{"id":"https://openalex.org/W7220806477","doi":null,"title":"Generative digital twins for longitudinal simulation and augmentation of multi-modal patient data","display_name":"Generative digital twins for longitudinal simulation and augmentation of multi-modal patient data","publication_year":2025,"publication_date":"2025-04-10","ids":{"openalex":"https://openalex.org/W7220806477"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/129388","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/129388","pdf_url":"https://www.ideals.illinois.edu/items/136429/bitstreams/445876/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ideals.illinois.edu/items/136429/bitstreams/445876/data.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018694879","display_name":"Brandon Theodorou","orcid":"https://orcid.org/0000-0002-8926-2378","observed_orcids":["https://orcid.org/0000-0002-8926-2378"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Theodorou, Brandon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5018694879"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.18459999561309814,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10350","display_name":"Electronic Health Records Systems","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-electronic-health-records","display_name":"synthetic electronic health records","score":0.890999972820282},{"id":"https://openalex.org/keywords/data-privacy","display_name":"data privacy","score":0.5320000052452087},{"id":"https://openalex.org/keywords/data-augmentation","display_name":"data augmentation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/diagnostic-imaging","display_name":"diagnostic imaging","score":0.5920000076293945},{"id":"https://openalex.org/keywords/data-repair","display_name":"data repair","score":0.5400000214576721},{"id":"https://openalex.org/keywords/data-quality","display_name":"data quality","score":0.46799999475479126},{"id":"https://openalex.org/keywords/data-sharing","display_name":"data sharing","score":0.531000018119812},{"id":"https://openalex.org/keywords/dataset-bias","display_name":"data bias","score":0.328000009059906},{"id":"https://openalex.org/keywords/missing-data","display_name":"missing data","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.623199999332428},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5333999991416931},{"id":"https://openalex.org/C3018822202","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Patient data","level":2,"score":0.44780001044273376},{"id":"https://openalex.org/C39890363","wikidata":"https://www.wikidata.org/wiki/Q36108","display_name":"Generative grammar","level":2,"score":0.4318999946117401},{"id":"https://openalex.org/C3020672099","wikidata":"https://www.wikidata.org/wiki/Q857354","display_name":"Longitudinal data","level":2,"score":0.38749998807907104},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.3804999887943268},{"id":"https://openalex.org/C167966045","wikidata":"https://www.wikidata.org/wiki/Q5532625","display_name":"Generative model","level":3,"score":0.32749998569488525},{"id":"https://openalex.org/C51632099","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Training set","level":2,"score":0.2953000068664551},{"id":"https://openalex.org/C133462117","wikidata":"https://www.wikidata.org/wiki/Q4929239","display_name":"Data collection","level":2,"score":0.257099986076355},{"id":"https://openalex.org/C126042441","wikidata":"https://www.wikidata.org/wiki/Q1324888","display_name":"Frame (networking)","level":2,"score":0.2533000111579895}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/129388","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/129388","pdf_url":"https://www.ideals.illinois.edu/items/136429/bitstreams/445876/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"}],"best_oa_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/129388","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/129388","pdf_url":"https://www.ideals.illinois.edu/items/136429/bitstreams/445876/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220806477.pdf","grobid_xml":"https://content.openalex.org/works/W7220806477.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W2157016683","https://openalex.org/W2543774860","https://openalex.org/W2964029788","https://openalex.org/W2965435808","https://openalex.org/W2965570621","https://openalex.org/W3092609815","https://openalex.org/W3094502228","https://openalex.org/W3110257065","https://openalex.org/W3133542152","https://openalex.org/W3175343838","https://openalex.org/W3200691852","https://openalex.org/W3213836217","https://openalex.org/W4221155892","https://openalex.org/W4308614312","https://openalex.org/W4366208220","https://openalex.org/W4372336638","https://openalex.org/W4378576258","https://openalex.org/W4388092421","https://openalex.org/W4393632381","https://openalex.org/W4394659038","https://openalex.org/W7133229083"],"related_works":["https://openalex.org/W7171725244","https://openalex.org/W7223116830","https://openalex.org/W7115928026","https://openalex.org/W6903941525","https://openalex.org/W6960119226","https://openalex.org/W7171694318","https://openalex.org/W2996331803","https://openalex.org/W7027801483","https://openalex.org/W4393138189","https://openalex.org/W7161271262"],"abstract_inverted_index":{"Generative":[0,148],"modeling":[1],"and":[2,23,40,69,79,100,140,158,168,186,198,213,234,249,257,282,298,309,313,328,337],"digital":[3,91,191],"twin":[4,92,192],"technologies":[5],"have":[6],"emerged":[7],"as":[8,34,334,342],"transformative":[9],"approaches":[10,193],"to":[11,95,120,136,156,209,225,240,265,287,291,304,318,321,348],"addressing":[12],"critical":[13,206],"challenges":[14,86],"in":[15,31,47,275],"healthcare,":[16],"particularly":[17],"regarding":[18],"data":[19,63,77,122,126,178,210],"availability,":[20],"privacy,":[21,214],"completeness,":[22],"quality.While":[24],"machine":[25,222],"learning":[26,223],"has":[27],"demonstrated":[28],"significant":[29],"potential":[30,219],"areas":[32],"such":[33],"patient":[35,103,232],"outcome":[36],"prediction,":[37],"drug":[38],"discovery,":[39],"clinical":[41,49,230],"trial":[42],"optimization,":[43],"its":[44],"widespread":[45],"application":[46],"real-world":[48,201],"settings":[50],"remains":[51],"constrained":[52],"by":[53,87],"the":[54,196,352],"inherent":[55,138],"limitations":[56,60],"of":[57,74,113,132,171,175,200,254,272,277,351,354],"medical":[58,154,176],"data.These":[59],"include":[61],"fragmented":[62],"repositories,":[64],"modality-specific":[65],"gaps,":[66],"missing":[67],"data,":[68],"stringent":[70],"privacy":[71],"requirements,":[72],"all":[73,253,271,350],"which":[75],"restrict":[76],"sharing":[78,123],"integration.My":[80],"PhD":[81],"research":[82,105,356],"addresses":[83],"these":[84,189],"fundamental":[85],"developing":[88],"innovative":[89],"generative":[90,145,190],"frameworks":[93],"designed":[94],"robustly":[96],"simulate,":[97],"repair,":[98],"augment,":[99],"enhance":[101],"multi-modal":[102,202],"data.This":[104],"comprises":[106],"several":[107],"key":[108],"methodological":[109],"contributions:":[110],"(i)":[111],"Generation":[112],"privatized":[114],"synthetic":[115],"electronic":[116],"health":[117],"records":[118],"(EHRs)":[119],"facilitate":[121],"without":[124],"compromising":[125],"quality":[127,141],"or":[128],"realism;":[129],"(ii)":[130],"Enhancement":[131],"existing":[133],"EHR":[134],"datasets":[135,160],"address":[137],"biases":[139],"concerns":[142],"through":[143],"advanced":[144,221],"modeling;":[146],"(iii)":[147],"augmentation":[149],"techniques":[150,224],"specifically":[151],"tailored":[152],"for":[153,220,252,270,302,332],"imaging":[155,177],"repair":[157],"complete":[159],"via":[161],"conditional":[162],"simulation,":[163],"improving":[164],"downstream":[165],"analytical":[166],"performance;":[167],"(iv)":[169],"Creation":[170],"universal,":[172],"modality-agnostic":[173],"representations":[174],"that":[179],"enable":[180],"robust":[181],"model":[182],"development":[183],"despite":[184],"heterogeneous":[185],"limited":[187],"datasets.Collectively,":[188],"significantly":[194],"improve":[195],"usability":[197],"integrity":[199],"healthcare":[203,236],"data.By":[204],"overcoming":[205],"barriers":[207],"related":[208],"incompleteness,":[211],"fragmentation,":[212],"this":[215,260],"work":[216],"unlocks":[217],"greater":[218],"be":[226],"practically":[227],"applied,":[228],"enhancing":[229],"decision-making,":[231],"care,":[233],"overall":[235],"outcomes.I":[237],"would":[238,262,316,346],"like":[239,264,317,347],"thank":[241,266],"my":[242,245,278,280,283,289,307,340,355],"family,":[243],"including":[244],"wife,":[246],"parents,":[247],"sister,":[248],"everyone":[250],"else":[251],"their":[255],"love":[256],"support":[258],"throughout":[259,339],"process.I":[261],"also":[263],"Professor":[267,292,295],"Jimeng":[268],"Sun":[269],"his":[273],"guidance":[274],"each":[276],"research,":[279],"academics,":[281],"career.Next,":[284],"I":[285,315,345],"want":[286],"express":[288],"gratitude":[290],"Arindam":[293],"Banerjee,":[294],"Jim":[296],"Rehg,":[297],"Dr.":[299,322,325,329],"Cao":[300,323],"Xiao":[301],"agreeing":[303],"serve":[305],"on":[306],"committee":[308],"providing":[310],"invaluable":[311],"feedback":[312],"advice.Additionally,":[314],"show":[319],"appreciation":[320],"Xiao,":[324],"Lucas":[326],"Glass,":[327],"Faraz":[330],"Faghri":[331],"serving":[333],"both":[335],"collaborators":[336],"mentors":[338],"growth":[341],"a":[343],"researcher.Furthermore,":[344],"recognize":[349],"members":[353],"lab":[357]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-07T00:00:00"}