{"id":"https://openalex.org/W7220830381","doi":"https://doi.org/10.64898/2026.09.30.755655","title":"Vertical climbing in mice: a translationally relevant measure of pain-related impact on natural behaviour","display_name":"Vertical climbing in mice: a translationally relevant measure of pain-related impact on natural behaviour","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7220830381","doi":"https://doi.org/10.64898/2026.09.30.755655"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.30.755655","doi":"https://doi.org/10.64898/2026.09.30.755655","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.30.755655","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.09.30.755655.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.09.30.755655.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5128746289","display_name":"Morten E. Malmberg","orcid":"https://orcid.org/0009-0000-9849-080X","observed_orcids":["https://orcid.org/0009-0000-9849-080X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Morten E. Malmberg","raw_affiliation_strings":["University of Copenhagen;"],"raw_orcid":"https://orcid.org/0009-0000-9849-080X","affiliations":[{"raw_affiliation_string":"University of Copenhagen;","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118915157","display_name":"Tobias Bro","orcid":"https://orcid.org/0009-0009-9404-8243","observed_orcids":["https://orcid.org/0009-0009-9404-8243"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Tobias Bro","raw_affiliation_strings":["University of Copenhagen;"],"raw_orcid":"https://orcid.org/0009-0009-9404-8243","affiliations":[{"raw_affiliation_string":"University of Copenhagen;","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140539816","display_name":"Edward Ciputra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Edward Ciputra","raw_affiliation_strings":["University of Copenhagen;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Copenhagen;","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157809745","display_name":"Jannie Jutta Jeppesen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jannie Jutta Jeppesen","raw_affiliation_strings":["Copenhagen University Hospital;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Copenhagen University Hospital;","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104326964","display_name":"Carolyn Marie Goddard","orcid":"https://orcid.org/0009-0000-5356-1336","observed_orcids":["https://orcid.org/0009-0000-5356-1336"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Carolyn Marie Goddard","raw_affiliation_strings":["University of Copenhagen;"],"raw_orcid":"https://orcid.org/0009-0000-5356-1336","affiliations":[{"raw_affiliation_string":"University of Copenhagen;","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025853388","display_name":"Ida Buur Kanneworff","orcid":"https://orcid.org/0009-0002-5697-1271","observed_orcids":["https://orcid.org/0009-0002-5697-1271"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ida Buur Kanneworff","raw_affiliation_strings":["University of Copenhagen;"],"raw_orcid":"https://orcid.org/0009-0002-5697-1271","affiliations":[{"raw_affiliation_string":"University of Copenhagen;","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042842469","display_name":"Heather N. Allen","orcid":"https://orcid.org/0000-0003-0771-1959","observed_orcids":["https://orcid.org/0000-0003-0771-1959"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather N Allen","raw_affiliation_strings":["University of Florida;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida;","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063169896","display_name":"Helene Dragelund Garcia","orcid":"https://orcid.org/0000-0003-1303-1140","observed_orcids":["https://orcid.org/0000-0003-1303-1140"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Helene Dragelund Garcia","raw_affiliation_strings":["University of Copenhagen;"],"raw_orcid":"https://orcid.org/0000-0003-1303-1140","affiliations":[{"raw_affiliation_string":"University of Copenhagen;","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083833114","display_name":"Kathrine Louise Jensen","orcid":"https://orcid.org/0000-0001-8985-9126","observed_orcids":["https://orcid.org/0000-0001-8985-9126"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathrine Louise Jensen","raw_affiliation_strings":["Zyneyro;"],"raw_orcid":"https://orcid.org/0000-0001-8985-9126","affiliations":[{"raw_affiliation_string":"Zyneyro;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107095336","display_name":"Yingyu Tang","orcid":"https://orcid.org/0009-0007-3490-6694","observed_orcids":["https://orcid.org/0009-0007-3490-6694"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Yingyu Tang","raw_affiliation_strings":["University of Copenhagen;"],"raw_orcid":"https://orcid.org/0009-0007-3490-6694","affiliations":[{"raw_affiliation_string":"University of Copenhagen;","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079082651","display_name":"Pernille Colding-J\u00f8rgensen","orcid":"https://orcid.org/0000-0002-0163-1790","observed_orcids":["https://orcid.org/0000-0002-0163-1790"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Pernille Colding Joergensen","raw_affiliation_strings":["University of Copenhagen;"],"raw_orcid":"https://orcid.org/0000-0002-0163-1790","affiliations":[{"raw_affiliation_string":"University of Copenhagen;","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157873339","display_name":"Kholud Walid El Masri","orcid":"https://orcid.org/0009-0005-6876-1687","observed_orcids":["https://orcid.org/0009-0005-6876-1687"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kholud Walid El Masri","raw_affiliation_strings":["University of Copenhagen;"],"raw_orcid":"https://orcid.org/0009-0005-6876-1687","affiliations":[{"raw_affiliation_string":"University of Copenhagen;","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157845958","display_name":"Andrea Soeberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Andrea Soeberg","raw_affiliation_strings":["University of Copenhagen;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Copenhagen;","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157824550","display_name":"Astrid Thostrup Davidsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Astrid Thostrup Davidsen","raw_affiliation_strings":["University of Copenhagen;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Copenhagen;","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116574055","display_name":"Naomi K Grabus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naomi K Grabus","raw_affiliation_strings":["University of Florida;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida;","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048707153","display_name":"Karina Obelitz\u2010Ryom","orcid":"https://orcid.org/0000-0002-2771-4842","observed_orcids":["https://orcid.org/0000-0002-2771-4842"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Karina Obelitz-Ryom","raw_affiliation_strings":["Copenhagen University Hospital;"],"raw_orcid":"https://orcid.org/0000-0002-2771-4842","affiliations":[{"raw_affiliation_string":"Copenhagen University Hospital;","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011457704","display_name":"Anja Holm","orcid":"https://orcid.org/0000-0001-8796-1872","observed_orcids":["https://orcid.org/0000-0001-8796-1872"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anja Holm","raw_affiliation_strings":["Copenhagen University Hospital;"],"raw_orcid":"https://orcid.org/0000-0001-8796-1872","affiliations":[{"raw_affiliation_string":"Copenhagen University Hospital;","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087143360","display_name":"Sarah Louise Christensen","orcid":"https://orcid.org/0000-0002-7985-4783","observed_orcids":["https://orcid.org/0000-0002-7985-4783"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Sarah Louise T Christensen","raw_affiliation_strings":["Copenhagen University Hospital;"],"raw_orcid":"https://orcid.org/0000-0002-7985-4783","affiliations":[{"raw_affiliation_string":"Copenhagen University Hospital;","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056733085","display_name":"Chelsea Hopkins","orcid":"https://orcid.org/0000-0003-1320-7644","observed_orcids":["https://orcid.org/0000-0003-1320-7644"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chelsea Hopkins","raw_affiliation_strings":["University of Glasgow"],"raw_orcid":"https://orcid.org/0000-0003-1320-7644","affiliations":[{"raw_affiliation_string":"University of Glasgow","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045727011","display_name":"Anne\u2010Marie Heegaard","orcid":"https://orcid.org/0000-0003-2754-0800","observed_orcids":["https://orcid.org/0000-0003-2754-0800"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anne-Marie Heegaard","raw_affiliation_strings":["University of Copenhagen;"],"raw_orcid":"https://orcid.org/0000-0003-2754-0800","affiliations":[{"raw_affiliation_string":"University of Copenhagen;","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071960807","display_name":"Kenneth Lindegaard Madsen","orcid":"https://orcid.org/0000-0001-9274-6691","observed_orcids":["https://orcid.org/0000-0001-9274-6691"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kenneth Lindegaard Madsen","raw_affiliation_strings":["University of Copenhagen;"],"raw_orcid":"https://orcid.org/0000-0001-9274-6691","affiliations":[{"raw_affiliation_string":"University of Copenhagen;","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085580232","display_name":"Andreas Toft S\u00f8rensen","orcid":"https://orcid.org/0000-0001-5887-9247","observed_orcids":["https://orcid.org/0000-0001-5887-9247"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Toft Sorensen","raw_affiliation_strings":["Zyneyro;"],"raw_orcid":"https://orcid.org/0000-0001-5887-9247","affiliations":[{"raw_affiliation_string":"Zyneyro;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012031138","display_name":"Rajesh Khanna","orcid":"https://orcid.org/0000-0002-9066-2969","observed_orcids":["https://orcid.org/0000-0002-9066-2969"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajesh Khanna","raw_affiliation_strings":["University of Florida;"],"raw_orcid":"https://orcid.org/0000-0002-9066-2969","affiliations":[{"raw_affiliation_string":"University of Florida;","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049450993","display_name":"Klas Abelson","orcid":"https://orcid.org/0000-0002-4986-7882","observed_orcids":["https://orcid.org/0000-0002-4986-7882"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Klas SP Abelson","raw_affiliation_strings":["University of Copenhagen;"],"raw_orcid":"https://orcid.org/0000-0002-4986-7882","affiliations":[{"raw_affiliation_string":"University of Copenhagen;","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013205812","display_name":"Otto Kalliokoski","orcid":"https://orcid.org/0000-0001-6531-3487","observed_orcids":["https://orcid.org/0000-0001-6531-3487"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Otto Kalliokoski","raw_affiliation_strings":["University of Copenhagen;"],"raw_orcid":"https://orcid.org/0000-0001-6531-3487","affiliations":[{"raw_affiliation_string":"University of Copenhagen;","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016924881","display_name":"Sara Hestehave","orcid":"https://orcid.org/0000-0002-1837-521X","observed_orcids":["https://orcid.org/0000-0002-1837-521X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Sara Hestehave","raw_affiliation_strings":["University of Copenhagen;"],"raw_orcid":"https://orcid.org/0000-0002-1837-521X","affiliations":[{"raw_affiliation_string":"University of Copenhagen;","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5016924881"],"corresponding_institution_ids":["https://openalex.org/I124055696"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.02199999988079071,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vertical-climbing","display_name":"vertical climbing","score":0.9160000085830688},{"id":"https://openalex.org/keywords/pain-outcome-measures","display_name":"pain outcome measures","score":0.531000018119812},{"id":"https://openalex.org/keywords/translational-pain-research","display_name":"translational pain research","score":0.734000027179718},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.7649999856948853},{"id":"https://openalex.org/keywords/postoperative-pain","display_name":"postoperative pain","score":0.6690000295639038},{"id":"https://openalex.org/keywords/inflammatory-pain","display_name":"inflammatory pain","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cancer-induced-bone-pain","display_name":"cancer-induced bone pain","score":0.8479999899864197},{"id":"https://openalex.org/keywords/fibrous-dysplasia","display_name":"fibrous dysplasia","score":0.9229999780654907},{"id":"https://openalex.org/keywords/facial-neuropathy","display_name":"facial neuropathy","score":0.921999990940094},{"id":"https://openalex.org/keywords/gabapentin","display_name":"gabapentin","score":0.8450000286102295},{"id":"https://openalex.org/keywords/naltrexone","display_name":"naltrexone","score":0.996999979019165},{"id":"https://openalex.org/keywords/mechanical-allodynia","display_name":"mechanical allodynia","score":0.7720000147819519},{"id":"https://openalex.org/keywords/mouse-behavior","display_name":"mouse behavior","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C95038775","wikidata":"https://www.wikidata.org/wiki/Q22857","display_name":"Climbing","level":2,"score":0.9427000284194946},{"id":"https://openalex.org/C2777972943","wikidata":"https://www.wikidata.org/wiki/Q409587","display_name":"Naltrexone","level":4,"score":0.6184999942779541},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.5896999835968018},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5152000188827515},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.35109999775886536},{"id":"https://openalex.org/C2780009758","wikidata":"https://www.wikidata.org/wiki/Q6804172","display_name":"Measure (data warehouse)","level":2,"score":0.3206000030040741},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3037000000476837},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.29660001397132874},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2935999929904938},{"id":"https://openalex.org/C2780773136","wikidata":"https://www.wikidata.org/wiki/Q3396223","display_name":"Pongidae","level":2,"score":0.29249998927116394},{"id":"https://openalex.org/C2776436953","wikidata":"https://www.wikidata.org/wiki/Q5163215","display_name":"Consistency (knowledge bases)","level":2,"score":0.2904999852180481},{"id":"https://openalex.org/C2776608144","wikidata":"https://www.wikidata.org/wiki/Q410352","display_name":"Gabapentin","level":3,"score":0.2881999909877777},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.275299996137619},{"id":"https://openalex.org/C3020172569","wikidata":"https://www.wikidata.org/wiki/Q967168","display_name":"Wheel running","level":2,"score":0.27149999141693115},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.2662999927997589},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2621000111103058},{"id":"https://openalex.org/C2778399450","wikidata":"https://www.wikidata.org/wiki/Q412221","display_name":"Clonidine","level":2,"score":0.26019999384880066},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.2599000036716461},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.2522999942302704}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.64898/2026.09.30.755655","doi":"https://doi.org/10.64898/2026.09.30.755655","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.30.755655","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.09.30.755655.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pure.atira.dk:openaire/18f109b6-c1b8-415b-a54b-72d844509c6c","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/18f109b6-c1b8-415b-a54b-72d844509c6c","pdf_url":"https://curis.ku.dk/ws/files/580891085/Vertical_climbing_in_mice.pdf","source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/preprint"}],"best_oa_location":{"id":"doi:10.64898/2026.09.30.755655","doi":"https://doi.org/10.64898/2026.09.30.755655","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.30.755655","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/07/2026.09.30.755655.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327253","display_name":"Novo Nordisk Foundation Center for Basic Metabolic Research","ror":"https://ror.org/02s32fb62"},{"id":"https://openalex.org/F4320330262","display_name":"Centro de Investiga\u00e7\u00e3o em Biomedicina","ror":"https://ror.org/00k3me475"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220830381.pdf","grobid_xml":"https://content.openalex.org/works/W7220830381.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4412208701","https://openalex.org/W4366210825","https://openalex.org/W2650664123","https://openalex.org/W4229040535","https://openalex.org/W7142577043","https://openalex.org/W3109858200","https://openalex.org/W4392542896","https://openalex.org/W6989266649","https://openalex.org/W2771017922","https://openalex.org/W2033571114"],"abstract_inverted_index":{"Despite":[0],"urgent":[1],"need":[2],"for":[3],"better":[4],"analgesics,":[5],"drug":[6],"development":[7],"has":[8],"been":[9],"complicated":[10],"by":[11,42,196],"incomplete":[12],"bench-to-bedside":[13],"translation.":[14],"A":[15],"likely":[16],"contributing":[17],"factor":[18],"is":[19,208],"the":[20,24,34,111,178],"poor":[21],"connection":[22],"between":[23],"experimenter-evoked":[25],"pain-related":[26,62,75,123,132,222],"measures":[27],"often":[28],"used":[29],"in":[30,54,70,103,170,181,194,225],"preclinical":[31],"models,":[32,105],"and":[33,67,96,113,175,217],"clinical":[35],"symptoms,":[36],"like":[37,153],"broader":[38],"functional":[39,223],"impairment,":[40],"reported":[41],"patients.":[43],"Here,":[44],"we":[45],"asked":[46],"whether":[47],"vertical":[48,206],"climbing,":[49],"a":[50,59,71,121,209,215],"species-specific":[51],"elective":[52,211],"behaviour":[53,119,212],"mice,":[55],"could":[56],"serve":[57],"as":[58,120],"measure":[60,220],"of":[61,74,79,115,118,141,221],"impairment.":[63],"We":[64],"tested":[65],"male":[66],"female":[68],"mice":[69,171,182],"wide":[72],"range":[73],"models":[76,78],"including":[77],"post-operative":[80],"pain,":[81,89,93],"inflammatory":[82],"injury,":[83,174],"osteoarthritis,":[84],"rheumatoid":[85],"arthritis,":[86],"cancer-induced":[87],"bone":[88],"fibrous":[90],"dysplasia,":[91],"neuropathic":[92,173],"migraine-related":[94],"pain":[95,192],"facial":[97],"neuropathy.":[98],"Vertical":[99],"climbing":[100,127,169,179,207],"was":[101,165],"reduced":[102],"all":[104],"across":[106],"five":[107],"different":[108],"laboratories,":[109],"demonstrating":[110],"robustness":[112],"consistency":[114],"this":[116],"type":[117],"novel":[122],"outcome":[124],"measure.":[125],"Reduced":[126],"correlated":[128],"significantly":[129],"with":[130,149,172,190],"established":[131],"measures,":[133],"but":[134],"its":[135],"time":[136],"course":[137],"diverged":[138],"from":[139,186],"that":[140,183,204,213],"evoked":[142],"mechanical":[143],"allodynia,":[144],"while":[145],"aligned":[146],"more":[147],"closely":[148],"other":[150],"non-evoked":[151],"behaviours,":[152],"burrowing,":[154],"home":[155],"cage":[156],"activity,":[157],"wheel":[158],"running":[159],"or":[160],"weight":[161],"bearing.":[162],"Pharmacological":[163],"validation":[164],"bidirectional:":[166],"gabapentin":[167],"restored":[168],"naltrexone":[176],"reinstated":[177],"deficit":[180],"had":[184],"recovered":[185],"intraplantar":[187],"CFA,":[188],"consistent":[189],"persistent":[191],"held":[193],"remission":[195],"endogenous":[197],"opioid":[198],"signalling.":[199],"Overall,":[200],"our":[201],"results":[202],"indicate":[203],"voluntary":[205],"stable,":[210],"provides":[214],"robust":[216],"translationally":[218],"relevant":[219],"impairment":[224],"mice.":[226]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-08T00:00:00"}