{"id":"https://openalex.org/W7220762147","doi":null,"title":"Hepatic phospholipid remodeling in metabolic disorders","display_name":"Hepatic phospholipid remodeling in metabolic disorders","publication_year":2023,"publication_date":"2023-11-27","ids":{"openalex":"https://openalex.org/W7220762147"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/121982","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/121982","pdf_url":"https://www.ideals.illinois.edu/items/129172/bitstreams/431021/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ideals.illinois.edu/items/129172/bitstreams/431021/data.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157663601","display_name":"Ye Tian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tian, Ye","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5157663601"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.5346999764442444,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.5346999764442444,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.3310999870300293,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lpcat3","display_name":"LPCAT3","score":0.8370000123977661},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.878000020980835},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hepatic-glucose-production","display_name":"hepatic glucose production","score":0.8939999938011169},{"id":"https://openalex.org/keywords/fgf21","display_name":"FGF21","score":0.984000027179718},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.753000020980835},{"id":"https://openalex.org/keywords/adipose-tissue-glucose-uptake","display_name":"adipose tissue glucose uptake","score":0.9520000219345093},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.6119999885559082},{"id":"https://openalex.org/keywords/membrane-phospholipid-composition","display_name":"membrane phospholipid composition","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4828000068664551},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.3847000002861023},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3831999897956848},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.364300012588501},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35929998755455017},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3522000014781952},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.30379998683929443},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.28999999165534973},{"id":"https://openalex.org/C2908801736","wikidata":"https://www.wikidata.org/wiki/Q9368","display_name":"Liver metabolism","level":2,"score":0.2736000120639801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24979999661445618}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/121982","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/121982","pdf_url":"https://www.ideals.illinois.edu/items/129172/bitstreams/431021/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/121982","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/121982","pdf_url":"https://www.ideals.illinois.edu/items/129172/bitstreams/431021/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220762147.pdf","grobid_xml":"https://content.openalex.org/works/W7220762147.grobid-xml"},"referenced_works_count":319,"referenced_works":["https://openalex.org/W1476543482","https://openalex.org/W1500080863","https://openalex.org/W1506621956","https://openalex.org/W1564861448","https://openalex.org/W1575864823","https://openalex.org/W1685802105","https://openalex.org/W1830916533","https://openalex.org/W1901372019","https://openalex.org/W1966549856","https://openalex.org/W1967968986","https://openalex.org/W1969660985","https://openalex.org/W1969706853","https://openalex.org/W1970160164","https://openalex.org/W1971050831","https://openalex.org/W1971557848","https://openalex.org/W1972416270","https://openalex.org/W1973939264","https://openalex.org/W1974083452","https://openalex.org/W1975794822","https://openalex.org/W1976336399","https://openalex.org/W1980440749","https://openalex.org/W1983477298","https://openalex.org/W1984821297","https://openalex.org/W1987015736","https://openalex.org/W1988476536","https://openalex.org/W1988760657","https://openalex.org/W1989026904","https://openalex.org/W1991655565","https://openalex.org/W1995353658","https://openalex.org/W1998265194","https://openalex.org/W2000081372","https://openalex.org/W2000537121","https://openalex.org/W2001425475","https://openalex.org/W2002757015","https://openalex.org/W2008688211","https://openalex.org/W2009138882","https://openalex.org/W2012652496","https://openalex.org/W2013898467","https://openalex.org/W2014631569","https://openalex.org/W2015140940","https://openalex.org/W2015256188","https://openalex.org/W2016161059","https://openalex.org/W2016322846","https://openalex.org/W2017511982","https://openalex.org/W2018762738","https://openalex.org/W2019010829","https://openalex.org/W2022657181","https://openalex.org/W2025139842","https://openalex.org/W2026529462","https://openalex.org/W2029958712","https://openalex.org/W2030727312","https://openalex.org/W2034150302","https://openalex.org/W2035816889","https://openalex.org/W2038831349","https://openalex.org/W2038961236","https://openalex.org/W2039703352","https://openalex.org/W2054311777","https://openalex.org/W2056442594","https://openalex.org/W2057843591","https://openalex.org/W2062059387","https://openalex.org/W2064695336","https://openalex.org/W2067740038","https://openalex.org/W2068053039","https://openalex.org/W2069366328","https://openalex.org/W2070053386","https://openalex.org/W2071991978","https://openalex.org/W2076598575","https://openalex.org/W2076687053","https://openalex.org/W2079355772","https://openalex.org/W2080092217","https://openalex.org/W2081271380","https://openalex.org/W2082164921","https://openalex.org/W2085243036","https://openalex.org/W2085390667","https://openalex.org/W2086102771","https://openalex.org/W2090697965","https://openalex.org/W2093361250","https://openalex.org/W2093824918","https://openalex.org/W2093976705","https://openalex.org/W2096629131","https://openalex.org/W2096727743","https://openalex.org/W2097533439","https://openalex.org/W2098591455","https://openalex.org/W2098974443","https://openalex.org/W2100573537","https://openalex.org/W2103042528","https://openalex.org/W2103845188","https://openalex.org/W2104439004","https://openalex.org/W2104816318","https://openalex.org/W2106515170","https://openalex.org/W2107943478","https://openalex.org/W2111653877","https://openalex.org/W2114650931","https://openalex.org/W2115801316","https://openalex.org/W2121351699","https://openalex.org/W2123098050","https://openalex.org/W2125872855","https://openalex.org/W2126317966","https://openalex.org/W2128817061","https://openalex.org/W2128963767","https://openalex.org/W2133396278","https://openalex.org/W2133706171","https://openalex.org/W2133770419","https://openalex.org/W2134944069","https://openalex.org/W2135009079","https://openalex.org/W2139636031","https://openalex.org/W2139807366","https://openalex.org/W2142769596","https://openalex.org/W2144408228","https://openalex.org/W2146632745","https://openalex.org/W2147086344","https://openalex.org/W2147259528","https://openalex.org/W2148563903","https://openalex.org/W2149476546","https://openalex.org/W2150961941","https://openalex.org/W2152311269","https://openalex.org/W2153974854","https://openalex.org/W2154914594","https://openalex.org/W2155676489","https://openalex.org/W2156760391","https://openalex.org/W2158477352","https://openalex.org/W2158603948","https://openalex.org/W2158619126","https://openalex.org/W2159988116","https://openalex.org/W2160347316","https://openalex.org/W2161690611","https://openalex.org/W2161925283","https://openalex.org/W2162633290","https://openalex.org/W2163572207","https://openalex.org/W2167898988","https://openalex.org/W2168929358","https://openalex.org/W2169456326","https://openalex.org/W2170150986","https://openalex.org/W2179438025","https://openalex.org/W2182190275","https://openalex.org/W2199001876","https://openalex.org/W2205982384","https://openalex.org/W2210672989","https://openalex.org/W2230222215","https://openalex.org/W2236161220","https://openalex.org/W2262495123","https://openalex.org/W2265009122","https://openalex.org/W2270265950","https://openalex.org/W2303094910","https://openalex.org/W2332137635","https://openalex.org/W2332282497","https://openalex.org/W2333834718","https://openalex.org/W2336377425","https://openalex.org/W2346205130","https://openalex.org/W2359667967","https://openalex.org/W2405373297","https://openalex.org/W2415876542","https://openalex.org/W2488598394","https://openalex.org/W2519479884","https://openalex.org/W2520590970","https://openalex.org/W2523163592","https://openalex.org/W2548058740","https://openalex.org/W2553725030","https://openalex.org/W2591567957","https://openalex.org/W2599649240","https://openalex.org/W2602059628","https://openalex.org/W2605493286","https://openalex.org/W2606596305","https://openalex.org/W2609051652","https://openalex.org/W2613180696","https://openalex.org/W2619003201","https://openalex.org/W2735896722","https://openalex.org/W2743155225","https://openalex.org/W2747598946","https://openalex.org/W2759997926","https://openalex.org/W2763635492","https://openalex.org/W2767801219","https://openalex.org/W2770129291","https://openalex.org/W2772781313","https://openalex.org/W2774743973","https://openalex.org/W2779749520","https://openalex.org/W2784611114","https://openalex.org/W2786209083","https://openalex.org/W2788261792","https://openalex.org/W2789232986","https://openalex.org/W2789833091","https://openalex.org/W2790198401","https://openalex.org/W2790705492","https://openalex.org/W2795187531","https://openalex.org/W2795702337","https://openalex.org/W2803214510","https://openalex.org/W2808548053","https://openalex.org/W2810166530","https://openalex.org/W2810423511","https://openalex.org/W2884907724","https://openalex.org/W2886865853","https://openalex.org/W2890819762","https://openalex.org/W2891007226","https://openalex.org/W2894504469","https://openalex.org/W2896758254","https://openalex.org/W2897277000","https://openalex.org/W2898846041","https://openalex.org/W2899043265","https://openalex.org/W2899384460","https://openalex.org/W2899457119","https://openalex.org/W2900089257","https://openalex.org/W2906984192","https://openalex.org/W2912766252","https://openalex.org/W2929623625","https://openalex.org/W2934425456","https://openalex.org/W2937870159","https://openalex.org/W2941033601","https://openalex.org/W2941241726","https://openalex.org/W2943053066","https://openalex.org/W2944723988","https://openalex.org/W2944774501","https://openalex.org/W2947535015","https://openalex.org/W2949260941","https://openalex.org/W2950464315","https://openalex.org/W2955961495","https://openalex.org/W2961810377","https://openalex.org/W2964122735","https://openalex.org/W2969632049","https://openalex.org/W2969841699","https://openalex.org/W2969928163","https://openalex.org/W2971269466","https://openalex.org/W2972605348","https://openalex.org/W2973125925","https://openalex.org/W2974758394","https://openalex.org/W2976391621","https://openalex.org/W2980926085","https://openalex.org/W2981129394","https://openalex.org/W2982178384","https://openalex.org/W2983777909","https://openalex.org/W2987979134","https://openalex.org/W2990303726","https://openalex.org/W2991127841","https://openalex.org/W2993083975","https://openalex.org/W3000479870","https://openalex.org/W3004350202","https://openalex.org/W3005992462","https://openalex.org/W3009258273","https://openalex.org/W3011157697","https://openalex.org/W3011781546","https://openalex.org/W3014806942","https://openalex.org/W3014941724","https://openalex.org/W3015361084","https://openalex.org/W3016050178","https://openalex.org/W3029979731","https://openalex.org/W3032349611","https://openalex.org/W3033502398","https://openalex.org/W3035690333","https://openalex.org/W3036753141","https://openalex.org/W3036971773","https://openalex.org/W3037761084","https://openalex.org/W3045964060","https://openalex.org/W3047927732","https://openalex.org/W3048842392","https://openalex.org/W3081770539","https://openalex.org/W3081986616","https://openalex.org/W3082989514","https://openalex.org/W3084740474","https://openalex.org/W3086213814","https://openalex.org/W3087320494","https://openalex.org/W3087544811","https://openalex.org/W3089284732","https://openalex.org/W3100423115","https://openalex.org/W3103984707","https://openalex.org/W3106037240","https://openalex.org/W3109831279","https://openalex.org/W3111037701","https://openalex.org/W3111390227","https://openalex.org/W3117083078","https://openalex.org/W3117151028","https://openalex.org/W3119743465","https://openalex.org/W3124041059","https://openalex.org/W3126379854","https://openalex.org/W3129190575","https://openalex.org/W3131972496","https://openalex.org/W3133249754","https://openalex.org/W3153262091","https://openalex.org/W3161775233","https://openalex.org/W3163858333","https://openalex.org/W3164845562","https://openalex.org/W3167467420","https://openalex.org/W3173421961","https://openalex.org/W3181456162","https://openalex.org/W3182732609","https://openalex.org/W3184395450","https://openalex.org/W3197515876","https://openalex.org/W3203570622","https://openalex.org/W3207086349","https://openalex.org/W3209079142","https://openalex.org/W3216340137","https://openalex.org/W4200035916","https://openalex.org/W4200415237","https://openalex.org/W4200471271","https://openalex.org/W4210503972","https://openalex.org/W4213415596","https://openalex.org/W4223538540","https://openalex.org/W4224211323","https://openalex.org/W4234319976","https://openalex.org/W4240449862","https://openalex.org/W4280608682","https://openalex.org/W4282945007","https://openalex.org/W4283159936","https://openalex.org/W4283257487","https://openalex.org/W4283696069","https://openalex.org/W4284962315","https://openalex.org/W4288010199","https://openalex.org/W4293522720","https://openalex.org/W4305013887","https://openalex.org/W4308149416","https://openalex.org/W4316507314","https://openalex.org/W4318940447","https://openalex.org/W4320717239","https://openalex.org/W4321077653","https://openalex.org/W4362460079","https://openalex.org/W4363677464","https://openalex.org/W4366782395","https://openalex.org/W4367179757","https://openalex.org/W4383198320","https://openalex.org/W4386158268","https://openalex.org/W4386283147"],"related_works":["https://openalex.org/W7220800046","https://openalex.org/W2409845837","https://openalex.org/W4292753326","https://openalex.org/W2414445588","https://openalex.org/W2403064484","https://openalex.org/W4384947020","https://openalex.org/W7039400287","https://openalex.org/W2295999656","https://openalex.org/W2417596853","https://openalex.org/W2528574841"],"abstract_inverted_index":{"models.Mechanistically,":[0],"Lpcat3":[1,57],"deficiency":[2],"directly":[3],"facilitates":[4],"insulin":[5,45,54],"receptor":[6],"endocytosis,":[7],"signal":[8],"transduction":[9],"and":[10,15,26,36,47,53,70],"hepatic":[11,34],"glucose":[12,27],"production":[13],"suppression,":[14],"indirectly":[16],"enhances":[17],"fibroblast":[18],"growth":[19],"factor":[20],"21":[21],"(FGF21)":[22],"secretion,":[23],"energy":[24,48],"expenditure,":[25],"uptake":[28],"in":[29,56],"adipose":[30],"tissue.These":[31],"findings":[32],"identify":[33],"LPCAT3":[35],"membrane":[37],"phospholipid":[38],"composition":[39],"as":[40],"a":[41,65],"novel":[42],"regulator":[43],"of":[44,64,67,76],"sensitivity":[46],"metabolism.The":[49],"dissociation":[50],"between":[51],"NASH":[52,68],"resistance":[55],"liver":[58],"knockout":[59],"mice":[60],"recapitulated":[61],"the":[62,74],"phenotype":[63],"subpopulation":[66],"patients":[69],"shed":[71],"light":[72],"on":[73],"pathogenesis":[75],"metabolic":[77],"disorders.":[78]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-07T00:00:00"}
