{"id":"https://openalex.org/W7220737864","doi":"https://doi.org/10.1016/j.clinme.2026.100653","title":"Neuro-oncological emergencies requiring critical care intervention","display_name":"Neuro-oncological emergencies requiring critical care intervention","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7220737864","doi":"https://doi.org/10.1016/j.clinme.2026.100653","pmid":"https://pubmed.ncbi.nlm.nih.gov/42838418","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13697252"},"language":"en","primary_location":{"id":"doi:10.1016/j.clinme.2026.100653","doi":"https://doi.org/10.1016/j.clinme.2026.100653","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.clinme.2026.100653","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1470211826001028/pdf","source":{"id":"https://openalex.org/S186589310","display_name":"Clinical Medicine","issn_l":"1470-2118","issn":["1470-2118","1473-4893"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310311682","host_organization_name":"Royal College of Physicians","host_organization_lineage":["https://openalex.org/P4310311682"],"host_organization_lineage_names":["Royal College of Physicians"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1470211826001028/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010682361","display_name":"Joshua A. Kornbluth","orcid":"https://orcid.org/0000-0002-7676-6366","observed_orcids":["https://orcid.org/0000-0002-7676-6366"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joshua A. Kornbluth","raw_affiliation_strings":["Department of Neurology (Neurocritical Care), Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA. Electronic address: jkornbluth@tuftsmedicalcenter.org"],"raw_orcid":"https://orcid.org/0000-0002-7676-6366","affiliations":[{"raw_affiliation_string":"Department of Neurology (Neurocritical Care), Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA. Electronic address: jkornbluth@tuftsmedicalcenter.org","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147707124","display_name":"Jessica Wallace","orcid":"https://orcid.org/0000-0002-9796-584X","observed_orcids":["https://orcid.org/0000-0002-9796-584X"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Wallace","raw_affiliation_strings":["Department of Neurology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028359072","display_name":"David Y. Hwang","orcid":"https://orcid.org/0000-0002-2150-4289","observed_orcids":["https://orcid.org/0000-0002-2150-4289"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Y. Hwang","raw_affiliation_strings":["Division of Neurocritical Care, Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC, USA"],"raw_orcid":"https://orcid.org/0000-0002-2150-4289","affiliations":[{"raw_affiliation_string":"Division of Neurocritical Care, Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010682361"],"corresponding_institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":2.7418,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.93552135,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"26","issue":"5","first_page":"100653","last_page":"100653"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.35989999771118164,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.35989999771118164,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.2563000023365021,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.17430000007152557,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.9100000262260437},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.9390000104904175},{"id":"https://openalex.org/keywords/intracranial-hypertension","display_name":"intracranial hypertension","score":0.9380000233650208},{"id":"https://openalex.org/keywords/peritumoral-edema","display_name":"peritumoral edema","score":0.9800000190734863},{"id":"https://openalex.org/keywords/brain-herniation","display_name":"brain herniation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/seizures","display_name":"seizures","score":0.824999988079071},{"id":"https://openalex.org/keywords/status-epilepticus","display_name":"status epilepticus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nonconvulsive-status-epilepticus","display_name":"nonconvulsive status epilepticus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intracranial-hemorrhage","display_name":"intracranial hemorrhage","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acute-hydrocephalus","display_name":"acute hydrocephalus","score":0.9779999852180481},{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurocritical-care","display_name":"neurocritical care","score":0.8880000114440918},{"id":"https://openalex.org/keywords/neurosurgical-referral","display_name":"neurosurgical referral","score":0.6779999732971191},{"id":"https://openalex.org/keywords/goals-of-care","display_name":"goals of care","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9648000001907349},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.5734000205993652},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.5620999932289124},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.45419999957084656},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4156999886035919},{"id":"https://openalex.org/C203915360","wikidata":"https://www.wikidata.org/wiki/Q352454","display_name":"Critical care nursing","level":3,"score":0.35569998621940613},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3450999855995178},{"id":"https://openalex.org/C545288138","wikidata":"https://www.wikidata.org/wiki/Q860447","display_name":"Emergency medical services","level":2,"score":0.329800009727478},{"id":"https://openalex.org/C2984752397","wikidata":"https://www.wikidata.org/wiki/Q3259956","display_name":"Primary care","level":2,"score":0.24580000340938568},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.23659999668598175}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003422","descriptor_name":"Critical Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004630","descriptor_name":"Emergencies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D013226","descriptor_name":"Status Epilepticus","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D019586","descriptor_name":"Intracranial Hypertension","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D054556","descriptor_name":"Venous Thromboembolism","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.clinme.2026.100653","doi":"https://doi.org/10.1016/j.clinme.2026.100653","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.clinme.2026.100653","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1470211826001028/pdf","source":{"id":"https://openalex.org/S186589310","display_name":"Clinical Medicine","issn_l":"1470-2118","issn":["1470-2118","1473-4893"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310311682","host_organization_name":"Royal College of Physicians","host_organization_lineage":["https://openalex.org/P4310311682"],"host_organization_lineage_names":["Royal College of Physicians"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13697252","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13697252/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13697252/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Med (Lond)","raw_type":"Text"},{"id":"pmid:42838418","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42838418","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical medicine (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:bb33952021664ede85950700e7fc9600","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bb33952021664ede85950700e7fc9600","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Medicine, Vol 26, Iss 5, Pp 100653- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.clinme.2026.100653","doi":"https://doi.org/10.1016/j.clinme.2026.100653","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.clinme.2026.100653","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1470211826001028/pdf","source":{"id":"https://openalex.org/S186589310","display_name":"Clinical Medicine","issn_l":"1470-2118","issn":["1470-2118","1473-4893"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310311682","host_organization_name":"Royal College of Physicians","host_organization_lineage":["https://openalex.org/P4310311682"],"host_organization_lineage_names":["Royal College of Physicians"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220737864.pdf","grobid_xml":"https://content.openalex.org/works/W7220737864.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1971722995","https://openalex.org/W1976940945","https://openalex.org/W1985688848","https://openalex.org/W1995369709","https://openalex.org/W2029569324","https://openalex.org/W2252496421","https://openalex.org/W2345853022","https://openalex.org/W2905654445","https://openalex.org/W2980367337","https://openalex.org/W3013230683","https://openalex.org/W3030835493","https://openalex.org/W3032874098","https://openalex.org/W3145262237","https://openalex.org/W3174034807","https://openalex.org/W4226023675","https://openalex.org/W4283644627","https://openalex.org/W4389657646","https://openalex.org/W4399281866"],"related_works":["https://openalex.org/W3012555273","https://openalex.org/W7156003744","https://openalex.org/W3037783386","https://openalex.org/W4399783457","https://openalex.org/W2340875423","https://openalex.org/W4255285210","https://openalex.org/W4382723561","https://openalex.org/W2955193445","https://openalex.org/W2396197715","https://openalex.org/W2505120006"],"abstract_inverted_index":{"Patients":[0],"with":[1],"primary":[2],"or":[3],"metastatic":[4],"brain":[5],"tumours":[6],"can":[7],"deteriorate":[8],"abruptly,":[9],"and":[10,25,44,47,59,87,101,117,121],"the":[11,16,23,29,69,93,122],"acute":[12,57],"physician":[13,71],"is":[14,108],"often":[15],"first":[17],"to":[18,34,115],"respond.":[19],"This":[20],"review":[21],"covers":[22,64],"recognition":[24],"initial":[26],"management":[27],"of":[28,126,128],"neurological":[30],"emergencies":[31,67],"most":[32],"likely":[33],"need":[35],"critical":[36],"care:":[37],"raised":[38],"intracranial":[39,55],"pressure":[40],"from":[41],"peritumoural":[42],"oedema":[43],"herniation;":[45],"seizures":[46],"status":[48,52],"epilepticus,":[49],"including":[50],"non-convulsive":[51],"epilepticus":[53],"(NCSE);":[54],"haemorrhage;":[56],"hydrocephalus;":[58],"venous":[60],"thromboembolism.":[61],"It":[62],"also":[63],"two":[65],"treatment-related":[66],"that":[68],"general":[70],"must":[72],"now":[73],"recognise:":[74],"immune":[75,88],"effector":[76],"cell-associated":[77],"neurotoxicity":[78],"syndrome":[79],"after":[80],"chimeric":[81],"antigen":[82],"receptor":[83],"(CAR)":[84],"T-cell":[85],"therapy,":[86],"checkpoint":[89],"inhibitor":[90],"encephalitis.":[91],"Throughout,":[92],"text":[94],"indicates":[95],"whether":[96],"recommendations":[97],"rest":[98],"on":[99,103,109],"guidelines":[100],"where":[102],"observational":[104],"data.":[105],"The":[106],"focus":[107],"recognising":[110],"time-critical":[111],"treatment,":[112],"timely":[113],"escalation":[114],"neurosurgical":[116],"neurocritical":[118],"care":[119],"services,":[120],"early,":[123],"values-based":[124],"discussion":[125],"goals":[127],"care.":[129]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-07T00:00:00"}
