596199","https://openalex.org/W4412877884","https://openalex.org/W4413279951","https://openalex.org/W4413432708","https://openalex.org/W4413982225","https://openalex.org/W4414559001","https://openalex.org/W4415315501","https://openalex.org/W4416826902","https://openalex.org/W7116827782","https://openalex.org/W7118168814","https://openalex.org/W7127632293","https://openalex.org/W7129190404","https://openalex.org/W7135033050","https://openalex.org/W7155629181"],"related_works":["https://openalex.org/W4399363269","https://openalex.org/W4296515421","https://openalex.org/W7048932393","https://openalex.org/W2610842596","https://openalex.org/W7127961329","https://openalex.org/W7204215254","https://openalex.org/W3201107584","https://openalex.org/W3113903917","https://openalex.org/W2099126089","https://openalex.org/W7223189254"],"abstract_inverted_index":{"Introduction":[0],"Candidozyma":[1],"auris":[2,59,69,229,267,278],"is":[3],"an":[4],"emerging":[5],"multidrug-resistant":[6,276],"fungal":[7],"pathogen,":[8],"and":[9,79,88,104,119,125,142,162,185,206,224,240,268],"widespread":[10],"fluconazole":[11],"(FLC)":[12],"resistance":[13,56,174,249],"severely":[14],"limits":[15],"clinical":[16,128],"treatment":[17],"options.":[18],"Overexpression":[19],"of":[20,29,67,76,101,148,220,253,262],"the":[21,98,120,235,251],"efflux":[22],"transporter":[23],"CDR1":[24,89,126,140,156,207],"represents":[25],"a":[26,73,191,200,216,259,271],"major":[27],"driver":[28],"azole":[30,55,144,225,241],"resistance;":[31],"however,":[32],"how":[33],"oxidative":[34,51,221,238],"stress":[35,52,222,239],"modulates":[36],"this":[37],"process":[38],"remains":[39],"poorly":[40],"understood.":[41],"This":[42,166,211],"study":[43,212],"aimed":[44],"to":[45,96,270],"identify":[46],"novel":[47],"regulators":[48],"that":[49,168],"connect":[50],"adaptation":[53,223,264],"with":[54],"in":[57,116,187,227,265],"C.":[58,68,228,266,277],".":[60,70,230,279],"Methods":[61],"We":[62,82,110],"constructed":[63],"SLA1":[64,71,124,131,179,205,214,244],"deletion":[65,132],"mutants":[66],"encodes":[72],"conserved":[74],"regulator":[75],"cytoskeletal":[77],"organization":[78],"membrane":[80],"trafficking.":[81],"evaluated":[83],"mitochondrial":[84,92,105,134,177],"homeostasis,":[85],"mtROS":[86,137],"accumulation,":[87,138],"expression.":[90],"Pharmacological":[91,146],"perturbation":[93],"was":[94],"used":[95],"disentangle":[97],"individual":[99],"effects":[100],"ROS":[102,152,169],"accumulation":[103],"dysfunction":[106],"on":[107],"FLC":[108,164],"resistance.":[109,145,165,242],"further":[111,150],"assessed":[112],"cell":[113,182],"envelope":[114,183],"integrity,":[115],"vivo":[117,188],"virulence,":[118,189],"transcriptional":[121],"correlation":[122,203],"between":[123,204,237],"using":[127],"isolates.":[129],"Results":[130],"triggered":[133],"dysfunction,":[135],"increased":[136],"upregulated":[139],",":[141,157],"enhanced":[143],"disruption":[147],"mitochondria":[149],"raised":[151],"levels":[153],"yet":[154],"suppressed":[155],"depleted":[158],"ATP,":[159],"accumulated":[160],"NADH,":[161],"abolished":[163],"indicates":[167],"elevation":[170],"alone":[171],"cannot":[172],"sustain":[173],"under":[175],"severe":[176],"impairment.":[178],"knockout":[180],"compromised":[181],"integrity":[184],"attenuated":[186],"revealing":[190],"fitness":[192],"trade-off":[193],"during":[194],"antifungal":[195,248],"adaptation.":[196],"Clinical":[197],"isolates":[198],"exhibited":[199],"significant":[201],"inverse":[202],"transcript":[208],"levels.":[209],"Discussion":[210],"identifies":[213],"as":[215],"previously":[217],"uncharacterized":[218],"modulator":[219],"susceptibility":[226],"Mitochondrial":[231],"functional":[232],"status":[233],"governs":[234],"relationship":[236],"The":[243],"-dependent":[245],"axis":[246],"promotes":[247],"at":[250],"expense":[252],"reduced":[254],"virulence.":[255],"These":[256],"findings":[257],"reveal":[258],"new":[260],"mechanism":[261],"drug":[263],"point":[269],"potential":[272],"target":[273],"for":[274],"combating":[275]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-08T00:00:00"}