{"id":"https://openalex.org/W7220737832","doi":"https://doi.org/10.26434/chemrxiv.15009963/v1","title":"Single-Polynucleotide Encapsulation in Lipid Nanoparticles via Single-Step Assembly at Physiological pH","display_name":"Single-Polynucleotide Encapsulation in Lipid Nanoparticles via Single-Step Assembly at Physiological pH","publication_year":2026,"publication_date":"2026-10-06","ids":{"openalex":"https://openalex.org/W7220737832","doi":"https://doi.org/10.26434/chemrxiv.15009963/v1"},"language":"en","primary_location":{"id":"doi:10.26434/chemrxiv.15009963/v1","doi":"https://doi.org/10.26434/chemrxiv.15009963/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15009963/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009963/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009963/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5136450633","display_name":"GUICHONNET Maxime","orcid":"https://orcid.org/0009-0006-7340-0517","observed_orcids":["https://orcid.org/0009-0006-7340-0517"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I205747304","display_name":"Institut National Polytechnique de Toulouse","ror":"https://ror.org/033p9g875","country_code":"FR","type":"education","lineage":["https://openalex.org/I205747304"]},{"id":"https://openalex.org/I4210087602","display_name":"Laboratoire de G\u00e9nie Chimique","ror":"https://ror.org/003jnac13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I205747304","https://openalex.org/I4210087602","https://openalex.org/I4210095849","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Maxime Guichonnet","raw_affiliation_strings":["Laboratoire de G\u00e9nie Chimique","Universit\u00e9 de Toulouse, CNRS, INPT, UPS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de G\u00e9nie Chimique","institution_ids":["https://openalex.org/I4210087602"]},{"raw_affiliation_string":"Universit\u00e9 de Toulouse, CNRS, INPT, UPS","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I205747304","https://openalex.org/I4405258862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136404846","display_name":"MIRANDE-NEY Johanna","orcid":"https://orcid.org/0009-0001-0390-4449","observed_orcids":["https://orcid.org/0009-0001-0390-4449"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I205747304","display_name":"Institut National Polytechnique de Toulouse","ror":"https://ror.org/033p9g875","country_code":"FR","type":"education","lineage":["https://openalex.org/I205747304"]},{"id":"https://openalex.org/I4210087602","display_name":"Laboratoire de G\u00e9nie Chimique","ror":"https://ror.org/003jnac13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I205747304","https://openalex.org/I4210087602","https://openalex.org/I4210095849","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Johanna Mirande-Ney","raw_affiliation_strings":["Laboratoire de G\u00e9nie Chimique","Universit\u00e9 de Toulouse, CNRS, INPT, UPS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de G\u00e9nie Chimique","institution_ids":["https://openalex.org/I4210087602"]},{"raw_affiliation_string":"Universit\u00e9 de Toulouse, CNRS, INPT, UPS","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I205747304","https://openalex.org/I4405258862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005358998","display_name":"Anne-Sophie Kirstetter","orcid":"https://orcid.org/0000-0003-3896-5767","observed_orcids":["https://orcid.org/0000-0003-3896-5767"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I205747304","display_name":"Institut National Polytechnique de Toulouse","ror":"https://ror.org/033p9g875","country_code":"FR","type":"education","lineage":["https://openalex.org/I205747304"]},{"id":"https://openalex.org/I4210087602","display_name":"Laboratoire de G\u00e9nie Chimique","ror":"https://ror.org/003jnac13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I205747304","https://openalex.org/I4210087602","https://openalex.org/I4210095849","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne-Sophie Kirstetter","raw_affiliation_strings":["Laboratoire de G\u00e9nie Chimique","Universit\u00e9 de Toulouse, CNRS, INPT, UPS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de G\u00e9nie Chimique","institution_ids":["https://openalex.org/I4210087602"]},{"raw_affiliation_string":"Universit\u00e9 de Toulouse, CNRS, INPT, UPS","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I205747304","https://openalex.org/I4405258862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044677723","display_name":"Martine Meireles","orcid":"https://orcid.org/0000-0003-2112-0936","observed_orcids":["https://orcid.org/0000-0003-2112-0936"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I205747304","display_name":"Institut National Polytechnique de Toulouse","ror":"https://ror.org/033p9g875","country_code":"FR","type":"education","lineage":["https://openalex.org/I205747304"]},{"id":"https://openalex.org/I4210087602","display_name":"Laboratoire de G\u00e9nie Chimique","ror":"https://ror.org/003jnac13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I205747304","https://openalex.org/I4210087602","https://openalex.org/I4210095849","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Martine Meireles","raw_affiliation_strings":["Laboratoire de G\u00e9nie Chimique","Universit\u00e9 de Toulouse, CNRS, INPT, UPS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de G\u00e9nie Chimique","institution_ids":["https://openalex.org/I4210087602"]},{"raw_affiliation_string":"Universit\u00e9 de Toulouse, CNRS, INPT, UPS","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I205747304","https://openalex.org/I4405258862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051447891","display_name":"S\u00e9bastien Teychen\u00e9","orcid":"https://orcid.org/0000-0002-4840-1829","observed_orcids":["https://orcid.org/0000-0002-4840-1829"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I205747304","display_name":"Institut National Polytechnique de Toulouse","ror":"https://ror.org/033p9g875","country_code":"FR","type":"education","lineage":["https://openalex.org/I205747304"]},{"id":"https://openalex.org/I4210087602","display_name":"Laboratoire de G\u00e9nie Chimique","ror":"https://ror.org/003jnac13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I205747304","https://openalex.org/I4210087602","https://openalex.org/I4210095849","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S\u00e9bastien Teychen\u00e9","raw_affiliation_strings":["Laboratoire de G\u00e9nie Chimique","Universit\u00e9 de Toulouse, CNRS, INPT, UPS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de G\u00e9nie Chimique","institution_ids":["https://openalex.org/I4210087602"]},{"raw_affiliation_string":"Universit\u00e9 de Toulouse, CNRS, INPT, UPS","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I205747304","https://openalex.org/I4405258862"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086548455","display_name":"Kevin Roger","orcid":"https://orcid.org/0000-0001-7914-0951","observed_orcids":["https://orcid.org/0000-0001-7914-0951"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I205747304","display_name":"Institut National Polytechnique de Toulouse","ror":"https://ror.org/033p9g875","country_code":"FR","type":"education","lineage":["https://openalex.org/I205747304"]},{"id":"https://openalex.org/I4210087602","display_name":"Laboratoire de G\u00e9nie Chimique","ror":"https://ror.org/003jnac13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I205747304","https://openalex.org/I4210087602","https://openalex.org/I4210095849","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Kevin Roger","raw_affiliation_strings":["Laboratoire de G\u00e9nie Chimique","Universit\u00e9 de Toulouse, CNRS, INPT, UPS"],"raw_orcid":"https://orcid.org/0000-0001-7914-0951","affiliations":[{"raw_affiliation_string":"Laboratoire de G\u00e9nie Chimique","institution_ids":["https://openalex.org/I4210087602"]},{"raw_affiliation_string":"Universit\u00e9 de Toulouse, CNRS, INPT, UPS","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I205747304","https://openalex.org/I4405258862"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-nanoparticles","display_name":"lipid nanoparticles","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nonviral-gene-delivery","display_name":"non-viral gene delivery","score":0.7289999723434448},{"id":"https://openalex.org/keywords/solvent-exchange","display_name":"solvent exchange","score":0.8159999847412109},{"id":"https://openalex.org/keywords/assembly-pathways","display_name":"assembly pathways","score":0.6570000052452087},{"id":"https://openalex.org/keywords/pegylated-lipids","display_name":"PEGylated lipids","score":0.8740000128746033},{"id":"https://openalex.org/keywords/intracellular-delivery","display_name":"intracellular delivery","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6920999884605408},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6531000137329102},{"id":"https://openalex.org/C187428577","wikidata":"https://www.wikidata.org/wiki/Q898396","display_name":"Ionic strength","level":3,"score":0.5116000175476074},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.47839999198913574},{"id":"https://openalex.org/C111921641","wikidata":"https://www.wikidata.org/wiki/Q80756","display_name":"Polynucleotide","level":2,"score":0.4291999936103821},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4223000109195709},{"id":"https://openalex.org/C2182769","wikidata":"https://www.wikidata.org/wiki/Q62500","display_name":"Ionic bonding","level":3,"score":0.41339999437332153},{"id":"https://openalex.org/C138631740","wikidata":"https://www.wikidata.org/wiki/Q967847","display_name":"Nanomaterials","level":2,"score":0.412200003862381},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4106000065803528},{"id":"https://openalex.org/C11268172","wikidata":"https://www.wikidata.org/wiki/Q421110","display_name":"Micelle","level":3,"score":0.3977000117301941},{"id":"https://openalex.org/C30095370","wikidata":"https://www.wikidata.org/wiki/Q899488","display_name":"Protonation","level":3,"score":0.37860000133514404},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3765999972820282},{"id":"https://openalex.org/C146088050","wikidata":"https://www.wikidata.org/wiki/Q744818","display_name":"Transmission electron microscopy","level":2,"score":0.37040001153945923},{"id":"https://openalex.org/C66882249","wikidata":"https://www.wikidata.org/wiki/Q169336","display_name":"Homogeneous","level":2,"score":0.36399999260902405},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.33550000190734863},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.32499998807907104},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.323199987411499},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.32179999351501465},{"id":"https://openalex.org/C190818770","wikidata":"https://www.wikidata.org/wiki/Q6964123","display_name":"Nanoreactor","level":3,"score":0.3127000033855438},{"id":"https://openalex.org/C26856880","wikidata":"https://www.wikidata.org/wiki/Q910150","display_name":"Self-assembly","level":2,"score":0.3084000051021576},{"id":"https://openalex.org/C14631669","wikidata":"https://www.wikidata.org/wiki/Q896108","display_name":"Dynamic light scattering","level":3,"score":0.29989999532699585},{"id":"https://openalex.org/C67407626","wikidata":"https://www.wikidata.org/wiki/Q5723218","display_name":"Amphiphile","level":4,"score":0.27889999747276306},{"id":"https://openalex.org/C132841051","wikidata":"https://www.wikidata.org/wiki/Q4165337","display_name":"Small-angle neutron scattering","level":4,"score":0.27070000767707825},{"id":"https://openalex.org/C2776102837","wikidata":"https://www.wikidata.org/wiki/Q3132229","display_name":"Surfactin","level":4,"score":0.2703000009059906},{"id":"https://openalex.org/C131888329","wikidata":"https://www.wikidata.org/wiki/Q3027679","display_name":"Small-angle X-ray scattering","level":3,"score":0.263700008392334},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.26179999113082886},{"id":"https://openalex.org/C199529486","wikidata":"https://www.wikidata.org/wiki/Q7557912","display_name":"Solid lipid nanoparticle","level":3,"score":0.25600001215934753},{"id":"https://openalex.org/C104015590","wikidata":"https://www.wikidata.org/wiki/Q1451740","display_name":"Neutron scattering","level":3,"score":0.25040000677108765}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.26434/chemrxiv.15009963/v1","doi":"https://doi.org/10.26434/chemrxiv.15009963/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15009963/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009963/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.26434/chemrxiv.15009963/v1","doi":"https://doi.org/10.26434/chemrxiv.15009963/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15009963/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009963/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220737832.pdf","grobid_xml":"https://content.openalex.org/works/W7220737832.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4390619935","https://openalex.org/W7130558884","https://openalex.org/W4313622517","https://openalex.org/W6969346107","https://openalex.org/W4328107217","https://openalex.org/W4382796976","https://openalex.org/W4413847736","https://openalex.org/W4410975532","https://openalex.org/W2936110492","https://openalex.org/W4212776259"],"abstract_inverted_index":{"Lipid":[0],"nanoparticles":[1,57,173,205],"(LNPs)":[2],"are":[3],"the":[4,40,125,165],"leading":[5],"nonviral":[6],"platform":[7],"for":[8,48,190,238],"polynucleotide":[9,116],"delivery,":[10],"but":[11],"structural":[12,160],"heterogeneity":[13,242],"and":[14,23,93,97,155,180,206,217,232],"poorly":[15],"controlled":[16],"loading":[17,208],"states":[18],"limit":[19],"quantitative":[20],"structure\u2013function":[21],"analysis":[22],"rational":[24],"formulation":[25,86],"design.":[26],"Standard":[27],"protocols":[28],"use":[29],"rapid":[30,69,76,137],"mixing":[31,147],"under":[32],"acidic":[33,85],"conditions":[34],"followed":[35],"by":[36,164],"buffer":[37],"exchange,":[38,135],"reflecting":[39],"assumption":[41],"that":[42,55,124,158],"ionizable":[43],"lipid":[44,151],"protonation":[45],"is":[46,128,162],"required":[47],"nucleic":[49],"acid":[50],"complexation.":[51],"Here,":[52],"we":[53],"show":[54],"lipid\u2013polynucleotide":[56],"can":[58],"instead":[59],"be":[60],"assembled":[61],"directly":[62],"at":[63,243],"near-physiological":[64],"pH":[65,89,156],"through":[66],"a":[67,80,107,187,200,211,227,236],"single":[68],"micromixing":[70],"step.":[71],"Under":[72],"near-stoichiometric":[73],"lipid-to-polynucleotide":[74],"conditions,":[75,148],"solvent":[77,134],"exchange":[78],"yields":[79],"homogeneous":[81],"nanoparticle":[82,230],"population":[83],"without":[84],"or":[87],"post-assembly":[88],"adjustment.":[90],"Small-angle":[91],"X-ray":[92],"neutron":[94],"scattering":[95],"(SAXS":[96],"SANS),":[98],"together":[99],"with":[100,112],"cryogenic":[101],"transmission":[102],"electron":[103],"microscopy":[104],"(cryo-TEM),":[105],"reveal":[106],"common":[108],"core\u2013multishell":[109],"architecture":[110],"consistent":[111],"encapsulation":[113],"of":[114,146,229],"one":[115],"strand":[117],"per":[118],"particle.":[119],"In":[120],"situ":[121],"SAXS":[122],"shows":[123],"final":[126],"structure":[127,231],"established":[129],"within":[130],"submillisecond":[131],"timescales":[132],"during":[133],"indicating":[136],"cooperative":[138],"coassembly":[139],"rather":[140,168,246],"than":[141,169,247],"postmixing":[142],"restructuring.":[143],"Systematic":[144],"variation":[145],"stoichiometry,":[149],"PEGylated":[150],"content,":[152],"ionic":[153],"strength,":[154],"demonstrates":[157],"this":[159],"regime":[161],"selected":[163],"assembly":[166,198,224,234],"pathway":[167],"composition":[170],"alone.":[171],"The":[172],"remain":[174],"structurally":[175],"stable":[176],"over":[177],"extended":[178],"periods":[179],"retain":[181],"intracellular":[182],"delivery":[183],"activity,":[184],"while":[185],"providing":[186],"constrained":[188],"system":[189],"probing":[191],"formulation-dependent":[192],"effects.":[193],"These":[194],"results":[195],"establish":[196],"physiological-pH":[197],"as":[199,210,226,235],"route":[201],"to":[202],"pathway-selected":[203],"single-polynucleotide":[204],"identify":[207],"state":[209],"design":[212],"variable":[213],"alongside":[214],"composition,":[215],"size,":[216],"surface":[218],"chemistry.":[219],"More":[220],"broadly,":[221],"they":[222],"highlight":[223],"history":[225],"determinant":[228],"pathway-directed":[233],"strategy":[237],"controlling":[239],"soft":[240],"nanomaterial":[241],"its":[244],"origin":[245],"after":[248],"formation.":[249]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-10-07T00:00:00"}
